Clinics and research in hepatology and gastroenterology最新文献

{"title":"Generalizability and confounding in chemotherapy-induced hepatotoxicity: A call for robust risk stratification","authors":"Koji Takahashi","doi":"10.1016/j.clinre.2026.102785","DOIUrl":"10.1016/j.clinre.2026.102785","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 3","pages":"Article 102785"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary diffuse large B-cell lymphoma of the liver mimicking ruptured hepatocellular carcinoma with hemorrhage","authors":"Tian-Qi Zhao , Wei Jiang , Cun-Jin Ge , Wei Liu","doi":"10.1016/j.clinre.2026.102786","DOIUrl":"10.1016/j.clinre.2026.102786","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 3","pages":"Article 102786"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the importance of coenzyme Q9, glutathione and mitochondrial complex activity in a high fat diet model by a multivariate approach","authors":"Francisco Baez , Damian Soria , Mario Contin , Carolina Caniffi , Valeria Tripodi","doi":"10.1016/j.clinre.2026.102766","DOIUrl":"10.1016/j.clinre.2026.102766","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 3","pages":"Article 102766"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FXR dysregulation as the metabolic nexus driving cholesterol gallstone disease","authors":"Sarvesh Sabarathinam , Nila Ganamurali , K K S Kartheekeyan , Manoj Kumar Narasimhan , Evelyn Sharon Sukumaran","doi":"10.1016/j.clinre.2026.102767","DOIUrl":"10.1016/j.clinre.2026.102767","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102767"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory ascites following pancreatoduodenectomy after preoperative oxaliplatin based chemotherapy: be aware of nodular regenerative hyperplasia!","authors":"Jennifer Candi , Emma Zuppi , Camille Besch , Thibault Wolf , Pietro Addeo","doi":"10.1016/j.clinre.2025.102753","DOIUrl":"10.1016/j.clinre.2025.102753","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102753"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal calprotectin in patients with concomitant primary sclerosing cholangitis and inflammatory bowel disease: a systematic review and meta-analysis","authors":"Giorgia Burrelli Scotti ,&nbsp;Fabrizio Zullo ,&nbsp;Marco Mattana ,&nbsp;Francesco Covotta ,&nbsp;Emanuela Ribichini ,&nbsp;Domenico Alvaro ,&nbsp;Vincenzo Cardinale","doi":"10.1016/j.clinre.2026.102764","DOIUrl":"10.1016/j.clinre.2026.102764","url":null,"abstract":"<div><h3>Background</h3><div>Primary sclerosing cholangitis (PSC) is strongly associated with inflammatory bowel disease (IBD), with up to 70% of PSC patients having concomitant IBD (PSC-IBD). Fecal Calprotectin (FC) is a validated surrogate biomarker of intestinal inflammation in IBD. Emerging evidence suggests that FC may also reflect biliary inflammation in PSC.</div></div><div><h3>Aim</h3><div>This study aimed to compare FC concentrations in patients with PSC-IBD versus IBD only.</div></div><div><h3>Methods</h3><div>A systematic literature search was performed (PROSPERO registration no. CRD42024600985). Studies reporting FC levels in both PSC-IBD and IBD-only patients were included. The outcome of interest was the difference in mean FC concentration between the two groups.</div></div><div><h3>Results</h3><div>Seven studies met the inclusion criteria. There was no significant difference in the mean FC levels between PSC-IBD and IBD patients (-5.10, 95% confidence interval [CI] -45.40 to -35.2; p= 0.8). The findings remained non-significant when endoscopic remission was considered (12.82, 95% CI -19.33 to 44.97; p= 0.43).</div></div><div><h3>Conclusions</h3><div>FC levels did not significantly differ between PSC-IBD and IBD groups. The available evidence is limited and heterogeneous. Larger, well-designed studies are needed to determine whether FC can serve as a surrogate biomarker of PSC progression, particularly in patients with endoscopic remission of colitis or without concomitant IBD.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102764"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of repeat hepatectomy with radiofrequency ablation for the survival of hepatocellular carcinoma with solitary intrahepatic recurrence after hepatectomy","authors":"Jialu Fu ,&nbsp;Jiafeng Chen ,&nbsp;Lei Jin ,&nbsp;Junfeng Huang ,&nbsp;Shengwei Mao ,&nbsp;Xuhui Zhao ,&nbsp;Weifeng Qu ,&nbsp;Rui Yang ,&nbsp;Yi Wang ,&nbsp;Yichao Bu ,&nbsp;Zhiqi Guan ,&nbsp;Jun Gao ,&nbsp;Xiaoling Wu ,&nbsp;Qianfu Zhao ,&nbsp;Tianhao Chu ,&nbsp;Guiqi Zhu ,&nbsp;Yuan Fang ,&nbsp;Yinghong Shi ,&nbsp;Weiren Liu","doi":"10.1016/j.clinre.2025.102750","DOIUrl":"10.1016/j.clinre.2025.102750","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare survival outcomes between repeat hepatectomy (RHT) and radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) patients with solitary intrahepatic recurrence after initial hepatic resection, and to identify associated prognostic factors.