Clinical Reviews in Allergy & Immunology最新文献

{"title":"Systemic Psoriasis: From Molecular Mechanisms to Global Management Strategies.","authors":"Suriyaraj Shanmugasundaram Prema, Deepankumar Shanmugamprema","doi":"10.1007/s12016-025-09089-4","DOIUrl":"https://doi.org/10.1007/s12016-025-09089-4","url":null,"abstract":"<p><p>Psoriasis is a chronic, immune-mediated inflammatory disorder marked by a complex interplay between genetic predisposition, cytokine dysregulation, and environmental triggers. Originally perceived as a superficial dermatological condition, it is now recognized as a systemic disease with far-reaching health implications. Advances in molecular genetics have uncovered over 80 susceptibility loci, with key variants such as HLA-C*06:02, IL23R, and CARD14 contributing to the multifactorial nature of the disorder. Central to its pathogenesis is the aberrant activation of the IL-23/Th17 axis, resulting in excessive production of proinflammatory cytokines that promote rapid keratinocyte proliferation and sustained inflammation. Epigenetic modifications further influence gene expression, while interactions with environmental factors, such as mechanical stress, ultraviolet exposure, and air pollution, exacerbate the inflammatory cascade. Recent progress in targeted therapeutic strategies, notably biologic agents and small molecule inhibitors, has transformed the treatment landscape by specifically modulating these pathogenic pathways. Such innovations are paving the way toward personalized medicine, aiming to optimize therapeutic outcomes and reduce the overall disease burden. This review offers a comprehensive synthesis of current knowledge on the genetic, immunologic, and molecular mechanisms underlying psoriasis. The review emphasizes recent advances in targeted therapies underlining the potential for translational applications that address both cutaneous manifestations and systemic inflammation. It also explores global disparities in psoriasis care and the need for inclusive approaches that bridge disparities and promote equitable, innovative disease management strategies.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"79"},"PeriodicalIF":11.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory Roles of Faecalibacterium prausnitzii and Akkermansia muciniphila in Autoimmune Diseases: Mechanistic Insights and Therapeutic Potential.","authors":"Eui Jeong Han, Ji-Seon Ahn, Yoon Jung Chae, Hea-Jong Chung","doi":"10.1007/s12016-025-09093-8","DOIUrl":"https://doi.org/10.1007/s12016-025-09093-8","url":null,"abstract":"<p><p>Alterations in gut microbiota composition are increasingly recognized as key contributors to autoimmune disease pathogenesis. While dominant phyla such as Firmicutes and Bacteroidetes have been extensively studied at the phylum level, the immunomodulatory roles of specific members within these groups particularly the abundant but mechanistically underexplored Faecalibacterium prausnitzii (a member of Firmicutes) and Akkermansia muciniphila (of Verrucomicrobia) remain insufficiently characterized. In particular, current literature primarily focuses on associative findings, and integrated analyses elucidating disease-specific mechanisms and therapeutic relevance are still lacking. In this review, we synthesize mechanistic and disease-specific evidence regarding these two bacterial species across six autoimmune diseases, including systemic lupus erythematosus (SLE), type 1 diabetes (T1D), and rheumatoid arthritis (RA). F. prausnitzii is consistently depleted in autoimmune contexts and exerts protective effects through multiple mechanisms, including short-chain fatty acid (SCFA) production, histone deacetylase (HDAC) inhibition, Treg induction, secretion of microbial anti-inflammatory molecules (MAM), enhancement of epithelial barrier integrity, and modulation of pro- and anti-inflammatory cytokine responses. In contrast, A. muciniphila modulates mucosal immunity via Toll-like receptor 2 (TLR2) activation and tight junction enhancement but exhibits more variable patterns depending on disease and host context. This review offers an integrative framework comparing how these two taxa influence shared immune pathways such as the Th17/Treg axis, SCFA-G protein-coupled receptor (GPR) signaling, and epithelial barrier modulation across distinct autoimmune phenotypes. We also discuss therapeutic implications, including their roles as next-generation probiotics and the translational challenges of clinical application. By focusing on two mechanistically distinct but clinically relevant microbes, this review bridges current knowledge gaps and highlights promising directions for precision microbiome interventions in autoimmune diseases.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"77"},"PeriodicalIF":11.