Clinics and research in hepatology and gastroenterology最新文献

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Predictive factors of spontaneous common bile duct clearance and unnecessary ERCP in patients with choledocholithiasis. 胆总管结石患者自发胆总管清扫和不必要的 ERCP 的预测因素。
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-12-13 DOI: 10.1016/j.clinre.2024.102515
Fábio Pereira Correia, Henrique Coelho, Mónica Francisco, Gonçalo Alexandrino, Joana Carvalho Branco, Jorge Canena, David Horta, Luís Carvalho Lourenço
{"title":"Predictive factors of spontaneous common bile duct clearance and unnecessary ERCP in patients with choledocholithiasis.","authors":"Fábio Pereira Correia, Henrique Coelho, Mónica Francisco, Gonçalo Alexandrino, Joana Carvalho Branco, Jorge Canena, David Horta, Luís Carvalho Lourenço","doi":"10.1016/j.clinre.2024.102515","DOIUrl":"10.1016/j.clinre.2024.102515","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic retrograde cholangiopancreatography (ERCP) is the first-line procedure for choledocholithiasis treatment. However, it is associated with a 10 % rate of adverse events. Spontaneous migration of common bile duct (CBD) stones occurs in 6-33 % of choledocholithiasis cases, making ERCP avoidable. This study aimed to identify predictors of spontaneous CBD stones' migration.</p><p><strong>Methods: </strong>Retrospective study including patients diagnosed with choledocholithiasis and submitted to ERCP. Patients were divided into 2 groups considering spontaneous stone migration (i.e.: the absence of CBD stones on ERCP). Data on patients' characteristics, imaging findings, biochemical analysis, and ERCP procedure were analyzed to identify predictors of spontaneous migration of CBD stones.</p><p><strong>Results: </strong>334 patients with a mean age of 71.7 years were included in the study: 76.6 % without and 23.4 % with spontaneous migration of CBD stones. Although some patients' features (gender and clinical presentation), imaging findings (diameters of the largest stone and CBD), biochemical analysis (bilirubin levels at diagnosis and pre-ERCP), and ERCP procedure characteristics (time from diagnosis to ERCP) were different between groups, only three variables were defined as predictors: the absence of acute cholangitis, the largest stone diameter ≤5 mm, and the bilirubin levels pre-ERCP ≤ 2mg/dL. When using those variables together there was a chance of 81-86 % to correctly distinguishing patients with and without spontaneous CBD stone migration.</p><p><strong>Conclusion: </strong>The size of the largest stone at diagnosis was validated as a predictor of CBD stones' spontaneous migration. Furthermore, two new predictors were identified: bilirubin levels pre-ERCP ≤ 2 mg/dL, and no acute cholangitis at the clinical presentation of choledocholithiasis. EUS and ERCP in the same session should be considered in patients with factors predictive of stone migration, especially when combined, to minimize unnecessary ERCP and possible complications.</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102515"},"PeriodicalIF":2.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction triplet chemotherapy in patients with rectal adenocarcinoma and synchronous metastases, an AGEO-FFCD study. 直肠腺癌和同步转移患者的诱导三联化疗,AGEO-FFCD 研究。
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-12-12 DOI: 10.1016/j.clinre.2024.102514
Victoire Dabout, Laurent Mineur, David Tougeron, Karine Le Malicot, Claire Gallois, Jean Marc Phelip, Anthony Turpin, Romain Cohen, Benedicte Demoustier, Vincent Hautefeuille, Christophe Locher, Charles-Briac Levaché, Emmanuel Mitry, Thierry Lecomte, Fabien Brocard, Deborah Hassid, Marie Porte, Gilles Breysacher, Jean-Paul Lagasse, Côme Lepage, Marine Valéry, Jean-Baptiste Bachet
{"title":"Induction triplet chemotherapy in patients with rectal adenocarcinoma and synchronous metastases, an AGEO-FFCD study.","authors":"Victoire Dabout, Laurent Mineur, David Tougeron, Karine Le Malicot, Claire Gallois, Jean Marc Phelip, Anthony Turpin, Romain Cohen, Benedicte Demoustier, Vincent Hautefeuille, Christophe Locher, Charles-Briac Levaché, Emmanuel Mitry, Thierry Lecomte, Fabien Brocard, Deborah Hassid, Marie Porte, Gilles Breysacher, Jean-Paul Lagasse, Côme Lepage, Marine Valéry, Jean-Baptiste Bachet","doi":"10.1016/j.clinre.2024.102514","DOIUrl":"10.1016/j.clinre.2024.102514","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aim of the study: &lt;/strong&gt;The management of synchronous metastatic rectal cancer (SMRC) is complex and multimodal, involving chemotherapy, surgery and/or radiotherapy. The aim of this study was firstly to confirm the efficacy of the induction FOLFIRINOX, and secondly to evaluate the different therapeutic strategies and outcomes of patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Patients and methods: &lt;/strong&gt;This French study combined data from a prospective FFCD trial and a multicenter cohort. Patients included had SMRC and had undergone induction triplet chemotherapy. Two groups of patients were defined according to the resectability of metastases at baseline: resectable (Res) and unresectable (URes). The primary endpoint was the objective response rate.