Clinical Otolaryngology最新文献

{"title":"Article Retraction in Otolaryngology Journals: A Thirty Year Analysis","authors":"Albina S. Islam,&nbsp;Elizabeth M. Mastoloni,&nbsp;John E. Fenton,&nbsp;Daniel H. Coelho","doi":"10.1111/coa.14285","DOIUrl":"10.1111/coa.14285","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To gain insight into the integrity of research in Otolaryngology-Head &amp; Neck Surgery (OHNS) literature through characterising retracted articles, analysing the reason for their retraction, and the trends in the collected data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pubmed, Embase, and Retraction Watch Database were queried for retracted articles published between the dates of 1/31/92 and 9/30/22. Articles with titles relating to OHNS subjects and published in OHNS journals, as determined by Scimago Journal and Country Ranking, were selected for further analysis. Variables recorded included journal name, journal impact factor, article type, article subspecialty subject, reason for retraction, whether re-published, number of authors, time to retraction, and article citations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on title and article content, 245 articles related to the field of OHNS were identified, of which 68 were published in OHNS journals and analysed for reason of retraction. Of those, 16 (23.5%) were replaced due to erratum concerns (spelling, formatting, etc.) rather than content or data-related issues and were excluded. Among the 52 (76.5%) permanent retractions the most common reasons for retraction include article duplication (<i>n</i> = 26), concerns/issues/errors with data (<i>n</i> = 7), and plagiarism (<i>n</i> = 5). The median time between publication and retraction was 2 years (range, 0–19). The median impact factor was 1.64 (range, 0.08–4.68). The median number of citations per article was 7 (range, 0–86).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Retractions continue to occur in the field of OHNS despite increasing education in ethical publication standards and safeguards. There are, however, improved time intervals to retraction indicating improved surveillance of published articles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"514-520"},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Function in Patients With Vestibular Neuritis Experiencing Prodromal Dizziness","authors":"Chisato Fujimoto,&nbsp;Keiko Sugasawa,&nbsp;Kentaro Ichijo,&nbsp;Mineko Oka,&nbsp;Teru Kamogashira,&nbsp;Makoto Kinoshita,&nbsp;Takuya Kawahara,&nbsp;Tatsuya Yamasoba","doi":"10.1111/coa.14284","DOIUrl":"10.1111/coa.14284","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>It is unknown whether prodromal dizziness (PD) before an attack of vestibular neuritis (VN) has an association with peripheral vestibular lesions. The purpose of this study was to investigate whether the severity of vestibular dysfunction has an association with the presence of PD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reviewed the medical records of 88 consecutive unilateral VN patients with unilateral canal paresis in caloric testing. Caloric test, cervical vestibular evoked myogenic potential test to air-conducted sound (ACS cVEMP), ocular vestibular evoked myogenic potential test to bone-conducted vibration (BCV oVEMP) and video head impulse test (vHIT) were used as vestibular function tests. Binomial logistic regression analyses were performed to see whether the subjects' age, sex, disease duration or the presence of PD is associated with the presence of vestibular dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen (19%) experienced an episode of PD. There was no significant association between the presence of PD and abnormality in ACS cVEMPs, BCV oVEMPs, vHIT for the posterior semicircular canal (SCC) or vHIT for the lateral SCC. The presence of PD had a significant positive association with abnormality in vHIT for the anterior SCC (ASCC) (<i>p</i> = 0.0248).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The presence of PD in VN may be associated with the peripheral vestibular lesion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"507-513"},"PeriodicalIF":1.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piloting of a Decision Aid for Recurrent Tonsillitis","authors":"Callum Hill,&nbsp;Kim Ah-See,&nbsp;Helen Moffat","doi":"10.1111/coa.14278","DOIUrl":"10.1111/coa.14278","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Currently, there is no adult-specific decision aid (DA) to support decision-making regarding recurrent tonsillitis. This study intends to address this gap by piloting a prototype DA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Randomised clinical trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Single centre trial at a tertiary otolaryngology department.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>Forty-three patients were randomised to either the DA or Treatment as Usual (TAU) group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>\u0000 <i>Primary objective</i>: To measure how patients rate the quality of their decision-making experience at the time of the decision and at follow-up (SURE scale).</p>\u0000 \u0000 <p>\u0000 <i>Secondary objective</i>: The level of decisional satisfaction at the time of the decision and follow-up, as well as to explore the numbers of people opting for surgery for each study condition (Shared tool and patient feedback).