Cognitive Neurodynamics最新文献

{"title":"Differential behaviors of calcium-induced calcium release in one dimensional dendrite by Nernst-Planck equation, cable model and pure diffusion model.","authors":"Yinyun Li","doi":"10.1007/s11571-023-09952-0","DOIUrl":"10.1007/s11571-023-09952-0","url":null,"abstract":"<p><p>The source and dynamics of calcium is the key factor that regulates dendritic integration. Apart from the voltage-gated and ligand-gated calcium influx, an important source of calcium is from inner store of endoplasmic reticulum with a regenerative process of calcium-induced calcium release (CICR). To trigger this process, inositol 1,4,5-trisphosphate (IP₃) and calcium are needed to satisfy certain requirements. The aim of our paper is to investigate how the CICR depends on the dynamics of membrane potential. We utilize one dimensional dendritic model to calculate membrane potential by Nernst-Planck Equation (NPE) and cable model and Pure Diffusion (PD) model, computational simulations are carried out to inject the calcium influx by synaptic stimulation and to predict subsequent CICR and calcium wave propagation. Our results demonstrate that CICR initiation and calcium wave propagation have much difference between electro-diffusion process of NPE and cable model. We find that cable model has lower threshold of IP₃ stimulation to trigger CICR but is more difficult for calcium propagation than NPE, PD model requires even higher threshold of IP₃ to initiate CICR process and calcium duration is shorter than NPE; the regenerative calcium wave propagates with faster speed in NPE than that in cable model and in PD model. Our work addresses the important role of electro-diffusion dynamics of charged ions in regulating CICR process in dendritic structure; and provides theoretical predictions for neurological process which requires sustaining calcium for downstream signaling processes.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46187119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"People see what they want to see: an EEG study.","authors":"Heeseung Yu, Eunkyoung Han","doi":"10.1007/s11571-023-09982-8","DOIUrl":"10.1007/s11571-023-09982-8","url":null,"abstract":"<p><p>This study explored selective exposure and confirmation bias in the choices participants made about which political videos to watch, and whether their political positions changed after they watched videos that either agreed with or opposed their positions on two controversial issues in South Korea: North Korea policy and social welfare policy. The participants completed questionnaires before and after they watched the videos, were asked to select thumbnails of videos before they watched any, and had their brain wave activity measured through electroencephalogram (EEG) as they watched both types of videos. The participants demonstrated selective exposure as they primarily selected video thumbnails with content that matched their political orientations, and they demonstrated confirmation bias as their questionnaire responses after they watched the videos indicated that their positions had hardened. There were also statistically significant differences in alpha, beta, sensory motor rhythm, low beta, mid beta, and fast alpha activity depending on the political orientation consistency between the participants and the videos. Future studies could expand this line of research beyond college students and beyond Asia, and longitudinal work could also be conducted to determine if the obtained patterns remain constant over time.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47255559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.","authors":"Min Dai, Pei-Ji Liang","doi":"10.1007/s11571-023-09950-2","DOIUrl":"10.1007/s11571-023-09950-2","url":null,"abstract":"<p><p>Two coordinated dynamic properties (adaptation and sensitization) are observed in retinal ganglion cells (RGCs) under the contrast stimulation. During sustained high-contrast period, adaptation decreases RGCs' responses while sensitization increases RGCs' responses. In mouse retina, adaptation and sensitization respectively show OFF- and ON-pathway-dominance. However, the mechanisms which drive the differentiation between adaptation and sensitization remain unclear. In the present study, multi-electrode recordings were conducted on isolated mouse retina under full-field contrast stimulation. Dynamic property was quantified based on the trend of RGC's firing rate during high-contrast period, light sensitivity was estimated by linear-nonlinear analysis and coding ability was estimated through stimulus reconstruction algorism. γ-Aminobutyric acid (GABA) receptors were pharmacologically blocked to explore the relation between RGCs' dynamic property and the activity of GABA receptors. It was found that GABA_A and GABA_C receptors respectively mediated the adaptation and sensitization processes in RGCs' responses. RGCs' dynamic property changes occurred after the blockage of GABA receptors were related to the modulation of the cells' light sensitivity. Further, the blockage of GABA_A (GABA_C) receptor significantly decreased RGCs' overall coding ability and eliminated the functional benefits of adaptation (sensitization). Our work suggests that the dynamic property of individual RGC is related to the balance between its GABA_A-receptor-mediated inputs and GABA_C-receptor-mediated inputs. Blockage of GABA receptors breaks the balance of retinal circuitry for signal processing, and down-regulates the visual information coding ability.