Clinical Psychopharmacology and Neuroscience最新文献_第9页

The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with Depression 小型重复性经颅磁刺激治疗抑郁症的疗效

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.409

Sangmin Lee, K. Jang, S. Yoon, J. Chae

引用次数: 12

Switching Antipsychotics to Blonanserin in Patients with Schizophrenia: An Open-label, Prospective, Multicenter Study 精神分裂症患者将抗精神病药物改为布兰色林:一项开放标签、前瞻性、多中心研究

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.423

Y. Woo, B. Yoon, Bong-hee Jeon, J. Seo, Beomwoo Nam, Sang-Yeol Lee, Y. Jae, Sae-Heon Jang, H. Eun, S. Won, Kwanghun Lee, Jonghun Lee, W. Bahk

{"title":"Switching Antipsychotics to Blonanserin in Patients with Schizophrenia: An Open-label, Prospective, Multicenter Study","authors":"Y. Woo, B. Yoon, Bong-hee Jeon, J. Seo, Beomwoo Nam, Sang-Yeol Lee, Y. Jae, Sae-Heon Jang, H. Eun, S. Won, Kwanghun Lee, Jonghun Lee, W. Bahk","doi":"10.9758/cpn.2019.17.3.423","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.423","url":null,"abstract":"Objective This study was performed to investigate the efficacy and tolerability of blonanserin in schizophrenic patients who were previously treated with other antipsychotics but, due to insufficient response, were switched to blonanserin. Methods A total of 52 patients with schizophrenia who were unresponsive to treatment with antipsychotic monotherapy or combination therapy were recruited into this 12-week, open-label, prospective, multicenter study. Patients were switched to blonanserin from their existing antipsychotics over a maximum 2-week tapering-off period. Efficacy was primarily evaluated using the 18-item Brief Psychiatric Rating Scale (BPRS). Assessments were performed at baseline, and at weeks 1, 2, 4, 8, and 12. Results Switching to blonanserin resulted in a significant decrease in the mean total score on the BPRS from baseline (56.8 ± 9.4) to week 12 (42.1 ± 13.8, p < 0.001). The most common adverse events were extrapyramidal symptoms (n = 12, 23.1%), insomnia (n = 10, 19.2%), and emotional arousal (n = 6, 11.5%). Overweight or obese patients (body mass index ≥ 23 kg/m2, n = 33) who switched to blonanserin exhibited significant weight loss from 75.2 ± 9.3 kg at baseline to 73.5 ± 9.2 kg at week 12 (p = 0.006). The total cholesterol (baseline, 236.1 ± 47.6 mg/dl; endpoint [week 12], 209.9 ± 28.0 mg/dl; p = 0.005) and prolactin levels (baseline, 80.0 ± 85.2 ng/ml; endpoint [week 12], 63.2 ± 88.9 ng/ml; p = 0.003) were also significantly improved in patients with hypercholesterolemia or hyperprolactinemia. Conclusion The results of the present study suggest that switching to blonanserin may be an effective strategy for schizophrenic patients unresponsive to other antipsychotic treatments.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"423 - 431"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48359039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Levels of Salivary Sialic Acid in Children with Autism Spectrum Disorder; Could It Be Related to Stereotypes and Hyperactivity? 自闭症谱系障碍患儿唾液唾液酸水平的研究它可能与刻板印象和多动症有关吗?

