Clinics and research in hepatology and gastroenterology最新文献_第10页

Residential proximity to pesticide-treated farmland is associated with elevated liver enzymes 居住在农药处理农田附近与肝酶升高有关。

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-29 DOI: 10.1016/j.clinre.2025.102703

Mahmood Moosazadeh , Zahra Charkazi , Narges Mirzaei Ilali , Reza Alizadeh-Navaei , Akbar Hedayatizadeh-Omran , Motahareh Kheradmand , Amirhossein Hessami

引用次数: 0

Clinical application value of MYO1-G methylation in plasma circulating tumor DNA combined with fecal occult blood test for early screening of colorectal cancer 血浆循环肿瘤DNA MYO1-G甲基化联合粪便潜血试验在大肠癌早期筛查中的临床应用价值

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-22 DOI: 10.1016/j.clinre.2025.102690

Di Kang , Jing Li , Jingquan Xu, Yangyang Li, Weiliang Song, Zili Zhang

{"title":"Clinical application value of MYO1-G methylation in plasma circulating tumor DNA combined with fecal occult blood test for early screening of colorectal cancer","authors":"Di Kang , Jing Li , Jingquan Xu, Yangyang Li, Weiliang Song, Zili Zhang","doi":"10.1016/j.clinre.2025.102690","DOIUrl":"10.1016/j.clinre.2025.102690","url":null,"abstract":"<div><h3>Objective</h3><div>Multiple screening strategies are guideline-endorsed for colorectal cancer (CRC). We investigated the clinical value of plasma circulating tumor DNA (ctDNA) MYO1-G methylation and fecal occult blood test (FOBT) combination in CRC screening.</div></div><div><h3>Methods</h3><div>Participants were allocated to the healthy control, colorectal polyp (Col-pol), and CRC groups. Blood and stool samples were collected at least 1 day before colonoscopy, and plasma ctDNA MYO1-G methylation was measured. The quantitative FOBT was conducted using a fully-automatic OC-Sensor analyzer. CRC patients were assigned to the high-methylation (n = 34) and low-methylation (n = 33) groups as per the median value of methylation ratio of ctDNA MYO1-G. The diagnostic value of plasma ctDNA MYO1-G methylation plus FOBT and the correlation between sensitivity and clinical variables were analyzed.</div></div><div><h3>Results</h3><div>Col-pol or CRC patients exhibited raised plasma ctDNA MYO1-G methylation copy number and methylation ratio, with CRC patients showing a higher ratio. There was no significant difference in the total copy number of MYO1-G among the three groups. Plasma ctDNA MYO1-G methylation plus FOBT could distinguish Col-pol (AUC = 0.823) and CRC (AUC = 0.955) patients from controls, and discriminate CRC from Col-pol (AUC = 0.844), displaying higher performance than FOBT. The sensitivity of their combination for assessing CRC was independent of gender, age, tumor size, clinical TNM stage, differentiation degree, pathological pattern, and histology, whereas FOBT sensitivity varied by age (<em>p</em> = 0.04), with higher sensitivity in CRC patients > 50 years old.</div></div><div><h3>Conclusion</h3><div>Plasma ctDNA MYO1-G methylation plus FOBT exhibits high diagnostic value for Col-pol/CRC.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 9","pages":"Article 102690"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent portal hypertension in alcohol-associated hepatitis: A mirror of inflammation rather than mortality predictor 酒精相关性肝炎持续性门脉高压：炎症的反映而非死亡率预测因子

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-25 DOI: 10.1016/j.clinre.2025.102693

Saqlain Haider

引用次数: 0

Advances and future perspectives in the pharmacological treatment of Helicobacter pylori infection: Taking advantage from artificial intelligence 幽门螺杆菌感染的药物治疗进展及未来展望：利用人工智能。

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-11-01 Epub Date: 2025-09-19 DOI: 10.1016/j.clinre.2025.102689

Maria Pina Dore , Elettra Merola , Giovanni Mario Pes

{"title":"Advances and future perspectives in the pharmacological treatment of Helicobacter pylori infection: Taking advantage from artificial intelligence","authors":"Maria Pina Dore , Elettra Merola , Giovanni Mario Pes","doi":"10.1016/j.clinre.2025.102689","DOIUrl":"10.1016/j.clinre.2025.102689","url":null,"abstract":"<div><div><em>Helicobacter pylori</em> remains a major cause of gastritis. Rising antibiotic resistance worldwide has undermined traditional therapies, leading to the decline of standard clarithromycin-based triple therapy, necessitating new treatment strategies. In this review, we summarize advances in <em>H. pylori</em> pharmacotherapy, including the use of novel agents (e.g., the potassium-competitive acid blocker vonoprazan and rifabutin-containing regimens), optimized regimens (such as 10–14 day bismuth quadruple therapy), and adjunctive approaches (probiotics). We highlight region-specific challenges, such as developing countries with high <em>H. pylori</em> prevalence and limited resources, where eradication rates with standard therapies can be extremely low. We also discuss how personalized approaches, including antibiotic susceptibility testing, local resistance surveillance, and even artificial intelligence (AI)-driven decision tools, can guide regimen choice (triple vs. quadruple vs. salvage) to maximize success. Cost considerations are also addressed, noting that expensive treatments, may limit their use especially in low-resource settings. Finally, we outline future directions, such as integrating AI into clinical support systems and expanding access to diagnostics, to improve <em>H. pylori</em> management, patient adherence, maximize treatment efficacy, minimize antimicrobial misuse, and improve global eradication success rates.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 9","pages":"Article 102689"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic factors drive early increase in hepatic steatosis despite improvement in non-invasive fibrosis markers after hepatitis C eradication with direct-acting antivirals: Letter to the editor 在使用直接作用的抗病毒药物根除丙型肝炎后，尽管非侵入性纤维化标志物有所改善，但代谢因素导致肝脂肪变性早期增加：致编辑的信。

