Cold Spring Harbor perspectives in medicine最新文献_第3页

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines. 新的疟疾预防模式：疫苗以外的长效干预措施。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-29 DOI: 10.1101/cshperspect.a041859

Cristina Donini, Richard K Amewu, Benoit Bestgen, Eric Guantai

{"title":"New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.","authors":"Cristina Donini, Richard K Amewu, Benoit Bestgen, Eric Guantai","doi":"10.1101/cshperspect.a041859","DOIUrl":"10.1101/cshperspect.a041859","url":null,"abstract":"Malaria prevention is key for protecting high-risk groups, such as children and pregnant women. Existing approaches, including insecticide-based vector control, infant vaccination, and targeted chemoprevention are successful in some contexts. However, new tools are needed to broaden the scope and enhance the effectiveness of preventive strategies, particularly in high transmission areas. This paper examines emerging modalities for malaria chemoprevention beyond vaccination, illustrating advances toward long-acting interventions that can provide sustained protection with fewer doses. The pharmacological rationale and essential considerations for the clinical development and deployment of monoclonal antibodies, long-acting oral agents, and long-acting injectable small-molecule formulations are explored with examples. These innovations represent a step-change in malaria prevention, improving operational feasibility and long-term impact in endemic settings. They also have the potential to transform malaria prevention from a disease control tool in high-burden settings to a strategy capable of accelerating malaria elimination.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management. 糖尿病与肺结核的相互作用：流行病学、筛查和临床管理。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-29 DOI: 10.1101/cshperspect.a041894

Vijay Viswanathan, Reshma Mirshad

引用次数: 0

Progression in Parkinson's Disease. 帕金森病的进展。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-01 DOI: 10.1101/cshperspect.a041641

Krithi Irmady, Serge Przedborski

引用次数: 0

From Empirical Discovery to Targeted Therapy: The Evolution of Tuberculosis Treatment. 从经验发现到靶向治疗：结核病治疗的演变。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-01 DOI: 10.1101/cshperspect.a041821

Natalie J E Waller, Kyu Y Rhee

{"title":"From Empirical Discovery to Targeted Therapy: The Evolution of Tuberculosis Treatment.","authors":"Natalie J E Waller, Kyu Y Rhee","doi":"10.1101/cshperspect.a041821","DOIUrl":"10.1101/cshperspect.a041821","url":null,"abstract":"Tuberculosis (TB) chemotherapy was once considered a crowning triumph of modern medicine but has since reemerged as a persisting paradox. While therapeutically still effective in most cases, current frontline treatments for TB remain largely unchanged from their introduction over 50 years ago and continue to require a minimum of 6 months of multidrug treatment to achieve durable cure, limiting both their individual and population level impact. Its impact has been further eroded by the emergence and spread of drug resistance. Although new antibiotics active against drug-resistant TB are beginning to emerge, their integration into shorter, more effective regimens has proven difficult. This review revisits the evolution of TB chemotherapy and explores how individual drug properties shape overall regimen efficacy and treatment duration. While initially shaped by efforts to prevent resistance-based treatment failures while minimizing toxicity, the empirical development of combination chemotherapies revealed additional determinants of treatment efficacy that extended beyond conventional antimicrobial potency and impacted treatment duration. By integrating classical findings with modern insights into pharmacology, lesion physiology, and bacterial persistence, we highlight the potential that mechanism-based insights into existing TB chemotherapies could guide the rational design of next-generation, treatment-shortening combinations.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosing Tuberculosis Infection: From the Host to the Pathogen. 诊断结核感染：从宿主到病原体。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-01 DOI: 10.1101/cshperspect.a041955

Delia Goletti, Alessandra Aiello, Shruthi Chandran, Adrian R Martineau

{"title":"Diagnosing Tuberculosis Infection: From the Host to the Pathogen.","authors":"Delia Goletti, Alessandra Aiello, Shruthi Chandran, Adrian R Martineau","doi":"10.1101/cshperspect.a041955","DOIUrl":"10.1101/cshperspect.a041955","url":null,"abstract":"Tuberculosis (TB) continues to pose a significant global health challenge. An estimated quarter of the world's population has a TB infection (TBI) with an immune response to Mycobacterium tuberculosis (Mtb) without clinical, microbiological, or radiological signs of TB disease. Individuals with TBI have a lifelong risk of reactivation, leading to TB disease in 5%-10% of cases during a lifetime. Current diagnostic tools, including interferon-γ release assays and skin tests, are endorsed by the World Health Organization (WHO) for identifying TBI and guiding preventive therapy. This paper outlines existing diagnostic methods for TBI and explores emerging experimental approaches, focused on detecting circulating bacillary components-such as DNA, mycobacterial proteins, peptides, lipoglycans, and lipoprotein antigens. The development of diagnostic tools that target bacillary elements directly-rather than relying solely on antigen-specific immune responses-could help overcome key limitations of current immunodiagnostic assays, thus offering viable alternatives or complementary solutions. However, these new experimental assays are still under research and not yet validated for clinical use.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adoptive Cell Therapy for Pediatric Solid Tumors. 儿童实体瘤的过继细胞治疗。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-01 DOI: 10.1101/cshperspect.a041636

