斑马鱼：骨骼肌研究的经验教训和见解。

IF 8.4 2区生物学 Q1 CELL BIOLOGY

Cold Spring Harbor perspectives in biology Pub Date : 2025-07-28 DOI:10.1101/cshperspect.a041515

Yansong Lu, Avnika A Ruparelia, Peter D Currie

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引用次数: 0

摘要

基因组编辑能力和实时成像能力方面的最新技术进步大大增加了斑马鱼模型在骨骼肌研究中的应用，从而在调节骨骼肌生长、再生和疾病的细胞和分子过程中取得了重要发现。肌肉干细胞和祖细胞在生长过程中的动力学特性，驱动再生的新型细胞相互作用的可视化，以及复杂疾病机制和肌肉疾病潜在治疗方法的识别，都突出了这一点。本文综述了这些最新进展，并讨论了斑马鱼在骨骼肌研究中的局限性和未来方向，重点是肌肉生长、再生和疾病。

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Zebrafish: Lessons and Insights into Skeletal Muscle Research.

Recent technological advances in genome editing capabilities and live imaging capacities have greatly increased the use of the zebrafish model in skeletal muscle research, leading to critical discoveries in the cellular and molecular processes regulating skeletal muscle growth, regeneration, and disease. This is highlighted by the characterization of muscle stem cell and progenitor cell dynamics during growth, the visualization of novel cellular interactions driving regeneration, and the identification of complex disease mechanisms and potential therapies for muscle diseases. This review highlights these latest advancements and discuss the limitations and future directions of zebrafish in skeletal muscle research, focusing on muscle growth, regeneration, and disease.

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来源期刊

Cold Spring Harbor perspectives in biology CELL BIOLOGY-

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

3-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.