</div></div><div><h3>Patients and Methods</h3><div>This study included 377 HCC patients with solitary intrahepatic recurrence after initial hepatectomy (RHT=280, RFA=97). Propensity score matching (PSM) was used to balance intergroup characteristics. Survival outcomes (OS and rRFS) were analyzed using Kaplan-Meier method and compared by log-rank test. Variables that were significant in univariate analysis were further included in multivariate analysis.</div></div><div><h3>Results</h3><div>No significant differences were observed in either OS or rRFS between RFA and RHT groups before (<em>P</em> = 0.37 for OS; <em>P</em> = 0.30 for rRFS) or after PSM (<em>P</em> = 0.58 for OS; <em>P</em> = 0.76 for rRFS). Era-stratified analysis (earlier cohort [1996–2005]: <em>P</em> = 0.40 for OS, <em>P</em> = 0.62 for rRFS; later cohort [2006–2010]: <em>P</em> = 0.18 for OS, <em>P</em> = 0.08 for rRFS) confirmed this finding. Subgroup analyses confirmed the equivalent survival outcomes between RFA and RHT in patients with tumors ≤ 3 cm or &gt; 3 cm but ≤ 5 cm. Multivariate analysis identified HBsAg positivity and tumor diameter &gt; 2 cm as independent risk factors for OS, while recurrence time ≤ 24 months was an independent risk factor for both OS and rRFS.</div></div><div><h3>Conclusion</h3><div>RFA provides comparable OS and rRFS to RHT for HCC patients with solitary intrahepatic recurrence ≤ 5 cm after hepatic resection.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102750"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Comparison of repeat hepatectomy with radiofrequency ablation for the survival of hepatocellular carcinoma with solitary intrahepatic recurrence after hepatectomy”","authors":"Kanishka Harariya ,&nbsp;Thakur Rohit Singh ,&nbsp;Ankita Kalra ,&nbsp;Swarupanjali Padhi ,&nbsp;Fayaz Ahamed","doi":"10.1016/j.clinre.2026.102762","DOIUrl":"10.1016/j.clinre.2026.102762","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102762"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BEND3 is associated with poor prognosis and treatment response in Hepatocellular Carcinoma","authors":"Valbert Oliveira Costa Filho ,&nbsp;Pedro Robson Costa Passos ,&nbsp;Márcia Valéria Pitombeira Ferreira ,&nbsp;Silvia Helena Barem Rabenhorst","doi":"10.1016/j.clinre.2026.102759","DOIUrl":"10.1016/j.clinre.2026.102759","url":null,"abstract":"","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102759"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted endoscopic submucosal dissection in gastrointestinal lesions: A systematic review and meta-analysis","authors":"Amany Mahmoud Genidy ,&nbsp;Abdelaziz Awad ,&nbsp;Omar Khaled Abdelsalam ,&nbsp;Belal Mohamed Hamed ,&nbsp;Nesma Mahmoud Ibrahim ,&nbsp;Ahmed K.M. Khaled ,&nbsp;Omar Saeed ,&nbsp;May Mahmoud Elgamal ,&nbsp;Manar A Balouz ,&nbsp;Ahmed Abdelgayed M Hussein ,&nbsp;Fatma S Mohamed ,&nbsp;Ahmed L. Youseif ,&nbsp;Jawad Mahmood","doi":"10.1016/j.clinre.2025.102752","DOIUrl":"10.1016/j.clinre.2025.102752","url":null,"abstract":"<div><h3>Introduction</h3><div>Endoscopic submucosal dissection (ESD) is an increasingly effective endoscopic technique worldwide. Robot-assisted ESD is a novel technique that enables complex movements by providing an extended range of motions to improve the visualization of the surgical field and provide better cosmetic surgical outcomes. We aim to systematically review and meta-analyze the efficacy and safety of robot-assisted ESD.</div></div><div><h3>Methods</h3><div>We followed the PRISMA guidelines for meta-analysis. We included studies reporting on patients with GI tumors or masses who underwent robot-assisted ESD. Our primary outcomes were en bloc resection rates, recurrence rates, and complications like bleeding and perforation. Secondary outcomes encompassed the length of the procedure, lesion size, complete resection rates, and duration of hospital stay. We used Joanna Briggs Institute's (JBI) Critical Appraisal Tool and the ROBINS-I tool for quality assessment. Continuous data were pooled as means, while dichotomous data were pooled as proportions with a 95 % confidence interval (95 % CI).</div></div><div><h3>Results</h3><div>Eight studies consisting of two clinical trials, three cohort studies, and three case reports with 115 participants were included. The en bloc resection rate was 97.400 %, 95 % CI (0.901, 0.993). According to the complete resection outcome, the rate was 82.900 %, 95 % CI (0.722, 0.900). Procedure time and Hospital Stay were 82.030 min 95 % CI: 48.130, 115.940), 1.640 days 95 % CI (-0.180, 3.740), respectively. The intraoperative bleeding rate was 1.800 %, 95 % CI (0.004, 0.068).</div></div><div><h3>Conclusion</h3><div>Our systematic review and meta-analysis demonstrated robot-assisted endoscopic submucosal dissection's potential efficacy and safety. However, future high-quality studies with larger sample sizes and extended follow-up periods are needed to support our initial findings further. Robot-assisted ESD may be promising in dealing with larger lesions, which are often challenging with conventional ESD.</div></div>","PeriodicalId":10424,"journal":{"name":"Clinics and research in hepatology and gastroenterology","volume":"50 2","pages":"Article 102752"},"PeriodicalIF":2.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}