Colloid and Interface Science Communications最新文献

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Enhanced microbiologically influenced corrosion resistance of 5Cr pipeline steel in the presence of Shewanella oneidensis MR-1 希瓦氏菌MR-1对5Cr管线钢耐腐蚀性能的影响
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.1016/j.colcom.2025.100841
Zehong Tian , Yufeng Zhang , Bei Liu , Lingke Li , Mingyu Li , Enze Zhou , Yameng Qi , Yalin Wu , Zhilin Li , Zishuai Zhou , Miaomiao Cui , Fuhui Wang , Dake Xu
{"title":"Enhanced microbiologically influenced corrosion resistance of 5Cr pipeline steel in the presence of Shewanella oneidensis MR-1","authors":"Zehong Tian ,&nbsp;Yufeng Zhang ,&nbsp;Bei Liu ,&nbsp;Lingke Li ,&nbsp;Mingyu Li ,&nbsp;Enze Zhou ,&nbsp;Yameng Qi ,&nbsp;Yalin Wu ,&nbsp;Zhilin Li ,&nbsp;Zishuai Zhou ,&nbsp;Miaomiao Cui ,&nbsp;Fuhui Wang ,&nbsp;Dake Xu","doi":"10.1016/j.colcom.2025.100841","DOIUrl":"10.1016/j.colcom.2025.100841","url":null,"abstract":"<div><div>Novel Cr-alloyed pipeline steels were developed, demonstrating exceptional resistance to microbiologically influenced corrosion (MIC). Particularly, the 5.0Cr steel exhibited remarkable mechanical properties with ultimate tensile strength reaching 878 MPa (1.25-fold higher than conventional X80 steel) while maintaining the elongation. In <em>Shewanella oneidensis</em> MR-1-containing environments, 5.0Cr steel displayed significantly lower corrosion metrics: weight loss (0.8 ± 0.3 mg cm<sup>−2</sup> vs. 18.1 ± 2.9 mg cm<sup>−2</sup> for X80 steel) and maximum pit depth (4.9 μm vs. 18.8 μm). This enhanced MIC resistance stems from a Cr-rich oxide layer that simultaneously inhibits bacterial adhesion (50 % biofilm thickness reduction) and restricts extracellular electron transfer (EET), as evidenced by 14-fold higher charge transfer resistance (30 kΩ cm<sup>2</sup> vs. 2 kΩ cm<sup>2</sup> for X80 steel). The findings establish a dual-protection mechanism through interfacial engineering of pipeline steel surfaces.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"67 ","pages":"Article 100841"},"PeriodicalIF":4.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multifunctional endothelial-mimetic surface: Synergistically combating thrombus formation by releasing nitric oxide, promoting fibrinolysis, and enhancing endothelialization 一种多功能的内皮模拟表面:通过释放一氧化氮,促进纤维蛋白溶解和增强内皮化来协同对抗血栓形成
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-07-01 Epub Date: 2025-05-19 DOI: 10.1016/j.colcom.2025.100847
Jun Sun , Sulei Zhang , Yichen Wang , Denghai Sheng , Shengjie Liu , Yu Rao , Aiqing Li , Yuchun Pan , John L. Brash , Xiaoli Liu , Hong Chen
{"title":"A multifunctional endothelial-mimetic surface: Synergistically combating thrombus formation by releasing nitric oxide, promoting fibrinolysis, and enhancing endothelialization","authors":"Jun Sun ,&nbsp;Sulei Zhang ,&nbsp;Yichen Wang ,&nbsp;Denghai Sheng ,&nbsp;Shengjie Liu ,&nbsp;Yu Rao ,&nbsp;Aiqing Li ,&nbsp;Yuchun Pan ,&nbsp;John L. Brash ,&nbsp;Xiaoli Liu ,&nbsp;Hong Chen","doi":"10.1016/j.colcom.2025.100847","DOIUrl":"10.1016/j.colcom.2025.100847","url":null,"abstract":"<div><div>Thrombus formation often leads to the failure of intravascular implants. Natural endothelium provides multifaceted antithrombotic functions through nitric oxide/ prostacyclin secretion to inhibit platelet activation, glycosaminoglycan mediated anticoagulation, and tissue-type plasminogen activator driven fibrinolysis. Therefore, surfaces mimicking these multiple endothelial functions are expected to have enhanced antithrombotic properties. In this study, polyvinyl chloride surface was rendered porous through solvent/nonsolvent-induced phase separation and loaded with a metal-organic framework, CuBTTri to catalyze nitric oxide release from a precursor. Furthermore, using layer-by-layer self-assembly, multiple bilayers of a poly(lysine-<em>co</em>-oligo(ethylene glycol) methyl ether methacrylate) copolymer (fibrinolysis-promoting), and sodium heparin (endothelial cell growth-promoting), were deposited on the un-etched side of the polyvinyl chloride. This modified surface was shown to be capable of releasing nitric oxide, destroying nascent thrombus, inhibiting smooth muscle cell growth, and promoting endothelial cell adhesion. This study represents a novel approach to developing multifunctional blood-contacting surfaces that mimic multiple properties of the endothelium.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"67 ","pages":"Article 100847"},"PeriodicalIF":4.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Responsive Janus emulsion as an unconventional indicator for a traditional argentometric titration 响应性 Janus 乳液作为传统精滴定法的非传统指示剂
