Clinical Otolaryngology最新文献

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Completion Thyroidectomy Trends and Rates: A Systematic Review and Meta-Analysis 完成甲状腺切除术的趋势和比率:系统回顾与元分析》。
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-26 DOI: 10.1111/coa.14262
Daniel Soibelman, Ohad Ronen
{"title":"Completion Thyroidectomy Trends and Rates: A Systematic Review and Meta-Analysis","authors":"Daniel Soibelman,&nbsp;Ohad Ronen","doi":"10.1111/coa.14262","DOIUrl":"10.1111/coa.14262","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In January 2016, the American Thyroid Association (ATA) published an update to the guidelines concerning the management of adult patients with thyroid nodules and well-differentiated thyroid cancers. One of the revised recommendations states that lobectomy is a reasonable surgical approach for low-risk patients. This systematic review compares the rates of completion thyroidectomy surgeries before and after the publication of the recent ATA guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was conducted according to the PRISMA guidelines of the preferred reporting items for systematic reviews and meta-analyses. PubMed and Embase databases were searched to find articles which demonstrate the rates of completion thyroidectomy surgeries in the last 6 years, before and after the recent ATA guidelines publication. Overall, 8744 titles and abstracts were screened, and 964 articles were fully assessed for eligibility. Eventually, 40 studies were included for data extraction. More than 48 000 patients with thyroid malignancy were included in the review, and were divided into three time periods according to the publication date of 2015 ATA guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that the rate of completion thyroidectomy was 51.8% before 2016 and 43.1% after the 2015 ATA guidelines publication. We observed a 17% reduction of early completion thyroidectomy surgeries since the 2015 ATA guidelines publication relative to previous periods, among patients with malignant pathology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Apparently, more centres worldwide implemented the new guidelines and prefer a conservative surgical approach as compared to the pre-ATA 2015 era.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"205-219"},"PeriodicalIF":1.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.14262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Retrospective Study on the Gender Differences in Clinical Manifestations of Bell's Palsy 贝尔氏麻痹临床表现的性别差异回顾性研究
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-21 DOI: 10.1111/coa.14259
Dong Keon Yon, Dokyoung Kim, Myung Chul Yoo, Sung Soo Kim, Hwa Sung Rim, Sang Hoon Kim, Jae Yong Byun, Seung Geun Yeo
{"title":"A Retrospective Study on the Gender Differences in Clinical Manifestations of Bell's Palsy","authors":"Dong Keon Yon,&nbsp;Dokyoung Kim,&nbsp;Myung Chul Yoo,&nbsp;Sung Soo Kim,&nbsp;Hwa Sung Rim,&nbsp;Sang Hoon Kim,&nbsp;Jae Yong Byun,&nbsp;Seung Geun Yeo","doi":"10.1111/coa.14259","DOIUrl":"10.1111/coa.14259","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Although many studies have assessed the clinical features and the factors affecting treatment outcomes of Bell's palsy, few have analysed differences between men and women. This study therefore evaluated whether the clinical features and treatment results, and the factors affecting them, differ between men and women with Bell's palsy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 1708 patients (791 men and 917 women) who presented with facial palsy to the otolaryngology department between January 1986 and December 2022. Clinical features and treatment outcomes were compared in men and women diagnosed with Bell's palsy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Age distribution, side affected by facial palsy, House-Brackmann (HB) Grade, underlying disease such as diabetes and hypertension, electroneuronography (ENoG) results, electromyography (EMG) results, and treatment methods did not differ significantly between men and women with Bell's palsy (<i>p</i> &gt; 0.05 each). Factors significantly associated with better prognosis in men included milder initial facial palsy and better electromyography (EMG) results (<i>p</i> &lt; 0.05). Factors significantly associated with better prognosis in women included younger age, milder initial facial palsy, and better EMG results (<i>p</i> &lt; 0.05). Women had significantly better prognosis than men when treated with steroids within 3 days of the onset of paralysis (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Milder initial facial palsy and better EMG results were associated with better prognosis in both men and women with Bell's palsy. Younger age at onset and early stage treatment with steroids were associated with a higher recovery rate in women, but not in men.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"307-315"},"PeriodicalIF":1.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Older Aboriginal and Torres Strait Islander People's Experiences With Hearing Loss and Audiological Services: A Scoping Review 老年土著居民和托雷斯海峡岛民在听力损失和听力服务方面的经历:范围审查》。
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-14 DOI: 10.1111/coa.14254
