Cold Spring Harbor perspectives in medicine最新文献_第2页

Lineage-Selective Dependencies in Pediatric Cancers. 小儿癌症的系谱选择依赖性

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-04-01 DOI: 10.1101/cshperspect.a041573

K Elaine Ritter, Adam D Durbin

{"title":"Lineage-Selective Dependencies in Pediatric Cancers.","authors":"K Elaine Ritter, Adam D Durbin","doi":"10.1101/cshperspect.a041573","DOIUrl":"10.1101/cshperspect.a041573","url":null,"abstract":"The quest for effective cancer therapeutics has traditionally centered on targeting mutated or overexpressed oncogenic proteins. However, challenges arise in cancers with low mutational burden or when the mutated oncogene is not conventionally targetable, which are common situations in childhood cancers. This obstacle has sparked large-scale unbiased screens to identify collateral genetic dependencies crucial for cancer cell growth. These screens have revealed promising targets for therapeutic intervention in the form of lineage-selective dependency genes, which may have an expanded therapeutic window compared to pan-lethal dependencies. Many lineage-selective dependencies regulate gene expression and are closely tied to the developmental origins of pediatric tumors. Placing lineage-selective dependencies in a transcriptional network model is helpful for understanding their roles in driving malignant cell behaviors. Here, we discuss the identification of lineage-selective dependencies and how two transcriptional models, core regulatory circuits and gene regulatory networks, can serve as frameworks for understanding their individual and collective actions, particularly in cancers affecting children and young adults.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebrafish Models for Drug Discovery and Therapeutic Validation against Non-Tuberculous Mycobacteria. 用于非结核分枝杆菌药物发现和治疗验证的斑马鱼模型。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-27 DOI: 10.1101/cshperspect.a041832

Matt D Johansen, Claire Hamela, Yi Ding, Laurent Kremer

引用次数: 0

Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults. 发展肿瘤学：儿童和青少年癌症的原理和治疗。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041847

Alex Kentsis, Alejandro Gutierrez

引用次数: 0

Threats from the Fungal Kingdom. 来自真菌王国的威胁。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041630

Arturo Casadevall

引用次数: 0

Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment. 正常发育和肿瘤微环境之间典型发育信号通路的相似之处。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041609

Julia Segal, James Cronk, Brendan Ball, Greta Forbes, Kailey Jackett, Kathy Li, Alondra Martinez Osorno, Emily San Andres Montalvan, Alice Browne, Jessica Lake, Rosandra N Kaplan

{"title":"Parallels in Canonical Developmental Signaling Pathways between Normal Development and the Tumor Microenvironment.","authors":"Julia Segal, James Cronk, Brendan Ball, Greta Forbes, Kailey Jackett, Kathy Li, Alondra Martinez Osorno, Emily San Andres Montalvan, Alice Browne, Jessica Lake, Rosandra N Kaplan","doi":"10.1101/cshperspect.a041609","DOIUrl":"https://doi.org/10.1101/cshperspect.a041609","url":null,"abstract":"The tumor microenvironment (TME) is comprised of both cellular and stromal elements and plays an essential role in the growth, survival, and dissemination of malignancies. The TME is an organized program that develops with a growing tumor, using many processes involved in normal tissue development. In multiple solid tumors, developmental pathways are used to recruit immunosuppressive cells, including immunosuppressive monocytes and neutrophils, tumor-associated macrophages, and regulatory T cells to block the antitumor immune response. In addition, stromal cells sustain tumor growth via trophic support, angiogenesis, repair mechanisms, and associated immunosuppression, driven, at least in part, by canonical developmental signaling pathways. The microenvironmental ecosystem shapes tumor progression from its earliest inception by modulating important programs that dictate tumor behavior, necessitating further consideration when studying the developmental origins of malignancy. Here, we review the role of developmental pathways in the formation and modulation of the TME in pediatric and adult solid tumors, including Wnt, Notch, Hippo, Hedgehog, TGF-β, BMP, SOX, and OCT.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging of Disease-Related Networks in Parkinson's Disease. 帕金森病疾病相关网络的影像学研究

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-17 DOI: 10.1101/cshperspect.a041841