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.415

E. Demirci, Yunus Guler, S. Ozmen, M. Canpolat, S. Kumandas

{"title":"Levels of Salivary Sialic Acid in Children with Autism Spectrum Disorder; Could It Be Related to Stereotypes and Hyperactivity?","authors":"E. Demirci, Yunus Guler, S. Ozmen, M. Canpolat, S. Kumandas","doi":"10.9758/cpn.2019.17.3.415","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.415","url":null,"abstract":"Objective Sialic acid (Sia) is an essential nutrient for brain development, learning, memory and cognition and plays a role in neurodevelopment of infants. The aim of this study was to determine whether Sia levels are significantly associated with the autism spectrum disorder (ASD). Methods Forty-six ASD children and 30 typically developing children aged 3 to 10 years were included in the study. Behavioral symptoms in ASD children was assessed by the Autism Behavior Checklist (AuBC), the Childhood Autism Rating Scale, and the Aberrant Behavior Checklist (ABC). After the collection of saliva samples, the supernatant was separated. All the samples kept at −80°C until Sia analysis was done. Results Sia level was found to be significantly lower in the ASD group when compared to healthy controls (p = 0.013). There was no correlation between severity of ASD and salivary Sia levels. We found a negative correlation between AuBC scores and Sia levels and a negative correlation in both ABC Stereotypic Behavior and Hyperactivity/Noncompliance subscales with Sia levels in ASD group. Conclusion The obtained data indicate that Sia levels could have an effect on autism-like behaviors, particularly on stereotypes and hyperactivity.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"415 - 422"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44191200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Frontal Alpha Asymmetry Correlates with Suicidal Behavior in Major Depressive Disorder 额叶α不对称性与抑郁症患者自杀行为的相关性

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.377

Yeonsoo Park, Wookyoung Jung, Sungkean Kim, H. Jeon, Seung-Hwan Lee

{"title":"Frontal Alpha Asymmetry Correlates with Suicidal Behavior in Major Depressive Disorder","authors":"Yeonsoo Park, Wookyoung Jung, Sungkean Kim, H. Jeon, Seung-Hwan Lee","doi":"10.9758/cpn.2019.17.3.377","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.377","url":null,"abstract":"Objective Based on the constant associations made between major depressive disorder (MDD) and alpha asymmetry, and MDD and suicide, this study aimed to examine the relationship between frontal alpha asymmetry and suicide in MDD patients. Methods Sixty-six MDD patients, of whom fifteen were male and fifty-one were female, were recruited. Independent groups were created based on the median score of frontal alpha asymmetry: the left dominant (LD) group and the right dominant (RD) group. The alpha band (8–12 Hz) and its sub-bands (i.e., low alpha band: 8–10 Hz; high alpha band: 10–12 Hz) were of interest. Source level alpha asymmetry was calculated as well. Results Suicidal behavior was positively correlated with the asymmetry indices of the low alpha band and the alpha band in the LD group and that of the high alpha band in the RD group. Source level analysis revealed positive correlations between suicidal behavior and the asymmetry index of the low alpha band in the LD group. Conclusion Frontal alpha asymmetry, especially that of the low alpha band, might reflect the cognitive deficits associated with suicidal behaviors in MDD patients.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"377 - 387"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45386483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review 精神分裂症患者血清催乳素和骨密度:一项系统综述

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.333

J. Lally, Abdullah Bin Sahl, K. Murphy, F. Gaughran, B. Stubbs

{"title":"Serum Prolactin and Bone Mineral Density in Schizophrenia: A Systematic Review","authors":"J. Lally, Abdullah Bin Sahl, K. Murphy, F. Gaughran, B. Stubbs","doi":"10.9758/cpn.2019.17.3.333","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.333","url":null,"abstract":"The relationship between serum prolactin and bone mineral density (BMD) in schizophrenia is unclear. We conducted a literature review of databases from inception until December 2018 for cross-sectional, case-control, prospective and retrospective studies analyzing correlations between serum prolactin and BMD measured using dual energy X-ray absorptiometry or quantitative ultrasound at any skeletal site in people with schizophrenia. Data was summarized with a best evidence synthesis. This review identified 15 studies (1 longitudinal study, 10 cross-sectional and 4 case-control studies; 1,360 individuals with a psychotic disorder; mean age 45.1 ± 9.4 [standard deviation] years, female 742 [54.6%], mean illness duration 17.7 ± 11.3 years) assessing the relationship between serum prolactin and BMD in schizophrenia. There was a statistically significant inverse correlation between serum prolactin and BMD identified in eight of the studies (53% of all studies), suggesting mixed evidence for an association between serum prolactin and BMD. Of those studies which identified a significant inverse correlation between serum prolactin and BMD (n = 5), 152 (52.1%) of patients were treated with prolactin raising antipsychotics, compared to 197 (48.1%) of patients in those studies which did not identify a significant correlation between prolactin and BMD. Available studies cannot resolve the link between excess prolactin and reduced BMD in schizophrenia. Future studies should be longitudinal in design and combine measures of serum prolactin along with other risk factors for reduced BMD such as smoking and vitamin D and sex hormone levels in assessing the relationship between prolactin and BMD in schizophrenia.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"51 4","pages":"333 - 342"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41244244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes 利鲁唑在表达肌萎缩侧索硬化症内表型细胞模型中的选择性抗氧化作用

