Clinical Reviews in Allergy & Immunology最新文献

Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases. 基于间充质基质细胞的疗法：治疗自身免疫性疾病的有效方法。

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-21 DOI: 10.1007/s12016-025-09030-9

Liming Li, Yong He, Junpeng Zhao, Huiqi Yin, Xiwei Feng, Xinyu Fan, Wei Wu, Qianjin Lu

{"title":"Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases.","authors":"Liming Li, Yong He, Junpeng Zhao, Huiqi Yin, Xiwei Feng, Xinyu Fan, Wei Wu, Qianjin Lu","doi":"10.1007/s12016-025-09030-9","DOIUrl":"https://doi.org/10.1007/s12016-025-09030-9","url":null,"abstract":"Autoimmune diseases are characterized by immune dysregulation, resulting in aberrant reactivity of T cells and antibodies to self-antigens, leading to various patterns of inflammation and organ dysfunction. However, current therapeutic agents exhibit broad-spectrum activity and lack disease-specific selectivity, leading to enduring adverse effects, notably severe infections, and malignancies, and patients often fail to achieve the intended clinical goals. Mesenchymal stromal cells (MSCs) are multipotent stromal cells that can be easily derived from various tissues, such as adipose tissue, umbilical cords, Wharton's jelly, placenta, and dental tissues. MSCs offer advantages due to their immunomodulatory and anti-inflammatory abilities, low immunogenicity, and a high capacity for proliferation and multipotent differentiation, making them excellent candidates for cell-based treatment in autoimmune disorders. This review will cover preclinical studies and clinical trials involving MSCs in autoimmune diseases, as well as the primary challenges associated with the clinical application of MSC therapies and strategies for maximizing their therapeutic potential.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"21"},"PeriodicalIF":8.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Significance of Mast Cell Exosomes (MC-EXOs) in Immune Response Coordination.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-20 DOI: 10.1007/s12016-025-09033-6

Daniel Elieh-Ali-Komi, Farzaneh Shafaghat, Shamila D Alipoor, Tohid Kazemi, Dmitrii Atiakshin, Polina Pyatilova, Marcus Maurer

{"title":"Immunomodulatory Significance of Mast Cell Exosomes (MC-EXOs) in Immune Response Coordination.","authors":"Daniel Elieh-Ali-Komi, Farzaneh Shafaghat, Shamila D Alipoor, Tohid Kazemi, Dmitrii Atiakshin, Polina Pyatilova, Marcus Maurer","doi":"10.1007/s12016-025-09033-6","DOIUrl":"10.1007/s12016-025-09033-6","url":null,"abstract":"Mast cells (MCs) communicate with other cells by direct cell-to-cell interaction, secreting mediators, and releasing exosomes (EXOs). MC-exosomes (MC-EXOs) contain proteins, lipids, mRNAs, and noncoding RNAs (ncRNAs), exhibit typical EXO markers such as heat shock proteins, tetraspanins, tumor susceptibility gene 101 protein (TSG101), and ALG-2-interacting protein X (ALIX), and are released constitutively or following MC degranulation. MC-EXOs also have signature MC markers like FcεRI and KIT (CD117), which allows for their identification and comparison with other EXO populations. Following their release, MC-EXOs may interact with the recipient cell(s) directly or be internalized and then release their protein and nucleic acid content. This may contribute to the regulation of immune responses and other biological processes and reprogramming of recipient cells. MC-EXO proteins may integrate and become a functional part of the recipient cell membrane. The mRNA transferred by MC-EXOs is functional and the transfer of exosomal RNA to other MCs results in the expression of donor MC proteins in the recipient MCs. Moreover, MCs may function as the recipients of EXOs that are released by other non-immune and immune cells, altering the secretome of MCs. In this review, we focus on how MC-EXOs modulate the biology of other cells and vice versa; and we highlight the role of MC-EXOs in the pathogenesis of allergic and non-allergic diseases.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"20"},"PeriodicalIF":8.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-18 DOI: 10.1007/s12016-025-09028-3

Yan Hao, Yujuan Yang, Hongfei Zhao, Ying Chen, Ting Zuo, Yu Zhang, Hang Yu, Limei Cui, Xicheng Song

