Clinical Psychopharmacology and Neuroscience最新文献_第9页

Haloperidol and Other Antipsychotics Exposure before Endometrial Cancer Diagnosis: A Population-based Case-control Study. 子宫内膜癌诊断前氟哌啶醇和其他抗精神病药物暴露:一项基于人群的病例对照研究。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.526

Wei-Ling Chen, Srinivasan Nithiyanantham, Yan-Chiao Mao, Chih-Hsin Muo, Chih-Pin Chuu, Shih-Ping Liu, Min-Wei Huang, Kuan-Pin Su

{"title":"Haloperidol and Other Antipsychotics Exposure before Endometrial Cancer Diagnosis: A Population-based Case-control Study.","authors":"Wei-Ling Chen, Srinivasan Nithiyanantham, Yan-Chiao Mao, Chih-Hsin Muo, Chih-Pin Chuu, Shih-Ping Liu, Min-Wei Huang, Kuan-Pin Su","doi":"10.9758/cpn.2022.20.3.526","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.526","url":null,"abstract":"Objective: Endometrial cancer is the most common malignancy of the female genital tract worldwide, and the associated relationship between endometrial cancer formation and various antipsychotics need to be confirmed.Methods: We conducted a case-control study by using data from Taiwan National Health Insurance Research Database to compare individual antipsychotic exposure between females with and without endometrial cancer. Among 14,079,089 females in the 12-year population-based national dataset, 9,502 females with endometrial cancer were identified. Their medical records of exposure to antipsychotics, including quetiapine, haloperidol, risperidone, olanzapine, amisulpride, clozapine, and aripiprazole, for up to 3 years before endometrial cancer diagnosis were reviewed. Daily dosage and cumulative exposure days were analyzed in the risky antipsychotic users. Additionally, the subsequent 5-year mortality rate of endometrial cancer among users of the risky antipsychotic were also analyzed.Results: Among endometrial cancer patients, the proportion of those who have used haloperidol before being diagnosed with endometrial cancer is significantly higher than other antipsychotic users. The significant odds ratio (OR) and a 95% confidence interval of 1.75 (1.31-2.34) were noted. Furthermore, haloperidol users were associated with a significantly higher 5-year mortality rate after getting endometrial cancer than non-users.Conclusion: There is a high correlation between the use of haloperidol and endometrial cancer formation. However, the underlying pathological biomechanisms require additional investigations.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"526-535"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/d6/cpn-20-3-526.PMC9329120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amisulpride Augmentation in Schizophrenia Patients with Poor Response to Olanzapine: A 4-week, Randomized, Rater-Blind, Controlled, Pilot Study. 对奥氮平反应不佳的精神分裂症患者阿米硫pride增强治疗:一项为期4周的随机、非盲、对照试验研究

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.567

Young Sup Woo, Sung-Yong Park, Bo-Hyun Yoon, Won-Seok Choi, Sheng-Min Wang, Won-Myong Bahk

{"title":"Amisulpride Augmentation in Schizophrenia Patients with Poor Response to Olanzapine: A 4-week, Randomized, Rater-Blind, Controlled, Pilot Study.","authors":"Young Sup Woo, Sung-Yong Park, Bo-Hyun Yoon, Won-Seok Choi, Sheng-Min Wang, Won-Myong Bahk","doi":"10.9758/cpn.2022.20.3.567","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.567","url":null,"abstract":"Objective: The purpose of this study was to compare the efficacy and tolerability of continued olanzapine (OLA) versus amisulpride (AMI) augmentation in schizophrenic patients with poor response to OLA monotherapy.Methods: The present 4-week, randomized, rater-blinded study included 25 patients with schizophrenia who were partially or completely unresponsive to treatment with OLA monotherapy. Eligible subjects were randomly assigned at a 1:1 ratio to continuation of OLA monotherapy (OLA group) or OLA with AMI augmentation (AMI group). Efficacy was primarily evaluated using the Positive and Negative Syndrome Scale (PANSS) at baseline and at 1, 2, and 4 weeks.Results: The changes in PANSS total score and PANSS-positive subscale score were significantly different (p < 0.05) between the OLA and AMI groups. The differences between the two groups in PANSS-negative subscale, PANSS-general subscale, Brief Psychiatric Rating Scale, and Clinical Global Impression-Severity (CGI-S) scale scores were not statistically significant.Conclusion: AMI augmentation could be an effective strategy for patients with schizophrenia who show inadequate early response to OLA monotherapy.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"567-572"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/7c/cpn-20-3-567.PMC9329105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Methylome-wide Association Study of Patients with Recent-onset Psychosis. 新发精神病患者的甲基组关联研究。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.462