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-03-15 DOI: 10.1016/j.colcom.2025.100827
Teodora Despotovski , Slavica Mitrović , Nikola Knežević , Milan Vraneš , Lidija Petrović , Marko Pavlović
{"title":"Responsive Janus emulsion as an unconventional indicator for a traditional argentometric titration","authors":"Teodora Despotovski ,&nbsp;Slavica Mitrović ,&nbsp;Nikola Knežević ,&nbsp;Milan Vraneš ,&nbsp;Lidija Petrović ,&nbsp;Marko Pavlović","doi":"10.1016/j.colcom.2025.100827","DOIUrl":"10.1016/j.colcom.2025.100827","url":null,"abstract":"<div><div>Argentometric titrations are traditional and widely recognized methods for detecting halide ions. However, their practical application is often constrained by challenges such as pH control and reliance on specific indicators. In this study, we introduce a novel optical indicator for argentometric titration, based on previously reported Janus droplet systems and employing cetyltrimethylammonium bromide (CTAB) and Zonyl as surfactants. Furthermore, Janus droplets were utilized to explore the impact of various cations on the efficiency of the CTAB surfactant, revealing that contact angle values are influenced by the cations' positions within the Hofmeister series.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100827"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioenergetic-active cryogels for potential application in wound healing 生物能量活性冷冻剂在伤口愈合中的潜在应用
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI: 10.1016/j.colcom.2025.100830
Qiaoyue Ren , Rui Wang , Bingfeng Wu , Dingming Huang , Ding Xiong , Yu Shi , Zhenming Wang
{"title":"Bioenergetic-active cryogels for potential application in wound healing","authors":"Qiaoyue Ren ,&nbsp;Rui Wang ,&nbsp;Bingfeng Wu ,&nbsp;Dingming Huang ,&nbsp;Ding Xiong ,&nbsp;Yu Shi ,&nbsp;Zhenming Wang","doi":"10.1016/j.colcom.2025.100830","DOIUrl":"10.1016/j.colcom.2025.100830","url":null,"abstract":"<div><div>Effective wound healing remains a challenge in clinical medicine due to limitations in traditional dressings, which often lack the necessary biocompatibility, breathability and ability to provide bioenergy. In this study, we developed bioenergetic-active cryogels using adenosine salts (AMP<img>2Na, ADP-2Na, and ATP<img>2Na) as crosslinkers to enhance tissue regeneration through improved energy metabolism. The cryogels feature a porous and loose structure that facilitates water and gas exchange, as well as the absorption of wound exudate. Additionally, ATP-2Na-coordinated cryogel (G-ATP) stimulates cellular proliferation and migration, while exhibiting anti-inflammatory properties, thus creating an optimal environment for wound repair. In vivo experiments in a full-thickness wound model showed accelerated healing with the G-ATP group, which outperformed control groups in wound contraction and collagen deposition. These findings suggest that G-ATP serve as breathable physical barriers and bioactive dressings that enhance healing by supporting cellular energy needs. This novel approach provides a promising platform for advanced wound care, with potential applications in tissue engineering and regenerative medicine.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100830"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scalable manufacturing of layered nanoparticle-polymer composite films through evaporative assembly 通过蒸发装配大规模制造层状纳米粒子-聚合物复合薄膜
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.1016/j.colcom.2025.100837
Shaveen Fernando, Surita R. Bhatia
{"title":"Scalable manufacturing of layered nanoparticle-polymer composite films through evaporative assembly","authors":"Shaveen Fernando,&nbsp;Surita R. Bhatia","doi":"10.1016/j.colcom.2025.100837","DOIUrl":"10.1016/j.colcom.2025.100837","url":null,"abstract":"<div><div>This work explores stratification, a prescribed spatial variation of components in a multi-component film, in particle-polymer films prepared by a single-step evaporative drying technique. Our overall goal is to develop a more efficient and cost-effective way to create vertically structured multi-component polymer and colloid films. Films containing poly(acrylic acid) (PAA) chains and polystyrene (PS) colloidal nanoparticles were analyzed using microbeam small-angle X-ray scattering (SAXS) and atomic force microscopy (AFM) to probe the impact of evaporation rates and colloid sizes on stratification behavior. Under slow drying conditions, particle-on-top stratification was observed, consistent with a diffusive model of stratification behavior. Conversely, moderate evaporation rates resulted in non-stratified configurations for certain mixtures. Fast evaporation, achieved by drying at elevated temperatures, induced polymer-on-top stratification, which aligns with predictions from simulations. Overall, this study proposes a more efficient method for creating vertically structured films, with implications for various industries.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100837"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning surface assembly of oleyl-capped nanoparticles in AOT microemulsion phase with optimal alkane-to-alkanol ratio 以最佳烷烃-烷醇比调整AOT微乳相中油基包覆纳米颗粒的表面组装