{"title":"Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.","authors":"Yan Hao, Yujuan Yang, Hongfei Zhao, Ying Chen, Ting Zuo, Yu Zhang, Hang Yu, Limei Cui, Xicheng Song","doi":"10.1007/s12016-025-09028-3","DOIUrl":"10.1007/s12016-025-09028-3","url":null,"abstract":"Allergic rhinitis (AR) is a common chronic inflammatory airway disease caused by inhaled allergens, and its prevalence has increased in recent decades. AR not only causes nasal leakage, itchy nose, nasal congestion, sneezing, and allergic conjunctivitis but also induces asthma, as well as sleep disorders, anxiety, depression, memory loss, and other phenomena that seriously affect the patient's ability to study and work, lower their quality of life, and burden society. The current methods used to diagnose and treat AR are still far from ideal. Multi-omics technology can be used to comprehensively and systematically analyze the differentially expressed DNA, RNA, proteins, and metabolites and their biological functions in patients with AR. These capabilities allow for an in-depth understanding of the intrinsic pathogenic mechanism of AR, the ability to explore key cells and molecules that drive its progression, and to design personalized treatment for AR. This article summarizes the progress made in studying AR by use of genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics in order to illustrate the important role of multi-omics technologies in facilitating the precise diagnosis and treatment of AR.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"19"},"PeriodicalIF":8.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-17 DOI: 10.1007/s12016-025-09021-w

Guangyang Xie, Xiaojing Chen, Yixia Gao, Ming Yang, Suqing Zhou, Liwei Lu, Haijing Wu, Qianjin Lu

{"title":"Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications.","authors":"Guangyang Xie, Xiaojing Chen, Yixia Gao, Ming Yang, Suqing Zhou, Liwei Lu, Haijing Wu, Qianjin Lu","doi":"10.1007/s12016-025-09021-w","DOIUrl":"10.1007/s12016-025-09021-w","url":null,"abstract":"As a heterogeneous B cell subset, age-associated B cells (ABCs) exhibit distinct transcription profiles, extrafollicular differentiation processes, and multiple functions in autoimmunity. TLR7 and TLR9 signals, along with IFN-γ and IL-21 stimulation, are both essential for ABC differentiation, which is also regulated by chemokine receptors including CXCR3 and CCR2 and integrins including CD11b and CD11c. Given their functions in antigen uptake and presentation, autoantibody and proinflammatory cytokine secretion, and T helper cell activation, ABCs display potential in the prognosis, diagnosis, and therapy for autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis, neuromyelitis optica spectrum disorders, and ankylosing spondylitis. Specifically targeting ABCs by inhibiting T-bet and CD11c and activating CD11b and ARA2 represents potential therapeutic strategies for SLE and RA. Although single-cell sequencing technologies have recently revealed the heterogeneous characteristics of ABCs, further investigations to explore and validate ABC-target therapies are still warranted.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"18"},"PeriodicalIF":8.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk Between the Skin Environment and Microbial Community in Immune-Related Skin Diseases.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-15 DOI: 10.1007/s12016-025-09029-2

Kecheng Liu, Shuting Deng, Yuan Zhou, Beilei Xu, Yu Zhang, Wei Li, Xiaochun Liu, Xu Yao

{"title":"Crosstalk Between the Skin Environment and Microbial Community in Immune-Related Skin Diseases.","authors":"Kecheng Liu, Shuting Deng, Yuan Zhou, Beilei Xu, Yu Zhang, Wei Li, Xiaochun Liu, Xu Yao","doi":"10.1007/s12016-025-09029-2","DOIUrl":"https://doi.org/10.1007/s12016-025-09029-2","url":null,"abstract":"The skin surface hosts diverse skin microbiota, including bacteria, fungi, and viruses. Intricate interactions between the skin microenvironment and microbial community are crucial for maintaining cutaneous homeostasis. This review explores the bidirectional relationship between the skin ecosystem and its microbiota. The skin microenvironment is shaped by a combination of intrinsic factors, dominated by sweat glands and pilosebaceous units, and external factors, such as UV radiation and personal care products, which create distinct niches that influence microbial colonization patterns across different skin regions. The skin microbiome, in turn, modulates the physical, chemical, immunological, and microbial barriers of the skin. We also discuss the alterations in this crosstalk in various immune-related skin conditions such as atopic dermatitis, psoriasis, rosacea, hidradenitis suppurativa, skin cancer, and aging. Understanding these interactions is vital for developing targeted microbiome-based therapies for various skin disorders. Further researches are needed to deepen insights into the microbial roles and their therapeutic potentials in skin health and disease.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"16"},"PeriodicalIF":8.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergic Reactions in Dental Practice: Classification of Medicines, Mechanisms of Action, and Clinical Manifestations.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-15 DOI: 10.1007/s12016-025-09032-7

