Circulating tumor DNA: A new tool to predict recurrence and guide treatment of colorectal cancer

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-05-07 DOI:10.1016/j.clinre.2025.102611

Erwan Vo-Quang , Annalice Gandini , Valerie Taly , Pierre Laurent-Puig , Aziz Zaanan , Julien Taieb

引用次数: 0

Abstract

Circulating tumor DNA (ctDNA) has emerged as a promising biomarker with diverse applications across different stages of colorectal cancer management. One of its primary roles is as a prognostic biomarker for detecting post-surgical molecular residual disease and predicting recurrence risk. Compared to traditional biomarkers and tissue biopsies, ctDNA provides a minimally invasive, dynamic, and comprehensive representation of tumor burden and molecular heterogeneity. However, challenges persist in standardizing ctDNA testing, improving sensitivity for early-stage disease, and ensuring widespread accessibility. In this review, we explore the biological characteristics of ctDNA, the methodologies for its detection, and its broad clinical applications in both localized and metastatic colorectal cancer.

查看原文本刊更多论文

循环肿瘤DNA：预测结直肠癌复发和指导治疗的新工具。

循环肿瘤DNA （ctDNA）已成为一种有前景的生物标志物，在结直肠癌治疗的不同阶段具有不同的应用。其主要作用之一是作为一种预后生物标志物，用于检测术后分子残留疾病和预测复发风险。与传统的生物标志物和组织活检相比，ctDNA提供了肿瘤负荷和分子异质性的微创、动态和全面的代表。然而，在标准化ctDNA检测、提高对早期疾病的敏感性和确保广泛可及性方面，挑战依然存在。在这篇综述中，我们探讨了ctDNA的生物学特性、检测方法及其在局部和转移性结直肠癌中的广泛临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.