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1016/j.colcom.2025.100836
Rebeca Fortes Martín, Sibylle Rustig, Ilko Bald, Joachim Koetz
{"title":"Tuning surface assembly of oleyl-capped nanoparticles in AOT microemulsion phase with optimal alkane-to-alkanol ratio","authors":"Rebeca Fortes Martín,&nbsp;Sibylle Rustig,&nbsp;Ilko Bald,&nbsp;Joachim Koetz","doi":"10.1016/j.colcom.2025.100836","DOIUrl":"10.1016/j.colcom.2025.100836","url":null,"abstract":"<div><div>A simplified procedure for the surface assembly of oleyl-capped nanoparticles from water-in-oil microemulsions is presented. Changing the heptane-to-pentanol ratio in the oil phase resulted in different surface assemblies. Remarkably, a minor proportion of heptane in pentanol enabled the formation of filament networks, without the assistance of other additives for clustering effects.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100836"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjusting morphologies of wound dressing by transferring skin textures through electrospinning technology 通过静电纺丝技术转移皮肤纹理来调整伤口敷料的形态
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1016/j.colcom.2025.100835
Huidan Wei , Jing Wen , Sai Yan , Han Zhang , Yuan Liu , Yuhan Xia , Jidong Li , Ran Cao , Meifang Zhu
{"title":"Adjusting morphologies of wound dressing by transferring skin textures through electrospinning technology","authors":"Huidan Wei ,&nbsp;Jing Wen ,&nbsp;Sai Yan ,&nbsp;Han Zhang ,&nbsp;Yuan Liu ,&nbsp;Yuhan Xia ,&nbsp;Jidong Li ,&nbsp;Ran Cao ,&nbsp;Meifang Zhu","doi":"10.1016/j.colcom.2025.100835","DOIUrl":"10.1016/j.colcom.2025.100835","url":null,"abstract":"<div><div>Surface topography and mechanical properties of wound dressing significantly influence cell behavior and tissue regeneration process. Skin has unique textures, which are often overlooked in the preparation of wound dressings. Herein, we fabricated biomimetic wound dressings by transferring the surface textures of skin through electrospinning technology. Specifically, the top and bottom surface of pig skin employed as substrates for the collection of electrospinning nanofibers composed of polylactic acid and gelatin (PLLA/GL). Due to the existence of hair on the top surface of pig skin, the transferred nanofiber membrane (skin-top) exhibited scattered small pores (∼50 μm). In contrast, the transferred nanofiber membrane with aluminum foil (Al) as substrate displayed a smooth surface. Benefit from the unique surface properties of skin, the skin-based nanofiber membrane demonstrated improved roughness and enhanced air permeability. Specifically, skin-top based wound dressing showed the best performance in promoting wound healing, including enhanced epithelialization and collagen deposition.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100835"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Horseradish peroxidase-catalyzed crosslinking injectable hydrogel for bone repair and regeneration 辣根过氧化物酶催化交联可注射水凝胶骨修复和再生
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.1016/j.colcom.2025.100828
Hongwei Pan , Yue Qu , Feng Wang , Shengbing Zhao , Gaigai Chen
{"title":"Horseradish peroxidase-catalyzed crosslinking injectable hydrogel for bone repair and regeneration","authors":"Hongwei Pan ,&nbsp;Yue Qu ,&nbsp;Feng Wang ,&nbsp;Shengbing Zhao ,&nbsp;Gaigai Chen","doi":"10.1016/j.colcom.2025.100828","DOIUrl":"10.1016/j.colcom.2025.100828","url":null,"abstract":"<div><div>In clinical practice, addressing severe bone defects resulting from trauma, tumors, infections or congenital disorders remains a challenge in the surgical domain. Although bone tissue has a certain capacity for self-repair, artificial substitute materials of bone are still required to facilitate the repair, especially for large-scale bone defects. At present, tissue engineering-related materials that mimic the structure, mechanical properties, and biological characteristics of natural bone have been widely used for addressing bone defects and promoting in situ bone regeneration. Hydrogels that emulate the properties of the extracellular matrix are prevalent materials in bone tissue engineering, with a particular emphasis on those crosslinked