Clinics and research in hepatology and gastroenterology最新文献

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Associations between single and combined exposures to environmental phenols and ulcerative colitis in American adults 美国成年人单一和综合暴露于环境酚类与溃疡性结肠炎之间的关系。
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-21 DOI: 10.1016/j.clinre.2024.102468
Fu Xiao, Yusong Wei, Peng Zou, Xiaobin Wu
{"title":"Associations between single and combined exposures to environmental phenols and ulcerative colitis in American adults","authors":"Fu Xiao,&nbsp;Yusong Wei,&nbsp;Peng Zou,&nbsp;Xiaobin Wu","doi":"10.1016/j.clinre.2024.102468","DOIUrl":"10.1016/j.clinre.2024.102468","url":null,"abstract":"<div><h3>Objective</h3><div>The etiology of ulcerative colitis (UC) is complex and involves multiple factors, with exposure to environmental toxins potentially contributing greatly to its pathogenesis. Therefore, this study was carried out with the purpose of delving into the associations between single and combined exposures to environmental phenols and UC among American adults.</div></div><div><h3>Methods</h3><div>Survey data from the 2009–2010 National Health and Nutrition Examination Survey were selected for our research. The associations between single and combined exposures to environmental phenols and the prevalence of UC were analyzed using weighted multivariate logistic regression models as well as Bayesian kernel machine regression (BKMR).</div></div><div><h3>Results</h3><div>A total of 1,422 adults aged 20 years old and above were included in this study, 17 of whom had UC. The correlation matrix showed strong associations between 2,4-dichlorophenol (2,4-DCP) and 2,5-dichlorophenol (2,5-DCP) (<em>R</em> = 0.81), as well as between 2,4,5-trichlorophenol (2,4,5-TCP) and 2,4,6-trichlorophenol (2,4,6-TCP) (<em>R</em> = 0.73). The logistic regression model revealed that, after adjusting for confounders, exposure to environmental phenols was positively associated with the prevalence of UC, with 2,4,6-TCP showing a significant association (OR = 2.37, 95 % CI = 1.10, 5.09, <em>P</em> = 0.037). The BKMR analysis indicated an upward trend in the overall effect of combined exposures to environmental phenols on UC. All five phenols contributed to this effect, with 2,4,6-TCP exhibiting the most pronounced effect. When other compounds were fixed at the 50th percentile, the impact of the five phenols on UC demonstrated a positive association, without any noteworthy interaction among the compounds.</div></div><div><h3>Conclusion</h3><div>Our findings suggested that exposure to environmental phenols may contribute to the occurrence of UC among American adults.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 9","pages":"Article 102468"},"PeriodicalIF":2.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of ramucirumab in gastric or gastroesophageal cancer: A systematic review and meta-analysis 雷莫芦单抗治疗胃癌或胃食管癌的有效性和安全性:系统回顾与荟萃分析
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-20 DOI: 10.1016/j.clinre.2024.102466
Rui Wu , Sijia Yuan , Yuxuan Wang , Yangli Nan , Zixiao Chen , Hong Yuan , Zixuan Wang , Zuojing Li , Dongsheng Zong
{"title":"Efficacy and safety of ramucirumab in gastric or gastroesophageal cancer: A systematic review and meta-analysis","authors":"Rui Wu ,&nbsp;Sijia Yuan ,&nbsp;Yuxuan Wang ,&nbsp;Yangli Nan ,&nbsp;Zixiao Chen ,&nbsp;Hong Yuan ,&nbsp;Zixuan Wang ,&nbsp;Zuojing Li ,&nbsp;Dongsheng Zong","doi":"10.1016/j.clinre.2024.102466","DOIUrl":"10.1016/j.clinre.2024.102466","url":null,"abstract":"<div><h3>Background</h3><p>Ramucirumab is considered a potential treatment for gastric or gastroesophageal cancer; however, its safety has not been evaluated. This meta-analysis aimed to evaluate the efficacy and safety of ramucirumab for treating gastric or gastroesophageal cancer.</p></div><div><h3>Methods</h3><p>The databases of PubMed, Embase, and Cochrane Library were searched through October 2023. The search focused on randomized controlled trials (RCTs) comparing ramucirumab (with or without chemotherapy) to a placebo (with or without chemotherapy) in patients with gastric or gastroesophageal cancer. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were pooled.