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal Neuroimmunology and Its Implications in Food Allergy.","authors":"Hongjie Chen, Jing Yang","doi":"10.1007/s12016-025-09090-x","DOIUrl":"10.1007/s12016-025-09090-x","url":null,"abstract":"<p><p>Decades of research have elucidated diverse aspects of neuroimmunology. This interdisciplinary field originates from the observation almost one century ago that local sensory signals in the skin regulate mast cell degranulation, a key event in allergic reactions. With this historical perspective, the current research has expanded in different dimensions, including hormonal mechanisms, direct immunomodulation by neural signals, and immune barriers in the central nervous system. Notably, neural innervations in the gastrointestinal tract can establish complex crosstalk with various immune cells through the release of specific neurotransmitters (e.g., norepinephrine or acetylcholine) or neuropeptides (e.g., calcitonin gene-related peptide), which engage the corresponding receptors expressed on immune cells (e.g., mast cells or innate lymphoid cells). Such neuroimmune interactions have become a frontier topic in biomedical science over the past years. In this review, we aim to summarize the current knowledge of neuroimmunology, with a focus on the gastrointestinal tract. We then highlight the implications of such neuroimmune interactions in the disease context of food allergy.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"76"},"PeriodicalIF":11.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Treatment Adherence in Chronic Spontaneous Urticaria: A Systematic Review.","authors":"Aditya Joshi, Lauren Gawey, Muhammad Rahman, Raveena Ghanshani, Khiem A Tran, Adam Friedman, Jennifer L Hsiao, Vivian Y Shi","doi":"10.1007/s12016-025-09092-9","DOIUrl":"10.1007/s12016-025-09092-9","url":null,"abstract":"<p><p>Chronic spontaneous urticaria (CSU) is characterized by recurrent wheals and/or angioedema without an identifiable trigger. Despite advances in therapy-including biologics such as omalizumab-suboptimal treatment adherence remains a major challenge, often resulting in poor symptom control and diminished quality of life. The objective of this study is to evaluate the existing literature on adherence in CSU and identify evidence-based strategies for improving long-term treatment engagement. A systematic literature search of PubMed and EMBASE was performed for articles published between 2000 and 2024 using the terms \"chronic spontaneous urticaria,\" \"chronic urticaria,\" \"chronic idiopathic urticaria,\" \"compliance,\" and \"adherence.\" Eligible studies reported original data on adherence-related factors in CSU. Each study was categorized to World Health Organization (WHO) adherence dimensions: social/economic, healthcare system, condition-related, therapy-related, and patient-related. Risk of bias assessment was conducted for each study included in the final selection. The search followed PRISMA guidelines, and the protocol was registered with PROSPERO (ID: CRD42024627967). Twenty-one studies (totaling 18,500 patients) met inclusion criteria. Common barriers included lack of preventative medication use, inconvenience, forgetfulness, dissatisfaction with healthcare providers, and logistical challenges in accessing in-office biologic administration. Patients previously treated with immunosuppressants had a poorer response to omalizumab, which may contribute to nonadherence due to perceived lack of efficacy. External factors such as the COVID-19 pandemic also contributed to nonadherence by reducing clinic visits and access to specialist referrals. Higher education level and employment were significantly associated with improved adherence. Proposed strategies include simplifying treatment regimens, enhancing patient education about CSU chronicity, providing telehealth or home medication administration options, and offering financial or social support programs. Multiple interrelated barriers contribute to treatment nonadherence in patients with CSU, underscoring the need for multifaceted, patient-centered interventions. Clear communication, simplified regimens, and supportive resources may enhance adherence and help achieve improved long-term clinical outcomes.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"74"},"PeriodicalIF":11.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Furry Animal Allergy: Lipocalins, Serum Albumins, and Secretoglobins-Cross-Reactivity, Diagnosis, and Management Strategies.","authors":"Weronika Gromek, Natalia Kołdej, Marcin Kurowski, Emilia Majsiak","doi":"10.1007/s12016-025-09086-7","DOIUrl":"10.1007/s12016-025-09086-7","url":null,"abstract":"<p><p>Furry animals are familiar companions in modern society. Despite multiple beneficial roles in economic and social contexts, they can be the source of allergenic compounds. Moreover, research indicates that these allergens could be detected even in households where animals are not present. Consequently, the risk of asthma exacerbation is increased. Furthermore, accurately diagnosing a genuine allergy to furry animals remains a significant challenge for medical practitioners. Therefore, this review aims to gather and summarize valid information regarding three main groups of allergens associated with furry animals, including lipocalins, serum albumins, and secretoglobins. In this manuscript, we clarify the molecular structure of allergens, discuss cross-reactions between them, and highlight their clinical importance. We also outline the diagnostic techniques for furry animal allergy, as well as novel, emerging therapies. Additionally, we discuss the occupational risks of allergies for both laboratory workers and cattle farmers.