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;146 patients were included in 16 French centers and 65 patients in the FFCD1102 trial. In overall population the median age of patients was 59 years, 86% of tumors were of the lower or middle rectum, 33% were well-differentiated, 53% were RAS mutated and 7% BRAF mutated. Triplet induction was associated with 80% of objective response and 92% of disease control. After the induction phase, 69% and 48% of patients of Res and URes groups underwent rectal surgery, and secondary metastases resection was done in 79% and 39% of patients, respectively. Median overall survival (OS) for Res was 56.3 months (95% CI: 22.54-NA). Median OS for URes who had or not secondary metastases resection were 45.1 months (95% CI: 39.89-NA) and 21.1 months (95% CI 17.31-27.1), respectively. Patients with BRAF mutated tumors were more likely to have unresectable disease, and had worse survivals than the patients with RAS mutated or RAS/BRAF wild-type.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Triplet induction chemotherapy is a treatment of choice in selected patients with SMRC, allowing to adapt the therapeutic strategy to the response and invasiveness of the various sites.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Structured abstract: &lt;/strong&gt;The management of metastatic rectal cancer is essentially based on three main therapeutic approaches: surgery, radiotherapy/chemoradiotherapy and chemotherapy. Induction triplet chemotherapy appears as a good choice for fit and young patients. It allows to adapt the therapeutic strategy to the response and invasiveness of the various sites. In this study dedicated to patients undergoing treatment for rectal cancer with synchronous metastases, FOLFIRINOX-based induction chemotherapy was associated with objective response rate of 77% and disease control rate of 92%. These results are similar with those of the FFCD 1102 trial and confirm the efficacy of induction chemotherapy with FOLFIRINOX with or without targeted therapy in these patients in daily routine practice. Surgery for metastases is a key factor in determining patient's outcome and triplet induction chemotherapy, associated with high response rates, enables a significant percentage of patients to undergo surgery and appears therefore to ","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102514"},"PeriodicalIF":2.6,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A heterogeneous subtype of biliary epithelial senescence may be involved in the pathogenesis of primary biliary cholangitis.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-12-09 DOI: 10.1016/j.clinre.2024.102512
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
{"title":"A heterogeneous subtype of biliary epithelial senescence may be involved in the pathogenesis of primary biliary cholangitis.","authors":"Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma","doi":"10.1016/j.clinre.2024.102512","DOIUrl":"10.1016/j.clinre.2024.102512","url":null,"abstract":"<p><strong>Background & aims: </strong>Biliary epithelial senescence is involved in the pathogenesis of primary biliary cholangitis (PBC). We hypothesized that a unique subtype of programmed death-ligand 1 (PD-L1)-positive senescent biliary epithelial cells (BECs) may be related to the pathogenesis of PBC in association with cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) pathway.</p><p><strong>Approach & results: </strong>The expression of PD-L1, STING and their association with senescent markers p16<sup>INK4a</sup> and p21<sup>WAF1/Cip1</sup> were immunohistochemically determined in livers taken from the patients with PBC (n = 87) and 97 diseased and normal control livers. The expression of PD-L1 was significantly increased in a part of senescent BECs with p21<sup>WAF1/Cip1</sup> expression in BECs in the damaged small bile ducts in PBC, compared to control livers (p < 0.01). In contrast, PD-L1 was not expressed in BECs in ductular reactions. The expression of STING was significantly increased in BECs in small bile ducts and ductular reactions in PBC, compared to control livers (p < 0.01). The expression of PD-L1, STING and senescence associated secretory phenotypes (SASPs) including interferon (IFN)-beta was significantly increased in senescent BECs induced by a treatment with serum depletion or glycochenodeoxycholic acid (GCDC) for 4-7 days (p < 0.01) and the increase was significantly suppressed by a knockdown of STING using siRNA (p < 0.01). Induction of cellular senescence induced by a treatment with serum depletion or GCDC was significantly suppressed by a knockdown of STING in BECs. (p < 0.01).</p><p><strong>Conclusion: </strong>A unique subtype of senescent BECs with PD-L1 expression associated with cGAS-STING pathway may be involved in the pathogenesis of PBC.</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102512"},"PeriodicalIF":2.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The flaming and pulled up anorectal line: Ulcerative colitis-associated squamous metaplasia of the lower rectum.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-12-09 DOI: 10.1016/j.clinre.2024.102513
Vincent Zimmer
{"title":"The flaming and pulled up anorectal line: Ulcerative colitis-associated squamous metaplasia of the lower rectum.","authors":"Vincent Zimmer","doi":"10.1016/j.clinre.2024.102513","DOIUrl":"10.1016/j.clinre.2024.102513","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102513"},"PeriodicalIF":2.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An ileo-anal pouch doing the twist (with video).
