Clinical Psychopharmacology and Neuroscience最新文献

Tight Junction Proteins and Blood-brain Barrier Integrity in Pediatric Obsessive-compulsive Disorder: A Study on Claudin-5, Claudin-12, Occludin, Tricellulin, and Angulin-1. 紧密连接蛋白与儿童强迫症血脑屏障完整性：Claudin-5、Claudin-12、Occludin、Tricellulin和Angulin-1的研究。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-05-02 DOI: 10.9758/cpn.25.1293

Filiz Akın-Kınay, Necati Uzun, İbrahim Kılınç, Ahmet Osman Kılıç

{"title":"Tight Junction Proteins and Blood-brain Barrier Integrity in Pediatric Obsessive-compulsive Disorder: A Study on Claudin-5, Claudin-12, Occludin, Tricellulin, and Angulin-1.","authors":"Filiz Akın-Kınay, Necati Uzun, İbrahim Kılınç, Ahmet Osman Kılıç","doi":"10.9758/cpn.25.1293","DOIUrl":"10.9758/cpn.25.1293","url":null,"abstract":"Objective: Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by the presence of obsessions and/or compulsions that cause significant distress and functional impairment. Despite extensive research, its etiopathogenesis remains incompletely understood. Recent evidence suggests that dysfunction in tight junctions may contribute to the pathophysiology of various psychiatric disorders. Tight junction proteins play a crucial role in maintaining blood-brain barrier integrity and regulating neuronal signaling. This study aims to investigate the involvement of tight junction proteins in the etiopathogenesis of OCD, providing new insights into their potential role in the disorder's neurobiological mechanisms.Methods: A total of 41 medication-free children and adolescents with OCD and 41 healthy controls were included in this study. The participants filled out self-report scales to determine various psychological variables. Blood samples were collected from all participants to measure the levels of claudin-5, claudin-12, occludin, angulin-1, and tricellulin.Results: The levels of claudin-5, claudin-12, occludin, and tricellulin were significantly higher in the OCD group compared to the control group. However, there was no significant difference in angulin-1 levels between the groups.Conclusion: Our findings indicate that claudin-5, claudin-12, occludin, and tricellulin levels differ between individuals with OCD and healthy controls. These results suggest that tight junction proteins may contribute to the etiopathogenesis of OCD. Further research is needed to better understand the relationship between OCD and tight junction proteins.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"444-452"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a Depression Model Using Dexamethasone-treated Three-dimensional Cultured Rat Cortical Cells. 地塞米松处理的三维培养大鼠皮质细胞抑郁模型的建立。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-03-10 DOI: 10.9758/cpn.25.1269

Mi Kyoung Seo, Sehoon Jeong, Woo Seok Cheon, Dong Yun Lee, Sumin Lee, Gyu-Hui Lee, Deok-Gyeong Kang, Dae-Hyun Seog, Seong-Ho Kim, Jung Goo Lee, Sung Woo Park