</p></div><div><h3>Results</h3><p>Seven RCTs with a total of 2613 patients were included. Compared with placebo (with or without chemotherapy), ramucirumab (with or without chemotherapy) significantly improved OS (HR: 0.90, 95% CI: 0.82–0.99, <em>p</em> = 0.030), PFS (HR: 0.74, 95% CI: 0.60–0.90, <em>p</em> = 0.003), ORR (OR: 1.39, 95% CI: 1.15–1.67, <em>p</em> &lt; 0.001), and DCR (OR: 1.91, 95% CI: 1.38–2.63, <em>p</em> &lt; 0.001). However, ramucirumab (with or without chemotherapy) also increased the incidence of decreased appetite (OR: 1.29, 95% CI: 1.09–1.53, <em>p</em> = 0.004), diarrhea (OR: 1.39, 95% CI: 1.01–1.91, <em>p</em> = 0.05), hypertension (OR: 3.13, 95% CI: 2.03–4.83, <em>p</em> &lt; 0.00001), and bleeding or hemorrhage (OR: 2.34, 95% CI: 1.93–2.85, <em>p</em> &lt; 0.00001).</p></div><div><h3>Conclusions</h3><p>Ramucirumab (with or without chemotherapy) can improve OS, PFS, ORR and DCR in patients with gastric or gastroesophageal cancer. However, it may also increase the incidence of specific AEs.</p></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 8","pages":"Article 102466"},"PeriodicalIF":2.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of sarcopenia on liver cirrhosis with complicating oesophageal and gastric varices after endoscopic therapy 肌肉疏松症对肝硬化并发食道和胃静脉曲张内窥镜治疗的影响。
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-13 DOI: 10.1016/j.clinre.2024.102459
Ning-Bo Hao , Ying Zhou , Dan Zhang , Yan-Nan Li , Tian Tian , Yan-Jun Guo , Ying Zhang , Chang-Zheng Li
{"title":"Effect of sarcopenia on liver cirrhosis with complicating oesophageal and gastric varices after endoscopic therapy","authors":"Ning-Bo Hao ,&nbsp;Ying Zhou ,&nbsp;Dan Zhang ,&nbsp;Yan-Nan Li ,&nbsp;Tian Tian ,&nbsp;Yan-Jun Guo ,&nbsp;Ying Zhang ,&nbsp;Chang-Zheng Li","doi":"10.1016/j.clinre.2024.102459","DOIUrl":"10.1016/j.clinre.2024.102459","url":null,"abstract":"<div><p>Several investigators have reported that sarcopenia is common in patients with liver cirrhosis. However, few studies have probed the association between sarcopenia and liver cirrhosis complicated with oesophageal and gastric variceal bleeding (LC-EGVB). We aimed to investigate the impact of sarcopenia on rebleeding after endoscopic therapy in patients with LC-EGVB. Computed tomography (CT) radiographs from the third lumbar vertebra were selected to analyse body composition, including skeletal muscle tissue, visceral and subcutaneous adipose tissue using SliceOmatic software. Sarcopenia was defined using validated cutoff values for patients with liver cirrhosis: 44.77 cm<sup>2</sup>/m<sup>2</sup> for men and 32.50 cm<sup>2</sup>/m<sup>2</sup> for women. A total of 187 patients with LC-EGVB and 309 controls were included in this study. The rate of sarcopenia in controls (17.4 %) was significantly lower than that in patients with LC-EGVB (41.2 %). Patients with LC-EGVB exhibiting sarcopenia showed a high prevalence of portal vein thrombosis and rebleeding rate at 1 year. The rate of sarcopenia in the rebleeding group was significantly higher than that in the non-rebleeding group. Univariate and multivariate analyses showed that sarcopenia was an independent risk factor for rebleeding within 1 year in patients with LC-EGVB. Patients with LC-EGVB displayed a high prevalence of sarcopenia. Sarcopenia was observed to be an independent risk factor for rebleeding within 1 year.</p></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 8","pages":"Article 102459"},"PeriodicalIF":2.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2210740124001803/pdfft?md5=3243313f0ea47f7a7c47b8ff6a80e2d1&pid=1-s2.0-S2210740124001803-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a nomogram for postoperative surgical site infections in patients undergoing bowel resection for Crohn's disease 制定克罗恩病肠道切除术患者术后手术部位感染的提名图
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-12 DOI: 10.1016/j.clinre.2024.102462
Boxuan Lu , Meiling Zhang , Zhihui Wang , Wenhao Zhang , Yinxiao Lu , Jianfeng Gong , Zhifang Wu , Qing Ji