Yan-Hong Piao, Yin Cui, Fatima Zahra Rami, Ling Li, Maryam Karamikheirabad, Shi Hyun Kang, Sung-Wan Kim, Jung Jin Kim, Bong Ju Lee, Young-Chul Chung

{"title":"Methylome-wide Association Study of Patients with Recent-onset Psychosis.","authors":"Yan-Hong Piao, Yin Cui, Fatima Zahra Rami, Ling Li, Maryam Karamikheirabad, Shi Hyun Kang, Sung-Wan Kim, Jung Jin Kim, Bong Ju Lee, Young-Chul Chung","doi":"10.9758/cpn.2022.20.3.462","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.462","url":null,"abstract":"Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls.Methods: The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled.Results: We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed.Conclusion: Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"462-473"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/da/cpn-20-3-462.PMC9329103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40538545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Region and Sex-specific Changes in Mitochondrial Biogenesis Induced by Acute Trimethyltin Exposure. 急性三甲基锡暴露诱导线粒体生物发生的脑区和性别特异性变化。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.474

Jung Ho Lee, Eun Hye Jang, Soon Ae Kim

{"title":"Brain Region and Sex-specific Changes in Mitochondrial Biogenesis Induced by Acute Trimethyltin Exposure.","authors":"Jung Ho Lee, Eun Hye Jang, Soon Ae Kim","doi":"10.9758/cpn.2022.20.3.474","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.474","url":null,"abstract":"Objective: In this study, we investigated sex- and region-specific effects of acute trimethyltin (TMT) exposure on mitochondrial biogenesis.Methods: We treated TMT to primary neuronal cultures and 4-week-old male and female mice. We measured the mitochondrial DNA copy numbers using the quantitative polymerase chain reaction method. We also measured mitochondrial biogenesis related genes (sirtuin-1, estrogen-related receptor alpha, cytochrome C oxidase subunit IV) by western blotting.Results: The mitochondrial DNA copy number increased in the primary hippocampal neuron; however, it decreased in the primary cortical neuron. The mitochondrial copy number increased in the hippocampus and decreased in the cortex in the TMT treated female mice, though the mitochondrial copy number increased in both cortex and hippocampus in the TMT treated male mice. TMT treatment increased sirtuin-1 expression in the male hippocampus but did not in the female brain. In the female brain, estrogen-related receptor alpha expression decreased in the cortex though there is no significant change in the male brain. The protein level of mitochondrial protein, cytochrome C oxidase subunit IV, increased in both cortex and hippocampus after TMT injection in male mice brain, but not in female mice brain.Conclusion: Our data suggest that acute TMT exposure induces distinct sex-specific metabolic characteristics in the brain before significant sexual maturation.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"474-481"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/dd/cpn-20-3-474.PMC9329116.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40538546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Levels of Ammonia and Carnitine in Patients Treated with Valproic Acid: A Meta-analysis. 丙戊酸治疗患者血氨和肉碱水平:荟萃分析。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.536

Saaya Yokoyama, Norio Sugawara, Kazushi Maruo, Norio Yasui-Furukori, Kazutaka Shimoda

{"title":"Blood Levels of Ammonia and Carnitine in Patients Treated with Valproic Acid: A Meta-analysis.","authors":"Saaya Yokoyama, Norio Sugawara, Kazushi Maruo, Norio Yasui-Furukori, Kazutaka Shimoda","doi":"10.9758/cpn.2022.20.3.536","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.536","url":null,"abstract":"Objective: Long-term valproic acid (VPA) administration is associated with adverse metabolic effects, including hyperammonemia and hypocarnitinemia. However, the pathogeneses of these adverse events remain unclear, and not enough reviews have been performed. The aim of this study was to conduct a meta-analysis of studies examining blood levels of ammonia and carnitine in patients treated with VPA.Methods: We conducted database searches (PubMed, Web of Science) to identify studies examining blood levels of ammonia and carnitine in patients treated with VPA. A meta-analysis was performed to conduct pre- and post-VPA treatment comparisons, cross-sectional comparisons between groups with and without VPA use, and estimations of the standardized correlations between blood levels of ammonia, carnitine, and VPA.Results: According to the cross-sectional comparisons, the blood ammonia level in the VPA group was significantly higher than that in the non-VPA group. Compared to that in the non-VPA group, the blood carnitine level in the VPA group was significantly lower. In the meta-analysis of correlation coefficients, the blood VPA level was moderately correlated with blood ammonia and blood free carnitine levels in the random effects model. Furthermore, the blood ammonia level was moderately correlated with the blood free carnitine level.Conclusion: Although the correlation between ammonia and free carnitine levels in blood was significant, the moderate strength of the correlation does not allow clinicians to infer free carnitine levels from the results of ammonia levels. Clinicians should measure both blood ammonia and free carnitine levels, especially in patients receiving high dosages of VPA.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"536-547"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/fa/cpn-20-3-536.PMC9329117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of Power Spectral Density in Salience Network during Thought-action Fusion Induction Paradigm in Obsessive-compulsive Disorder. 强迫症思维-行动融合诱导范式中显著性网络功率谱密度的变化