{"title":"Establishment of a Depression Model Using Dexamethasone-treated Three-dimensional Cultured Rat Cortical Cells.","authors":"Mi Kyoung Seo, Sehoon Jeong, Woo Seok Cheon, Dong Yun Lee, Sumin Lee, Gyu-Hui Lee, Deok-Gyeong Kang, Dae-Hyun Seog, Seong-Ho Kim, Jung Goo Lee, Sung Woo Park","doi":"10.9758/cpn.25.1269","DOIUrl":"10.9758/cpn.25.1269","url":null,"abstract":"Objective: In vitro models are useful for exploring the molecular mechanisms underlying impaired neuroplasticity in depression. In this study, we developed a three-dimensional spheroid model in which we investigated the effects of the synthetic glucocorticoid dexamethasone on key pathways involved in neuroplasticity, specifically BDNF, sirtuin 1, and mTORC1 signaling.Methods: A micro-spheroid device was fabricated using photolithography and soft lithography, and cortical spheroids were generated from primary rat cortical cells. These spheroids, which contained neurons, astrocytes, microglia, and oligodendrocytes, were treated with various concentrations of dexamethasone.Results: Dexamethasone treatment (100, 200, and 300 μM) resulted in a dose-dependent reduction in cell viability, BDNF mRNA expression, and neurite outgrowth. At 100 μM, dexamethasone reduced the expression of BDNF and sirtuin 1 and decreased the phosphorylation of ERK1/2. It also decreased the phosphorylation of mTORC1, 4E-BP1, and p70S6K, as well as synaptic proteins such as PSD-95 and GluA1.Conclusion: Dexamethasone treatment inhibited pathways related to neuroplasticity. While dexamethasone-treated spheroids may serve as a basis for developing an in vitro model of depression, further validation is needed to confirm their broader applicability.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"418-432"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hostility is Associated with Interferon γ Inducible Protein 10 in Opioid Maintenance Treatment Patients with Chronic Hepatitis C. 慢性丙型肝炎阿片类药物维持治疗患者的敌意与干扰素γ诱导蛋白10相关

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-06-11 DOI: 10.9758/cpn.24.1262

Kristin Nygård-Odeh, Hedda Soløy-Nilsen, Magnhild Gangsøy-Kristiansen, Ole Lars Brekke, Tom Eirik Mollnes, Michael Berk, Jørgen Gustav Bramness

{"title":"Hostility is Associated with Interferon γ Inducible Protein 10 in Opioid Maintenance Treatment Patients with Chronic Hepatitis C.","authors":"Kristin Nygård-Odeh, Hedda Soløy-Nilsen, Magnhild Gangsøy-Kristiansen, Ole Lars Brekke, Tom Eirik Mollnes, Michael Berk, Jørgen Gustav Bramness","doi":"10.9758/cpn.24.1262","DOIUrl":"10.9758/cpn.24.1262","url":null,"abstract":"Objective: Levels of circulating cytokines has been shown to be related to psychological distress. We have earlier shown that the symptoms of hostility may be related to levels of interferon γ inducible protein 10 (IP-10) in a group of general psychiatric in-patients receiving psychotropic medication. Here we investigate this association in a group of patients with chronic hepatitis C virus (HCV) infection with or without opioid maintenance treatment (OMT).Methods: In a cross-sectional study, out-patients were interviewed for psychological distress using the Symptoms Check-List-90-R (SCL-90-R) and blood samples were drawn to measure serum levels of IP-10. Hierarchical linear regression analysis was used to investigate the association between hostility and IP-10 hostility in the whole group, and in the non-OMT and the OMT-patients, respectively.Results: One hundred and twenty patients with chronic HCV infection were included, of whom 53 received OMT. There was no association between hostility and IP-10 in the patient group as a whole. In the OMT group we observed a negative association throughout the steps including adjusting for age, gender and BMI (β = -0.48, p = 0.011).Conclusion: We observed that only in OMT patients was there a negative association between hostility and IP-10. This might support previous findings that drugs, self-reported mental health symptoms and cytokines interact.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"488-493"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Heart Rate Variability Improves Machine Learning-based Prediction of Panic Disorder Symptom Severity. 整合心率变异性改善基于机器学习的恐慌症症状严重程度预测。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-03-25 DOI: 10.9758/cpn.24.1261

Jin Goo Lee, Jae-Jin Kim, Jeong-Ho Seok, Eunjoo Kim, Jooyoung Oh, Chang-Bae Bang, Byung-Hoon Kim

