Clinical Reviews in Allergy & Immunology最新文献_第5页

Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence. 过敏性鼻炎的环境危险因素、保护因素和生物标志物：证据的系统综述。

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-07-25 DOI: 10.1007/s12016-023-08964-2

Xianpeng Xu, Xinghong Liu, Jiongke Li, Xinxing Deng, Tianrong Dai, Qingjie Ji, Dajing Xiong, Hui Xie

{"title":"Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence.","authors":"Xianpeng Xu, Xinghong Liu, Jiongke Li, Xinxing Deng, Tianrong Dai, Qingjie Ji, Dajing Xiong, Hui Xie","doi":"10.1007/s12016-023-08964-2","DOIUrl":"10.1007/s12016-023-08964-2","url":null,"abstract":"Many potential environmental risk factors, protective factors, and biomarkers of AR have been published, but so far, the strength and consistency of their evidence are unclear. We conducted a comprehensive review of environmental risk, protective factors, and biomarkers for AR to establish the evidence hierarchy. We systematically searched Embase, PubMed, Cochrane Library, and Web of Science electronic database from inception to December 31, 2022. We calculated summary effect estimate (odds ratio (OR), relative risk (RR), hazard ratio (HR), and standardized mean difference (SMD)), 95% confidence interval, random effects p value, I2 statistic, 95% prediction interval, small study effects, and excess significance biases, and stratification of the level of evidence. Methodological quality was assessed by AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews 2). We retrieved 4478 articles, of which 43 met the inclusion criteria. The 43 eligible articles identified 31 potential environmental risk factors (10,806,206 total population, two study not reported), 11 potential environmental protective factors (823,883 total population), and 34 potential biomarkers (158,716 total population) for meta-analyses. The credibility of evidence was convincing (class I) for tic disorders (OR = 2.89, 95% CI 2.11-3.95); and highly suggestive (class II) for early-life antibiotic use (OR = 3.73, 95% CI 3.06-4.55), exposure to indoor dampness (OR = 1.49, 95% CI 1.27-1.75), acetaminophen exposure (OR = 1.54, 95% CI 1.41-1.69), childhood acid suppressant use (OR = 1.40, 95% CI 1.23-1.59), exposure to indoor mold (OR = 1.66, 95% CI 1.26-2.18), coronavirus disease 2019 (OR = 0.11, 95% CI 0.06-0.22), and prolonged breastfeeding (OR = 0.72, 95% CI 0.65-0.79). This study is registered in PROSPERO (CRD42022384320).","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"188-205"},"PeriodicalIF":8.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9865917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization. 紫杉烷的超敏反应：脱敏有效性和安全性的综合系统评价。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-08-17 DOI: 10.1007/s12016-023-08968-y

Rosalaura Virginia Villarreal-González, Sandra González-Díaz, Oscar Vidal-Gutiérrez, Alejandra Canel-Paredes, Carlos de la Cruz-de la Cruz, Mariano García-Campa, Alfonso López-Méndez, Sofía Alvarado-Ruiz, Mariana Castells

{"title":"Hypersensitivity Reactions to Taxanes: A Comprehensive and Systematic Review of the Efficacy and Safety of Desensitization.","authors":"Rosalaura Virginia Villarreal-González, Sandra González-Díaz, Oscar Vidal-Gutiérrez, Alejandra Canel-Paredes, Carlos de la Cruz-de la Cruz, Mariano García-Campa, Alfonso López-Méndez, Sofía Alvarado-Ruiz, Mariana Castells","doi":"10.1007/s12016-023-08968-y","DOIUrl":"10.1007/s12016-023-08968-y","url":null,"abstract":"Taxanes in the treatment of cancer are associated with a significant incidence of hypersensitivity reactions, which may preclude their use in patients in need of first line therapy. Drug desensitization induces transient immunological tolerance and has allowed the reintroduction of taxanes in highly allergic patients. Increase the knowledge of hypersensitivity reactions (HSR) during the administration of taxanes. A systematic review regarding the safety and efficacy of rapid drug desensitization (RDD) for taxanes HSR. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, was registered in PROSPERO(CRD42021242324) and a comprehensive search was conducted in Medline, Embase, Web of Science and Scopus databases. 25 studies encompassing 10 countries were identified and 976 patients with initial HSR to paclitaxel (n = 707) and docetaxel (n = 284), that underwent a total of 2,396 desensitizations. The most common symptoms were cutaneous (74.6%) with paclitaxel and respiratory (72.6%) with docetaxel. Severe initial hypersensitivity reactions including anaphylaxis occurred in 39.6% and 13% of paclitaxel and docetaxel cases respectively and during the first (87.4%) or second exposure (81.5%). Patients tolerated well RDD and breakthrough reactions (BTR) occurred in 32.2% of paclitaxel-treated patients and in 20.6% of docetaxel treated patients. Premedications included corticosteroids, antihistamines and leukotriene receptor antagonists. The most commonly used protocol was the BWH 3 bags 12 steps, all protocols showed a success rate between 95-100%, with no reported deaths. RDD is a safe and effective procedure in patients with HSR to taxanes and protocols should be standardized for wide range implementation.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"231-250"},"PeriodicalIF":9.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10014835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food Allergy Labeling Laws: International Guidelines for Residents and Travelers. 《食品过敏标签法：居民和旅行者国际指南》。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-05-09 DOI: 10.1007/s12016-023-08960-6