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-07-28 DOI: 10.1016/j.clinre.2025.102662

Leela Kumaran , Sheifali Gupta

引用次数: 0

Multiorgan fibrosis in Gaucher disease type I: an unmet goal of enzyme replacement therapy 戈谢病I型的多器官纤维化：酶替代治疗尚未实现的目标。

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-26 DOI: 10.1016/j.clinre.2025.102677

Zufit Hexner-Erlichman , Nimer Assy , Nayaf Habashi , Awni Yousif , Hanna Rosenbaum

{"title":"Multiorgan fibrosis in Gaucher disease type I: an unmet goal of enzyme replacement therapy","authors":"Zufit Hexner-Erlichman , Nimer Assy , Nayaf Habashi , Awni Yousif , Hanna Rosenbaum","doi":"10.1016/j.clinre.2025.102677","DOIUrl":"10.1016/j.clinre.2025.102677","url":null,"abstract":"<div><div>Gaucher disease (GD), the most common lysosomal storage disorders, is characterized by glucocerebroside accumulation within macrophages, leading to multisystem involvement including organomegaly, cytopenias, and bone disease. This study aimed to assess the presence and extent of hepatic, splenic, and bone marrow (BM) fibrosis in GD1 patients by using transient elastography (FibroScan®). Analysis a series of 26 adult GD1 patients, both treatment-naïve and enzyme replacement therapy (ERT) treated, was evaluated for liver and spleen stiffness. Eight patients with persistent cytopenia and hepatosplenomegaly underwent BM biopsy. Median liver and spleen stiffness were 4.8 kPa and 26 kPa, respectively. Mild liver fibrosis was identified in 77% of patients, moderate fibrosis in 15%, and cirrhosis in 7.7%, with comparable prevalence between naïve and treated groups. Splenic fibrosis was observed in 54% of patients, more frequently among those receiving ERT. A strong correlation was found between hepatic and splenic fibrosis, as well as between organ stiffness and fibrosis severity. Bone marrow fibrosis was detected in 75% of biopsied patients. These findings indicate that fibrotic progression may persist despite ERT and is not limited to the liver. Integrating non-invasive fibrosis assessment into routine GD1 monitoring may improve early detection and management of this disease complications.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 8","pages":"Article 102677"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective cohort study of the rectal microbiome in patients with suspected appendicitis 疑似阑尾炎患者直肠微生物组的前瞻性队列研究。

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.1016/j.clinre.2025.102675

Siv Fonnes , Sarah Mollerup , Sarah Juel Paulsen , Andreas Munk Petersen , Barbara Juliane Holzknecht , Henrik Westh , Jacob Rosenberg

{"title":"A prospective cohort study of the rectal microbiome in patients with suspected appendicitis","authors":"Siv Fonnes , Sarah Mollerup , Sarah Juel Paulsen , Andreas Munk Petersen , Barbara Juliane Holzknecht , Henrik Westh , Jacob Rosenberg","doi":"10.1016/j.clinre.2025.102675","DOIUrl":"10.1016/j.clinre.2025.102675","url":null,"abstract":"<div><h3>Purpose</h3><div>Diagnosing appendicitis is difficult. An infectious origin has been proposed, therefore signals from the microbiome could be a potential diagnostic measure. The aim was to evaluate the diagnostic potential of the rectal microbiome in patients with suspected appendicitis.</div></div><div><h3>Methods</h3><div>We included adult Danish patients with suspected appendicitis undergoing appendectomy in a prospective, observational cohort study. Patients were first grouped as patients with and without appendicitis according to histopathological findings, and second, as having uncomplicated or complicated appendicitis according to the surgical report. Rectal swabs were analysed with shotgun metagenomics. The outcomes were alpha diversity, beta diversity, and differential abundance of bacteria.</div></div><div><h3>Results</h3><div>Rectal swabs from 220 patients were analysed: 49 patients without appendicitis, 111 patients with uncomplicated and 60 patients with complicated appendicitis, respectively. Across all groups, both the alpha and beta diversity were similar. The relative abundance of bacterial genera and species was also similar across all groups. Thus, the three groups of patients had similar rectal microbiomes.</div></div><div><h3>Conclusion</h3><div>The rectal microbiome in adult patients with suspected appendicitis was similar and does not seem to have the potential to be used to diagnose neither appendicitis nor the severity of appendicitis preoperatively.</div></div><div><h3>Trial registration</h3><div>NCT03349814 (clinicaltrials.gov)</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 8","pages":"Article 102675"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis B and C in Pakistan: A silent crisis demanding urgent action 巴基斯坦的乙型和丙型肝炎：需要采取紧急行动的无声危机。

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI: 10.1016/j.clinre.2025.102684

Syeda Verisha Batool , Noor Fatima , Rabia Asim

引用次数: 0

Inflation as a gut health crisis: The SAFEGUARD framework 作为肠道健康危机的通货膨胀：保障框架

IF 2.4 4区医学

Clinics and research in hepatology and gastroenterology Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1016/j.clinre.2025.102673

Rushabh H. Doshi , Bhav Jain , Fatima Cody Stanford

引用次数: 0

Opportunistic fast-track sub-submerged true underwater endoscopic mucosal resection (uEMR) for a gravity-sided rectal lesion during screening colonoscopy 机会性快速通道水下真水下内镜粘膜切除术（uEMR）用于筛查结肠镜检查期间重侧直肠病变。