{"title":"Zebrafish: Lessons and Insights into Skeletal Muscle Research.","authors":"Yansong Lu, Avnika A Ruparelia, Peter D Currie","doi":"10.1101/cshperspect.a041515","DOIUrl":null,"url":null,"abstract":"<p><p>Recent technological advances in genome editing capabilities and live imaging capacities have greatly increased the use of the zebrafish model in skeletal muscle research, leading to critical discoveries in the cellular and molecular processes regulating skeletal muscle growth, regeneration, and disease. This is highlighted by the characterization of muscle stem cell and progenitor cell dynamics during growth, the visualization of novel cellular interactions driving regeneration, and the identification of complex disease mechanisms and potential therapies for muscle diseases. This review highlights these latest advancements and discuss the limitations and future directions of zebrafish in skeletal muscle research, focusing on muscle growth, regeneration, and disease.</p>","PeriodicalId":10494,"journal":{"name":"Cold Spring Harbor perspectives in biology","volume":" ","pages":""},"PeriodicalIF":8.4000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cold Spring Harbor perspectives in biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1101/cshperspect.a041515","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Recent technological advances in genome editing capabilities and live imaging capacities have greatly increased the use of the zebrafish model in skeletal muscle research, leading to critical discoveries in the cellular and molecular processes regulating skeletal muscle growth, regeneration, and disease. This is highlighted by the characterization of muscle stem cell and progenitor cell dynamics during growth, the visualization of novel cellular interactions driving regeneration, and the identification of complex disease mechanisms and potential therapies for muscle diseases. This review highlights these latest advancements and discuss the limitations and future directions of zebrafish in skeletal muscle research, focusing on muscle growth, regeneration, and disease.
期刊介绍：
Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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