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引用次数: 0
摘要
背景：原发性颅内生殖细胞瘤（ICGCT）通常通过肿瘤标志物和影像学检查来诊断，这样可以避免活检。标记物轻度升高的颅内生殖细胞瘤很少作为一个独立实体进行分层。方法：将59名患者分为三组：纯生殖细胞瘤（PG）、分泌性生殖细胞瘤（SG）和非生殖细胞瘤（NGGCTs）。结果显示5年后，三组（PG vs SG vs NGGCT）的无进展生存率和总生存率分别为91%对81%对59%，以及100%对82%对68%。组织学诊断和临床诊断的生殖细胞瘤之间的结果差异无统计学意义。结论：在无法进行活组织检查的情况下，临床诊断的标准得到了阐明，组织学诊断的生殖细胞瘤的疗效相当。
A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes.
Background: Primary intracranial germ cell tumors (ICGCT) are often diagnosed with tumor markers and imaging, which may avoid the need for a biopsy. An intracranial germ cell tumor with mild elevation of markers is seldom stratified as a distinct entity. Methods: Fifty-nine patients were stratified into three groups: pure germinoma (PG), secreting germinoma (SG) and non-germinomatous germ cell tumors (NGGCTs). Results: At 5 years, progression-free survival and overall survival of the three groups (PG vs SG vs NGGCT) were 91% versus 81% versus 59%, and 100% versus 82% versus 68%, respectively. There was no statistically significant difference in outcome among histologically and clinically diagnosed germinomas. Conclusion: A criterion for clinical diagnosis when a biopsy is not feasible is elucidated, and comparable outcomes were demonstrated with histologically diagnosed germinomas.
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