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Daily functioning in glioma survivors: associations with cognitive function, psychological factors and quality of life. 胶质瘤幸存者的日常功能：与认知功能、心理因素和生活质量的关系。
CNS Oncology Pub Date : 2022-06-01 Epub Date: 2022-05-18 DOI: 10.2217/cns-2022-0002
Kathleen Van Dyk, Lucy Wall, Brandon F Heimberg, Justin Choi, Catalina Raymond, Chencai Wang, Albert Lai, Timothy F Cloughesy, Benjamin M Ellingson, Phioanh Nghiemphu
{"title":"Daily functioning in glioma survivors: associations with cognitive function, psychological factors and quality of life.","authors":"Kathleen Van Dyk, Lucy Wall, Brandon F Heimberg, Justin Choi, Catalina Raymond, Chencai Wang, Albert Lai, Timothy F Cloughesy, Benjamin M Ellingson, Phioanh Nghiemphu","doi":"10.2217/cns-2022-0002","DOIUrl":"10.2217/cns-2022-0002","url":null,"abstract":"<p><p><b>Aim:</b> Understanding and supporting quality of life (QoL) and daily functioning in glioma patients is a clinical imperative. In this study, we examined the relationship between cognition, psychological factors, measures of health-related QoL and functioning in glioma survivors. <b>Materials & methods:</b> We examined neuropsychological, self-reported cognition, mood and QoL correlates of work and non-work-related daily functioning in 23 glioma survivors, and carried out linear models of the best predictors. <b>Results & conclusion:</b> A total of 13/23 participants were working at the time of enrollment. The best model for worse work-related functioning (R<sup>2</sup> = .83) included worse self-reported cognitive function, depression, loneliness and brain tumor symptoms. The best model for worse non-work-related functioning (R<sup>2</sup> = .61) included worse self-reported cognitive functioning, anxiety, sleep disturbance and physical functioning. Neuropsychological variables were not among the most highly correlated with function. Worse cognitive, particularly self-reported and psychosocial outcomes may compromise optimal functioning in glioma survivors.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/11/cns-11-84.PMC9134930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiotherapy-drug combinations in the treatment of glioblastoma: a brief review. 治疗胶质母细胞瘤的放疗-药物组合：简要回顾。
CNS Oncology Pub Date : 2022-06-01 Epub Date: 2022-05-23 DOI: 10.2217/cns-2021-0015
Patrick G McAleavey, Gerard M Walls, Anthony J Chalmers
{"title":"Radiotherapy-drug combinations in the treatment of glioblastoma: a brief review.","authors":"Patrick G McAleavey, Gerard M Walls, Anthony J Chalmers","doi":"10.2217/cns-2021-0015","DOIUrl":"10.2217/cns-2021-0015","url":null,"abstract":"<p><p>Glioblastoma (GBM) accounts for over 50% of gliomas and carries the worst prognosis of all solid tumors. Owing to the limited local control afforded by surgery alone, efficacious adjuvant treatments such as radiotherapy (RT) and chemotherapy are fundamental in achieving durable disease control. The best clinical outcomes are achieved with tri-modality treatment consisting of surgery, RT and systemic therapy. While RT-chemotherapy combination regimens are well established in oncology, this approach was largely unsuccessful in GBM until the introduction of temozolomide. The success of this combination has stimulated the search for other candidate drugs for concomitant use with RT in GBM. This review seeks to collate the current evidence for these agents and synthesize possible future directions for the field.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74497824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma. 口服 p-STAT3 抑制剂 WP1066 治疗复发性恶性胶质瘤患者的首次人体 I 期试验。
CNS Oncology Pub Date : 2022-06-01 Epub Date: 2022-05-16 DOI: 10.2217/cns-2022-0005