{"title":"Integrating Heart Rate Variability Improves Machine Learning-based Prediction of Panic Disorder Symptom Severity.","authors":"Jin Goo Lee, Jae-Jin Kim, Jeong-Ho Seok, Eunjoo Kim, Jooyoung Oh, Chang-Bae Bang, Byung-Hoon Kim","doi":"10.9758/cpn.24.1261","DOIUrl":"10.9758/cpn.24.1261","url":null,"abstract":"Objective: The association between panic disorder (PD) and heart rate variability (HRV) has long been studied with a focus on the imbalance of the autonomic nervous system. This study aims to demonstrate the predictive capability of HRV in determining PD severity using machine learning.Methods: Psychometric scales and various HRV components were measured from 507 PD patients who were recruited. We designed three experiments with different sets of input features for comparison. The input features of each experiment were 1) both psychometric scales and HRV together (ExSH), or 2) only the scales (ExS), or 3) only the HRV components. In each experiment, nine machine learning models were used to predict the Panic Disorder Severity Scale. We compared the predictive capability of the three sets of input features by statistically analyzing the performance metrics of the models in the three experiments. SHapley Additive exPlanation (SHAP) was further employed to assess the importance of the input features.Results: The Random Forest model in ExSH, which incorporated both psychometric scales and HRV, achieved the highest f1-score (76.50%) and sensitivity (75.35%). ExSH showed significantly higher sensitivity and f1-score compared to ExS. For the RF model of ExSH, the highest SHAP importance value was found for the Hamilton Rating Scale for Anxiety, followed by the Hamilton Depression Rating Scale, and the low-frequency power (LF).Conclusion: Our findings demonstrate that integrating HRV with psychometric scales improves machine learning-based prediction of PD severity. We also highlighted LF as a promising variable among HRV components.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"400-410"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review. 基于fmri的神经反馈治疗抑郁症的有效性：一项系统综述。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-06-09 DOI: 10.9758/cpn.25.1295

Ali Khaleghi, Hannaneh Samiei, Hadi Zarafshan, Shahab Alaedin Baloochi, Mohammad Reza Mohammadi

{"title":"Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review.","authors":"Ali Khaleghi, Hannaneh Samiei, Hadi Zarafshan, Shahab Alaedin Baloochi, Mohammad Reza Mohammadi","doi":"10.9758/cpn.25.1295","DOIUrl":"10.9758/cpn.25.1295","url":null,"abstract":"Objective: This systematic review explores the efficacy of fMRI-based neurofeedback as an alternative treatment for individuals with depression who do not respond well to traditional therapies.Methods: A comprehensive literature search across several databases (PubMed, Web of Science, ProQuest, Cochrane Library, and Google Scholar) identified 649 articles related to neurofeedback and depression, ultimately including 26 studies after eligibility assessments.Results: The majority of these studies, comprising both open-label and randomized controlled trials, reported significant reductions in depressive symptoms following neurofeedback interventions, which primarily targeted amygdala activity. Eighteen studies showed moderate to large effect sizes (Cohen's d values from 0.38 to 1.50) on validated depression measures. Notably, neurobiological changes were observed, including increased Blood Oxygenation Level Dependent (BOLD) activity and connectivity in emotion regulation regions such as the amygdala and prefrontal cortex. Some studies indicated sustained symptom improvements, with over 75% of patients applying learned strategies in daily life. However, methodological limitations and a moderate to high risk of bias were noted in several studies.Conclusion: fMRI-based neurofeedback presents a promising adjunctive therapy for depression, especially for patients who are resistant to standard treatments. Although current evidence shows positive effects on neural function and clinical outcomes, addressing methodological issues and standardizing study designs is essential. Future research should emphasize larger sample sizes and long-term efficacy while enhancing accessibility and cost-effectiveness in diverse clinical environments.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"337-355"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variability in Oxytocin Blood Levels in Rats: A Review and Experimental Insights. 大鼠血液中催产素水平的变异性：综述和实验见解。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-04-22 DOI: 10.9758/cpn.25.1273

Yong Yue, Guilin Liu, Rumi Murayama, Yi Cai, Tingting Zhu, Hirofumi Hashimoto, Naohiko Anzai, Kenji Hashimoto