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>\u0000 <i>Quality</i>: This study demonstrates no statistically significant difference in how patients rate the quality of their treatment decision between DA and TAU, both at baseline (<i>p</i> = 0.553) and follow-up (<i>p</i> = 0.062).</p>\u0000 \u0000 <p>\u0000 <i>Satisfaction</i>: This study showed a statistically significant level of decisional satisfaction at the time the decision was made for Qu2 of the Shared tool (<i>U</i> = 113, <i>p</i> = 0.026). No other significant difference was found between participants who received the DA and TAU.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The DA is an acceptable and useful tool that could be incorporated into the pathway for recurrent tonsillitis, helping to eliminate physician implicit bias. However, preliminary qualitative evidence from this pilot study does not suggest that including the DA improves the quality of decision-making.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> IRAS ID - 230 362</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"500-506"},"PeriodicalIF":1.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Balance and Fear of Falling in Patients With Benign Paroxysmal Positional Vertigo: A Controlled Cross-Sectional Study","authors":"Dilek Baday-Keskin,&nbsp;Mustafa Burak Taş,&nbsp;Nuray Bayar-Muluk","doi":"10.1111/coa.14281","DOIUrl":"10.1111/coa.14281","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to evaluate the factors influencing balance and fear of falling (FOF) in patients with benign paroxysmal positional vertigo (BPPV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>A controlled cross-sectional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Single center study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 31 patients with BPPV and 30 controls were included in this cross-sectional study. The handgrip strength (HGS) was measured using the Jamar hydraulic hand dynamometer. Ultrasound measurements of muscle thickness (MT) of the biceps brachii, medial head of gastrocnemius, and lateral head of gastrocnemius were recorded. MT/body mass index was calculated. FOF was assessed using the Falls Efficacy Scale (FES). The Berg Balance Scale (BBS) was used to assess the participants' balance. The timed up and go test (TUG) was used to evaluate physical function. The video head impulse test (VHIT) was used to evaluate the semicircular canals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The FES scores and TUG duration were higher and the BBS scores were lower in patients with BPPV compared with the control group (<i>p</i> &lt; 0.001). Univariate analysis showed that dominant HGS (<i>B</i> = −1.380, <i>p</i> = 0.012), BMI (<i>B</i> = 2.391, <i>p</i> = 0.011), and female gender (<i>B</i> = 18.369, <i>p</i> = 0.036) were associated factors for the FES in patients with BPPV. Age (<i>B</i> = −0.239, <i>p</i> &lt; 0.001), dominant HGS (<i>B</i> = 0.441, <i>p</i> &lt; 0.001), BMI (<i>B</i> = −0.503, <i>p</i> = 0.032) and R ASC (<i>B</i> = −12.601, <i>p</i> = 0.006) were associated variables for the BBS. Age was an associated factor for the TUG (<i>B</i> = 0.158, <i>p</i> = 0.017).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Lower HGS, higher BMI and female gender were associated factors for greater FOF in patients with BPPV. Clinicians should be aware of risk factors and educate patients regarding balance and FOF.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"492-499"},"PeriodicalIF":1.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Funding, Publication Rate and Characteristics of Paediatric Sleep Apnea Clinical Trials: A Cross-Sectional Analysis","authors":"Elizabeth M. Puyo,&nbsp;Jonathan M. Carnino,&nbsp;Frances Rodriguez Lara,&nbsp;Jessica R. Levi","doi":"10.1111/coa.14280","DOIUrl":"10.1111/coa.14280","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this study is to characterise available clinical trial information for paediatric obstructive sleep apnea (OSA) and identify opportunities for future research to better treat children with this condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional analysis of paediatric OSA clinical trials was conducted using the International Clinical Trials Registry. Criteria for inclusion included sleep apnea trials with participants &lt; 18 years old and an interventional design. We assessed the information available on the database to identify recent trends in research. We used PubMed to examine publication rate. NIH RePORTER was used to characterise funding patterns for trials conducted in the United States.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 91 trials analysed, 54% of trials were conducted in the United States. The number of paediatric OSA clinical trials has been increasing since 2005. Patients aged 6, 7 and/or 8 were enrolled in 70% of trials, whereas infants under 12 months of age were only represented in approximately 9%. Overall, 31.9% had results reported directly on the registry, while 57% had results published. Median time to trial completion by sponsor for US trials was 3.04 years for NIH-sponsored trials, 1.29 years for industry-sponsored trials, and 1.96 years for non-funded sources. The NIH funded 56% of US trials.