John de Groot, Martina Ott, Jun Wei, Cynthia Kassab, Dexing Fang, Hinda Najem, Barbara O'Brien, Shiao-Pei Weathers, Carlos Kamiya Matsouka, Nazanin K Majd, Rebecca A Harrison, Gregory N Fuller, Jason T Huse, James P Long, Raymond Sawaya, Ganesh Rao, Tobey J MacDonald, Waldemar Priebe, Michael DeCuypere, Amy B Heimberger
{"title":"A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma.","authors":"John de Groot, Martina Ott, Jun Wei, Cynthia Kassab, Dexing Fang, Hinda Najem, Barbara O'Brien, Shiao-Pei Weathers, Carlos Kamiya Matsouka, Nazanin K Majd, Rebecca A Harrison, Gregory N Fuller, Jason T Huse, James P Long, Raymond Sawaya, Ganesh Rao, Tobey J MacDonald, Waldemar Priebe, Michael DeCuypere, Amy B Heimberger","doi":"10.2217/cns-2022-0005","DOIUrl":"10.2217/cns-2022-0005","url":null,"abstract":"<p><p><b>Aim:</b> To ascertain the maximum tolerated dose (MTD)/maximum feasible dose (MFD) of WP1066 and p-STAT3 target engagement within recurrent glioblastoma (GBM) patients. <b>Patients & methods:</b> In a first-in-human open-label, single-center, single-arm 3 + 3 design Phase I clinical trial, eight patients were treated with WP1066 until disease progression or unacceptable toxicities. <b>Results:</b> In the absence of significant toxicity, the MFD was identified to be 8 mg/kg. The most common adverse event was grade 1 nausea and diarrhea in 50% of patients. No treatment-related deaths occurred; 6 of 8 patients died from disease progression and one was lost to follow-up. Of 8 patients with radiographic follow-up, all had progressive disease. The longest response duration exceeded 3.25 months. The median progression-free survival (PFS) time was 2.3 months (95% CI: 1.7 months-NA months), and 6-month PFS (PFS6) rate was 0%. The median overall survival (OS) rate was 25 months (95% CI: 22.5 months-NA months), with an estimated 1-year OS rate of 100%. Pharmacokinetic (PK) data demonstrated that at 8 mg/kg, the T<sub>1/2</sub> was 2-3 h with a dose dependent increase in the C<sub>max</sub>. Immune monitoring of the peripheral blood demonstrated that there was p-STAT3 suppression starting at a dose of 1 mg/kg. <b>Conclusion:</b> Immune analyses indicated that WP1066 inhibited systemic immune p-STAT3. WP1066 had an MFD identified at 8 mg/kg which is the target allometric dose based on prior preclinical modeling in combination with radiation therapy and a Phase II study is being planned for newly diagnosed MGMT promoter unmethylated glioblastoma patients.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82007685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight about the characteristics and surgical resectability of adult pilocytic astrocytoma: tertiary center experience. 洞察成人柔毛细胞星形细胞瘤的特点和手术切除可能性：三级中心的经验。
CNS Oncology Pub Date : 2022-04-06 DOI: 10.2217/cns-2021-0014
Baha'eddin A Muhsen, Abdelmajid I Aljariri, Maher Elayyan, Hawazen Hirbawi, Mahmoud A Masri
{"title":"Insight about the characteristics and surgical resectability of adult pilocytic astrocytoma: tertiary center experience.","authors":"Baha'eddin A Muhsen, Abdelmajid I Aljariri, Maher Elayyan, Hawazen Hirbawi, Mahmoud A Masri","doi":"10.2217/cns-2021-0014","DOIUrl":"10.2217/cns-2021-0014","url":null,"abstract":"<p><p><b>Aim:</b> Adult pilocytic astrocytoma is a rare tumor. We aim to contribute to understanding its clinical course and prognosis. <b>Patients & methods:</b> We searched our database for patients older than 18 years with pathology-proven pilocytic astrocytoma. Patients' clinical data were analyzed. <b>Results:</b> Fifteen patients were identified. The median age at diagnosis was 25 years (range: 18-56). Tumors were supratentorial in 47%. Gross-total and near-total resections were achieved in 40%, and sub-total resection in 47%. One (7%) recurrence and no mortality were encountered during a median follow-up of 11 months (range: 1-76). <b>Conclusion:</b> Pilocytic astrocytoma behaves differently in adults compared with pediatrics. It tends to arise in surgically challenging areas where the extent of resection may be limited. Total resection should be the main therapy whenever feasible. The survival rates are good, and recurrence is low.