The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence?

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI:10.9758/cpn.2022.20.4.694

YoungHo Kim, Sung-Doo Won, Hyejin Kwon, Changwoo Han

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引用次数: 0

Abstract

Objective: The ratio of 2nd and 4th digit length (2D:4D) is considered to be a sexually dimorphic trait. Low 2D:4D is implicated in alcohol dependence and heroin dependence and correlated with psychological traits such as aggression, physical aggression, and sensation. The purpose of this study is to compare the 2D:4D between methamphetamine (METH) dependence and controls and the 2D:4D ratio that is a potential biomarker for METH dependence.

Methods: In this study, 40 patients diagnosed with METH dependence in Eulji University Gangnam Eulji Hospital and 50 healthy volunteers were all employees in the same hospital. Images of participants' hands were created using a scanning device. The images contained both the right and left hands; computer software was used to measure the 2D:4D ratio for both hands. We compared the ratios, analyzed by t test, between the METH dependence group and the control group.

Results: The mean 2D:4D values were 0.941 (right hand) and 0.943 (left hand) for the patients with METH dependence; in contrast, they were 0.961 (right hand) and 0.961 (left hand) for the control group. These values were significantly smaller than the control in patients' right hands (p = 0.003) and left hands (p = 0.012).

Conclusion: Patients with METH dependence had smaller 2D:4D ratios than those in the control group, which is similar to the results from the previous substance use disorder studies. Thus, elevated prenatal testosterone levels during the gonadal period could be related to future METH problems. Furthermore, the 2D:4D ratio is a potential marker for the prediction of METH dependence.

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第2位和第4位手指长度的比例:甲基苯丙胺依赖的生物标志物?

目的:第2和第4个手指长度的比例(2D:4D)被认为是两性二态特征。低2D:4D与酒精依赖和海洛因依赖有关，并与攻击性、身体攻击和感觉等心理特征相关。本研究的目的是比较甲基苯丙胺(冰毒)依赖与对照之间的2D:4D比值，以及作为冰毒依赖潜在生物标志物的2D:4D比值。方法:选取乙支大学江南乙支医院诊断为甲基苯丙胺依赖的40例患者和50例健康志愿者，均为同一医院的员工。参与者的手的图像是用扫描设备创建的。这些图像包含了右手和左手;用电脑软件测量双手的2D:4D比例。我们用t检验比较了冰毒依赖组和对照组之间的比率。结果:冰毒依赖患者的2D:4D均值分别为0.941(右手)和0.943(左手);对照组为0.961(右手)和0.961(左手)。这些数值在患者右手(p = 0.003)和左手(p = 0.012)中显著小于对照组。结论:甲基苯丙胺依赖患者的2D:4D比值小于对照组，这与以往物质使用障碍研究的结果相似。因此，性腺期产前睾酮水平升高可能与未来的冰毒问题有关。此外，2D:4D比值是预测冰毒依赖的潜在标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.