Yoshikazu Nakano, Martin Niethammer, David Eidelberg

{"title":"Imaging of Disease-Related Networks in Parkinson's Disease.","authors":"Yoshikazu Nakano, Martin Niethammer, David Eidelberg","doi":"10.1101/cshperspect.a041841","DOIUrl":"https://doi.org/10.1101/cshperspect.a041841","url":null,"abstract":"Functional neuroimaging techniques are increasingly being used to advance the diagnosis and management of Parkinson's disease (PD). Methods such as [18F]-fluorodeoxyglucose positron emission tomography (FDG PET), resting-state functional magnetic resonance imaging (rs-fMRI), arterial spin labeling (ASL) MRI, and single-photon emission computed tomography (SPECT) enable the identification of disease-specific patterns like the PD-related pattern (PDRP) and PD cognition-related pattern (PDCP), which correlate with motor and cognitive symptoms. Network analysis using graph theory further elucidates the alterations in brain connectivity associated with PD, providing insights into disease progression and response to treatment. Moreover, these neuroimaging patterns assist in distinguishing PD from atypical parkinsonian syndromes, enhancing diagnostic accuracy. Understanding the impact of genetic variants like LRRK2 and GBA1 on functional connectivity highlights the potential for precision medicine in PD. As neuroimaging technologies evolve, their integration into clinical practice will be pivotal in the personalized management of PD, offering improved diagnostic precision and targeted therapeutic interventions.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Studying Cancer Immunology in Mice. 研究小鼠癌症免疫学的进展。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-03 DOI: 10.1101/cshperspect.a041682

Marcus Bosenberg

引用次数: 0

Toxin-Induced Animal Models of Parkinson's Disease. 毒素诱导的帕金森病动物模型。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-03 DOI: 10.1101/cshperspect.a041643

Kim Tieu, Said S Salehe, Harry J Brown

引用次数: 0

Angiogenesis: Biology and Pathology, Second Edition. 血管生成：血管生成：生物学与病理学》，第二版。

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-03 DOI: 10.1101/cshperspect.a041779

Diane R Bielenberg, Patricia A D'Amore

{"title":"Angiogenesis: Biology and Pathology, Second Edition.","authors":"Diane R Bielenberg, Patricia A D'Amore","doi":"10.1101/cshperspect.a041779","DOIUrl":"10.1101/cshperspect.a041779","url":null,"abstract":"During development, the first blood vessels are formed by the de novo assembly of angioblasts, endothelial cell precursors, in a process called vasculogenesis. All subsequent sprouting of blood vessels from pre-existing vessels is termed angiogenesis and is a process that continues throughout our lifespan during physiological processes such as wound healing as well as in number of pathological conditions, such as tumor growth and age-related macular degeneration. The circulatory system pumps blood from the heart out to the organs through arteries and deliveries oxygen and nutrients via capillaries to tissues and cells and returns carbon dioxide and waste products back through veins. Each organ varies in its blood vessel patterning, reflecting specialization to accomplish diverse functions including vascular permeability, filtration, immune trafficking, and hormone regulation. Approximately 90% of the fluid extravasated into the interstitium is recycled back to the circulatory system via the unidirectional lymphatic system. Lymphatic capillaries drain fluid, proteins, and cells from tissues and transport this lymph fluid through collecting lymphatic ducts toward lymph nodes. Eventually lymphatic fluid from the right and left lymphatic ducts joins the subclavian veins and recirculates throughout the circulatory system. These two intricate vascular systems, working in cooperation, help to maintain essential bodily functions such as fluid dynamics, tissue homeostasis, blood pressure, metabolism, and immunity. However, dysfunction of these systems is associated with a host of pathological conditions, including cardiovascular diseases, obesity, retinopathy, hypoxia, necrosis, and vascular malformations.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer. 癌症中脂肪酸和胆固醇代谢与细胞应激反应途径的相互作用

IF 7.8 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2025-03-03 DOI: 10.1101/cshperspect.a041548

Alina M Winkelkotte, Kamal Al-Shami, Adriano B Chaves-Filho, Felix C E Vogel, Almut Schulze

{"title":"Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer.","authors":"Alina M Winkelkotte, Kamal Al-Shami, Adriano B Chaves-Filho, Felix C E Vogel, Almut Schulze","doi":"10.1101/cshperspect.a041548","DOIUrl":"10.1101/cshperspect.a041548","url":null,"abstract":"Lipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received substantial attention, the roles of lipids in the metabolic reprogramming of cancer cells are less well understood. However, since the first description of de novo fatty acid biosynthesis in cancer tissues almost 70 years ago, numerous studies have investigated the complex functions of altered lipid metabolism in cancer. Here, we will summarize the mechanisms by which oncogenic signaling pathways regulate fatty acid and cholesterol metabolism to drive rapid proliferation and protect cancer cells from environmental stress. The review also discusses the role of fatty acid metabolism in metabolic plasticity required for the adaptation to changing microenvironments during cancer progression and the connections between fatty acid and cholesterol metabolism and ferroptosis.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":7.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0