{"title":"Correspondence on “Evaluation of long-term changes in liver function and structure in patients exposed to SARS-CoV-2 infection: a prospective study”","authors":"Hinpetch Daungsupawong , Viroj Wiwanitkit","doi":"10.1016/j.clinre.2025.102628","DOIUrl":"10.1016/j.clinre.2025.102628","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 7","pages":"Article 102628"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of the fibrosis-3 index for predicting liver fibrosis 5 years after achieving sustained virological response in patients with chronic hepatitis C","authors":"Kazuya Kariyama , Hidenori Toyoda , Takashi Kumada , Satoshi Yasuda , Yoshihiko Tachi , Takanori Hirai , Shohei Shiota , Akiko Wakuta , Kazuhiro Nouso","doi":"10.1016/j.clinre.2025.102625","DOIUrl":"10.1016/j.clinre.2025.102625","url":null,"abstract":"<div><h3>Aim</h3><div>Non-invasive tests for liver fibrosis frequently use serum aminotransferases; however, their accuracy may be influenced by hepatitis virus eradication. This study evaluated the effectiveness of the age-independent FIB-3 index in patients with chronic hepatitis C who achieved sustained virological response (SVR).</div></div><div><h3>Methods</h3><div>A total of 115 patients who achieved SVR following interferon therapy were analyzed. Liver fibrosis was assessed by biopsy before treatment and 5 years after achieving SVR. The diagnostic accuracies of the FIB-3 and FIB-4 indices were compared using Receiver Operating Characteristic (ROC) curve analysis and representative cutoff values (FIB-3:3.5, FIB-4:2.67), with a specific focus on age-stratified performance.</div></div><div><h3>Results</h3><div>Age-stratified analysis revealed distinct patterns in fibrosis index performance before and after SVR. Among patients aged ≥ 65 years, both indices demonstrated poor accuracy pre-SVR (FIB-3:0.35, FIB-4:0.29) but markedly improved post-SVR, with FIB-3 demonstrating significantly superior performance (accuracy: 0.82 vs 0.64). This improvement was primarily due to better specificity (FIB-3:0.85 vs FIB-4,0.60) while maintaining high sensitivity (0.62 vs 0.87). In patients aged < 65 years, both indices exhibited modest improvement post-SVR, with no significant differences observed.</div></div><div><h3>Conclusions</h3><div>At established cutoff values, the FIB-3 index demonstrated significantly higher diagnostic performance than the FIB-4 index, particularly in patients aged ≥ 65 years who achieved SVR. These findings suggest that the FIB-3 index is a reliable tool for long-term monitoring of liver fibrosis after hepatitis C eradication.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 7","pages":"Article 102625"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronic kidney disease in isolated core antibody positive hepatitis B patients: Risk analysis from NHANES 2017–2020 study","authors":"Ke Mi , Tingdan Ye , Calvin Q. Pan","doi":"10.1016/j.clinre.2025.102627","DOIUrl":"10.1016/j.clinre.2025.102627","url":null,"abstract":"<div><h3>Background</h3><div>The association between isolated hepatitis B core antibody (HBcAb) positivity and chronic kidney disease (CKD) remains debated. While some studies suggest HBV infection increases CKD risk, others report inconclusive findings. This study evaluated the association between isolated HBcAb positivityand CKD in the U.S. population.</div></div><div><h3>Methods</h3><div>Data from adult participants in the NHANES 2017–2020 pre-pandemic cycle were analyzed based on prespecified eligibility criteria. Participants were categorized into isolated HBcAb positive and non-infected groups. Weighted means and percentages described participant characteristics, while logistic regression models evaluated the association between isolated HBcAb positive and CKD. Multivariate logistic regression identified CKD risk factors among isolated HBcAb positive individuals.</div></div><div><h3>Results</h3><div>Among 7,582 participants (7072 non- infected and 510 isolated HBcAb positive), CKD prevalence was higher in isolated HBcAb positive individuals (7.9 %vs. 5.2 %, <em>P</em> = 0.018). Unadjusted analyses showed isolated HBcAb positivity increased CKD risk (OR = 1.25, 95 % CI: 1.04–1.50, <em>P</em> = 0.019). However, adjusted analyses revealed an inverse association (OR = 0.76, 95 % CI: 0.60–0.98, <em>P</em> = 0.034). In isolated HBcAb positive individuals, older age (OR = 1.06, <em>P</em> = 0.017) and serum urea nitrogen (BUN) elevation (OR = 1.20, <em>P</em> = 0.001) were associated with higher CKD risk, while higher education lever reduced the risk (OR = 0.28, <em>P</em> = 0.030).</div></div><div><h3>Conclusion</h3><div>Although CKD prevalence was higher in isolated HBcAb positive patients, There was no positive association between isolated HBcAb positivity and CKD. Older age and elevated BUN levels were significantly associated with higher CKD risk, while elevated education lever reduced the risk. These findings highlight the needs for individualized monitoring and management of at-risk HBV-infected patients when offering antiviral therapy and monitoring after clinical cure of hepatitis B.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 7","pages":"Article 102627"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of article types of the top-100 cited articles on gastrointestinal endoscopy","authors":"Yanqing Song , Lei Deng , Yanhua Peng , Rui Zhou","doi":"10.1016/j.clinre.2025.102630","DOIUrl":"10.1016/j.clinre.2025.102630","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 7","pages":"Article 102630"},"PeriodicalIF":2.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julien Kirchgesner , Jeremy Augustin , Thomas Bazin , Pamela Freiha , Alexandre Nuzzo , Philippe Seksik , Iradj Sobhani , Pablo Bartolucci , Mathieu Uzzan