Maria Zofia Lisiecka

{"title":"Allergic Reactions in Dental Practice: Classification of Medicines, Mechanisms of Action, and Clinical Manifestations.","authors":"Maria Zofia Lisiecka","doi":"10.1007/s12016-025-09032-7","DOIUrl":"https://doi.org/10.1007/s12016-025-09032-7","url":null,"abstract":"Allergic reactions in dental practice have been a serious problem, causing various clinical symptoms and having a significant impact on the quality of dental care. This study examined various aspects of allergic reactions, their causes, mechanisms of development, and prevalence in dental practice. The purpose of the study was to conduct a comprehensive analysis of allergic reactions, their classification, clinical manifestations, and mechanisms of development, and to identify the most common causes of such reactions. To achieve this goal, a systematic literature review was conducted. As a result of the study, different types of allergic reactions and mechanisms of their development were identified. Among them, special attention was paid to immediate hypersensitivity reactions mediated by immunoglobulin E (IgE). Delayed-type reactions mediated by sensitised T lymphocytes were also considered. Pseudoallergic reactions occupied a separate place in the classification of allergic reactions. The study emphasised the importance of cross-reactions, in which several structurally similar molecules bind to the same IgE antibodies or T lymphocytes. The main results of the study showed that allergic reactions can be triggered by a variety of allergens. Prominent among these were local anaesthetics such as lidocaine and benzocaine, antibiotics including penicillins and cephalosporins, latex products such as gloves and cofferdams, acrylic materials used in dental prostheses and fillings, and metal alloys containing nickel, chromium, and cobalt. The study has contributed to a better understanding of the factors causing allergic reactions in dental practice and the mechanisms of their development. This is important for improving the diagnosis and management of such cases, thereby improving the quality of dental care provided.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"17"},"PeriodicalIF":8.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-11 DOI: 10.1007/s12016-025-09023-8

Keni Chang, Peiming Luo, Zizhen Guo, Lufei Yang, Jincheng Pu, Fang Han, Feiyang Cai, Jianping Tang, Xuan Wang

{"title":"Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.","authors":"Keni Chang, Peiming Luo, Zizhen Guo, Lufei Yang, Jincheng Pu, Fang Han, Feiyang Cai, Jianping Tang, Xuan Wang","doi":"10.1007/s12016-025-09023-8","DOIUrl":"10.1007/s12016-025-09023-8","url":null,"abstract":"Sjögren's syndrome (SS) is a chronic autoimmune disorder that primarily affects the exocrine glands. Due to the intricate nature of the disease progression, the exact mechanisms underlying SS are not completely understood. Recent research has highlighted the complex interplay between immune dysregulation and metabolic abnormalities in inflammatory diseases. Notably, lipid metabolism has emerged as a crucial factor in the modulation of immune function and the progression of autoimmune diseases, including SS. This review explores the prevalence of dyslipidemia in SS, emphasizing its role in the onset, progression, and prognosis of the disease. We specifically described the impact of altered lipid metabolism in exocrine glands and its association with disease-specific features, including inflammation and glandular dysfunction. Additionally, we discussed the potential clinical implications of lipid metabolism regulation, including the role of polyunsaturated fatty acids (PUFAs) and their deficits in SS pathogenesis. By identifying lipid metabolism as a promising therapeutic target, this review highlights the need for further research into lipid-based interventions for the management of SS.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"15"},"PeriodicalIF":8.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders. 自身免疫性疾病中与 T 细胞和 B 细胞相关的新机制和生物标志物。

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-11 DOI: 10.1007/s12016-025-09022-9

Azhagu Madhavan Sivalingam

{"title":"Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders.","authors":"Azhagu Madhavan Sivalingam","doi":"10.1007/s12016-025-09022-9","DOIUrl":"https://doi.org/10.1007/s12016-025-09022-9","url":null,"abstract":"Autoimmune diseases are characterized by the dysregulation of B-cells, which are responsible for antibody production against pathogens, and T-cells, which play a crucial role in cell-mediated immunity, including both helper and cytotoxic T-cells. These disorders frequently present with abnormal responses from both B- and T-cells, which can have a significant impact on cardiovascular health, particularly among the female patients. Key mechanisms contributing to these diseases include the activation of the NLRP3 inflammasome impaired efferocytosis is the process by which phagocytes clear apoptotic cells to maintain immune and developmental balance. Defects in this process can lead to inflammatory and autoimmune disorders. The gut microbiota helps defend against pathogens and signals immune cells, playing a vital role in human health and is involved in many aspects of the body. Novel therapeutic strategies such as nanomedicine and targeted treatments are being developed to restore immune balance. The significance of thymic homeostasis the influence of viral infections and the presence of tertiary lymphoid structures highlight the need for multidisciplinary approaches in the management of these conditions. A case study of a 9-year-old girl diagnosed with seronegative autoimmune encephalitis, who displayed severe obsessive-compulsive disorder (OCD) and aggressive behavior, exemplifies the complexities involved in treatment. Promising interventions, including CAR-T-cell therapy and nanomedicine, are under development for various autoimmune diseases, such as vitiligo and refractory autoimmune rheumatic diseases (ARDs). Furthermore, emerging therapies, including CAR-T-cell therapy, mRNA-based strategies, and microbiome modulation, are being explored alongside advancements in personalized medicine and early diagnostic techniques to improve patient outcomes for individuals affected by autoimmune diseases.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"14"},"PeriodicalIF":8.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-11 DOI: 10.1007/s12016-024-09020-3