Ayesha Chowdhury, Rong Tian, Paul McIlhiney, Dona M. P. Jayakody
{"title":"Older Aboriginal and Torres Strait Islander People's Experiences With Hearing Loss and Audiological Services: A Scoping Review","authors":"Ayesha Chowdhury,&nbsp;Rong Tian,&nbsp;Paul McIlhiney,&nbsp;Dona M. P. Jayakody","doi":"10.1111/coa.14254","DOIUrl":"10.1111/coa.14254","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>In Australia, older Aboriginal and Torres Strait Islander people have the highest prevalence of hearing loss, for which dedicated audiological services are available.</p>\u0000 \u0000 <p>However, there is limited research on the experiences older Aboriginal and Torres Strait Islander people have with hearing loss and audiological services. Therefore, this study aimed to consolidate existing literature with a scoping review, specifically on the above to identify gaps and guide future research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Ten databases, including electronic journal databases and government databases, were systematically searched. Additional studies were sought from article reference lists, review articles, conference abstracts and Google Scholar. We identified 540 records and 22 of them met our inclusion criteria. Our inclusion criteria constituted research of any design on the experiences of older Aboriginal and Torres Strait Islander people (aged 45+ years) with hearing loss and audiological services.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Seventeen studies reported on experiences with hearing loss, four studies reported on experiences with audiological services and one study reported on both experiences. Prevalence of hearing loss was estimated to be 20%–34% in older Aboriginal and Torres Strait Islander people; a discrepancy between self-reported and objective hearing difficulties was also identified. Audiological services currently available to older Aboriginal and Torres Strait Islander people were also underutilised.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Future research on older Aboriginal and Torres Strait Islander people is required to uncover: (1) the reasons for underreported hearing loss; (2) types of hearing loss experienced; (3) barriers to accessing audiological services; and (4) best hearing-loss management and rehabilitation practices.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"191-204"},"PeriodicalIF":1.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffusion-Weighted Imaging Does Not Differentiate Between Bacterial and Fungal Skull Base Osteomyelitis 弥散加权成像无法区分细菌性和真菌性颅底骨髓炎
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-12 DOI: 10.1111/coa.14256
Arun G. Karthat, Soumya Regi, Habie Thomas, Katti B. Sara, P. Beula Subashini, Rajan Sundaresan, Regi Thomas
{"title":"Diffusion-Weighted Imaging Does Not Differentiate Between Bacterial and Fungal Skull Base Osteomyelitis","authors":"Arun G. Karthat,&nbsp;Soumya Regi,&nbsp;Habie Thomas,&nbsp;Katti B. Sara,&nbsp;P. Beula Subashini,&nbsp;Rajan Sundaresan,&nbsp;Regi Thomas","doi":"10.1111/coa.14256","DOIUrl":"10.1111/coa.14256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Apparent diffusion coefficient (ADC) value helps in differentiating infections from neoplasms on magnetic resonance imaging (MRI). We investigate the diffusion-weighted images in skull base osteomyelitis (SBO) to evaluate if ADC values can differentiate fungal and bacterial SBO and to analyse the microbiology of all SBO patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Retrospective observational study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Quaternary care referral centre.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>A retrospective review of 142 patients diagnosed and treated for SBO patients from January 2010 to May 2023 was done.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measure</h3>\u0000 \u0000 <p>Chi-square or Fisher's exact test was used to compare ADC values of bacterial and fungal SBO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The most common pathogens isolated were <i>Pseudomonas</i> (42.2%), <i>Aspergillus</i> (30.98%), and \u0000 <i>S. aureus</i>\u0000 (23.94%). The average ADC value of affected soft tissues among patients was 1.13 ± 0.26 × 10<sup>−3</sup> mm2/s compared to the average ADC value of normal soft tissue, 1.34 ± 0.31 × 10<sup>−3</sup> mm2/s. There was no statistical significance when comparing the average ADC values of bacterial and fungal SBO patients (<i>p</i> value = 0.142).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that though infection due to <i>Pseudomonas</i> was the commonest, it was detected only in 42.2% of patients. More than half of the cases had organisms other than <i>Pseudomonas</i>, demanding the clinician to obtain deeper biopsies early in the course of the disease for microbiological analysis. DWI does not help differentiate bacterial and fungal SBO, again emphasising the need for deeper tissue biopsies in all these patients to assist in the early identification of the pathogen.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"300-306"},"PeriodicalIF":1.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is It Safe to Cauterise Both Sides of the Nasal Septum at the Same Time in Children With Nosebleeds? 同时灼烧流鼻血儿童的两侧鼻中隔安全吗?