{"title":"Development of a nomogram for postoperative surgical site infections in patients undergoing bowel resection for Crohn's disease","authors":"Boxuan Lu ,&nbsp;Meiling Zhang ,&nbsp;Zhihui Wang ,&nbsp;Wenhao Zhang ,&nbsp;Yinxiao Lu ,&nbsp;Jianfeng Gong ,&nbsp;Zhifang Wu ,&nbsp;Qing Ji","doi":"10.1016/j.clinre.2024.102462","DOIUrl":"10.1016/j.clinre.2024.102462","url":null,"abstract":"<div><h3>Background</h3><p>Surgical site infection (SSI) is a significant concern due to its potential to cause delayed wound healing and prolonged hospital stays. This study aims to develop a predictive model in patients with Crohn's disease.</p></div><div><h3>Methods</h3><p>We conducted single-factor and multi-factor logistic regression analyses to identify risk factors, resulting in the development of a logistic regression model and the creation of a nomogram. The model's effect was validated by employing enhanced bootstrap resampling techniques, calibration curves, and DCA curves. Finally, we investigated the risk factors for wall and intra-abdominal infections separately.</p></div><div><h3>Results</h3><p>90 of 675 patients (13.3 %) developed SSI. Several independent risk factors for SSI were identified, including higher postoperative day one neutrophil count (<em>p</em> = 0.033), higher relative blood loss (<em>p</em> = 0.018), female gender (<em>p</em> = 0.021), preoperative corticosteroid use (<em>p</em> = 0.007), Montreal classification A1 and L2 (<em>p</em> &lt; 0.05), previous intestinal resection (<em>p</em> = 0.017), and remaining lesions (<em>p</em> = 0.015). Additionally, undergoing strictureplasty (<em>p</em> = 0.041) is a protective factor against SSI. These nine variables were used to develop an SSI prediction model presented as a nomogram. The model demonstrated strong discrimination (adjusted C-statistic=0.709, 95 % CI: 0.659∼0.757) and precise calibration. The decision curve showed that the nomogram was clinically effective within a probability threshold range of 3 % to 54 %. Further subgroup analysis revealed distinct risk factors for wall infections and intra-abdominal infections.</p></div><div><h3>Conclusion</h3><p>We established a new predictive model, which can guide the prevention and postoperative care of SSI after Crohn's disease bowel resection surgery to minimize its occurrence rate.</p></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 8","pages":"Article 102462"},"PeriodicalIF":2.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of different modalities of exercise on Fatty Liver Index in patients with metabolic syndrome: The RESOLVE randomized trial 不同运动方式对代谢综合征患者脂肪肝指数的影响:RESOLVE 随机试验
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-12 DOI: 10.1016/j.clinre.2024.102461
Alexis Couret , James A King , Bruno Pereira , Daniel Courteix , Philippe Obert , Agnes Vinet , Guillaume Walther , Bruno Lesourd , Robert Chapier , Marek Zak , Reza Bagheri , Chris U Ugbolue , Armand Abergel , David Thivel , Frédéric Dutheil , Gaël Ennequin
{"title":"Effect of different modalities of exercise on Fatty Liver Index in patients with metabolic syndrome: The RESOLVE randomized trial","authors":"Alexis Couret ,&nbsp;James A King ,&nbsp;Bruno Pereira ,&nbsp;Daniel Courteix ,&nbsp;Philippe Obert ,&nbsp;Agnes Vinet ,&nbsp;Guillaume Walther ,&nbsp;Bruno Lesourd ,&nbsp;Robert Chapier ,&nbsp;Marek Zak ,&nbsp;Reza Bagheri ,&nbsp;Chris U Ugbolue ,&nbsp;Armand Abergel ,&nbsp;David Thivel ,&nbsp;Frédéric Dutheil ,&nbsp;Gaël Ennequin","doi":"10.1016/j.clinre.2024.102461","DOIUrl":"10.1016/j.clinre.2024.102461","url":null,"abstract":"<div><h3>Introduction</h3><p>Metabolic associated liver disease (MASLD) is the most common liver disease in the world especially in people with metabolic syndrome. First-line treatments mainly consist in lifestyle modifications for these populations. The main objective of this study is to assess the effect of a short intervention program with different exercise modalities on Fatty Liver Index (FLI) in patients with metabolic syndrome.</p></div><div><h3>Methods</h3><p>85 patients (40 men, 45 women) with metabolic syndrome and liver steatosis were randomized in 3 groups for a 3 weeks residential program: <em>Re group</em>—high-resistance-moderate-endurance; <em>rE group</em>—moderate-resistance with high-endurance and <em>re group</em>—moderate-resistance with moderate-endurance. Patients also followed a negative energy balance of 500 kcal/day. Then, a follow-up of 1 year with interviews with dieticians and exercise physicians to maintain lifestyle modification was performed. Anthropometric, cardiometabolic and hepatic outcomes were performed at baseline, at the end of the 3-week residential program, 3 months, 6 months and 12 months after baseline.