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-023-09950-2.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41430758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha band modulation caused by selective attention to music enables EEG classification.","authors":"Kana Mizokuchi, Toshihisa Tanaka, Takashi G Sato, Yoshifumi Shiraki","doi":"10.1007/s11571-023-09955-x","DOIUrl":"10.1007/s11571-023-09955-x","url":null,"abstract":"<p><p>Humans are able to pay selective attention to music or speech in the presence of multiple sounds. It has been reported that in the speech domain, selective attention enhances the cross-correlation between the envelope of speech and electroencephalogram (EEG) while also affecting the spatial modulation of the alpha band. However, when multiple music pieces are performed at the same time, it is unclear how selective attention affects neural entrainment and spatial modulation. In this paper, we hypothesized that the entrainment to the attended music differs from that to the unattended music and that spatial modulation in the alpha band occurs in conjunction with attention. We conducted experiments in which we presented musical excerpts to 15 participants, each listening to two excerpts simultaneously but paying attention to one of the two. The results showed that the cross-correlation function between the EEG signal and the envelope of the unattended melody had a more prominent peak than that of the attended melody, contrary to the findings for speech. In addition, the spatial modulation in the alpha band was found with a data-driven approach called the common spatial pattern method. Classification of the EEG signal with a support vector machine identified attended melodies and achieved an accuracy of 100% for 11 of the 15 participants. These results suggest that selective attention to music suppresses entrainment to the melody and that spatial modulation of the alpha band occurs in conjunction with attention. To the best of our knowledge, this is the first report to detect attended music consisting of several types of music notes only with EEG.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44399707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexity decline of hippocampal CA1 circuit model due to cholinergic deficiency associated with Alzheimer's disease.","authors":"YeZi Li, XiaoLi Yang, SiLu Yan, ZhongKui Sun","doi":"10.1007/s11571-023-09958-8","DOIUrl":"10.1007/s11571-023-09958-8","url":null,"abstract":"<p><p>A hallmark of Alzheimer's disease (AD) is cholinergic system dysfunction, directly affecting the hippocampal neurons. Previous experiments have demonstrated that reduced complexity is one significant effect of AD on electroencephalography (EEG). Motivated by these, this study explores reduced EEG complexity of cholinergic deficiency in AD by neurocomputation. We first construct a new hippocampal CA1 circuit model with cholinergic action. M-current <math><msub><mi>I</mi><mi>M</mi></msub></math> and calcium-activated potassium current <math><msub><mi>I</mi><mrow><mi>AHP</mi></mrow></msub></math> are newly introduced in the model to describe cholinergic input from the medial septum. Then, by enhancing <math><msub><mi>I</mi><mi>M</mi></msub></math> and <math><msub><mi>I</mi><mrow><mi>AHP</mi></mrow></msub></math> to mimic cholinergic deficiency, how cholinergic deficiency influences the model complexity is investigated by sample entropy (SampEn) and approximate entropy (ApEn). Numerical results show a more severe cholinergic deficit with lower model complexity. Furthermore, we conclude that the decline of SampEn and ApEn is due to the greatly diminished excitability of model neurons. These suggest that decreased neuronal excitability due to cholinergic impairment may contribute to reduced EEG complexity in AD. Subsequently, statistical analysis between simulated AD patients and normal control (NC) groups demonstrates that SampEn and auto-mutual-information (AMI) decrease rates significantly differ. Compared to NC, AD patients have a lower SampEn and a less negative AMI decline rate. These imply a low rate of new-generation information in AD brains with cholinergic deficits. Interestingly, the statistical correlation between SampEn and AMI is analyzed, and they have a large negative Pearson correlation coefficient. Thus, AMI reduction rates may be a complementary tool for complex analysis. Our modeling and complex analysis are expected to provide a deeper understanding of the reduced EEG complexity resulting from cholinergic deficiency.