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-11 DOI: 10.1111/coa.14258
Ivy Drake, Hazel Fountain, Haytham Kubba
{"title":"Is It Safe to Cauterise Both Sides of the Nasal Septum at the Same Time in Children With Nosebleeds?","authors":"Ivy Drake,&nbsp;Hazel Fountain,&nbsp;Haytham Kubba","doi":"10.1111/coa.14258","DOIUrl":"10.1111/coa.14258","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>It is often recommended that, in children with bilateral epistaxis, only one side of the nasal septum should be cauterised at a time in order to reduce the risk of septal perforation. This advice may have been reasonable when hot wire electrocautery was in common use. The risk of septal perforation after silver nitrate cautery is unknown but probably low.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective case note review of children attending the nurse-led epistaxis clinic between 2019 and 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine hundred and twenty children were seen in the nurse-led clinic between January 2019 and December 2022. Six hundred and one children (79%) underwent nasal cautery. Simultaneous bilateral nasal cautery was carried out in 176 (29%) children. Our follow up period ranged between 303 and 1744 days, with a median of 809.5 days. No child presented to emergency or ENT services with septal perforation or any other complication of simultaneous bilateral nasal cautery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>To the author's knowledge, this is the largest study assessing the safety of simultaneous bilateral nasal cautery with silver nitrate in children. No adverse results have been found after cauterising both sides of the septum at the same sitting, and doing so potentially saves time and money for patients and the health service.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"295-299"},"PeriodicalIF":1.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Hypothyroidism and Tracheostomal Stenosis in Laryngectomized Patients: A Retrospective Cohort Study 甲状腺功能减退症与喉切除术患者气管狭窄之间的关系:一项回顾性队列研究
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-10 DOI: 10.1111/coa.14253
Roee Noy, Nadeem Habashi, Jacob T. Cohen, Yotam Shkedy
{"title":"Association Between Hypothyroidism and Tracheostomal Stenosis in Laryngectomized Patients: A Retrospective Cohort Study","authors":"Roee Noy,&nbsp;Nadeem Habashi,&nbsp;Jacob T. Cohen,&nbsp;Yotam Shkedy","doi":"10.1111/coa.14253","DOIUrl":"10.1111/coa.14253","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"381-386"},"PeriodicalIF":1.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of 3D Exoscope for Free Flaps Microanastomosis in Head and Neck Reconstruction 在头颈部重建中使用 3D 外窥镜进行游离皮瓣微吻合术。
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-10 DOI: 10.1111/coa.14255
Maxime Tabey, Xavier Dubernard, Emilien Chebib, Nathaniel Assouly, Le-Uyen France Truong, Marc Labrousse, Esteban Brenet
{"title":"Use of 3D Exoscope for Free Flaps Microanastomosis in Head and Neck Reconstruction","authors":"Maxime Tabey,&nbsp;Xavier Dubernard,&nbsp;Emilien Chebib,&nbsp;Nathaniel Assouly,&nbsp;Le-Uyen France Truong,&nbsp;Marc Labrousse,&nbsp;Esteban Brenet","doi":"10.1111/coa.14255","DOIUrl":"10.1111/coa.14255","url":null,"abstract":"","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"387-391"},"PeriodicalIF":1.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Fat Graft Myringoplasty Augmented With Hyaluronic Acid for Managing Large-Sized Eardrum Perforations; A Prospective Comparative Randomised Study 内窥镜脂肪移植耳廓成形术辅以透明质酸治疗大型鼓膜穿孔;一项前瞻性随机对比研究。
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-10 DOI: 10.1111/coa.14252
Mahmoud F. Mandour, Mohamed Tomoum, Mohamed N. Elsheikh, Amani El-Gharib, Saad Elzayat, Maurizio Barbara, Valerio Margani, Haitham H. Elfarargy, Mohamed Amer
{"title":"Endoscopic Fat Graft Myringoplasty Augmented With Hyaluronic Acid for Managing Large-Sized Eardrum Perforations; A Prospective Comparative Randomised Study","authors":"Mahmoud F. Mandour,&nbsp;Mohamed Tomoum,&nbsp;Mohamed N. Elsheikh,&nbsp;Amani El-Gharib,&nbsp;Saad Elzayat,&nbsp;Maurizio Barbara,&nbsp;Valerio Margani,&nbsp;Haitham H. Elfarargy,&nbsp;Mohamed Amer","doi":"10.1111/coa.14252","DOIUrl":"10.1111/coa.14252","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We aimed to assess the outcomes of fat graft myringoplasty augmented with hyaluronic acid in closing large-sized eardrum perforations compared to the traditional underlay cartilage-perichondrium composite myringoplasty (CPCM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Study Design</h3>\u0000 \u0000 <p>It was a prospective randomised comparative