Systemic inflammatory biomarkers in primary central nervous system lymphoma versus high-grade glioma: exploratory, comparative and correlative analysis

Q1 Medicine

CNS Oncology Pub Date : 2022-04-04 DOI:10.2217/cns-2022-0004

T. Gupta, P. Nayak, Y. Baviskar, Meetakshi Gupta, A. Moiyadi, S. Epari, A. Janu, N. Purandare, V. Rangarajan, B. Bagal, Abhishek Chatterjee, G. Sastri

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Abstract

Aim: To assess systemic inflammatory biomarkers in non invasive differential diagnosis of primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG). Materials & methods: Patients with similar morphology (PCNSL or HGG) on conventional neuro-imaging were included. Systemic inflammatory indices were calculated from pretreatment complete blood counts and liver function tests and compared against histopathology as reference standard. Results: Mean values of absolute lymphocyte count and prognostic nutritional index were significantly different between PCNSL (n = 42) versus HGG (n = 16). Area under receiver operating characteristics curve for absolute lymphocyte count and prognostic nutritional index in the diagnosis of PCNSL was 0.70 and 0.72 respectively suggesting fair and acceptable diagnostic accuracy. Conclusion: Systemic inflammatory biomarkers complement established clinico-radiological features and aid in the differential diagnosis of PCNSL from HGG.

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原发性中枢神经系统淋巴瘤与高级别胶质瘤的系统性炎症生物标志物:探索性、比较性和相关性分析

目的:评估系统性炎症生物标志物在原发性中枢神经系统淋巴瘤(PCNSL)与高级别胶质瘤(HGG)的无创鉴别诊断中的价值。材料与方法:纳入常规神经影像学形态学相似(PCNSL或HGG)的患者。通过预处理全血细胞计数和肝功能检查计算全身炎症指数，并与组织病理学作为参考标准进行比较。结果:PCNSL (n = 42)和HGG (n = 16)的绝对淋巴细胞计数和预后营养指数的平均值有显著差异。绝对淋巴细胞计数和预后营养指数对PCNSL诊断的受者工作特征曲线下面积分别为0.70和0.72，表明诊断准确性是公平和可接受的。结论:全身性炎症生物标志物补充了已建立的临床放射学特征，有助于PCNSL与HGG的鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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