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.438

G. Sala, A. Arosio, E. Conti, S. Beretta, C. Lunetta, N. Riva, C. Ferrarese, L. Tremolizzo

{"title":"Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes","authors":"G. Sala, A. Arosio, E. Conti, S. Beretta, C. Lunetta, N. Riva, C. Ferrarese, L. Tremolizzo","doi":"10.9758/cpn.2019.17.3.438","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.438","url":null,"abstract":"Objective Until recently, riluzole was the only drug licensed for amyotrophic lateral sclerosis (ALS). In spite of its efficacy, the mechanism of action remains elusive, and both blocking of glutamate release and antioxidant properties have been postulated. Here we characterized human SH-SY5Y neuroblastoma cell lines, taking advantage of their insensitivity to excitotoxic insults, in order to selectively assess the presence of a direct antioxidant effect of riluzole. Methods SH-SY5Y cells, either parental or overexpressing the G93A SOD1 mutation, were exposed for 24 hours to the selected stimuli. Results Riluzole (1–10 μM) was able to counteract the effects of H2O2 exposure (200 μM/24 hr), limiting both cell death and whole-cell reactive oxygen species (ROS) increase. The same experiments were repeated using SH-SY5Y cells carrying the familial ALS-related G93A-SOD1 mutation and constitutively expressing two-fold increased whole-cell ROS levels with respect to wild-type cells: riluzole was ineffective in this paradigm. Analogously, riluzole was ineffective in preventing cell death induced by exposing SH-SY5Y cells to 3-morpholino-sydnonimine (SIN-1, 1.5 mM/24 hr), a reactive nitrogen species (RNS) donor. Conclusion Our data support a direct antioxidant action of riluzole. Furthermore, the lack of efficacy of riluzole observed in the SOD1 cell model mirrors the lack of efficacy already demonstrated in cognate mouse models of ALS, plausibly reflecting differences in the underlying pathogenic mechanisms. Finally, riluzole inefficacy against nitrosative stress might support the idea that a combined therapeutic intervention may result more effective in ALS patients, as in the case of co-administration of edaravone, a drug known to reduce RNS.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"438 - 442"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49398244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats 青春期阿立哌唑治疗对神经发育正常大鼠认知功能和多巴胺D2受体表达的长期影响

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.400

Hyung Jun Choi, S. Im, Hae Ri Park, Subin Park, C. Kim, Seunghyong Ryu

{"title":"Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats","authors":"Hyung Jun Choi, S. Im, Hae Ri Park, Subin Park, C. Kim, Seunghyong Ryu","doi":"10.9758/cpn.2019.17.3.400","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.400","url":null,"abstract":"Objective This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. Methods Adolescent male Sprague-Dawley rats were injected intraperitoneally with aripiprazole, risperidone, or vehicle control for 3 weeks (postnatal day 36–56). After a 2-week washout period, locomotion, anxiety, and spatial working memory were evaluated in adulthood (postnatal day 71–84), using an open field test, elevated plus maze, and Y-maze, respectively. In addition, we assessed D2R levels in the dorsolateral and medial prefrontal cortex (PFC), dorsal and ventral striatum, and hippocampus using western blot analysis. Results Spontaneous alternation performance (SAP) in the Y-maze, a measure of spatial working memory, differed significantly among the 3 groups (F = 3.89, p = 0.033). A post-hoc test confirmed that SAP in the aripiprazole group was significantly higher than that in the risperidone group (post-hoc test p = 0.013). D2R levels in the medial PFC (F = 8.72, p = 0.001) and hippocampus (F = 13.54, p < 0.001) were different among the 3 groups. D2R levels in the medial PFC and hippocampus were significantly lower in the aripiprazole-treated rats than that in the risperidone-treated rats (post-hoc test p = 0.025 and p < 0.001, respectively) and controls (post-hoc test p < 0.001, all). Conclusion This study showed that aripiprazole treatment in adolescence could influence cognitive function and dopaminergic neurotransmission into early adulthood.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"400 - 408"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41933067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Validation of the Korean Version of the Depression in Old Age Scale and Comparison with Other Depression Screening Questionnaires Used in Elderly Patients in Medical Settings 韩国版老年抑郁症量表的验证及与其他医疗机构老年患者抑郁症筛查问卷的比较