</p></div><div><h3>Results</h3><p>This study demonstrated that all three training programs significantly improve FLI and that this effect was lasting among the follow-up (<em>p</em> &lt; 0.001). More specifically, the <em>Re</em> group exhibited a more pronounced decrease in FLI compared with re (<em>p</em> &lt; 0.05). Finally, the decrease in FLI was associated with improvement in anthropometric and cardiometabolic outcomes at 3-weeks (<em>p</em> &lt; 0.001) and 3-months (<em>p</em> &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>Short duration program is effective to improve FLI and cardiometabolic parameters in MASLD patients. Encourage to increase physical activity even for a short duration is relevant in this population.</p></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 8","pages":"Article 102461"},"PeriodicalIF":2.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors and inpatient outcomes of aspiration pneumonia in patients with percutaneous endoscopic gastrostomy tube: An analysis of national inpatient sample 经皮内镜胃造瘘管患者吸入性肺炎的预测因素和住院结果:全国住院病人样本分析。
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-12 DOI: 10.1016/j.clinre.2024.102463
Chengu Niu , Jing Zhang , Abdullah Orakzai , L K Teja Boppana , Ahmed Elkhapery , Basil Verghese , Patrick I Okolo 3rd
{"title":"Predictors and inpatient outcomes of aspiration pneumonia in patients with percutaneous endoscopic gastrostomy tube: An analysis of national inpatient sample","authors":"Chengu Niu ,&nbsp;Jing Zhang ,&nbsp;Abdullah Orakzai ,&nbsp;L K Teja Boppana ,&nbsp;Ahmed Elkhapery ,&nbsp;Basil Verghese ,&nbsp;Patrick I Okolo 3rd","doi":"10.1016/j.clinre.2024.102463","DOIUrl":"10.1016/j.clinre.2024.102463","url":null,"abstract":"<div><h3>Background</h3><div>Percutaneous endoscopic gastrostomy (PEG) tubes are commonly inserted to provide a route for enteral feeding in patients who are unlikely to have adequate oral intake for prolonged periods of time. This study aims to determine the incidence of aspiration pneumonia among PEG tube patients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of NIS database records (October 2015 to December 2020) for patients with PEG. Primary and secondary outcomes were assessed using ICD-10-CM/PCS codes.</div></div><div><h3>Results</h3><div>We identified a total of 2,053,560 weighted hospitalizations involving patients with PEG tube. Those with aspiration pneumonia were older (mean age 67.01 vs. 63.85, <em>p</em> &lt; 0.01) and were predominantly male. At baseline, the aspiration pneumonia group had higher rates of dementia (AOR 1.22, 95 % CI: 1.19–1.24), malnutrition (AOR 1.13, 95 % CI: 1.11–1.15), cerebrovascular disease (AOR 1.29, 95 % CI 1.25–1.33), cardiac arrhythmias (AOR 1.05, 95 % CI 1.03–1.08), congestive heart failure (AOR 1.20, 95 % CI 1.17–1.24), COPD (AOR 1.18, 95 % CI 1.15–1.20), paralysis (AOR 1.06, 95 % CI 1.03–1.09), alcohol abuse (AOR 1.12, 95 % CI 1.07–1.17), and psychoses (AOR 1.07, 95 % CI 1.02–1.13). Those with aspiration pneumonia exhibited increased mortality (<em>p</em> &lt; 0.01, AOR 1.59, 95 % CI 1.54–1.65), higher incidence of severe sepsis (AOR 2.03, 95 % CI 1.98–2.07) and longer hospital stays, and accrued greater hospital charges (<em>p</em> &lt; 0.01). Notably, while GERD is typically considered a risk factor for AP, our findings indicated that GERD was associated with a decreased risk of AP in this patient population.</div></div><div><h3>Conclusion</h3><div>Patients with a PEG tube who develop aspiration pneumonia experience increased mortality rates, extended hospitalizations, a higher frequency of septic shock, and augmented healthcare consumption. Notably, old male, congestive heart failure, cerebrovascular disease, dementia, and COPD play a pivotal role in predicting these outcomes.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 9","pages":"Article 102463"},"PeriodicalIF":2.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Camrelizumab combined with transcatheter arterial chemoembolization for intermediate or advanced hepatocellular carcinoma: A systematic review and meta-analysis Camrelizumab 联合经导管动脉化疗栓塞治疗中晚期肝细胞癌: 系统综述和荟萃分析。
