Proceedings of the Bulgarian Academy of Sciences最新文献_第4页

Clinopodium vulgare L. Extract Counteracts DNA Damaging Action of Radiomimetic Zeocin Accelerating DSBS Rejoining in Saccharomyces Cerevisiae Clinopodium vulgare L.提取物可抵消仿辐射沸石素对DNA的损伤作用，加速酿酒酵母中DSBS的重新连接

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-02-29 DOI: 10.7546/crabs.2024.02.04

T. Todorova, Iviyana Ivanova, P. Parvanova, S. Chankova

{"title":"Clinopodium vulgare L. Extract Counteracts DNA Damaging Action of Radiomimetic Zeocin Accelerating DSBS Rejoining in Saccharomyces Cerevisiae","authors":"T. Todorova, Iviyana Ivanova, P. Parvanova, S. Chankova","doi":"10.7546/crabs.2024.02.04","DOIUrl":"https://doi.org/10.7546/crabs.2024.02.04","url":null,"abstract":"The aim of the present work was to evaluate the potential of Clinopodium vulgare water leaves extract to decrease the DNA damaging action of zeocin and to throw more light on the mode of action. \u0000Single and combined treatments with 10, 100, and 1000 µg/ml plant extract and 100 µg/ml zeocin were performed on 551 (haploid) and D7ts1 (diploid) yeast strains. The protective potential, the magnitude of the repair capacity, and the role of incubation conditions were studied based on double strand breaks' (DSB) induction and rejoining. \u0000The results provided new evidence that despite the different ploidy both strains are DSBs repair proficient but differ in their repair capacity although comparable levels of initially induced DSBs were measured. The diploid strain D7ts1 was found to possess better-expressed repair capacity than the haploid strain 551. The combined treatment with Clinopodium vulgare L. extract at concentrations' range of 10—1000 µg/ml and zeocin resulted in a significant decrease in DSBs levels. It could be suggested that priming the cells with various concentrations of the extract results in an acceleration of DSBs rejoining when 30 min recovery time at optimal experimental conditions is given. When incubation is performed on ice the repair processes are impeded but not fully blocked. Such a study confirms that the difference in the repair capacity of the cells could be one of the possible mechanisms, participating in cell protection against different DNA damaging factors. The combined application of Clinopodium vulgare L. extract at concentrations range of 10—1000 µg/ml protects yeast DNA against zeocin-induced DSBs by acceleration of DSB rejoining.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Riboflavin Increases Serum Glutamine Levels in Rats with Streptozotocin-induced Diabetes 核黄素能提高链脲佐菌素诱发糖尿病大鼠的血清谷氨酰胺水平

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-02-29 DOI: 10.7546/crabs.2024.02.12

M. Hristov, Z. Sabit, Tsvetomir Kirilov, R. Tzoneva, Sonia Apostolova, Irina Georgieva, P. Andreeva-Gateva

引用次数: 0

Structure of Zoocenoses in the Ephemeral Pond Lilov Vir, Western Bulgaria 保加利亚西部短暂池塘 Lilov Vir 中动物的结构

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-02-29 DOI: 10.7546/crabs.2024.02.05

Pencho Ivanov, L. Pehlivanov

{"title":"Structure of Zoocenoses in the Ephemeral Pond Lilov Vir, Western Bulgaria","authors":"Pencho Ivanov, L. Pehlivanov","doi":"10.7546/crabs.2024.02.05","DOIUrl":"https://doi.org/10.7546/crabs.2024.02.05","url":null,"abstract":"This study aimed to observe the development of zoocenoses in an ephemeral karst water body providing a dynamically changing habitat and unstable hydrological regime with an emphasis on assessing the main factors influencing the structure of the macrozoobenthos and zooplankton communities. The study was conducted in Pond Lilov Vir near Karlukovo Vil., Western Bulgaria. The main physicochemical parameters and the concentrations of nutrients were recorded. The macrozoobenthos (MZB) and zooplankton samples were taxonomically determined and statistical analyses of the obtained results were performed. The results have shown that the pond supports a variety of species and species typical to temporary waters. The variation in hydroperiod (HP) duration over the years leads to the formation of different communities. Longer HPs suggest greater biodiversity. In drying pools, especially those with a short HP, the leading factor for structuring communities is the abiotic environmental factors-HP and water volume (WVOL). Biotic factors, such as competition and predation, are not leading, due to the lack of fish and insufficient time for the development of invertebrate predators.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"24 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140408909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fruit Disease Classification and Localization Using Region Based Regression 利用基于区域的回归进行水果病害分类和定位

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-02-29 DOI: 10.7546/crabs.2024.02.18

