卵巢透明细胞癌:子宫内膜异位症相关癌症的治疗难题。

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Ruby Yun-Ju Huang, Jimmy Jin-Che Lin
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引用次数: 0

摘要

卵巢透明细胞癌(OCCC)是上皮性卵巢癌的一种组织学亚型,具有不同的病理特征、分子特征和生物学功能。与西半球和欧洲相比,卵巢透明细胞癌在东亚的发病率较高,且与子宫内膜异位症有关。卵巢癌亚型对常规治疗方案相对耐受,经分期调整后的预后最差,因此迫切需要优化治疗方案,改善患者预后。为实现这一目标,需要更好的患者分层策略。对肿瘤异质性进行全面、深入的多维分析可有助于制定这些策略。了解肿瘤间的异质性有助于我们根据预后或预测特征对 OCCC 患者进行分层。最近的基因组学、表观基因组学和转录组学分析使我们能够从综合的角度来看待 OCCC 中的各种异质性,这将为未来的新型转化研究和临床开发铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ovarian Clear Cell Carcinoma: An Endometriosis-Associated Cancer with Therapeutic Challenges.

Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer with distinct pathological features, molecular profiles, and biological functions. OCCC has high incidence rates in East Asia compared to the Western hemisphere and Europe and is associated with endometriosis. With its relative resistance to conventional treatment regimens and the worst stage-adjusted prognosis among ovarian cancer subtypes, there is an urgent need to optimize therapeutic options and to improve patient outcomes. To achieve this goal, better patient stratification strategies are required. These strategies could derive from comprehensive and in-depth multidimensional analysis of tumor heterogeneity. Understanding intertumor heterogeneity could assist us in stratifying OCCC patients based on features that are prognostic or predictive. Recent genomic, epigenomic, and transcriptomic profiling analyses allow us to provide an integrative perspective on the diverse heterogeneity in OCCC that could pave the way for novel translational research and clinical development in the future.

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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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