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-12 DOI: 10.1016/j.clinre.2024.102465
Li Liu, Wenyu He, Jiaoping Liu
{"title":"Camrelizumab combined with transcatheter arterial chemoembolization for intermediate or advanced hepatocellular carcinoma: A systematic review and meta-analysis","authors":"Li Liu,&nbsp;Wenyu He,&nbsp;Jiaoping Liu","doi":"10.1016/j.clinre.2024.102465","DOIUrl":"10.1016/j.clinre.2024.102465","url":null,"abstract":"<div><h3>Objective</h3><div>This review assesses the efficacy and safety of the combination of transarterial chemoembolization (TACE) and camrelizumab for treating advanced hepatocellular carcinoma (HCC) and is to provide a goal, evidence-based medical foundation for effectively guiding clinical practice.</div></div><div><h3>Methods</h3><div>We conducted a computerized search of six electronic databases to identify studies pertinent to the combination of TACE and camrelizumab for treating advanced HCC. For further analysis of clinical indicators and adverse events data, we utilized random or fixed-effect models to account for heterogeneity between studies.</div></div><div><h3>Results</h3><div>As of May 30, 2023, 12 articles were included for Meta-analysis, encompassing 1123 patients with advanced HCC. The results indicated that the combined objective response rate (ORR) and disease control rate (DCR) were 51.1 % and 86.8 %, respectively. Regarding survival indicators, the combined overall survival (OS) and progression-free survival (PFS) were 24.26 months and 11.84 months, respectively. Among the adverse events observed, the highest incidence rates for TACE combined with camrelizumab were fever (all grade: 46.5 %, ≥grade III: 5.0 %), hypertension (all grade: 32.2 %, ≥grade III: 8.5 %), transaminase elevation (all grade: 34.7 %, ≥grade III: 13.4 %), and nausea and vomiting (all grade: 43.9 %, ≥grade III: 2.5 %).</div></div><div><h3>Conclusions</h3><div>This study demonstrated the efficacy and safety of combining TACE with camrelizumab in treating patients with advanced HCC, providing valuable evidence for its prospective clinical application. However, due to the limited availability of clinical data, it is essential to design larger-scale and multi-center clinical randomized controlled trials in the future to validate and confirm these findings definitively.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 9","pages":"Article 102465"},"PeriodicalIF":2.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing baseline VAF in circulating tumor DNA and tumor tissues predicting prognosis of patients with colorectal cancer liver metastases after curative resection 比较循环肿瘤DNA和肿瘤组织中的基线VAF,预测切除术后结直肠癌肝转移患者的预后
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-12 DOI: 10.1016/j.clinre.2024.102464
Ke-min Jin , Quan Bao , Ting-ting Zhao , Hong-wei Wang , Long-fei Huang , Kun Wang , Bao-cai Xing
{"title":"Comparing baseline VAF in circulating tumor DNA and tumor tissues predicting prognosis of patients with colorectal cancer liver metastases after curative resection","authors":"Ke-min Jin ,&nbsp;Quan Bao ,&nbsp;Ting-ting Zhao ,&nbsp;Hong-wei Wang ,&nbsp;Long-fei Huang ,&nbsp;Kun Wang ,&nbsp;Bao-cai Xing","doi":"10.1016/j.clinre.2024.102464","DOIUrl":"10.1016/j.clinre.2024.102464","url":null,"abstract":"<div><h3>Introduction</h3><div>The prognostic value of baseline variant allele frequency (VAF) in circulating tumor DNA (ctDNA) of colorectal cancer liver metastases (CRLM) patients after curative resection was rarely investigated.</div></div><div><h3>Methods</h3><div>A single-center prospective study was performed to investigate the prognostic impact of baseline VAF in ctDNA and matched tumor tissues of CRLM patients after curative resection between May 2019 and May 2021 by the Illumina NovoSeq 6000 platform. The relationship of the tumor burden score (TBS) and the VAF in ctDNA and matched tumor tissues was evaluated by the Pearson correlation method. The survival curves of recurrence-free survival (RFS) and overall survival (OS) were plotted. Factors associated with RFS were calculated using Cox regression analysis, and an integrated prognostic model using significant baseline variables was proposed.