Annamalai Kavitha, Samuel Raja, Palaniswami Sampath

{"title":"Fruit Disease Classification and Localization Using Region Based Regression","authors":"Annamalai Kavitha, Samuel Raja, Palaniswami Sampath","doi":"10.7546/crabs.2024.02.18","DOIUrl":"https://doi.org/10.7546/crabs.2024.02.18","url":null,"abstract":"Fruit disease classification using computer vision techniques is completely viral upon machine learning capabilities. The complete analysis is based upon regression using region proposal networks and their optimization using Gradient Clipping methodology. Fruit diseases such as flyspeck, blotch, scab and rot are detected and classified using the Region proposal network regression. The recent works carried out on the fruit disease detection and classification on agricultural crops were gathered and surveyed in this paper. Finally the very recent work carried out using regression and computer vision techniques were identified and applied to the data collected here with 6231 images and 24 classes. The diseased and disinfected were filtered for training purpose into 3110 images as diseases and the rest as disinfected. The hyperparameters tuning optimization was able to fit only the random data images, instead gradient clipping resulted in the proper limit cropping of the diseased portions of the crop footage. To improve the training data stability regression was employed with this optimization to show the results obtained from 95.3% to 97.8%. Here, the RCNN classification using neural networks resulted in the overall accuracy of the fruit disease classification model to 95.83%, where the Gradient Clipping optimization resulted in the improvement of accuracy of model to 97.8%.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140413823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fundamental Theorems for Timelike Surfaces in the Minkowski 4-Space 闵科夫斯基 4 空间中时序曲面的基本定理

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-02-29 DOI: 10.7546/CRABS.2024.02.01

Victoria Bencheva, V. Milousheva

引用次数: 0

Analysis of the Regularity of Distribution of Natural Landscapes in the Greater Caucasus Depending on Physical-Geographical Characteristics Using GIS Technology 利用 GIS 技术分析大高加索地区自然景观分布的规律性取决于自然地理特征

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-02-29 DOI: 10.7546/crabs.2024.02.07

A. Hajiyeva, Firuza Jafarova

{"title":"Analysis of the Regularity of Distribution of Natural Landscapes in the Greater Caucasus Depending on Physical-Geographical Characteristics Using GIS Technology","authors":"A. Hajiyeva, Firuza Jafarova","doi":"10.7546/crabs.2024.02.07","DOIUrl":"https://doi.org/10.7546/crabs.2024.02.07","url":null,"abstract":"Natural geographic conditions play an important role in the formation and development of landscapes. Various factors of natural conditions, especially the absolute height of the relief, slope, aspect, horizontal and vertical fragmentation, have been widely studied since the 20th century. Nowadays, these factors are studied through geographic information technologies, on the basis of satellite images and Remote Sensing materials. Therefore, our research is dedicated to the actual topic. We also conducted analyses based on modern methods in the Great Caucasus natural region, which is our research area. At this time, we have analyzed the absolute height of the relief, aspect and inclination of the slopes using the Digital Elevation Model of the area. As a result of the conducted researches, we have determined that desert and semi-desert landscapes were formed in areas with low absolute height and inclination, and forest, alpine, subalpine, nival and subnival landscapes were formed in areas with high absolute height and inclination. Forests are mostly found on the northern slopes, and semi-desert and desert landscapes are widespread on the southern slopes.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140409791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Bacterial Pathogens in Patients with Cystic Fibrosis 囊性纤维化患者的肺部细菌病原体

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-01-29 DOI: 10.7546/crabs.2024.01.13

N. Kolarova-Yaneva, Valentina Edreva, Nikolay Yanev, L. Beshev, Vania Nedkova

{"title":"Pulmonary Bacterial Pathogens in Patients with Cystic Fibrosis","authors":"N. Kolarova-Yaneva, Valentina Edreva, Nikolay Yanev, L. Beshev, Vania Nedkova","doi":"10.7546/crabs.2024.01.13","DOIUrl":"https://doi.org/10.7546/crabs.2024.01.13","url":null,"abstract":"The aim of the research is to perform microbiological analysis of respiratory tract samples in patients with cystic fibrosis and to verify the aetiology, prevalence and antibiotic sensitivity of the isolated pathogens. \u0000Sixteen patients with cystic fibrosis aged from 3 months to 30 years were included. Twenty-nine respiratory and one digestive tract samples were tested. The identification of isolated pathogens was performed using conventionalbreak methods and automated miniAPI and VITEK 2 systems (bioMerieux, France). Antibiotic sensitivity of all isolates was determined by a disk diffusion test or the minimum inhibitory concentration method. \u0000A total of 34 microbial strains from 15 patients were isolated: Gram-positive bacteria 12 (35.29%), Gram-negative bacteria 20 (58.82%) and yeast-like fungi 2 (5.88%). S. aureus is the dominant pathogen among Gram-positive bacteria. Most of the Gram-negative bacteria are identified as P. aeruginosa and other non-fermenting glucose bacteria and the rest as H. influenzae and E. coli. P. aeruginosa was isolated from patients in different age groups. The strains showed good sensitivity to antibiotics. \u0000Microorganisms isolated from the respiratory tract in patient with cystic fibrosis vary over the period of follow-up. Gram-negative bacteria, especially P. aeruginosa, are dominant but showed good sensitivity to antimicrobial agents and no multidrug-resistant strains were isolated.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"54 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140486971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echocardiography and Biomarker-based Regression Models for the Detection of Gestational Hypertension in Pregnant Women 检测孕妇妊娠高血压的超声心动图和生物标记回归模型