through HRP-mediated, which have garnered considerable interest due to their high efficiency of preparation, mild reaction conditions, controllable properties, and excellent biocompatibility. However, the suboptimal osteogenic capability inherent in HRP-mediated crosslinked hydrogels necessitates the integration of additional osteogenic activity materials, such as biological calcium phosphates, biomimetic scaffolds, growth factors, synthetic peptides, and nanomaterials, to bolster the hydrogel scaffolds' osteogenic potential. This manuscript provides a concise overview of the standard methodologies for crafting injectable hydrogels, highlighting the HRP catalytic reaction mechanism, and strategies for modulating hydrogel attributes. Furthermore, this paper delves into the recent advancements in HRP-mediated crosslinked hydrogel scaffolds, highlighting their role in bone defect repair within the realm of bone tissue engineering. These insights establish a robust foundation for the innovation, development, and clinical application of bone tissue substitutes that prioritize biosafety.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100828"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of enhanced hydrophobic polysilazane coatings with high transparency and durability 高透明耐用增强型疏水性聚硅氮烷涂料的合成与表征
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI: 10.1016/j.colcom.2025.100832
Yinggang Liu , Zunqing Liu , Guofei Chen , Xingzhong Fang
{"title":"Synthesis and characterization of enhanced hydrophobic polysilazane coatings with high transparency and durability","authors":"Yinggang Liu ,&nbsp;Zunqing Liu ,&nbsp;Guofei Chen ,&nbsp;Xingzhong Fang","doi":"10.1016/j.colcom.2025.100832","DOIUrl":"10.1016/j.colcom.2025.100832","url":null,"abstract":"<div><div>The development of transparent hydrophobic coatings with durability is crucial required both optical transparency and hydrophobic properties for application. In this study, a series of durable, transparent and hydrophobic coatings were prepared by dispersing hydrophobic fumed silica (SiO<sub>2</sub>) in the fluorinated polysilazanes (FPSZ) matrix and then spraying the mixture onto microscope slides. The coating FPC-1 achieved excellent comprehensive performances showing a water contact angle of 125°, a transmittance of 88.9 % at 400 nm, a pencil hardness of 6H, and an adhesion class of 5B. In addition, the coating of FPC-1 could withstand chemical corrosion for 7 days and 100 cycles of abrasion without significant degradation. These coatings show has great potential for applications in transparent optical devices.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100832"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mitochondrial-targeted nanomedicine based on hollow mesoporous silica nanoparticles for enhanced colorectal cancer therapy 一种基于中空介孔二氧化硅纳米颗粒的线粒体靶向纳米药物,用于增强结直肠癌治疗
IF 4.7 3区 材料科学
Colloid and Interface Science Communications Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1016/j.colcom.2025.100833
Jin Liu , Tianle Liu , Chi Zhang , Ziyou Wang , Xinyi Zhang , Chuanchuan Hao , Dan Wang , Guohui Cheng
{"title":"A mitochondrial-targeted nanomedicine based on hollow mesoporous silica nanoparticles for enhanced colorectal cancer therapy","authors":"Jin Liu ,&nbsp;Tianle Liu ,&nbsp;Chi Zhang ,&nbsp;Ziyou Wang ,&nbsp;Xinyi Zhang ,&nbsp;Chuanchuan Hao ,&nbsp;Dan Wang ,&nbsp;Guohui Cheng","doi":"10.1016/j.colcom.2025.100833","DOIUrl":"10.1016/j.colcom.2025.100833","url":null,"abstract":"<div><div>By focusing on mitochondria as a therapeutic target, strategies can be devised to deplete ATP levels, thereby potentially circumventing the emergence of MDR. In this study, we developed a surface-modified hyaluronic acid (HA), mitochondrial targeted hollow mesoporous silicon nanomedicine (PB@HMSN-HA) co-loaded with berberine (BBR) and paclitaxel (PTX) for enhanced colorectal cancer therapy. The modified HA can selectively bind to tumor cells that overexpress the CD44 receptor, leading to the accumulation of PB@HMSN-HA at the tumor site and improving tumor targeting efficiency. After cellular internalization, the liberated positively charged BBR, which is specifically targeted to mitochondria, induces a reduction in ATP levels. Depletion of ATP subsequently results in a reduction of drug efflux, thereby amplifying the antitumor efficacy of PTX. Therefore, this combination therapy strategy targeting mitochondria serves as an important reference for clinical oncological chemotherapy.</div></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"66 ","pages":"Article 100833"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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