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.415

Sang Won Lee, Eunji Kim, Tae Yang Jang, Heajung Choi, Seungho Kim, Huijin Song, Moon Jung Hwang, Yongmin Chang, Seung Jae Lee

{"title":"Alterations of Power Spectral Density in Salience Network during Thought-action Fusion Induction Paradigm in Obsessive-compulsive Disorder.","authors":"Sang Won Lee, Eunji Kim, Tae Yang Jang, Heajung Choi, Seungho Kim, Huijin Song, Moon Jung Hwang, Yongmin Chang, Seung Jae Lee","doi":"10.9758/cpn.2022.20.3.415","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.415","url":null,"abstract":"Objective: Recent studies highlighted the triple-network model which illustrated the interactions among three large-scale networks including salience network (SN). The functional magnetic resonance imaging used in this study was designed to investigate the characteristics of three large-scale networks associated with the thought-action fusion (TAF) in patients with obsessive-compulsive disorder (OCD) using power spectral density (PSD) analysis.Methods: This study included 32 OCD patients and 38 age-matched healthy controls (HC). The TAF task was modified from the experiment of Rassin. PSD from time courses in large-scale networks of each subject was measured to compare between the groups for both TAF and resting state.Results: In SN, OCD reported lower power in the low-frequency domain of SN compared to HC using the two-sample t test during the TAF task (t = -2.395, p = 0.019) but not in the resting state. The PSD in the low-frequency domain of the SN had a significant negative correlation with state score in the guilty inventory (r = -0.361, p = 0.042) in OCD patients.Conclusion: This study suggests that OCD patients showed reduced SN power which can be prominent in a certain situation, such as TAF. In addition, the PSD alterations in SN cause difficulty in processing ambiguous emotional cues in social situations, and the difficulty can be connected with a negative feeling (e.g., guilt).","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"415-426"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/51/cpn-20-3-415.PMC9329118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40539157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Psychiatric Comorbidities in Adults with DiGeorge Syndrome. 成人迪乔治综合征的精神合并症。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.498

Hiren Patel, Ramu Vadukapuram, Zeeshan Mansuri, Chintan Trivedi, Kanwarjeet Singh Brar, Uzma Beg, Jigar Patel, Aalamgeer Ibrahim, Muhammad Khalid Zafar

{"title":"Psychiatric Comorbidities in Adults with DiGeorge Syndrome.","authors":"Hiren Patel, Ramu Vadukapuram, Zeeshan Mansuri, Chintan Trivedi, Kanwarjeet Singh Brar, Uzma Beg, Jigar Patel, Aalamgeer Ibrahim, Muhammad Khalid Zafar","doi":"10.9758/cpn.2022.20.3.498","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.498","url":null,"abstract":"Objective: DiGeorge Syndrome (DGS) is a common multisystem disorder associated with deletions on chromosome 22q11.2. Our objective is to evaluate the psychiatric comorbidities and demographics of patients suffering from DGS in a nationally representative dataset on inpatient hospitalizations.Methods: The Nationwide Inpatient Sample for the year 2005-2017 was used for this study. Data on patients with DiGeorge syndrome were collected by using the International Classification of Diseases code. Univariate and multi- variate logistic regression analysis was performed.Results: In our study, the average age was 30.4 years (n = 6,563), with 59.9% male, and 61.8% of patients were white. There was a high prevalence of mood disorders (24.7%) and anxiety disorders (16.4%), followed by schizo- phrenia and other psychotic condition (14.0%). In patients with mood disorders, 8% had Major Depressive Disorder, and 7% had bipolar depression. Overall composite of psychiatric comorbidities was present in 2,959 (45.1%) of patients. The mean length of stay was 6.58 days, and 77% of patients had routine discharge to home. In the adjusted analysis, the average length of stay was 8.6 days vs. 6.7 days (p < 0.001) in patients with and without psychiatry comorbidities. In comparison to routine discharge, patients with psychiatry comorbidities were more likely to be discharged to other healthcare facilities (odds ratio [OR]: 1.28, p < 0.001) and discharged against medical advice (OR: 3.45, p < 0.001).Conclusion: Patients with DGS have worse outcomes with a higher rate of discharge to other healthcare facilities and a higher rate of being discharged against medical advice. Further large scale randomize studies are indicated.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"498-503"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/15/cpn-20-3-498.PMC9329110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40538549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders. 植物乳杆菌PS128在焦虑障碍患者中的临床应用价值