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8988253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90973840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic inflammatory biomarkers in primary central nervous system lymphoma versus high-grade glioma: exploratory, comparative and correlative analysis 原发性中枢神经系统淋巴瘤与高级别胶质瘤的系统性炎症生物标志物:探索性、比较性和相关性分析
CNS Oncology Pub Date : 2022-04-04 DOI: 10.2217/cns-2022-0004
T. Gupta, P. Nayak, Y. Baviskar, Meetakshi Gupta, A. Moiyadi, S. Epari, A. Janu, N. Purandare, V. Rangarajan, B. Bagal, Abhishek Chatterjee, G. Sastri
{"title":"Systemic inflammatory biomarkers in primary central nervous system lymphoma versus high-grade glioma: exploratory, comparative and correlative analysis","authors":"T. Gupta, P. Nayak, Y. Baviskar, Meetakshi Gupta, A. Moiyadi, S. Epari, A. Janu, N. Purandare, V. Rangarajan, B. Bagal, Abhishek Chatterjee, G. Sastri","doi":"10.2217/cns-2022-0004","DOIUrl":"https://doi.org/10.2217/cns-2022-0004","url":null,"abstract":"Aim: To assess systemic inflammatory biomarkers in non invasive differential diagnosis of primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG). Materials & methods: Patients with similar morphology (PCNSL or HGG) on conventional neuro-imaging were included. Systemic inflammatory indices were calculated from pretreatment complete blood counts and liver function tests and compared against histopathology as reference standard. Results: Mean values of absolute lymphocyte count and prognostic nutritional index were significantly different between PCNSL (n = 42) versus HGG (n = 16). Area under receiver operating characteristics curve for absolute lymphocyte count and prognostic nutritional index in the diagnosis of PCNSL was 0.70 and 0.72 respectively suggesting fair and acceptable diagnostic accuracy. Conclusion: Systemic inflammatory biomarkers complement established clinico-radiological features and aid in the differential diagnosis of PCNSL from HGG.","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86789680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges of imaging interpretation to predict oligodendroglioma grade: a report from the Neuro-Oncology Branch. 影像学解释预测少突胶质瘤分级的挑战:来自神经肿瘤科的一份报告。
CNS Oncology Pub Date : 2022-03-01 Epub Date: 2022-02-10 DOI: 10.2217/cns-2021-0005
Orwa Aboud, Ritu Shah, Elizabeth Vera, Eric Burton, Brett Theeler, Jing Wu, Lisa Boris, Martha Quezado, Jennifer Reyes, Kathleen Wall, Mark R Gilbert, Terri S Armstrong, Marta Penas-Prado
{"title":"Challenges of imaging interpretation to predict oligodendroglioma grade: a report from the Neuro-Oncology Branch.","authors":"Orwa Aboud,&nbsp;Ritu Shah,&nbsp;Elizabeth Vera,&nbsp;Eric Burton,&nbsp;Brett Theeler,&nbsp;Jing Wu,&nbsp;Lisa Boris,&nbsp;Martha Quezado,&nbsp;Jennifer Reyes,&nbsp;Kathleen Wall,&nbsp;Mark R Gilbert,&nbsp;Terri S Armstrong,&nbsp;Marta Penas-Prado","doi":"10.2217/cns-2021-0005","DOIUrl":"https://doi.org/10.2217/cns-2021-0005","url":null,"abstract":"<p><p><b>Background:</b> To illustrate challenges of imaging interpretation in patients with oligodendroglioma seen at a referral center and evaluate interrater reliability. <b>Methods:</b> Two neuro-oncologists reviewed diagnostic preradiation MRIs of oligodendroglioma patients; interrater reliability was calculated with the kappa coefficient (k). A neuroradiologist measured presurgical apparent diffusion coefficient (ADC), if available. <b>Results:</b> Extensive enhancement was noted in four of 58 patients, k = 0.7; necrosis in seven of 58, k = 0.61; calcification in seven of 17, k = 1.0; diffusion restriction in two of 39 patients, k = 1.0 (all only in grade 3). ADC values with receiver operator characteristic analysis for area under the curve were 0.473, not significantly different from the null hypothesis (p = 0.14). <b>Conclusions:</b> Extensive enhancement, necrosis and calcification correlated with grade 3 oligodendroglioma in our sample. However, interrater variability is an important limitation when assessing radiographic features, supporting the need for standardization of imaging protocols and their interpretation.