Francesca Chang, Lauren Eng, Christopher Chang

{"title":"Food Allergy Labeling Laws: International Guidelines for Residents and Travelers.","authors":"Francesca Chang, Lauren Eng, Christopher Chang","doi":"10.1007/s12016-023-08960-6","DOIUrl":"10.1007/s12016-023-08960-6","url":null,"abstract":"The prevalence of food allergies varies by country, as does each country's food allergen labeling. While labeling laws may vary by country, most follow the Codex Alimentarius. Even developing countries have some degree of labeling guidelines for food allergies, but it is highly developed countries that tend to implement stricter labeling regulations to protect their citizens and tourists. Different organizations, both domestic and international, such as Food Allergy Research and Education (FARE), work to advance food allergen labeling laws around the globe. Eating out and traveling can be anxiety-provoking for people with food allergies, especially when traveling to international destinations. Furthermore, experiences that young children, teenagers, and parents have with food allergies can have psychosocial and social impacts. To evaluate food allergen labeling laws across the globe, official legal documents outlining the laws pertaining to foods and allergen food labeling were reviewed for each respective country or region. These were organized according to continent, then region or country. The majority of countries require that major food groups be listed on food labels, including milk, egg, soy, wheat, peanuts, treenuts, fish, and shellfish. There are individual variations across regions depending on staples in respective diets. With increasing rates of food allergies worldwide, legislative action is needed to ensure that people living with food allergies can more safely purchase and consume foods. Until then, the work of avoiding accidental ingestions and anaphylaxis remains primarily with the individual, who must educate themselves on labeling laws and implement other protective measures.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"148-165"},"PeriodicalIF":9.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9505127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant. 脓毒症和新冠肺炎期间，促炎和抗炎反应是伴随的。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-07-03 DOI: 10.1007/s12016-023-08965-1

Jean-Marc Cavaillon

引用次数: 1

Treatable Traits in Systemic Sclerosis. 系统性硬化症的可治疗特征。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-08-21 DOI: 10.1007/s12016-023-08969-x

Francesco Amati, Gabriele Bongiovanni, Antonio Tonutti, Francesca Motta, Anna Stainer, Giuseppe Mangiameli, Stefano Aliberti, Carlo Selmi, Maria De Santis

{"title":"Treatable Traits in Systemic Sclerosis.","authors":"Francesco Amati, Gabriele Bongiovanni, Antonio Tonutti, Francesca Motta, Anna Stainer, Giuseppe Mangiameli, Stefano Aliberti, Carlo Selmi, Maria De Santis","doi":"10.1007/s12016-023-08969-x","DOIUrl":"10.1007/s12016-023-08969-x","url":null,"abstract":"Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically characterized by vascular abnormalities and inflammatory and fibrotic involvement of the skin and internal organs resulting in high morbidity and mortality. The clinical phenotype of SSc is heterogeneous, and serum autoantibodies together with the extent of skin involvement have a predictive value in the risk stratification. Current recommendations include an organ-based management according to the predominant involvement with only limited individual factors included in the treatment algorithm. Similar to what has been proposed for other chronic diseases, we hypothesize that a \"treatable trait\" approach based on relevant phenotypes and endotypes could address the unmet needs in SSc stratification and treatment to maximize the outcomes. We provide herein a comprehensive review and a critical discussion of the literature regarding potential treatable traits in SSc, focusing on established and candidate biomarkers, with the purpose of setting the bases for a precision medicine-based approach. The discussion, structured based on the organ involvement, allows to conjugate the pathogenetic mechanisms of tissue injury with the proposed predictors, particularly autoantibodies and other serum biomarkers. Ultimately, we are convinced that precision medicine is the ideal guide to manage a complex condition such as SSc for which available treatments are largely unsatisfactory.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"251-276"},"PeriodicalIF":9.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19, Coronavirus Vaccines, and Possible Association with Lipschütz Vulvar Ulcer: A Systematic Review. 新冠肺炎，冠状病毒疫苗，以及与Lipschütz Vulvar溃疡的可能关联：系统综述。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-10-01 Epub Date: 2023-06-26 DOI: 10.1007/s12016-023-08961-5