Giuseppe A Ramirez, Chiara Cardamone, Sara Lettieri, Micaela Fredi, Ilaria Mormile

{"title":"Clinical and Pathophysiological Tangles Between Allergy and Autoimmunity: Deconstructing an Old Dichotomic Paradigm.","authors":"Giuseppe A Ramirez, Chiara Cardamone, Sara Lettieri, Micaela Fredi, Ilaria Mormile","doi":"10.1007/s12016-024-09020-3","DOIUrl":"10.1007/s12016-024-09020-3","url":null,"abstract":"Allergic and autoimmune disorders are characterised by dysregulation of the immune responses to otherwise inert environmental substances and autoantigens, leading to inflammation and tissue damage. Their incidence has constantly increased in the last decades, and their co-occurrence defies current standards in patient care. For years, allergy and autoimmunity have been considered opposite conditions, with IgE and Th2 lymphocytes cascade driving canonical allergic manifestations and Th1/Th17-related pathways accounting for autoimmunity. Conversely, growing evidence suggests that these conditions not only share some common inciting triggers but also are subtended by overlapping pathogenic pathways. Permissive genetic backgrounds, along with epithelial barrier damage and changes in the microbiome, are now appreciated as common risk factors for both allergy and autoimmunity. Eosinophils and mast cells, along with autoreactive IgE, are emerging players in triggering and sustaining autoimmunity, while pharmacological modulation of B cells and Th17 responses has provided novel clues to the pathophysiology of allergy. By combining clinical and therapeutic evidence with data from mechanistic studies, this review provides a state-of-the-art update on the complex interplay between allergy and autoimmunity, deconstructing old dichotomic paradigms and offering potential clues for future research.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"13"},"PeriodicalIF":8.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases.

IF 8.4 2区医学

Clinical Reviews in Allergy & Immunology Pub Date : 2025-02-10 DOI: 10.1007/s12016-024-09019-w

Limei Cui, Yujuan Yang, Yan Hao, Hongfei Zhao, Yu Zhang, Tong Wu, Xicheng Song

{"title":"Nanotechnology-Based Therapeutics for Airway Inflammatory Diseases.","authors":"Limei Cui, Yujuan Yang, Yan Hao, Hongfei Zhao, Yu Zhang, Tong Wu, Xicheng Song","doi":"10.1007/s12016-024-09019-w","DOIUrl":"10.1007/s12016-024-09019-w","url":null,"abstract":"Under the concept of \"one airway, one disease\", upper and lower airway inflammatory diseases share similar pathogenic mechanisms and are collectively referred to as airway inflammatory diseases. With industrial development and environmental changes, the incidence of these diseases has gradually increased. Traditional treatments, including glucocorticoids, antihistamines, and bronchodilators, have alleviated much of the discomfort experienced by patients. However, conventional drug delivery routes have inherent flaws, such as significant side effects, irritation of the respiratory mucosa, and issues related to drug deactivation. In recent years, nanomaterials have emerged as excellent carriers for drug delivery and are being increasingly utilized in the treatment of airway inflammatory diseases. These materials not only optimize the delivery of traditional medications but also facilitate the administration of various new drugs that target novel pathways, thereby enhancing the treatment outcomes of inflammatory diseases. This study reviews the latest research on nano-drug delivery systems used in the treatment of airway inflammatory diseases, covering traditional drugs, immunotherapy drugs, antimicrobial drugs, plant-derived drugs, and RNA drugs. The challenges involved in developing nano-delivery systems for these diseases are discussed, along with a future outlook. This review offers new insights that researchers can utilize to advance further research into the clinical application of nano-drug delivery systems for treating airway inflammatory diseases.","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"12"},"PeriodicalIF":8.4,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0