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite a growing interest in paediatric OSA, continued focus on reporting and publishing results in a timely manner is essential to further advance the care of children with OSA. Future research should aim to address the gaps in age representation and focus on early intervention to treat age groups with higher prevalence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"485-491"},"PeriodicalIF":1.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and Neck Squamous Cell Carcinoma of Unknown Primary—Who Can Be Offered Surgery as the Sole Treatment Modality? A Systematic Review","authors":"Arunjit Takhar,&nbsp;Mark D. Wilkie,&nbsp;Devraj Srinivasan,&nbsp;Emma King","doi":"10.1111/coa.14279","DOIUrl":"10.1111/coa.14279","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Evaluate the role of surgery as the sole treatment modality for patients with cervical head and neck squamous cell carcinoma of unknown primary (HNSCCUP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Systematic review of observational cohort studies with qualitative synthesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>PubMed, Ovid EMBASE, and Cochrane Controlled register of Trials (CENTRAL) were screened from January 2000 up to October 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>Patients with HNSCCUP after completing diagnostic workup subsequently treated with single-modality surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>The primary outcome was 3-year overall survival (OS). Secondary outcomes included disease-free survival (DFS), primary emergence, regional recurrence, and distant metastasis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fourteen eligible studies were identified, including 1780 patients, of whom 294 received surgery as their sole treatment (seven studies) with 3-year OS ranging from 43.9% to 100%. 3-year DFS was reported in four studies (<i>n</i> = 62) ranging from 42.8% to 67.0%. 5-year OS and DFS were available in three studies (<i>n</i> = 31), ranging from 36.6% to 75.0%, and 43.6% to 67.0%, respectively. The rate of primary emergence ranged from 11.1% to 33.3% (seven studies, <i>n</i> = 157), regional relapse from 0.0% to 50.0% (five studies, <i>n</i> = 60) and distant metastasis from 0.0% to 3.3% (three studies, <i>n</i> = 45). Patients undergoing surgery as a sole treatment had predominantly p16/HPV positive N1 (TNM7) disease without ECS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Outcomes for HNSCCUP patients undergoing surgery alone range widely in the literature but may be reasonable in a subset of patients with early-stage p16/HPV positive disease. Data is lacking for p16/HPV negative disease where the potential primary site is more varied and primary emergence appears more common.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"399-414"},"PeriodicalIF":1.7,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence Trends in Head and Neck Cancer Subsites: A National Population-Based Study (2001–2020)","authors":"Kelten Clements,&nbsp;Alex D. McMahon,&nbsp;Lesley Bhatti,&nbsp;Craig Smith,&nbsp;Claire Paterson,&nbsp;Catriona M. Douglas,&nbsp;David I. Conway","doi":"10.1111/coa.14271","DOIUrl":"10.1111/coa.14271","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This descriptive epidemiological study aims to investigate trends in head and neck cancer (HNC) within the anatomical divisions of laryngeal, oropharyngeal, and oral cavity cancers over the past two decades.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Retrospective population-based observational study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Scotland, a constituent country of the United Kingdom, with a population of 5.5 million.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>Newly diagnosed HNC patients in Scotland registered in the Scottish Cancer Registry from 2001 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Trends in age-standardised incidence rates from 2001 to 2020 for each HNC subsite, anatomical division, and individual sociodemographic using joinpoint regression analysis and Poisson regression analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, HNC incidence rates have remained stable, with an average annual percentage change (AAPC) of 0.29% (<i>p</i> = 0.34). However, oropharyngeal cancer showed a significant increase in incidence rates with an AAPC of 3.76% (<i>p</i> &lt; 0.001); the tonsils (C09) and the base of the tongue (C01) experienced the greatest increases in AAPC of 4.63% (<i>p</i> = 0.001) and 4.79% (<i>p</i> &lt; 0.001), respectively. Conversely, laryngeal cancer rates declined significantly, with an AAPC of −2.56% (<i>p</i> &lt; 0.001). This decline was primarily influenced by annual reductions of −2.40% (<i>p</i> = 0.09) in cancers affecting the glottis (C32.0). Incidence rates for oral cavity cancer remained mostly stable, with an AAPC of −0.60% (<i>p</i> = 0.08).