Atopic Dermatitis: The Relationship Between Immune Mediators and Skin Lipid Barrier.

IF 8.4 2区医学 Q1 ALLERGY

Clinical Reviews in Allergy & Immunology Pub Date : 2025-05-14 DOI:10.1007/s12016-025-09057-y

Huayan You, Yunsheng Liang

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引用次数: 0

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is prevalent worldwide with complex etiology. Skin barrier defects and abnormal immune activation are crucial in the occurrence and development of AD. In the classic model of the skin barrier, lipids are essential for the formation and maintenance of this barrier as a "mortar" component. However, abnormally activated immune responses promote the lipid barrier deficiency through the secretion of various types of immune mediators directly or indirectly. In this review, we first introduce the skin lipid barrier (SLB) under both normal and abnormal conditions, highlighting the contributions of lipids derived from keratinocytes and sebaceous glands (SGs). Subsequently, the relationships between the immune mediators of Th1, Th2, Th17, Th22, and other types (adipokines, prostaglandins, leukotrienes) and SLB are elaborated in turn. Finally, the therapies for restoring SLB to treat AD are summarized, with a focus on the restoration effect of dupilumab on SLB. We hope that this review will offer a comprehensive perspective for understanding the pathogenesis of lipid metabolism disorders and SLB deficiency caused by immune mediators in AD. It also aims to provide guidance for further research on targeting inflammatory mediators to restore SLB.

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特应性皮炎：免疫介质与皮肤脂质屏障的关系。

特应性皮炎（AD）是一种慢性炎症性皮肤病，在世界范围内流行，病因复杂。皮肤屏障缺损和免疫激活异常是AD发生发展的关键。在皮肤屏障的经典模型中，脂质作为“砂浆”成分对形成和维持这一屏障至关重要。然而，异常激活的免疫反应通过直接或间接地分泌各种类型的免疫介质促进脂质屏障的缺乏。在这篇综述中，我们首先介绍了正常和异常情况下的皮肤脂质屏障（SLB），强调了角质形成细胞和皮脂腺（SGs）的脂质的贡献。随后依次阐述了免疫介质Th1、Th2、Th17、Th22及其他类型（脂肪因子、前列腺素、白三烯）与SLB的关系。最后，总结了恢复SLB治疗AD的治疗方法，重点介绍了dupilumab对SLB的恢复作用。我们希望通过这一综述，为了解AD中免疫介质引起的脂质代谢紊乱和SLB缺乏的发病机制提供一个全面的视角。旨在为进一步研究靶向炎性介质恢复SLB提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Reviews in Allergy & Immunology 医学-过敏

CiteScore

22.30

自引率

1.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.