Cold Spring Harbor perspectives in biology最新文献_第3页

Enteric Glia. 肠胶质细胞

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-04-01 DOI: 10.1101/cshperspect.a041368

Meenakshi Rao, Brian D Gulbransen

引用次数: 0

Rediscovering and Unrediscovering Gregor Mendel: His Life, Times, and Intellectual Context. 重新发现和重新发现格里高尔-孟德尔：他的生平、时代和思想背景》（Rediscovering and Unrediscovering Gregor Mendel: His Life, Times, and Intellectual Context.

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-04-01 DOI: 10.1101/cshperspect.a041812

Sander Gliboff

引用次数: 0

Physical Forces in Regeneration of Cells and Tissues. 细胞和组织再生中的物理力

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-04-01 DOI: 10.1101/cshperspect.a041527

Sindy K Y Tang, Wallace F Marshall

引用次数: 0

Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models. 组织活性物质：将力学和信号传导整合到动力学模型中。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-04-01 DOI: 10.1101/cshperspect.a041653

David B Brückner, Edouard Hannezo

{"title":"Tissue Active Matter: Integrating Mechanics and Signaling into Dynamical Models.","authors":"David B Brückner, Edouard Hannezo","doi":"10.1101/cshperspect.a041653","DOIUrl":"10.1101/cshperspect.a041653","url":null,"abstract":"The importance of physical forces in the morphogenesis, homeostatic function, and pathological dysfunction of multicellular tissues is being increasingly characterized, both theoretically and experimentally. Analogies between biological systems and inert materials such as foams, gels, and liquid crystals have provided striking insights into the core design principles underlying multicellular organization. However, these connections can seem surprising given that a key feature of multicellular systems is their ability to constantly consume energy, providing an active origin for the forces that they produce. Key emerging questions are, therefore, to understand whether and how this activity grants tissues novel properties that do not have counterparts in classical materials, as well as their consequences for biological function. Here, we review recent discoveries at the intersection of active matter and tissue biology, with an emphasis on how modeling and experiments can be combined to understand the dynamics of multicellular systems. These approaches suggest that a number of key biological tissue-scale phenomena, such as morphogenetic shape changes, collective migration, or fate decisions, share unifying design principles that can be described by physical models of tissue active matter.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facioscapulohumeral Dystrophy: Molecular Basis and Therapeutic Opportunities. 面岬肱骨营养不良症：分子基础和治疗机会。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-04-01 DOI: 10.1101/cshperspect.a041492

Tessa Arends, Danielle C Hamm, Silvère van der Maarel, Stephen J Tapscott

引用次数: 0

Epigenetics of Human Telomeres. 人类端粒的表观遗传学。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041706

Nicole Bettin, Mélina Vaurs, Anabelle Decottignies

{"title":"Epigenetics of Human Telomeres.","authors":"Nicole Bettin, Mélina Vaurs, Anabelle Decottignies","doi":"10.1101/cshperspect.a041706","DOIUrl":"https://doi.org/10.1101/cshperspect.a041706","url":null,"abstract":"Human telomeric heterochromatin is unusual in that it does not show the enrichment of canonical repressive histone marks H3K9me3 or H4K20me3 seen in constitutive heterochromatin. Instead, human telomeres exhibit both facultative heterochromatin and euchromatin marks, consistent with their epigenetically regulated transcription into TERRA noncoding RNA. Additionally, telomeric DNA is out of phase with the DNA helical repeat and has no nucleosome positioning signal. Yet, human telomeric DNA forms a columnar structure of tightly stacked nucleosomes, alternating with open states, and regulated by histone tails and shelterin protein binding. We discuss the proposed mechanisms regulating human telomeric chromatin and the consequences that telomeric chromatin properties have on various cellular processes, such as telomere transcription, the regulation of shelterin binding, and the activation of the alternative lengthening of telomeres mechanism. Together, we summarize current evidence on the combination of hetero- and euchromatic properties of human telomeres that may help explain their crucial protective functions and plasticity to regulate telomere maintenance pathways and damage signaling.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function. 在循环中：端粒重复的不寻常DNA结构及其对端粒功能的影响。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041694

Elia Zanella, Ylli Doksani

{"title":"In the Loop: Unusual DNA Structures at Telomeric Repeats and Their Impact on Telomere Function.","authors":"Elia Zanella, Ylli Doksani","doi":"10.1101/cshperspect.a041694","DOIUrl":"https://doi.org/10.1101/cshperspect.a041694","url":null,"abstract":"Telomeric repeats recruit the shelterin complex to prevent activation of the double-strand break response at chromosome ends. Thousands of TTAGGG repeats are present at each chromosome end to ensure telomere function. This abundance of G-rich repeats comes with the propensity to generate unusual DNA structures. The telomere loop (t-loop) structure, generated by strand invasion of the 3' overhang in the internal repeats, contributes to telomere function. G4-DNA is promoted by the stretches of G-rich repeats in a single-stranded form and may affect telomere replication and elongation by telomerase. The intramolecular homology can lead to the formation of internal loops (i-loops) via intramolecular recombination at sites of telomeric damage, which can promote the excision of telomeric repeats as extrachromosomal circular DNA. Shelterin promotes t-loops, counteracting the accumulation of pathological structures either directly or via the recruitment of specialized helicases. Here, we will discuss the current evidence for the formation of unusual DNA structures at telomeres and possible implications for telomere function.","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteins of the Triadic Excitation-Contraction Coupling Complex in Skeletal Muscle. 骨骼肌三联兴奋-收缩耦合复合体的蛋白质。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041482

Ting Chang, Rachel Sue Zhen Yee, George G Rodney, Susan L Hamilton

引用次数: 0

Telomeric Repeat-Containing RNA: Biogenesis, Regulation, and Functions. 端粒重复序列RNA：生物发生、调控和功能。

IF 6.9 2区生物学

Cold Spring Harbor perspectives in biology Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041683

Patricia L Abreu, Valentina Riva, Luca Zardoni, Claus M Azzalin

引用次数: 0

Telomeres and Human Disease. 端粒与人类疾病