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"75"},"PeriodicalIF":11.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Susac Syndrome: A Systematic Review and Survival Analysis.","authors":"Gian Marco Pace, Luca Canali, Domenico Villari, Giuseppe Spriano, Giuseppe Mercante, Isabelle Mosnier, Daniele Bernardeschi, Giovanni Colombo, Matteo Di Bari","doi":"10.1007/s12016-025-09087-6","DOIUrl":"10.1007/s12016-025-09087-6","url":null,"abstract":"<p><p>The aim of this study is to analyze data from all cases of Susac syndrome that have been published in the literature. This study was conducted in conformity with the PRISMA statement. A systematic review and survival analysis was performed for overall survival (OS) and progression-free survival (PFS). A total of 435 patients (males: 32.6%, n = 142), derived from 176 studies, were included in the analysis. The median age at diagnosis was 35 years (n = 433/435; range 7-69). Neurological symptoms were the most frequent (87.4%, n = 380/435). Among audio-vestibular symptoms (84.3%, n = 365/433), hearing loss was the most common manifestation (87.9%, n = 327/372). Branch retinal artery occlusions (BRAOs) were observed in 91.6% of patients (n = 261/285), while ophthalmological symptoms were reported in 78.9% (n = 288/365). The complete triad at onset was present in only 20.1% (n = 61/304) of cases. Complete recovery without sequelae was achieved in 59.5% (n = 44/74) of patients which reported neurological involvement, 39.7% (n = 27/68) of those with ophthalmological symptoms, and 17.7% (n = 11/62) of those with audio-vestibular symptoms. Partial recovery was observed in 36.5% (n = 27/74), 50.0% (n = 34/68), and 38.7% (n = 24/62) of patients, respectively. In a subgroup of 123 patients with available follow-up data (median duration: 12 months), 82.1% (n = 101) remained stable with controlled disease, 12.2% (n = 15) experienced a relapse, and 5.7% (n = 7) died. OS at 1 and 3 years was 94% (95% CI 88-97%). PFS was 89% at 1 year (95% CI: 80-94%) and 83% at 3 years (95% CI: 69-91%). Susac syndrome presents a significant clinical challenge. While presentations and outcomes are very heterogeneous, mortality is uncommon. The potential for relapse and long-term sequelae highlights the need for greater awareness and deeper understanding of the disease.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"73"},"PeriodicalIF":11.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Clock Disruption and Non-type 2 Asthma: A Hypothesis-Driven Perspective on Immune, Epithelial, and Steroid Response.","authors":"Haohua Huang, Xiaoxiao Jiang, Qian Du, Hua Liao, Shaoxi Cai, Hangming Dong","doi":"10.1007/s12016-025-09088-5","DOIUrl":"https://doi.org/10.1007/s12016-025-09088-5","url":null,"abstract":"<p><p>Asthma is a major chronic non-communicable respiratory disease, affecting over 300 million individuals globally, with an adult prevalence of 4.3%. Despite advances in individualized treatment, a subset of patients, particularly those with non-type 2 (non-T2) asthma, fails to achieve optimal disease control. Non-T2 asthma, characterized by steroid resistance and heterogeneous immune responses, remains a therapeutic challenge. Emerging evidence suggests that circadian rhythm disruption may modulate key pathological processes relevant to non-T2 asthma, including immune imbalance, epithelial barrier dysfunction, and impaired glucocorticoid sensitivity. This review investigates evidence of an association between circadian clock dysfunction and non-type 2 asthma pathogenesis, and proposes a hypothesis-driven framework to guide future studies. Chronotherapeutic strategies and clock-targeted interventions may offer promising avenues for future research and individualized treatment.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"72"},"PeriodicalIF":8.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Biologics for Systemic Lupus Erythematosus (SLE): A Systematic Review and Network Meta-Analysis.","authors":"Ziyan Ding, Hui Zhang, Fan Huang, Yian Liu, Qian Zhou, Dingyuan Hu, Liming Chen, Yanting Li, Rui Ding, Xiaoyan Nie, Yi Fang","doi":"10.1007/s12016-025-09082-x","DOIUrl":"10.1007/s12016-025-09082-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to use Bayesian network meta-analysis to compare the efficacy and safety of biologics for systemic lupus erythematosus (SLE). A comprehensive and systematic search of electronic databases (PubMed, Medline, Cochrane Library, EMBASE, Web of Science, CNKI, and WanFang Data) was conducted from 2014 to September 2024. Our study only included randomized controlled trials with full articles that enrolled adult SLE patients treated with biologics, in comparison with standard therapy. The primary efficacy endpoints were SLE Responder Index 4 (SRI4) and BICLA (BILAG-Based Composite Lupus Assessment). The safety endpoints were adverse events (AEs) and serious adverse events (SAEs). R 4.4.3 and RStudio were used to conduct the network meta-analysis. RevMan 5.4 was used to assess the included literature. 