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45323489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mathematical derivation and mechanism analysis of beta oscillations in a cortex-pallidum model.","authors":"Minbo Xu, Bing Hu, Zhizhi Wang, Luyao Zhu, Jiahui Lin, Dingjiang Wang","doi":"10.1007/s11571-023-09951-1","DOIUrl":"10.1007/s11571-023-09951-1","url":null,"abstract":"<p><p>In this paper, we develop a new cortex-pallidum model to study the origin mechanism of Parkinson's oscillations in the cortex. In contrast to many previous models, the globus pallidus internal (GPi) and externa (GPe) both exert direct inhibitory feedback to the cortex. Using Hopf bifurcation analysis, two new critical conditions for oscillations, which can include the self-feedback projection of GPe, are obtained. In this paper, we find that the average discharge rate (ADR) is an important marker of oscillations, which can divide Hopf bifurcations into two types that can uniformly be used to explain the oscillation mechanism. Interestingly, the ADR of the cortex first increases and then decreases with increasing coupling weights that are projected to the GPe. Regarding the Hopf bifurcation critical conditions, the quantitative relationship between the inhibitory projection and excitatory projection to the GPe is monotonically increasing; in contrast, the relationship between different coupling weights in the cortex is monotonically decreasing. In general, the oscillation amplitude is the lowest near the bifurcation points and reaches the maximum value with the evolution of oscillations. The GPe is an effective target for deep brain stimulation to alleviate oscillations in the cortex.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46555643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the grid cell activity based on cognitive space transformation.","authors":"Zhihui Zhang, Fengzhen Tang, Yiping Li, Xisheng Feng","doi":"10.1007/s11571-023-09972-w","DOIUrl":"10.1007/s11571-023-09972-w","url":null,"abstract":"<p><p>The grid cells in the medial entorhinal cortex are widely recognized as a critical component of spatial cognition within the entorhinal-hippocampal neuronal circuits. To account for the hexagonal patterns, several computational models have been proposed. However, there is still considerable debate regarding the interaction between grid cells and place cells. In response, we have developed a novel grid-cell computational model based on cognitive space transformation, which established a theoretical framework of the interaction between place cells and grid cells for encoding and transforming positions between the local frame and global frame. Our model not only can generate the firing patterns of the grid cells but also reproduces the biological experiment results about the grid-cell global representation of connected environments and supports the conjecture about the underlying reason. Moreover, our model provides new insights into how grid cells and place cells integrate external and self-motion cues.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48712961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal avalanche dynamics regulated by spike-timing-dependent plasticity under different topologies and heterogeneities.","authors":"Jiayi Yang, Peihua Feng, Ying Wu","doi":"10.1007/s11571-023-09966-8","DOIUrl":"10.1007/s11571-023-09966-8","url":null,"abstract":"<p><p>Neuronal avalanches, a critical state of network self-organization, have been widely observed in electrophysiological records at different signal levels and spatial scales of the brain, which has significant influence on information transmission and processing in the brain. In this paper, the collective behavior of neuron firing is studied based on Leaky Integrate-and-Fire model and we induce spike-timing-dependent plasticity (STDP) to update the connection weight through competition between adjacent neurons in different network topologies. The result shows that STDP can facilitate the synchronization of the network and increase the probability of large-scale neuron avalanche obviously. Moreover, both the structure of STDP and network connection density can affect the generation of avalanche critical states, specifically, learning rate has positive correlation effect on the slope of power-law distribution and time constant has negative correction on it. However, when we the increase of heterogeneity in network, STDP can only has obvious promotion in synchrony under suitable level of heterogeneity. And we find that the process of long-term potentiation is sensitive to the adjustment of time constant and learning rate, unlike long-term depression, which is only sensitive to learning rate in heterogeneity network. It is suggested that presented results could facilitate our understanding on synchronization in various neural networks under the effect of STDP learning rules.