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.369

Young-Eun Jung, Moon-Doo Kim, W. Bahk, Y. Woo, Beomwoo Nam, J. Seo, Sae-Heon Jang, H. Sung, I. Shim, B. Yoon, Ji Sun Kim, Y. Kwon

{"title":"Validation of the Korean Version of the Depression in Old Age Scale and Comparison with Other Depression Screening Questionnaires Used in Elderly Patients in Medical Settings","authors":"Young-Eun Jung, Moon-Doo Kim, W. Bahk, Y. Woo, Beomwoo Nam, J. Seo, Sae-Heon Jang, H. Sung, I. Shim, B. Yoon, Ji Sun Kim, Y. Kwon","doi":"10.9758/cpn.2019.17.3.369","DOIUrl":"https://doi.org/10.9758/cpn.2019.17.3.369","url":null,"abstract":"Objective The Depression in Old Age Scale (DIA-S) is a new screening tool for assessing depression in the elderly. The primary aims of this study were to describe the validation of the Korean version of the DIA-S (K-DIA-S) and to compare its validity with that of other depression screening questionnaires used in elderly outpatients in medical settings. Methods A total of 385 elderly outpatients completed the K-DIA-S and underwent the Mini International Neuropsychiatric Interview to diagnose depressive disorders. Other measures included the 15-item short form of the Geriatric Depression Scale (SGDS), the 9-item depression module of the Patient Health Questionnaire (PHQ-9), and the Montgomery–Asberg Depression Rating Scale (MADRS). Reliability and validity tests, an optimal cutoff point estimate, and receiver operating characteristic curve analysis were performed to investigate the diagnostic validity of the K-DIA-S. Areas under the curves (AUCs) for the K-DIA-S, SGDS, and PHQ-9 were compared statistically. Results The K-DIA-S showed good internal consistency and strong correlations with the SGDS (r = 0.853), PHQ-9 (r = 0.739), and MADRS (r = 0.772). The cut-off point of the K-DIA-S that can be recommended for screening depressive symptoms was a score of 4. For “any depressive disorder”, the AUC (standard error) for the K-DIA-S was 0.896 (0.015), which was significantly larger than that for the PHQ-9 (p = 0.033). Conclusion The present findings suggest that the K-DIA-S has good psychometric properties and is a valid and reliable tool for assessing depressive symptoms in elderly populations and medically ill patients.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"17 1","pages":"369 - 376"},"PeriodicalIF":3.2,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44583231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Rhabdomyolysis and Neuroleptic Malignant Syndrome Associated with Very Low-dose Antipsychotics in Children and Adolescent 儿童和青少年中与极低剂量抗精神病药物相关的横纹肌溶解和抗精神病药物恶性综合征

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.450

Jong-Il Park, T. Park

引用次数: 4

New Onset Obsessive Compulsive Disorder Following High Frequency Repetitive Transcranial Magnetic Stimulation over Left Dorsolateral Prefrontal Cortex for Treatment of Negative Symptoms in a Patient with Schizophrenia 高频重复经颅磁刺激左背外侧前额叶皮质治疗精神分裂症患者阴性症状后新发强迫症

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2019-08-01 DOI: 10.9758/cpn.2019.17.3.443

H. Garg, Saurabh Kumar, Swarndeep Singh, Nand Kumar, R. Verma

引用次数: 5