Stefano A Vismara, Andrea Ridolfi, Pietro B Faré, Mario G Bianchetti, Sebastiano A G Lava, Samuele Renzi, Benedetta Terziroli Beretta Piccoli, Gregorio P Milani, Lisa Kottanattu

{"title":"COVID-19, Coronavirus Vaccines, and Possible Association with Lipschütz Vulvar Ulcer: A Systematic Review.","authors":"Stefano A Vismara, Andrea Ridolfi, Pietro B Faré, Mario G Bianchetti, Sebastiano A G Lava, Samuele Renzi, Benedetta Terziroli Beretta Piccoli, Gregorio P Milani, Lisa Kottanattu","doi":"10.1007/s12016-023-08961-5","DOIUrl":"10.1007/s12016-023-08961-5","url":null,"abstract":"Lipschütz genital ulcer is a self-limited, non-sexually acquired disorder characterized by the sudden onset of a few ulcers. A primary Epstein-Barr virus infection is currently considered the most recognized cause. Recent reports document cases temporally related with coronavirus disease 2019 (COVID-19) or immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We carried out a review of the literature to investigate the possible association between COVID-19 or the immunization against SARS-CoV-2 and genital ulcer. The pre-registered study (CRD42023376260) was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology. Excerpta Medica, the National Library of Medicine, and Web of Sciences were searched. Inclusion criteria encompassed instances of acute Lipschütz ulcer episodes that were temporally linked to either COVID-19 or a vaccination against SARS-CoV-2. Eighteen articles were retained. They provided information on 33 patients 15 (14-24) years of age (median and interquartile range), who experienced a total of 39 episodes of Lipschütz ulcer temporally associated with COVID-19 (N = 18) or an immunization against SARS-CoV-2 (N = 21). The possible concomitant existence of an acute Epstein-Barr virus infection was excluded in 30 of the 39 episodes. The clinical presentation and the disease duration were similar in episodes temporally associated with COVID-19 and in those associated with an immunization against SARS-CoV-2. In conclusion, COVID-19 and immunization against SARS-CoV-2 add to Epstein-Barr virus as plausible triggers of Lipschütz genital ulcer.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"166-171"},"PeriodicalIF":9.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9683874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmunity in Primary Immunodeficiencies (PID). 原发性免疫缺陷(PID)的自身免疫。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-08-01 DOI: 10.1007/s12016-022-08942-0

Grace T Padron, Vivian P Hernandez-Trujillo

引用次数: 3

The Treatment of Primary Immune Deficiencies: Lessons Learned and Future Opportunities. 原发性免疫缺陷的治疗：经验教训与未来机遇。

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-08-01 Epub Date: 2022-07-01 DOI: 10.1007/s12016-022-08950-0

Kenneth Paris, Luke A Wall

{"title":"The Treatment of Primary Immune Deficiencies: Lessons Learned and Future Opportunities.","authors":"Kenneth Paris, Luke A Wall","doi":"10.1007/s12016-022-08950-0","DOIUrl":"10.1007/s12016-022-08950-0","url":null,"abstract":"Primary immunodeficiency is a group of disorders associated with susceptibility to infectious agents and the development of various comorbidities. Many primary immunodeficiencies are complicated by immune dysregulation, autoinflammation, or autoimmunity which impacts multiple organ systems. Major advances in the treatment of these disorders have occurred over the last half-century, and deeper molecular understanding of many disorders combined with clinically available genetic testing is allowing for use of precision therapy for several primary immunodeficiencies. Patients with antibody deficiencies who rely on immunoglobulin replacement therapy now have many treatment options with products that are much safer and better tolerated compared to the past. Newborn screening for severe combined immunodeficiency, now implemented throughout the USA and in many countries worldwide, has lowered the age at which many patients are diagnosed with these diseases. Early diagnosis of severe combined immunodeficiency allows infants to proceed to definitive therapy such as stem cell transplantation or gene therapy prior to facing potentially life-threatening infections. While stem cell transplantation continues to carry significant risks, knowledge gained over recent decades is allowing for improved survival with less toxicity and less graft versus host disease.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"65 1","pages":"19-30"},"PeriodicalIF":8.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9775453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vernal Keratoconjunctivitis: A Systematic Review. 春季角膜结膜炎：一项系统综述。