</div></div><div><h3>Results</h3><div>There were 121 patients with baseline ctDNA and matched tumor tissues enrolled in the study. A total of 417 mutations spanning 20 genes were identified in baseline tumor tissues of 119/121 (98.3 %) cases. The overall mutations in tumor tissues were completely covered by ctDNA in 52 of 121(43.0 %) patients. Baseline VAF in ctDNA but not in tumor tissues was significantly correlated to TBS of CRLM (<em>R</em> = 0.36, <em>p</em> &lt; 0.001). Significantly longer RFS but not OS was observed in patients with lower VAF in ctDNA compared to those with higher one (<em>p</em> &lt; 0.001 and <em>p</em> = 0.33 respectively). Multivariate Cox regression analysis showed higher VAF in baseline ctDNA was an independent risk factor for RFS. An integrated prognostic model including baseline metastasis location and VAF in ctDNA outperformed the traditional CRS model in predicting RFS.</div></div><div><h3>Conclusion</h3><div>Baseline VAF in ctDNA but not in tumor tissues influenced RFS of CRLM patients after curative resection.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 9","pages":"Article 102464"},"PeriodicalIF":2.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baylor College of Medicine (BCM) model predicts recurrence after mucosectomy of colorectal lateral spreading tumors in European cohorts 贝勒医学院 (BCM) 模型可预测欧洲队列中结直肠侧蔓延肿瘤黏液切除术后的复发情况
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-07 DOI: 10.1016/j.clinre.2024.102460
Juan D. Gomez Cifuentes , Scott Berger , Aaron P Thrift , Gyanprakash Ketwaroo
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引用次数: 0
Gut microbiota–NLRP3 inflammasome crosstalk in metabolic dysfunction-associated steatotic liver disease 代谢功能障碍相关脂肪性肝病中的肠道微生物群-NLRP3炎症小体串联作用
IF 2.6 4区 医学
Clinics and research in hepatology and gastroenterology Pub Date : 2024-09-02 DOI: 10.1016/j.clinre.2024.102458
Tingting Yu , Lei Luo , Juan Xue , Wenqian Tang , Xiaojie Wu , Fan Yang
{"title":"Gut microbiota–NLRP3 inflammasome crosstalk in metabolic dysfunction-associated steatotic liver disease","authors":"Tingting Yu ,&nbsp;Lei Luo ,&nbsp;Juan Xue ,&nbsp;Wenqian Tang ,&nbsp;Xiaojie Wu ,&nbsp;Fan Yang","doi":"10.1016/j.clinre.2024.102458","DOIUrl":"10.1016/j.clinre.2024.102458","url":null,"abstract":"<div><p>Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with metabolic dysfunction, ranging from hepatic steatosis with or without mild inflammation to nonalcoholic steatohepatitis, which can rapidly progress to liver fibrosis and even liver cancer. In 2023, after several rounds of Delphi surveys, a new consensus recommended renaming NAFLD as metabolic dysfunction-associated steatotic liver disease (MASLD). Ninety-nine percent of NAFLD patients meet the new MASLD criteria related to metabolic cardiovascular risk factors under the \"multiple parallel hits\" of lipotoxicity, insulin resistance (IR), a proinflammatory diet, and an intestinal microbiota disorder, and previous research on NAFLD remains valid. The NLRP3 inflammasome, a well-known member of the pattern recognition receptor (PRR) family, can be activated by danger signals transmitted by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), as well as cytokines involved in immune and inflammatory responses. The activation of the NLRP3 inflammasome pathway by MASLD triggers the production of the inflammatory cytokines IL-1β and IL-18. In MASLD, while changes in the composition and metabolites of the intestinal microbiota occur, the disrupted intestinal microbiota can also generate the inflammatory cytokines IL-1β and IL-18 by damaging the intestinal barrier, negatively regulating the liver on the gut–liver axis, and further aggravating MASLD. Therefore, modulating the gut–microbiota–liver axis through the NLRP3 inflammasome may emerge as a novel therapeutic approach for MASLD patients. In this article, we review the evidence regarding the functions of the NLRP3 inflammasome and the intestinal microbiota in MASLD, as well as their interactions in this disease.</p></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"48 8","pages":"Article 102458"},"PeriodicalIF":2.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2210740124001797/pdfft?md5=ecdf2be5d876b10bdf05a4018b786fb3&pid=1-s2.0-S2210740124001797-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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