{"title":"Variability in Oxytocin Blood Levels in Rats: A Review and Experimental Insights.","authors":"Yong Yue, Guilin Liu, Rumi Murayama, Yi Cai, Tingting Zhu, Hirofumi Hashimoto, Naohiko Anzai, Kenji Hashimoto","doi":"10.9758/cpn.25.1273","DOIUrl":"10.9758/cpn.25.1273","url":null,"abstract":"Oxytocin, often called the \"love hormone,\" is well-known for its roles in childbirth and lactation. Beyond these traditional functions, it plays a vital role in emotional and social behaviors, mood regulation, stress responses, and various physiological processes. Blood oxytocin levels are typically low under basal conditions but increase significantly during labor, breastfeeding, sexual activity, and positive social interactions. However, reported plasma oxytocin levels in humans and rodents vary widely across studies. In this study, we reviewed plasma oxytocin levels in rats from research conducted over the past decade, emphasizing the notable discrepancies observed between studies. Furthermore, we investigated the effects of two anesthetic protocols (inhaled isoflurane and a combination of three anesthetics) and the proteinase inhibitor aprotinin on plasma oxytocin levels in adult male rats. Our findings revealed that neither the anesthetics nor aprotinin significantly affected plasma oxytocin levels. We also discussed potential factors contributing to the marked differences in reported rat blood oxytocin levels.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"500-512"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability. 妊娠中期抑郁症状对母胎心率变异性的影响

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-02-13 DOI: 10.9758/cpn.24.1256

Heeyeon Kim, Kyungun Jhung, Dukyong Yoon, Jihoon Seo, Hee Young Cho, Jin Young Park

{"title":"Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability.","authors":"Heeyeon Kim, Kyungun Jhung, Dukyong Yoon, Jihoon Seo, Hee Young Cho, Jin Young Park","doi":"10.9758/cpn.24.1256","DOIUrl":"10.9758/cpn.24.1256","url":null,"abstract":"Objective: This study explores how maternal depressive symptoms during the second trimester, a critical phase for autonomic nervous system (ANS) development, affect maternal and fetal heart rate variability (HRV) in the third trimester, with implications for infant development.Methods: We examined the effects of second trimester maternal depression on subsequent maternal and fetal HRV. A cohort of women in early or late second trimester completed depression assessments using the Edinburgh Postnatal Depression Scale (EPDS) and underwent HRV evaluations in the third trimester.Results: Among 118 participants, 97 completed the EPDS at 14-20 weeks, with 12 showing depressive symptoms. At 21-28 weeks, 111 participants were assessed, and 24 were identified as possibly depressive. Depressive symptoms were linked to increased maternal pNN50% (percentage of successive NN intervals differing by more than 50 ms) and decreased detrended fluctuation analysis alpha, indicating hemodynamic shifts. Their fetuses showed reduced root mean square of successive differences, standard deviation of successive differences, and short-term and long-term variability indices, suggesting weakened parasympathetic activity.Conclusion: Prenatal depression influences maternal physiological adaptation and fetal ANS development, highlighting HRV as a potential biomarker for predicting neurodevelopment. Early identification and treatment of mid-pregnancy depressive symptoms may help mitigate potential risks to infant neurodevelopment.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"368-378"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addendum: Factors Affecting Continuation of Aripiprazole Long-acting Injection in the Real World. 附录：现实生活中影响阿立哌唑长效注射液继续使用的因素。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-05-26 DOI: 10.9758/cpn.24.1232.corr

Soyeon Chang, Seri Maeng, Yangsik Kim, Jae-Nam Bae, Jeong-Seop Lee, Won-Hyoung Kim

引用次数: 0

Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons. 线索诱导的谷氨酸磁共振波谱在成瘾研究中的应用：目前的证据，赞成和反对。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-04-21 DOI: 10.9758/cpn.24.1254