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This analysis highlights that behind a stable HNC incidence rate over the past 20 years, there are differential trends among various anatomical divisions with an overall increasing burden of oropharyngeal cancer and declining rates of laryngeal cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"474-484"},"PeriodicalIF":1.7,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations for Suspected Head and Neck Squamous Cell Carcinoma of Unknown Primary (HNSCCUP): A National Cohort Study","authors":"John C. Hardman,&nbsp;James Constable,&nbsp;Andrew Williamson,&nbsp;Sian Dobbs,&nbsp;Christopher Hogan,&nbsp;Kate Hulse,&nbsp;Shivun Khosla,&nbsp;Kristijonas Milinis,&nbsp;Ben Tudor-Green,&nbsp;Vinidh Paleri,&nbsp;INTEGRATE (The UK ENT Trainee Research Network)","doi":"10.1111/coa.14272","DOIUrl":"10.1111/coa.14272","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Head and neck squamous cell carcinoma from unknown primary (HNSCCUP) is a rare and challenging condition. This study aimed to investigate the diagnostic pathways of suspected HNSCCUP patients in the United Kingdom.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective observational cohort study was conducted, over 5 years from January 2015, in UK Head and Neck centres of consecutive adults undergoing 18F-Fluorodeoxyglucose-PET-CT (PET-CT) within 3 months of diagnosis with metastatic cervical squamous cell carcinoma. Patients with no primary site on examination and no previous head and neck cancer were eligible.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data for 965 patients were received from 57 centres; 68.5% were HPV-related disease. Three investigation cycles were observed: ultrasound with biopsy, cross-sectional imaging (MRI and/or CT) and PET-CT, at median times of 17, 29.5 and 46 days from referral. No primary was identified on PET-CT in 49.8% (<i>n</i> = 478/960). Diagnostic tonsillectomy was performed in 58.2% (<i>n</i> = 278/478) and tongue base mucosectomy (TBM) in 21.7% (<i>n</i> = 104/479). Ipsilateral tonsillectomy carried the highest diagnostic yield (18.7%, <i>n</i> = 52/278), followed by TBM (15.4%, <i>n</i> = 16/104). Contralateral tonsillectomy, performed in 49.0% (<i>n</i> = 234/478), carried the lowest yield (0.9%, <i>n</i> = 2/234). PET-CT with concurrent MRI was associated with higher primary site detection than PET-CT with concurrent CT (<i>p</i> = 0.003). A minority of patients undergoing treatment with curative intent received first-definitive-treatment within 62 days of referral (15.2%, <i>n</i> = 77/505, median 92 days, IQR: 71–117).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most patients experienced a protracted diagnostic pathway and waited over 3 months for definitive treatment. Earlier PET-CT with concurrent MRI may expedite diagnosis. TBM appears more productive than contralateral tonsillectomy for primary site detection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"462-473"},"PeriodicalIF":1.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Usability of ChatGPT-4 and Google Gemini in Patient Education About Rhinosinusitis","authors":"Çağrı Becerik,&nbsp;Selçuk Yıldız,&nbsp;Çiğdem Tepe Karaca,&nbsp;Sema Zer Toros","doi":"10.1111/coa.14273","DOIUrl":"10.1111/coa.14273","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Artificial intelligence (AI) based chat robots are increasingly used by users for patient education about common diseases in the health field, as in every field. This study aims to evaluate and compare patient education materials on rhinosinusitis created by two frequently used chat robots, ChatGPT-4 and Google Gemini.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>One hundred nine questions taken from patient information websites were divided into 4 different categories: general knowledge, diagnosis, treatment, surgery and complications, then asked to chat robots. The answers given were evaluated by two different expert otolaryngologists, and on questions where the scores were different, a third, more experienced otolaryngologist finalised the evaluation. Questions were scored from 1 to 4: (1) comprehensive/correct, (2) incomplete/partially correct, (3) accurate and inaccurate data, potentially misleading and (4) completely inaccurate/irrelevant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In evaluating the answers given by ChatGPT-4, all answers in the Diagnosis category were evaluated as comprehensive/correct. In the evaluation of the answers given by Google Gemini, the answers evaluated as completely inaccurate/irrelevant in the treatment category were found to be statistically significantly higher, and the answers evaluated as incomplete/partially correct in the surgery and complications category were found to be statistically significantly higher. In the comparison between the two chat robots, in the treatment category, ChatGPT-4 had a higher correct evaluation rate than Google Gemini and was found to be statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The answers given by ChatGPT-4 and Google Gemini chat robots regarding rhinosinusitis were evaluated as sufficient and informative.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"456-461"},"PeriodicalIF":1.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rebleeding After Secondary Post-Tonsillectomy Bleeding: Risk Factors Identified From a Single-Centre Retrospective Study of 448 Cases","authors":"Max Lee,&nbsp;Andrew Wood,&nbsp;Omid Ahmadi,&nbsp;Bert van der Werf,&nbsp;Kumanan Selvarajah","doi":"10.1111/coa.14275","DOIUrl":"10.1111/coa.14275","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 3","pages":"565-572"},"PeriodicalIF":1.7,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}