29 randomized controlled trials with a total of 13,712 patients met the inclusion criteria. The network meta-analysis indicated that compared with standard therapy, telitacicept (OR 5.2, 95% CI 1.4-20.0) demonstrated superior efficacy in achieving SRI4 response, deucravacitinib (OR 1.6, 95% CI 1.0-2.5), and anifrolumab (OR 1.6, 95% CI 1.3-2.0) all exhibited significant BICLA response in moderate-to-severe SLE patients. Regarding safety, it was observed that there were no significant statistical differences among the various treatment options. Cluster analysis revealed that deucravacitinib exhibited the best efficacy-safety profile. Deucravacitinib suggested a favorable profile between efficacy and safety. Telitacicept showed the most pronounced improvement in SRI-4 response, but was associated with higher rates of AEs and SAEs, whereas anifrolumab and deucravacitinib displayed advantages in reducing SAEs. For patients with elevated baseline IFN signatures, anti-type I interferon biologics such as anifrolumab and sifalimumab are recommended to maximize clinical benefits. The reliance on indirect comparisons necessitates cautious interpretation of these findings, so further research should prioritize direct head-to-head trials to validate the efficacy and safety profiles of these biologics.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"70"},"PeriodicalIF":8.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquaporins in Allergic Response: A New Player.","authors":"Adriano Martínez Villarreal, Valeria Grattz Lamadrid, Andrés Sanchez, Marlon Múnera","doi":"10.1007/s12016-025-09083-w","DOIUrl":"10.1007/s12016-025-09083-w","url":null,"abstract":"<p><p>Aquaporins (AQPs) are transmembrane proteins that facilitate the transport of water and small solutes across cell membranes. Their expression in organs such as the skin, lungs, gastrointestinal tract, and immune system has been implicated in the pathophysiology of various allergic diseases. Emerging evidence suggests that AQPs, particularly AQP1, AQP3, AQP4, AQP5, AQP7, and AQP9, are differentially regulated during allergic responses, contributing to symptoms such as mucosal hypersecretion, edema, and skin dryness. In atopic dermatitis, AQP3 overexpression correlates with increased transepidermal water loss, while in food allergy models, downregulation of AQP4 and AQP8 is associated with allergic diarrhea. In asthma, altered expression of AQP1, AQP3, and AQP5 has been linked to airway inflammation, eosinophil migration, and mucus production. The cAMP/CREB and NFκB signaling pathways have been identified as key regulators of AQP5 expression, providing potential therapeutic targets. Several experimental studies using herbal extracts have demonstrated anti-inflammatory effects mediated through upregulation of AQP1 and AQP5 and suppression of proinflammatory cytokines. A proposed integrative model suggests that AQPs participate in both the sensitization and effector phases of the allergic response, influencing antigen presentation, immune cell migration, and mediator release. Despite promising preclinical findings, human studies remain limited. Further clinical research is warranted to validate AQPs as biomarkers and therapeutic targets in allergic diseases, especially considering the increasing global prevalence of these conditions.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"71"},"PeriodicalIF":8.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UHRF1 in Immune Regulation and Diseases: Mechanisms and Therapeutic Implications.","authors":"Tingyue Guo, Yihui Ruan, Bo Wu, Shulan Sun, Hongxu Liu","doi":"10.1007/s12016-025-09079-6","DOIUrl":"https://doi.org/10.1007/s12016-025-09079-6","url":null,"abstract":"<p><p>As a key epigenetic regulator, E3 ubiquitin-ligase ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) is essential for maintaining genomic stability. The aberrant activation of UHRF1 has been strongly implicated in cancer progression. Emerging evidence indicates that UHRF1 serves as a pivotal orchestrator of immune homeostasis. This review provides an overview of the impact of UHRF1 on both innate and adaptive immunity, highlighting its epigenetic and regulatory roles in the development and function of macrophages, T lymphocytes, and B lymphocytes. Crucially, the protective mechanisms of UHRF1 in autoimmune disorders while concurrently detailing its tumor-promoting functions are dissected. Finally, this review discusses the therapeutic challenges and future perspectives for targeting UHRF1 in autoimmune disorders and cancers.</p>","PeriodicalId":10423,"journal":{"name":"Clinical Reviews in Allergy & Immunology","volume":"68 1","pages":"68"},"PeriodicalIF":8.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}