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.560

Xiaojuan Meng, Yajie Gao, Hang Qi, Yongyan Ding, Yaqing Sun

{"title":"Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders.","authors":"Xiaojuan Meng, Yajie Gao, Hang Qi, Yongyan Ding, Yaqing Sun","doi":"10.9758/cpn.2022.20.3.560","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.560","url":null,"abstract":"Objective: PS128 is a novel psycho biotic strain, it has been reported to play an important role in neuropsychiatric disorders. This study investigated the clinical effect of PS128 supplementation on patients with anxiety.Methods: A total of 200 patients with anxiety were recruited, and divided into two groups (n = 100/group). The control group received oral treatment with citalopram, and the PS128 group received PS128 capsules based on citalopram treatment. Hamilton Anxiety Scale (HAMA) and Self-Rating Anxiety Scale (SAS) were used to evaluate the anxiety levels. After 2 months of continuous administration, clinical efficacy was evaluated according to HAMA score.Results: There was no significant difference in HAMA and SAS scores between the two groups before treatment. With the treatment prolonged, the HAMA and SAS score decreased gradually in both control and PS128 groups, and the decrease rate of PS128 group was significantly greater than that of the control group. The clinical effective rates of PS128 group were higher than those in the control group, high levels of clinical cure rate were also detected in the PS128 group. Compared with the control group (22%), the incidence of adverse reactions was significantly reduced for patients in the PS128 group (4%).Conclusion: The treatment effect of citalopram combined with PS128 against anxiety is satisfactory clinically. It can greatly improve the anxiety symptoms of patients, increase the cure rate, reduce adverse reactions.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"560-566"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/47/cpn-20-3-560.PMC9329101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pulmonary Embolism during a Retrial of Low-dose Clozapine. 低剂量氯氮平再试验期间的肺栓塞。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.578

Gregg Alan Robbins-Welty, Shannon Coats, Andrew N Tuck, Bryan K Lao, Zachary Lane

{"title":"Pulmonary Embolism during a Retrial of Low-dose Clozapine.","authors":"Gregg Alan Robbins-Welty, Shannon Coats, Andrew N Tuck, Bryan K Lao, Zachary Lane","doi":"10.9758/cpn.2022.20.3.578","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.3.578","url":null,"abstract":"Pulmonary emboli (PE) are increasingly recognized as an adverse effect of clozapine. However, little is known about the characteristics or mechanisms of clozapine-associated PE. We present a case of a 34-year-old with treatment-refractory schizophrenia who developed rhabdomyolysis during his first clozapine trial. During re-trial on a lower dose than his initial trial, the patient developed chest pain that he attributed to \"pacemakers.\" The pleuritic description and associated tachycardia prompted medical workup and the patient was ultimately diagnosed with a clozapine-associated PE. The patient's only risk factors for PE were obesity and tobacco use, while his hypercoagulability workup was unrevealing. Clozapine use was continued at a lower dose following these adverse effects given inefficacy of other agents in managing the patient's psychotic symptoms. The patient experienced significant relief of psychotic symptoms with continued clozapine therapy and a course of electroconvulsive therapy. The patient's presentation was unusual in that it occurred during a retrial of clozapine, after the initial trial was stopped when he developed rhabdomyolysis. This case demonstrates the importance of maintaining vigilance for PE in patients on clozapine as well as not dismissing somatic complaints in patients experiencing psychosis. Additionally, given his history rhabdomyolysis, an uncommon adverse effect of clozapine, the development of a second uncommon adverse effect (PE) raises the question of whether these events may be associated.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 3","pages":"578-580"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/ec/cpn-20-3-578.PMC9329109.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea. 抗精神病药物使用对精神分裂症患者死亡率的累积影响:韩国一项全国性人群队列研究。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-08-31 DOI: 10.9758/cpn.2022.20.3.573

Gyurin Kim, Soo Jung Rim, Minkyung Jo, Min Geu Lee, Se Jin Park, Subin Park

引用次数: 0