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/3e/cns-11-83.PMC8988255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39906197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab. 复发性idh野生型胶质母细胞瘤对派姆单抗激光间质热治疗的延长反应
CNS Oncology Pub Date : 2022-03-01 DOI: 10.2217/cns-2021-0013
Helen Hwang, Jiayi Huang, Karam Khaddour, Omar H Butt, George Ansstas, Jie Chen, Ruth Gn Katumba, Albert H Kim, Eric C Leuthardt, Jian L Campian
{"title":"Prolonged response of recurrent <i>IDH</i>-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab.","authors":"Helen Hwang,&nbsp;Jiayi Huang,&nbsp;Karam Khaddour,&nbsp;Omar H Butt,&nbsp;George Ansstas,&nbsp;Jie Chen,&nbsp;Ruth Gn Katumba,&nbsp;Albert H Kim,&nbsp;Eric C Leuthardt,&nbsp;Jian L Campian","doi":"10.2217/cns-2021-0013","DOIUrl":"https://doi.org/10.2217/cns-2021-0013","url":null,"abstract":"<p><p>Despite the improved understanding of the molecular and genetic heterogeneity of glioblastoma, there is still an unmet need for better therapeutics, as treatment approaches have remained unchanged in recent years. Research into the role of the immune microenvironment has generated enthusiasm for testing immunotherapy (specifically, immune checkpoint inhibitors). However, to date, trials of immunotherapy in glioblastoma have not demonstrated a survival advantage. Combination approaches aimed at optimally inducing response to immune checkpoint inhibitors with radiotherapy are currently being investigated. Herein, the authors describe their experience of the potential benefit and clinical outcomes of using combination pembrolizumab (an immune checkpoint inhibitor) and laser interstitial thermal therapy in a case series of patients with recurrent <i>IDH</i>-wild-type glioblastoma.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/8e/cns-11-81.PMC8988254.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9583438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Multi-joint steroid-induced avascular necrosis in a malignant brain tumor patient. 恶性脑肿瘤患者多关节类固醇诱导的缺血性坏死。
CNS Oncology Pub Date : 2021-12-01 Epub Date: 2021-10-12 DOI: 10.2217/cns-2021-0006
Jessica M Lewis-Gonzalez, Mallika P Patel, Katherine B Peters
{"title":"Multi-joint steroid-induced avascular necrosis in a malignant brain tumor patient.","authors":"Jessica M Lewis-Gonzalez,&nbsp;Mallika P Patel,&nbsp;Katherine B Peters","doi":"10.2217/cns-2021-0006","DOIUrl":"https://doi.org/10.2217/cns-2021-0006","url":null,"abstract":"<p><p>Avascular necrosis (AVN) is a rare but serious adverse event associated with the use of corticosteroids for long durations or at high doses. This case report describes a 47-year-old female patient with low-grade astrocytoma who was initiated on low-dose dexamethasone for symptom management. The patient developed joint pain 1 year after steroid exposure, then was found to have AVN of the hip followed by multiple other joints. This case report highlights the extent to which AVN can occur in patients with brain tumors following a short course of low-dose corticosteroids. Careful evaluation of and monitoring for the development of AVN should occur frequently in patients with brain tumors given the frequent use of corticosteroids for symptom management in this population.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/62/cns-10-78.PMC8610003.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39508362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes. 颅内原发性生殖细胞瘤的实用诊断方法及其治疗效果。