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-12-06 DOI: 10.1016/j.clinre.2024.102511
Flore de Castelbajac, Nicolas Billet, Laurence Monnier-Chollet, Aziz Zaanan, Philippe Seksik, Xavier Dray
{"title":"An ileo-anal pouch doing the twist (with video).","authors":"Flore de Castelbajac, Nicolas Billet, Laurence Monnier-Chollet, Aziz Zaanan, Philippe Seksik, Xavier Dray","doi":"10.1016/j.clinre.2024.102511","DOIUrl":"10.1016/j.clinre.2024.102511","url":null,"abstract":"<p><p>A 37-year-old female patient had a past history of proctocolectomy for Crohn's disease, with ileal J-pouch-anal anastomosis. She was admitted for acute obstructive symptoms. CT scan revealed a 180 twisted ileo-anal anastomosis without signs of severe ischemia (Fig. 1and video), prompting urgent endoscopic treatment. Lower endoscopy showed a complete spiral of the J-pouch which was easily untwisted and passed. Aspiration followed by placement of a multiperforated Faucher tube allowed immediate symptoms relief. The tube was withdrawn 2 days later and the patient was discharged on the same evening. Although the patient was warned for recurrences, no further episode had occurred at last (60 days) follow-up. The term \"twisted syndrome\" refers to the twisting of the ileal pouch around its mesenteric axis, creating a volvulus, possibly leading to acute intestinal obstruction. It is often caused by insufficient adhesion of the ileum to the pelvis or to excessive length of the mesentery. If untreated, the twist can disrupt vascularization, leading to pouch ischemia and necrosis. The treatment typically involves emergency endoscopy to untwist the pouch whereas redo pouch-surgery should be discussed to prevent future episodes. Other mechanisms of pouch obstruction include prolapse (also known as \"floppy pouch complex\") [2], inflammation, fibrosis, dysplasia or cancer related to inflammatory bowel disease, or rare extraluminal causes. This case highlights the importance of combining emergency CT-scan and endoscopy to diagnose various pouch complications, to untwist the pouch in case of a volvulus, and to enhance the strategy for pouch salvage. Three-dimensional CT-based pouchography is also an advanced option to better guide decisions [3].</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102511"},"PeriodicalIF":2.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward automated small bowel capsule endoscopy reporting using a summarizing machine learning algorithm: The SUM UP study.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-11-30 DOI: 10.1016/j.clinre.2024.102509
Charles Houdeville, Marc Souchaud, Romain Leenhardt, Lia Cmj Goltstein, Guillaume Velut, Hanneke Beaumont, Xavier Dray, Aymeric Histace
{"title":"Toward automated small bowel capsule endoscopy reporting using a summarizing machine learning algorithm: The SUM UP study.","authors":"Charles Houdeville, Marc Souchaud, Romain Leenhardt, Lia Cmj Goltstein, Guillaume Velut, Hanneke Beaumont, Xavier Dray, Aymeric Histace","doi":"10.1016/j.clinre.2024.102509","DOIUrl":"10.1016/j.clinre.2024.102509","url":null,"abstract":"<p><strong>Background and objectives: </strong>Deep learning (DL) algorithms demonstrate excellent diagnostic performance for the detection of vascular lesions via small bowel (SB) capsule endoscopy (CE), including vascular abnormalities with high (P2), intermediate (P1) or low (P0) bleeding potential, while dramatically decreasing the reading time. We aimed to improve the performance of a DL algorithm by characterizing vascular abnormalities using a machine learning (ML) classifier, and selecting the most relevant images for insertion into reports.</p><p><strong>Materials and methods: </strong>A training dataset of 75 SB CE videos was created, containing 401 sequences of interest that encompassed 1,525 images of various vascular lesions. Several image classification algorithms were tested, to discriminate \"typical angiodysplasia\" (P2/P1) and \"other vascular lesion\" (P0) and to select the most relevant image within sequences with repetitive images. The performances of the best-fitting algorithms were subsequently assessed on an independent test dataset of 73 full-length SB CE video recordings.