Muhammad Abdullah, Shih-Hsien Lin, Li-Chung Huang, Muhammad Imran Khan, Chun-Chia Kung, Yen Kuang Yang

{"title":"Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons.","authors":"Muhammad Abdullah, Shih-Hsien Lin, Li-Chung Huang, Muhammad Imran Khan, Chun-Chia Kung, Yen Kuang Yang","doi":"10.9758/cpn.24.1254","DOIUrl":"10.9758/cpn.24.1254","url":null,"abstract":"Cues, which induce craving, and may lead to relapse, are an important paradigm for addiction research. Visual cues related to addictive substances trigger powerful neurophysiological responses in the brains of addicts, leading to craving. However, the molecular mechanisms underlying these neurophysiological responses remain incompletely understood. While the role of dopamine in cue-induced phenomena has been extensively studied, the contribution of glutamate, a major excitatory neurotransmitter and a key player in cue-associated phenomena as proposed by animal studies, is less explored in humans. Functional magnetic resonance spectroscopy (fMRS) is a promising tool for investigating glutamatergic modulations in tasks. This review aims to evaluate the potential of fMRS in explaining the dynamics of glutamate during cue-induced phenomena in drug addiction. We discuss the clinical implications, strengths, and limitations of fMRS in this context and propose directions for future research.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"327-336"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association between Intranasal Esketamine and Treatment-emergent Insomnia in the Treatment of Treatment-resistant Major Depression: A Meta-analysis. 鼻用艾氯胺酮与治疗难治性重度抑郁症中出现的失眠症的关系：一项荟萃分析。

IF 2.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-04-08 DOI: 10.9758/cpn.25.1271

Cagdas Türkmen, Rutger Boesjes, Anne-Fleur Zandbergen, Jeanine Kamphuis, Wolfgang Viechtbauer, Robert A Schoevers, Jens H van Dalfsen

{"title":"The Association between Intranasal Esketamine and Treatment-emergent Insomnia in the Treatment of Treatment-resistant Major Depression: A Meta-analysis.","authors":"Cagdas Türkmen, Rutger Boesjes, Anne-Fleur Zandbergen, Jeanine Kamphuis, Wolfgang Viechtbauer, Robert A Schoevers, Jens H van Dalfsen","doi":"10.9758/cpn.25.1271","DOIUrl":"10.9758/cpn.25.1271","url":null,"abstract":"Objective: Intranasal (IN) esketamine represents a novel add-on treatment for treatment-resistant depression (TRD) with reported favourable effects on insomnia. IN esketamine treatment might similarly reduce the incidence of insomnia as an adverse event (AE). The present meta-analysis therefore investigated whether IN esketamine relative to placebo is associated with a lower incidence of insomnia as an AE in adults with TRD.Methods: Data were retrieved from seven randomised placebo-controlled trials evaluating the safety and efficacy of IN esketamine combined with a monoaminergic antidepressant in the treatment of TRD that reported data on insomnia as an AE. The study population (n = 1,311) comprised adult patients (aged ≥ 18 years) with a primary diagnosis of major depressive disorder. A mixed-effects logistic regression model was employed to compare the incidence of insomnia as an AE between the IN esketamine and placebo group.Results: Insomnia as an AE was reported by 52 patients (7.3%) in the IN esketamine group relative to 40 (6.7%) in the placebo group. IN esketamine compared to placebo was not associated with the odds of insomnia as an AE (OR = 1.07; 95% CI = 0.68-1.69; p = 0.76). There was no evidence for heterogeneity between the included trials.Conclusion: IN esketamine does not affect the occurrence of insomnia as an AE in the treatment of TRD. This contrasts previous findings demonstrating beneficial effects of esketamine on insomnia severity relative to placebo, although AE reporting may not capture insomnia improvements in a population with frequent baseline insomnia.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"23 3","pages":"494-499"},"PeriodicalIF":2.4,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12264661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0