Amy B Hont, Catherine M Bollard

引用次数: 0

Parkinson's Disease, Second Edition. 帕金森病，第二版。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-06-01 DOI: 10.1101/cshperspect.a041954

Serge Przedborski, Stanley Fahn

引用次数: 0

HIV-Associated Tuberculosis in Adults: Diagnosis and Clinical Management. 成人hiv相关结核：诊断和临床管理。

IF 10.1 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-05-26 DOI: 10.1101/cshperspect.a041889

Graeme Meintjes, Bianca Sossen

{"title":"HIV-Associated Tuberculosis in Adults: Diagnosis and Clinical Management.","authors":"Graeme Meintjes, Bianca Sossen","doi":"10.1101/cshperspect.a041889","DOIUrl":"10.1101/cshperspect.a041889","url":null,"abstract":"Human immunodeficiency virus (HIV)-associated tuberculosis (TB) is a leading cause of morbidity and mortality, and HIV fuels the TB epidemic in many countries. While there is overlap, there are also critical differences in the diagnosis and management of HIV-associated TB, compared to TB in HIV-uninfected patients. To prevent deaths, the diagnosis and treatment of TB in people with HIV (PWH) needs to occur without delay. Non-sputum-based samples are important to fill the diagnostic yield gap created by challenges obtaining sputum, and reduced sensitivity of sputum diagnostics in PWH. Management of rifampicin-susceptible HIV-associated TB remains a 6month regimen initially with four drugs; an alternative 4month rifapentine and moxifloxacin containing regimen cannot be used in certain PWH (those with CD4 count <100 cells/mm3) and is currently not widely available. Management of rifampicin-resistant TB now involves a 6month all-oral regimen for most patients, including PWH. While significant gains have recently been made toward decreasing mortality from HIV-associated TB, there are many ongoing challenges, some of which are being addressed in active clinical trials.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis Infection: Diagnosis and Management. 结核感染：诊断和管理。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-05-26 DOI: 10.1101/cshperspect.a041803

Ibrahim Abubakar, Jeremiah Chakaya, David Hui, Alimuddin Zumla

{"title":"Tuberculosis Infection: Diagnosis and Management.","authors":"Ibrahim Abubakar, Jeremiah Chakaya, David Hui, Alimuddin Zumla","doi":"10.1101/cshperspect.a041803","DOIUrl":"10.1101/cshperspect.a041803","url":null,"abstract":"Tuberculosis (TB) infection remains the largest reservoir sustaining the global TB epidemic and a critical target for TB elimination. Contemporary evidence has fundamentally reframed TB infection from a static latent state to a dynamic spectrum encompassing early clearance, contained infection, incipient disease, and asymptomatic TB, with heterogeneous risks of progression. This review synthesizes evidence on the natural history, epidemiology, diagnosis, treatment, and programmatic management of TB infection. It reviews World Health Organization (WHO)-recommended diagnostic tools, including interferon-γ release assays and antigen-specific skin tests, and highlights the limitations of current tests in predicting individual progression. Advances in TB preventive treatment, particularly short-course rifamycin-based regimens and evidence-based preventive therapy for drug-resistant TB exposure, are examined alongside persistent implementation gaps across the prevention cascade. The article also addresses priority populations, ethical considerations, and emerging research directions, including prognostic biomarkers, postexposure vaccines, and digital innovations. Effective TB infection management is presented as a central, integrated pillar of future TB elimination strategies.","PeriodicalId":10452,"journal":{"name":"Cold Spring Harbor perspectives in medicine","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate Immunity and Parkinson's Disease. 先天免疫和帕金森病。

IF 4.9 2区医学

Cold Spring Harbor perspectives in medicine Pub Date : 2026-05-01 DOI: 10.1101/cshperspect.a041640

Davina B Oludipe, Xiaoqing Du, Samia Akter, Chen Zhang, R Lee Mosley, Howard E Gendelman, Susmita Sil

引用次数: 0