</p><p><strong>Results: </strong>Following DL detection, a random forest (RF) method demonstrated a specificity of 91.1 %, an area under the receiving operating characteristic curve of 0.873, and an accuracy of 84.2 % for discriminating P2/P1 from P0 lesions while allowing an 83.2 % reduction in the number of reported images. In the independent testing database, after RF was applied, the output number decreased by 91.6 %, from 216 (IQR 108-432) to 12 (IQR 5-33). The RF algorithm achieved 98.0 % agreement with initial, conventional (human) reporting. Following DL detection, the RF method allowed better characterization and accurate selection of images of relevant (P2/P1) SB vascular abnormalities for CE reporting without impairing diagnostic accuracy. These findings pave the way for automated SB CE reporting.</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102509"},"PeriodicalIF":2.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and validation of a machine learning-based prediction model for short-term mortality in critically ill patients with liver cirrhosis.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-11-30 DOI: 10.1016/j.clinre.2024.102507
ZhanJin Wang, Fu Yuan Li, JunJie Cai, ZhangTuo Xue, Ying Zhou, Zhan Wang
{"title":"Construction and validation of a machine learning-based prediction model for short-term mortality in critically ill patients with liver cirrhosis.","authors":"ZhanJin Wang, Fu Yuan Li, JunJie Cai, ZhangTuo Xue, Ying Zhou, Zhan Wang","doi":"10.1016/j.clinre.2024.102507","DOIUrl":"10.1016/j.clinre.2024.102507","url":null,"abstract":"<p><strong>Objective: </strong>Critically ill patients with liver cirrhosis generally have a poor prognosis due to complications such as multiple organ failure. This study aims to develop a machine learning-based prediction model to forecast short-term mortality in critically ill cirrhotic patients in the intensive care unit (ICU), thereby assisting clinical decision-making for intervention and treatment.</p><p><strong>Methods: </strong>Machine learning models were developed using clinical data from critically ill cirrhotic patients in the MIMIC database, with multicenter validation performed using data from the eICU database and Qinghai University Affiliated Hospital(QUAH). Various machine learning models, including a Stacking ensemble model, were employed, with the SHAP method used to enhance model interpretability.</p><p><strong>Results: </strong>The Stacking ensemble model demonstrated superior predictive performance through internal and external validation, with AUC and AP values surpassing those of individual algorithms. The AUC values were 0.845 in the internal validation set, 0.819 in the eICU external validation, and 0.761 in the QUAH validation set. Additionally, the SHAP method highlighted key prognostic variables such as INR, bilirubin, and urine output. The model was ultimately deployed as a web-based calculator for bedside decision-making.</p><p><strong>Conclusion: </strong>The machine learning model effectively predicts short-term mortality risk in critically ill cirrhotic patients in the ICU, showing strong predictive performance and generalizability. The model's robust interpretability and its deployment as a web-based calculator suggest its potential as a valuable tool for assessing the prognosis of cirrhotic patients.</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102507"},"PeriodicalIF":2.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-11-29 DOI: 10.1016/j.clinre.2024.102510
Xiaoqing Cao, Yurou Kang, Ping Tai, Pei Zhang, Xin Lin, Fei Xu, Zhenlin Nie, Bangshun He