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-08-01 Epub Date: 2023-09-02 DOI: 10.1007/s12016-023-08970-4

Gaia Bruschi, Daniele Giovanni Ghiglioni, Laura Cozzi, Silvia Osnaghi, Francesco Viola, Paola Marchisio

{"title":"Vernal Keratoconjunctivitis: A Systematic Review.","authors":"Gaia Bruschi, Daniele Giovanni Ghiglioni, Laura Cozzi, Silvia Osnaghi, Francesco Viola, Paola Marchisio","doi":"10.1007/s12016-023-08970-4","DOIUrl":"10.1007/s12016-023-08970-4","url":null,"abstract":"Vernal keratoconjunctivitis (VKC) is a chronic, bilateral corneal and conjunctival problem which typically presents in young individuals. VKC is characterized by itching, photophobia, white mucous discharge, lacrimation, foreign body sensation, and pain due to corneal involvement of shield ulcers. Vernal keratoconjunctivitis is categorized within ocular diseases. The diagnosis is clinical, as no sure biomarkers pathognomonic of the disease have yet been identified. The VKC therapy relies on different types of drugs, from antihistamines and topical steroids to cyclosporine or tacrolimus eye drops. In extremely rare cases, there is also the need for surgical treatment for the debridement of ulcers, as well as for advanced glaucoma and cataracts, caused by excessive prolonged use of steroid eye drops. We performed a systematic review of the literature, according to PRISMA guideline recommendations. We searched the PubMed database from January 2016 to June 2023. Search terms were Vernal, Vernal keratoconjunctivitis, and VKC. We initially identified 211 articles. After the screening process, 168 studies were eligible according to our criteria and were included in the review. In this study, we performed a systematic literature review to provide a comprehensive overview of currently available diagnostic methods, management of VKC, and its treatments.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"277-329"},"PeriodicalIF":8.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

γδ T Cells and Allergic Diseases. γδT细胞与变态反应性疾病。

IF 9.1 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2023-08-01 Epub Date: 2023-07-03 DOI: 10.1007/s12016-023-08966-0

Uei-Hsiang Hsu, Bor-Luen Chiang

{"title":"γδ T Cells and Allergic Diseases.","authors":"Uei-Hsiang Hsu, Bor-Luen Chiang","doi":"10.1007/s12016-023-08966-0","DOIUrl":"10.1007/s12016-023-08966-0","url":null,"abstract":"Gamma-delta (γδ) T cells play an essential role in allergic diseases and have emerged as a potential treatment target in recent decades. To clarify the effects of γδ T cells on atopic illnesses, we reviewed the literature on the physical roles and functions of various subsets of γδ T cells, including type 1 T helper (Th1)-like, type 2 T helper- (Th2)-like, and type 17 T helper (Th17)-like γδ T cells. Mouse Vγ1 T cells increase interleukin (IL)-4 levels and trigger B cell class switching and immunoglobulin E production. Meanwhile, mouse Vγ4 T cells and human CD8lowVδ1 T cells secrete interferon-γ and exert an anti-allergy effect similar to that of Th1 cells. Moreover, mouse Vγ6 T cells produce IL-17A, while Th17-like γδ T cells enhance neutrophil and eosinophil infiltration in the acute phase of inflammation, but exert anti-inflammatory effects in the chronic phase. Human Vγ9δ2 T cells may exhibit Th1- or Th2-like characteristics in response to certain types of stimulation. In addition, the microbiota can modulate epithelial γδ T cell survival through aryl hydrocarbon receptors; these γδ T cells play crucial roles in the repair of epithelial damage, antibacterial protection, antigen tolerance, and effects of dysbiosis on allergic diseases.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":" ","pages":"172-182"},"PeriodicalIF":9.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10116601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0