{"title":"A series of Sickle cell disease-associated inflammatory bowel diseases: high prevalence of colonic involvement and primary sclerosing cholangitis","authors":"Julien Kirchgesner , Jeremy Augustin , Thomas Bazin , Pamela Freiha , Alexandre Nuzzo , Philippe Seksik , Iradj Sobhani , Pablo Bartolucci , Mathieu Uzzan","doi":"10.1016/j.clinre.2025.102615","DOIUrl":"10.1016/j.clinre.2025.102615","url":null,"abstract":"<div><h3>Objective</h3><div>Co-occurrence of Sickle Cell Disease (SCD) and Inflammatory Bowel Diseases (IBD) has been scarcely reported. Our aim was to explore the intersection between SCD and IBD, focusing on the impact of SCD on the natural course of IBD and drug safety.</div></div><div><h3>Methods</h3><div>We conducted a multicenter retrospective case-control study including consecutive patients diagnosed with IBD and SCD. Each IBD patient with SCD was matched with up to 4 IBD patients without SCD. Matching criteria were IBD type, sex, date of birth, length of follow-up and year of diagnosis. The primary outcome was a complicated IBD course.</div></div><div><h3>Results</h3><div>125 IBD patients were studied, including 24 SCD. 23/24 SCD patients had colonic involvement. 33.3 % had concomitant primary sclerosing cholangitis (PSC) compared to 1 % of controls (<em>p</em> < 0.001). Survival without a complicated IBD course was estimated at 58.7 % (CI95[49.6–69.5]) at 5 years for non-SCD patients, as compared to 63.3 % (CI95[45.7–87.6]) for SCD patients SCD (<em>p</em> = 0.36). The survival without the need of advanced therapy was estimated at 66.1 % (CI95[57.3–76.2]) at 5 years for non-SCD patient, and at 78.2 % (CI95[63–97.2]) in SCD patients (<em>p</em> = 0.45) Regarding treatment safety, 26.3 % of patients with SCD and 13.5 % of controls experienced adverse events with biologics (<em>p</em> = 0.17). There was one reported vaso-occlusive crisis associated with thiopurines.</div></div><div><h3>Conclusion</h3><div>Patients with SCD and IBD displayed a distinctive phenotype with constant colonic involvement and high prevalence of PSC.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 7","pages":"Article 102615"},"PeriodicalIF":2.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiayi Wang , Wanxin Long , Zehong Qi , Yangjie Liao , Jingbo Li
{"title":"Analgesics use and risk of pancreatitis: Result from the UK Biobank","authors":"Jiayi Wang , Wanxin Long , Zehong Qi , Yangjie Liao , Jingbo Li","doi":"10.1016/j.clinre.2025.102616","DOIUrl":"10.1016/j.clinre.2025.102616","url":null,"abstract":"<div><h3>Background</h3><div>Pancreatitis, an inflammatory pancreatic disorder, arises from various etiologies including alcohol, tobacco, and drug use. Although the initiation of pancreatitis has been strongly linked to several medications, the association between analgesic use and pancreatitis risk remains ambiguous in population-based studies.</div></div><div><h3>Methods</h3><div>This prospective cohort study involved 324,982 participants from the UK Biobank. Multivariable-adjusted Cox proportional hazards models were conducted to evaluate the longitudinal association between incident pancreatitis risk and analgesics use, encompassing opioids, non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol, antimigraine preparations, and the mix. Subgroup and sensitivity analyses were conducted to assess the potential effects of baseline factors.</div></div><div><h3>Results</h3><div>Over a median follow-up of 13.70 years, 2303 cases of pancreatitis were identified. In the fully adjusted model, analgesics utilization increased the risk of pancreatitis (HR 1.13, 95 % CI 1.04–1.23), acute pancreatitis (AP) (HR 1.11, 95 % CI 1.01–1.22), and chronic pancreatitis (CP) (HR 1.25, 95 % CI 1.00–1.56) (All the above <em>p</em> < 0.05). Furthermore, participants who used opioids presented the highest risk of pancreatitis (HR 1.85, 95 % CI 1.49–2.31, <em>p</em> < 0.001), and the mixed group (HR 1.35, 95 % CI 1.21–1.51, <em>p</em> < 0.001) followed. Compared to the non-analgesics group, the risk of both AP and CP also increased in the opioids and the mixed group. Subgroup analysis indicated that the impact of analgesics utilization on the pancreatitis risk may vary with certain covariates, such as age, cholelithiasis, etc. (p-interaction <0.05).</div></div><div><h3>Conclusion</h3><div>In this large population-based prospective cohort, analgesics utilization, particularly opioids and mixed analgesics, was linked to an increased risk of pancreatitis.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 7","pages":"Article 102616"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Precision oncology in colorectal cancer: An anatomical revolution through molecular-clinical integration across colonic subsites","authors":"Jiefeng Zhao, Daxing Miao","doi":"10.1016/j.clinre.2025.102613","DOIUrl":"10.1016/j.clinre.2025.102613","url":null,"abstract":"<div><div>Colorectal cancer (CRC) exhibits significant heterogeneity across different colonic subsites, which vary in embryological origin, microbiome, metabolome, and molecular profiles, affecting tumorigenesis, treatment response, and prognosis. We emphasize the importance of this subsite heterogeneity to advance precision medicine in CRC.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 6","pages":"Article 102613"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Guerra, Francesco Matarazzo, Giuseppe Giuliani, Andrea Coratti
{"title":"A wandering spleen","authors":"Francesco Guerra, Francesco Matarazzo, Giuseppe Giuliani, Andrea Coratti","doi":"10.1016/j.clinre.2025.102614","DOIUrl":"10.1016/j.clinre.2025.102614","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"49 6","pages":"Article 102614"},"PeriodicalIF":2.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}