{"title":"Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis.","authors":"Xiaoqing Cao, Yurou Kang, Ping Tai, Pei Zhang, Xin Lin, Fei Xu, Zhenlin Nie, Bangshun He","doi":"10.1016/j.clinre.2024.102510","DOIUrl":"10.1016/j.clinre.2024.102510","url":null,"abstract":"<p><strong>Background: </strong>To analyze the relationship between tumor-infiltrating lymphocytes (TILs) subtypes and infiltration locations and the prognosis of gastric cancer (GC) patients.</p><p><strong>Methods: </strong>Eligible articles were obtained through systematic retrieval and rigorous screening, collecting study information and extracting hazard ratio (HR), 95 % confidence interval (CI) for pooled analyses of disease-free survival (DFS) and overall survival (OS).</p><p><strong>Results: </strong>Higher CD4<sup>+</sup> TILs were correlated with favorable OS (HR=0.79, 95 %CI: 0.66-0.94, P = 0.009), the similar results were observed in tumor center and in infiltration margin. Higher CD8<sup>+</sup> TILs prolonged DFS (HR=0.69, 95 %CI: 0.51-0.95, P = 0.02) and OS (HR=0.96, 95 %CI: 0.94-0.99, P = 0.006); For OS, tumor center and infiltration margin groups showed positive results. Neither the overall analysis nor the subgroup analyses indicated that the level of FOXP3<sup>+</sup> TILs was associated with prognosis (DFS: HR=0.89, 95 %CI: 0.66-1.19, P = 0.42; OS: HR=0.98, 95 %CI: 0.85-1.13, P = 0.75). Pooled results revealed that higher CD3<sup>+</sup> TILs were correlated with favorable DFS (HR=0.69, 95 %CI: 0.56-0.84, P = 0.0003) but not OS (HR=1.00, 95 %CI: 0.99-1.01, P = 0.48).</p><p><strong>Conclusions: </strong>High infiltrating CD3<sup>+</sup>, CD4<sup>+</sup>, CD8<sup>+</sup> T cells prolong survival, and FOXP3<sup>+</sup> subset is not related to prognosis in GC. For CD4<sup>+</sup> and CD8<sup>+</sup>, positive correlations between the infiltration level and OS were present in tumor center and infiltration margin groups.</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102510"},"PeriodicalIF":2.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current advances in nanoparticle-based approaches for the hepatocellular carcinoma treatment.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-11-28 DOI: 10.1016/j.clinre.2024.102508
Sathishbabu Paranthaman, Umme Hani, Riyaz Ali M Osmani, Rohit R Bhosale, Nazima Haider
{"title":"Current advances in nanoparticle-based approaches for the hepatocellular carcinoma treatment.","authors":"Sathishbabu Paranthaman, Umme Hani, Riyaz Ali M Osmani, Rohit R Bhosale, Nazima Haider","doi":"10.1016/j.clinre.2024.102508","DOIUrl":"10.1016/j.clinre.2024.102508","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is the most common form of liver (LC) with a high mortality rate, driven by risk factors including viral hepatitis, alcoholic liver disease, and nonalcoholic steatohepatitis. The incident of HCC increases 2-4% of the worldwide population each year which would most certainly exceed one million per year by 2025. Despite advances in our knowledge, 25% of HCC tumors have actionable mutations which demands for innovative treatments strategies. In this perspective, we are providing a comprehensive summary of nanoparticles (NPs) based therapeutic approaches for HCC. We begin with an overview of HCC, concentrating on its pathogenesis, current conventional therapies, and their limitations. Then we delve into the therapeutic application of various nanoparticles (NPs) platforms for HCC, including polymeric micelles, dendrimers, liposomes, solid-lipid nanoparticles, nanostructured lipid carriers, exosomes, niosomes, mesoporous silica nanoparticles, carbon nanotubes. Special attention is given to the application of NPs in photothermal and photodynamic treatment was also investigated, with a focus on their effectiveness in targeted cancer ablation. Additionally, the review discusses recent patents and clinical studies that demonstrate the promise of NPs-based therapies in improving HCC treatment outcomes. This article underscores the potential of NPs based technologies to address the challenges faced by traditional therapies and offers insights into future directions for HCC management.</p>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":" ","pages":"102508"},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expansion of interventional endoscopy and day-case procedures: A nationwide longitudinal study of gastrointestinal endoscopy in France.
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-11-26 DOI: 10.1016/j.clinre.2024.102505
Hervé-Pierre Toudic, Marie Morvan, Noémi Reboux, Stanislas Chaussade, Olivier Gronier, Stéphane Koch, David Bernardini, Emmanuel Coron, Michel Robaszkiewicz, Lucille Quénéhervé
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