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-01-29 DOI: 10.7546/crabs.2024.01.16

Dolina G Gencheva, Fedya Nikolov, Ekaterina Uchikova, Rosen D Mihaylov, B. Pencheva

{"title":"Echocardiography and Biomarker-based Regression Models for the Detection of Gestational Hypertension in Pregnant Women","authors":"Dolina G Gencheva, Fedya Nikolov, Ekaterina Uchikova, Rosen D Mihaylov, B. Pencheva","doi":"10.7546/crabs.2024.01.16","DOIUrl":"https://doi.org/10.7546/crabs.2024.01.16","url":null,"abstract":"Hypertensive disorders of pregnancy are characterized by both higher cardiovascular risk for women and more pronounced structural and functional changes of the heart. Certain biomarkers and echocardiographic parameters could be utilized in regression models for more accurate detection of the presence of those hypertensive disorders. \u0000The aim of the study was to compare the differentiating abilities of several regression models for statistical certainty in establishing the diagnosis of gestational hypertension in pregnant women using echocardiographic parameters and biomarkers. \u0000A prospective, single-centre, clinical-epidemiological study was conducted with the participation of 36 women with gestational hypertension and 50 maternal and gestational age-matched healthy pregnant controls. Certain echocardiographic parameters and serum biomarkers – placental growth factor (PlGF), galectin-3, high-sensitivity C-reactive protein and Interleukin-6, were analyzed for the women using ROC curve analysis and binary logistic regression. \u0000We constructed three regression models, allowing very good differentiation between women with gestational hypertension and those with normotensive pregnancy. The model that included PlGF, left ventricular and right ventricular global longitudinal strain (LV GLS, RV GLS) had AUC 0.81, sensitivity and specificity of 86% and accuracy of 86%. The LV GLS and PlGF model had AUC of 0.90 with sensitivity 83%, specificity 88%, and accuracy 86%; and the LV GLS and RV GLS had AUC of 0.83, sensitivity 67%, specificity 92%, and accuracy 81%. \u0000All three combined models showed better accuracy compared to PlGF, LV GLS, RV GLS or any other echocardiographic parameter or biomarker alone, which could be promising for their implementation in clinical practice.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"35 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140489391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Technological Schemes for Construction of Open Mine Roads 露天矿山道路施工技术方案优化

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-01-29 DOI: 10.7546/crabs.2024.01.12

Danail Terziyski

引用次数: 0

An Endemic Species Nepeta phyllochlamys P. H. Davis: Composition of Essential Oil and Antimicrobial Activity of Extracts 一种特有物种 Nepeta phyllochlamys P. H. Davis：精油成分和提取物的抗菌活性

Proceedings of the Bulgarian Academy of Sciences Pub Date : 2024-01-29 DOI: 10.7546/crabs.2024.01.04

Zeynep Gülcan, Y. Köse, G. Işcan, M. Kürkçüoğlu

{"title":"An Endemic Species Nepeta phyllochlamys P. H. Davis: Composition of Essential Oil and Antimicrobial Activity of Extracts","authors":"Zeynep Gülcan, Y. Köse, G. Işcan, M. Kürkçüoğlu","doi":"10.7546/crabs.2024.01.04","DOIUrl":"https://doi.org/10.7546/crabs.2024.01.04","url":null,"abstract":"This study investigates the composition of essential oil and biological activities of Nepeta phyllochlamys P. H. Davis, a local endemic species from the Lamiaceae family. Samples of N. phyllochlamys were collected from three populations, and essential oil components were compared among these populations. The main components identified in samples from three localities included caryophyllene oxide, δ-pinene, linalool, T-cadinol, α-pinene, and 14-nor-kadin-5-en-4-one (isomer A). Remarkably, the chemical content of the plant exhibited variations based on geographical regions. Although the plant showed limited antibacterial and anticandidal activities in tests, this research holds significant importance due to several factors. N. phyllochlamys is a local endemic species and part of the widely used Nepeta genus in traditional practices. Moreover, there is a scarcity of studies conducted on N. phyllochlamys, and to the best of our knowledge, no previous research has explored its phytochemical profile and antimicrobial properties. This article contributes valuable insights into the antimicrobial effects of N. phyllochlamys, shedding light on its chemical composition through the application of the GC-FID and GC-MS method.","PeriodicalId":104760,"journal":{"name":"Proceedings of the Bulgarian Academy of Sciences","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0