study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Settings</h3>\u0000 \u0000 <p>It was held in tertiary referral institutions between May 2020 and April 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>We included 100 patients with a large-sized eardrum perforation (50%–75% of the eardrum surface area). Using the endoscopic transcanal approach, 50 patients were managed by fat graft myringoplasty augmented with hyaluronic acid, while CPCM managed the other 50 patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>We evaluated the closure rates 1, 6 months and 1 year after surgery. Also, we assessed the audiological performance of the patients with a successful closure before and 1 year after the operation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fat graft myringoplasty operation was statistically shorter than the CPCM. The closure rate 1 year after surgery was 92% in the first group and 86% in the second group, without a statistically significant difference between both groups. Successful air-bone gap closure to less than 10 dB occurred in 93.5% of group A and 81.4% of group B without a statistically significant difference. The mean postoperative air-bone gap was 5.3 ± 3.95 dB in the first group and 7.95 ± 5.17 dB in the second group, with a statistically significant difference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fat graft myringoplasty augmented with hyaluronic acid was a reliable, safe, simple, and effective manoeuvre to close large-sized eardrum perforations compared to the conventional CPCM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"288-294"},"PeriodicalIF":1.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal Effects of Gastroesophageal Reflux on Chronic Rhinosinusitis: A Bidirectional Two-Sample Mendelian Randomization Study 胃食管反流对慢性鼻炎的因果效应:双向双样本孟德尔随机研究
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-03 DOI: 10.1111/coa.14251
Xiang Xin, Yang Yang, Li Xuelei, Yao Hongbing, Tang Xinye, Liang Jia
{"title":"Causal Effects of Gastroesophageal Reflux on Chronic Rhinosinusitis: A Bidirectional Two-Sample Mendelian Randomization Study","authors":"Xiang Xin,&nbsp;Yang Yang,&nbsp;Li Xuelei,&nbsp;Yao Hongbing,&nbsp;Tang Xinye,&nbsp;Liang Jia","doi":"10.1111/coa.14251","DOIUrl":"10.1111/coa.14251","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Observational studies have shown a bidirectional association between gastroesophageal reflux (GER) and chronic rhinosinusitis (CRS) or chronic rhinitis (CR), but it is not clear whether this association is causal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study was to investigate the causality between GER and CRS or CR using bidirectional two-sample Mendelian randomization (MR) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using pooled data from large genome-wide association studies (GWAS), genetic loci independently associated with GER, CRS and CR in populations of European and American ancestry were selected as instrumental variables (IVs). The inverse variance weighted (IVW) method was used to analyse the random effects model of MR, and the odds ratio (OR) was used as the evaluation index to explore the bidirectional causality between GER and CRS or CR. Single nucleotide polymorphism (SNP) outliers were detected using MR-pleiotropy Residual Sum and Outliers (MR-PRESSO). The MR–Egger intercept test examined the horizontal pleiotropy of SNPs. The “leave-one-out” sensitivity analysis examined whether MR results were affected by a single SNP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The main results of IVW showed that GER increased the risk of CRS (OR = 1.3795, 95% CI = 1.188–1.603, <i>p</i> &lt; 0.0500) and CR (OR = 1.3941, 95% CI = 1.1671–1.6652, <i>p</i> &lt; 0.0500). The obtained SNPs as IVs for GER, CRS and CR had no significant horizontal pleiotropy, heterogeneity or bias. Regarding the reverse directions, no notable associations could be found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This MR analysis revealed that genetically predicted GER had a causal effect on an increased risk of CRS or CR, but not vice versa. These results have great implications for the management of CRS (especially for refractory CRS) or CR in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"50 2","pages":"280-287"},"PeriodicalIF":1.7,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety of Simultaneous Surgery for Pituitary Neoplasms and Rhinosinusitis 垂体肿瘤和鼻炎同期手术的安全性。
IF 1.7 4区 医学
Clinical Otolaryngology Pub Date : 2024-11-01 DOI: 10.1111/coa.14248
Hye-Bin Jang, Dong Hoon Lee, Shin Jung, Sang Chul Lim
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