Does the benefit of optimal MASH treatment depend on a reduction in myosteatosis?

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-06-14 DOI:10.1016/j.clinre.2025.102640

Nicolas Lanthier

引用次数: 0

Abstract

The muscle-liver axis, well known in cirrhosis, is also important in the multi-systemic disease known as metabolic dysfunction-associated steatohepatitis (MASH). The convincing results obtained with a triple peroxisome proliferator-activated receptor (PPAR) agonist in this setting confirm this hypothesis, demonstrating a beneficial effect not only on the severity of MASH in terms of steatosis, inflammation and fibrosis, but also in terms of hepatic and muscle insulin sensitivity. The pathophysiology of MASH and mechanism of action of triple PPAR agonist suggest that this may be related to improved lipid management in skeletal muscles and highlights the importance of studying the muscle-adipose tissue-liver axis in the management of MASH.

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最佳MASH治疗的益处是否取决于肌骨化病的减少？

众所周知，在肝硬化中，肌肉-肝脏轴在代谢功能障碍相关脂肪性肝炎（MASH）等多系统疾病中也很重要。在这种情况下，使用三重过氧化物酶体增殖激活受体（PPAR）激动剂获得的令人信服的结果证实了这一假设，表明不仅在脂肪变性、炎症和纤维化方面对MASH的严重程度有有益的影响，而且在肝脏和肌肉胰岛素敏感性方面也有有益的影响。MASH的病理生理和三重PPAR激动剂的作用机制表明，这可能与改善骨骼肌的脂质管理有关，并强调了研究肌肉-脂肪组织-肝脏轴在MASH管理中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.