CNS Oncology Pub Date : 2021-11-22 DOI: 10.2217/cns-2021-0012
Jeyaanth Venkatasai, Rajesh Balakrishnan, Balakrishnan Rajkrishna, Patricia Sebastain, Rikki Rorima John, Harshad Arvind Vanjare, Krishna Prabhu, Bijesh Nair, Leni Grace Mathew, Selvamani Backianathan
{"title":"A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes.","authors":"Jeyaanth Venkatasai, Rajesh Balakrishnan, Balakrishnan Rajkrishna, Patricia Sebastain, Rikki Rorima John, Harshad Arvind Vanjare, Krishna Prabhu, Bijesh Nair, Leni Grace Mathew, Selvamani Backianathan","doi":"10.2217/cns-2021-0012","DOIUrl":"10.2217/cns-2021-0012","url":null,"abstract":"<p><p><b>Background:</b> Primary intracranial germ cell tumors (ICGCT) are often diagnosed with tumor markers and imaging, which may avoid the need for a biopsy. An intracranial germ cell tumor with mild elevation of markers is seldom stratified as a distinct entity. <b>Methods:</b> Fifty-nine patients were stratified into three groups: pure germinoma (PG), secreting germinoma (SG) and non-germinomatous germ cell tumors (NGGCTs). <b>Results:</b> At 5 years, progression-free survival and overall survival of the three groups (PG vs SG vs NGGCT) were 91% versus 81% versus 59%, and 100% versus 82% versus 68%, respectively. There was no statistically significant difference in outcome among histologically and clinically diagnosed germinomas. <b>Conclusion:</b> A criterion for clinical diagnosis when a biopsy is not feasible is elucidated, and comparable outcomes were demonstrated with histologically diagnosed germinomas.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/0f/cns-10-79.PMC8610002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39645455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment patterns and outcomes for patients with newly diagnosed glioblastoma multiforme: a retrospective cohort study. 新诊断的多形性胶质母细胞瘤患者的治疗模式和结果:一项回顾性队列研究。
CNS Oncology Pub Date : 2021-09-01 Epub Date: 2021-08-11 DOI: 10.2217/cns-2021-0007
Srinivas Annavarapu, Anagha Gogate, Trang Pham, Kalatu Davies, Prianka Singh, Nicholas Robert
{"title":"Treatment patterns and outcomes for patients with newly diagnosed glioblastoma multiforme: a retrospective cohort study.","authors":"Srinivas Annavarapu,&nbsp;Anagha Gogate,&nbsp;Trang Pham,&nbsp;Kalatu Davies,&nbsp;Prianka Singh,&nbsp;Nicholas Robert","doi":"10.2217/cns-2021-0007","DOIUrl":"https://doi.org/10.2217/cns-2021-0007","url":null,"abstract":"<p><p><b>Aim:</b> Investigate real-world outcomes and healthcare utilization of patients with glioblastoma multiforme (GBM) related to O<sup>6</sup>-methylguanine DNA methyltransferase (MGMT) promoter testing and methylation. <b>Patients & methods:</b> US Oncology Network data were analyzed for patients receiving first-line (1L) treatment for GBM. <b>Results:</b> Most patients received 1L radiation with temozolomide. Unadjusted median overall survival (OS) was higher in tested versus untested (median:18.1 vs 11.8 months) and in methylated versus unmethylated (median: 25.5 vs 12.4 months). Untested status, unmethylated MGMT and older age were associated with reduced OS and longer 1L treatment with increased OS. Similar findings were observed for progression-free survival. Utilization was similar between cohorts. <b>Conclusion:</b> In community oncology practices, MGMT methylation and testing were predictive of better survival in GBM.</p>","PeriodicalId":10469,"journal":{"name":"CNS Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/e0/cns-10-76.PMC8461754.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39301194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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