Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons.

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2025-08-31 Epub Date: 2025-04-21 DOI:10.9758/cpn.24.1254

Muhammad Abdullah, Shih-Hsien Lin, Li-Chung Huang, Muhammad Imran Khan, Chun-Chia Kung, Yen Kuang Yang

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引用次数: 0

Abstract

Cues, which induce craving, and may lead to relapse, are an important paradigm for addiction research. Visual cues related to addictive substances trigger powerful neurophysiological responses in the brains of addicts, leading to craving. However, the molecular mechanisms underlying these neurophysiological responses remain incompletely understood. While the role of dopamine in cue-induced phenomena has been extensively studied, the contribution of glutamate, a major excitatory neurotransmitter and a key player in cue-associated phenomena as proposed by animal studies, is less explored in humans. Functional magnetic resonance spectroscopy (fMRS) is a promising tool for investigating glutamatergic modulations in tasks. This review aims to evaluate the potential of fMRS in explaining the dynamics of glutamate during cue-induced phenomena in drug addiction. We discuss the clinical implications, strengths, and limitations of fMRS in this context and propose directions for future research.

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线索诱导的谷氨酸磁共振波谱在成瘾研究中的应用：目前的证据，赞成和反对。

诱发渴望并可能导致复发的线索是成瘾研究的一个重要范例。与成瘾物质相关的视觉线索会在成瘾者的大脑中引发强烈的神经生理反应，导致渴望。然而，这些神经生理反应的分子机制仍然不完全清楚。虽然多巴胺在线索诱导现象中的作用已被广泛研究，但谷氨酸（一种主要的兴奋性神经递质，在动物研究中提出的线索相关现象中起关键作用）的作用在人类中却很少被探索。功能磁共振波谱（fMRS）是研究任务中谷氨酸调节的一种很有前途的工具。本文旨在评价fMRS在解释药物成瘾中线索诱导现象中谷氨酸的动态方面的潜力。在此背景下，我们讨论了fMRS的临床意义、优势和局限性，并提出了未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.