Zeinab A Dastgheib, Brian J Lithgow, Zahra K Moussavi
{"title":"重复经颅磁刺激对阿尔茨海默病症状的不同影响：来自前庭电成像的证据重复经颅磁刺激治疗能改变阿尔茨海默病的症状吗？这是显示谁将受益的线索。","authors":"Zeinab A Dastgheib, Brian J Lithgow, Zahra K Moussavi","doi":"10.1007/s11571-025-10310-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Repetitive transcranial magnetic stimulation (rTMS) has shown promise in enhancing cognitive function through neuroplasticity. This study investigates the impact of rTMS on Alzheimer's disease (AD) and AD with cerebrovascular disease (AD-CVD) symptomologies, using Electrovestibulography (EVestG).</p><p><strong>Methodology: </strong>Participants were recruited from a randomized, double-blind, placebo-controlled clinical trial on rTMS efficacy for mild to moderate AD. Thirty-five individuals who volunteered for the EVestG study (28 received active rTMS and 7 the sham treatment) were recorded at baseline, post-treatment, and two months' follow-up. EVestG recordings were analyzed to calculate normalized probability (NP) values for AD and AD-CVD symptomologies and compare with standard cognitive outcome.</p><p><strong>Results: </strong>Changes in NP values from pre to post active treatment showed improved participants exhibited opposite trends in AD and AD-CVD symptomologies compared to non-improved participants with a decrease in NP<sub>AD-CVD</sub> and a slight increase in NP<sub>AD</sub> value. Significant associations were found between changes in cognitive score and NP values, even after adjusting for age, sex, and multiple comparisons, indicating that patients with higher certainty of AD diagnosis (versus AD-CVD) were more likely to benefit from rTMS.</p><p><strong>Conclusion: </strong>These findings suggest rTMS cognitive improvement may result from reduced AD-CVD symptomatology, especially in patients with higher certainty of AD diagnoses, potentially due to increased cerebral blood flow (CBF).</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10310-5.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"120"},"PeriodicalIF":3.9000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311084/pdf/","citationCount":"0","resultStr":"{\"title\":\"Differential Impact of Repetitive Transcranial Magnetic Stimulation on Alzheimer's Disease Symptomology: Evidence from Electrovestibulography Does repetitive transcranial magnetic stimulation treatment alter Alzheimer's disease symptomology? a clue to show who will benefit.\",\"authors\":\"Zeinab A Dastgheib, Brian J Lithgow, Zahra K Moussavi\",\"doi\":\"10.1007/s11571-025-10310-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Repetitive transcranial magnetic stimulation (rTMS) has shown promise in enhancing cognitive function through neuroplasticity. This study investigates the impact of rTMS on Alzheimer's disease (AD) and AD with cerebrovascular disease (AD-CVD) symptomologies, using Electrovestibulography (EVestG).</p><p><strong>Methodology: </strong>Participants were recruited from a randomized, double-blind, placebo-controlled clinical trial on rTMS efficacy for mild to moderate AD. Thirty-five individuals who volunteered for the EVestG study (28 received active rTMS and 7 the sham treatment) were recorded at baseline, post-treatment, and two months' follow-up. EVestG recordings were analyzed to calculate normalized probability (NP) values for AD and AD-CVD symptomologies and compare with standard cognitive outcome.</p><p><strong>Results: </strong>Changes in NP values from pre to post active treatment showed improved participants exhibited opposite trends in AD and AD-CVD symptomologies compared to non-improved participants with a decrease in NP<sub>AD-CVD</sub> and a slight increase in NP<sub>AD</sub> value. 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Differential Impact of Repetitive Transcranial Magnetic Stimulation on Alzheimer's Disease Symptomology: Evidence from Electrovestibulography Does repetitive transcranial magnetic stimulation treatment alter Alzheimer's disease symptomology? a clue to show who will benefit.
Background: Repetitive transcranial magnetic stimulation (rTMS) has shown promise in enhancing cognitive function through neuroplasticity. This study investigates the impact of rTMS on Alzheimer's disease (AD) and AD with cerebrovascular disease (AD-CVD) symptomologies, using Electrovestibulography (EVestG).
Methodology: Participants were recruited from a randomized, double-blind, placebo-controlled clinical trial on rTMS efficacy for mild to moderate AD. Thirty-five individuals who volunteered for the EVestG study (28 received active rTMS and 7 the sham treatment) were recorded at baseline, post-treatment, and two months' follow-up. EVestG recordings were analyzed to calculate normalized probability (NP) values for AD and AD-CVD symptomologies and compare with standard cognitive outcome.
Results: Changes in NP values from pre to post active treatment showed improved participants exhibited opposite trends in AD and AD-CVD symptomologies compared to non-improved participants with a decrease in NPAD-CVD and a slight increase in NPAD value. Significant associations were found between changes in cognitive score and NP values, even after adjusting for age, sex, and multiple comparisons, indicating that patients with higher certainty of AD diagnosis (versus AD-CVD) were more likely to benefit from rTMS.
Conclusion: These findings suggest rTMS cognitive improvement may result from reduced AD-CVD symptomatology, especially in patients with higher certainty of AD diagnoses, potentially due to increased cerebral blood flow (CBF).
Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10310-5.
期刊介绍：
Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models.
The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome.
The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged.
1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics.
2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages.
3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.
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