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48727640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological and other features of working memory in older adults at risk for dementia.","authors":"Rachel A Patterson, Heather Brooks, Mina Mirjalili, Neda Rashidi-Ranjbar, Reza Zomorrodi, Daniel M Blumberger, Corinne E Fischer, Alastair J Flint, Ariel Graff-Guerrero, Nathan Herrmann, James L Kennedy, Sanjeev Kumar, Krista L Lanctôt, Linda Mah, Benoit H Mulsant, Bruce G Pollock, Aristotle N Voineskos, Wei Wang, Tarek K Rajji","doi":"10.1007/s11571-023-09938-y","DOIUrl":"10.1007/s11571-023-09938-y","url":null,"abstract":"<p><p>Theta-gamma coupling (TGC) is a neurophysiological process that supports working memory. Working memory is associated with other clinical and biological features. The extent to which TGC is associated with these other features and whether it contributes to working memory beyond these features is unknown. Two-hundred-and-three older participants at risk for Alzheimer's dementia-98 with mild cognitive impairment (MCI), 39 with major depressive disorder (MDD) in remission, and 66 with MCI and MDD (MCI + MDD)-completed a clinical assessment, N-back-EEG, and brain MRI. Among them, 190 completed genetic testing, and 121 completed [¹¹C] Pittsburgh Compound B ([11C] PIB) PET imaging. Hierarchical linear regressions were used to assess whether TGC is associated with demographic and clinical variables; Alzheimer's disease-related features (<i>APOE</i> ε4 carrier status and β-amyloid load); and structural features related to working memory. Then, linear regressions were used to assess whether TGC is associated with 2-back performance after accounting for these features. Other than age, TGC was not associated with any non-neurophysiological features. In contrast, TGC (β = 0.27; <i>p</i> = 0.006), age (β = - 0.29; <i>p</i> = 0.012), and parietal cortical thickness (β = 0.24; <i>p</i> = 0.020) were associated with 2-back performance. We also examined two other EEG features that are linked to working memory-theta event-related synchronization and alpha event-related desynchronization-and found them not to be associated with any feature or performance after accounting for TGC. Our findings suggest that TGC is a process that is independent of other clinical, genetic, neurochemical, and structural variables, and supports working memory in older adults at risk for dementia.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-023-09938-y.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48533353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing latent brain dynamics in Alzheimer's disease via recurrent neural network.","authors":"Tong Li, Jiang Wang, Shanshan Li, Kai Li","doi":"10.1007/s11571-023-09981-9","DOIUrl":"10.1007/s11571-023-09981-9","url":null,"abstract":"<p><p>The impairment of cognitive function in Alzheimer's disease (AD) is clearly correlated to abnormal changes in cortical rhythm. However, the mechanisms underlying this correlation are still poorly understood. Here, we investigate how network structure and dynamical characteristics alter their abnormal changes in cortical rhythm. To that end, biological data of AD and normal participates are collected. By extracting the energy characteristics of different sub-bands in EEG signals, we find that the rhythm of AD patients is special particularly in theta and alpha bands. The cortical rhythm of normal state is mainly at alpha band, while that of AD state shift to the theta band. Furthermore, recurrent neural network (RNN) is trained to explore the rhythm formation and transformation between two neural states from the perspective view of neurocomputation. It is found that the neural coupling strength decreases significantly under AD state when compared with normal state, which weakens the ability of information transmission in AD state. Besides, the low-dimensional properties of RNN are obtained. By analyzing the relationship between the cortical rhythm transition and the low-dimensional trajectory, it is concluded that the low-dimensional trajectory update is slower and the communication cost is higher in AD state, which explains the abnormal synchronization of AD brain network. Our work reveals the causes for the formation of abnormal brain synchronous functional network status, which may expand our understanding of the mechanism of cognitive impairment in AD and provide an EEG biomarker for early AD.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48231606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}