Clinical Psychopharmacology and Neuroscience最新文献_第8页

Latent Classes based on Clinical Symptoms of Military Recruits with Mental Health Issues and Their Distinctive Clinical Responses to Treatment over 6 Months. 基于心理健康问题新兵临床症状的潜在类别及其对6个月以上治疗的独特临床反应。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-05-30 DOI: 10.9758/cpn.23.1061

Eun-Hee Park, Duk-In Jon, Hyun Ju Hong, Myung Hun Jung, Narei Hong

{"title":"Latent Classes based on Clinical Symptoms of Military Recruits with Mental Health Issues and Their Distinctive Clinical Responses to Treatment over 6 Months.","authors":"Eun-Hee Park, Duk-In Jon, Hyun Ju Hong, Myung Hun Jung, Narei Hong","doi":"10.9758/cpn.23.1061","DOIUrl":"10.9758/cpn.23.1061","url":null,"abstract":"Objective: : This study aimed (1) to identify distinct subgroups of psychiatric patients referred for a mental health certificate for military service suitability and (2) to determine whether there is a difference in clinical features such as treatment responsiveness and prognosis among certain subgroups.Methods: : We conducted latent profile analysis (LPA) using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) clinical profiles of the participants. Linear mixed model analysis was performed to examine changes in the severity of clinical symptoms and functional level according to the treatment period of the latent classes derived from the LPA.Results: : The results indicated that the best-fitting model was a three-class model, comprising Class 1 (mild maladjustment), Class 2 (neurotic depression and anxiety), and Class 3 (highly vulnerable and hypervigilant). We demonstrated that the three subgroups displayed different characteristics in treatment responsiveness and clinical course based on their Clinical Global Impression-Severity and Global Assessment of Functioning scores over a treatment period of 6 months. While subjects in Classes 1 and 2 significantly improved over 6 months, those in Class 3 showed little or no improvement in our clinical parameters.Conclusion: : This study has yielded data with clinical implications for treatment planning and interventions for each subgroup classified that were based on MMPI-2 clinical profiles of military recruits who might be maladjusted to serve.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/71/cpn-21-4-778.PMC10591162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric Properties of the Korean Version of THINC-integrated Tool (THINC-it-K): A Tool for Screening Assessment of Cognitive Function in Patients with Major Depressive Disorder 韩国版 THINC-integrated Tool（THINC-it-K）的心理计量特性：用于筛查评估重度抑郁症患者认知功能的工具

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 DOI: 10.9758/cpn.23.1135

Y. Woo, Kyoung-Uk Lee, Changtae Hahn, Roger S. McIntyre, K. Teopiz, W. Bahk

引用次数: 0

Classifying Children with ADHD Based on Prefrontal Functional Near-infrared Spectroscopy Using Machine Learning. 基于机器学习的前额叶功能近红外光谱对ADHD儿童进行分类

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-05-22 DOI: 10.9758/cpn.22.1025

Chan-Mo Yang, Jaeyoung Shin, Johanna Inhyang Kim, You Bin Lim, So Hyun Park, Bung-Nyun Kim

{"title":"Classifying Children with ADHD Based on Prefrontal Functional Near-infrared Spectroscopy Using Machine Learning.","authors":"Chan-Mo Yang, Jaeyoung Shin, Johanna Inhyang Kim, You Bin Lim, So Hyun Park, Bung-Nyun Kim","doi":"10.9758/cpn.22.1025","DOIUrl":"10.9758/cpn.22.1025","url":null,"abstract":"Objective: : Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adults characterized by cognitive and emotional self-control deficiencies. Previous functional near-infrared spectroscopy (fNIRS) studies found significant group differences between ADHD children and healthy controls during cognitive flexibility tasks in several brain regions. This study aims to apply a machine learning approach to identify medication-naive ADHD patients and healthy control (HC) groups using task-based fNIRS data.Methods: : fNIRS signals from 33 ADHD children and 39 HC during the Stroop task were analyzed. In addition, regularized linear discriminant analysis (RLDA) was used to identify ADHD individuals from healthy controls, and classification performance was evaluated.Results: : We found that participants can be correctly classified in RLDA leave-one-out cross validation, with a sensitivity of 0.67, specificity of 0.93, and accuracy of 0.82.Conclusion: : RLDA using only fNIRS data can effectively discriminate children with ADHD from HC. This study suggests the potential utility of the fNIRS signal as a diagnostic biomarker for ADHD children.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/25/cpn-21-4-693.PMC10591175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47722287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Neuroplasticity after Treatment with Antiseizure: A Review. 抗癫痫治疗后的脑神经可塑性:综述

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-06-07 DOI: 10.9758/cpn.23.1058

Débora Lopes Silva de Souza, Hosana Mirelle Goes E Silva Costa, Francisca Idalina Neta, Paulo Leonardo Araujo de Gois Morais, Luís Marcos de Medeiros Guerra, Fausto Pierdoná Guzen, Lucídio Clebeson de Oliveira, JoséRodolfo Lopes de Paiva Cavalcanti, Cynthia Cavalcanti de Albuquerque, Claudio Lopes de Vasconcelos

{"title":"Brain Neuroplasticity after Treatment with Antiseizure: A Review.","authors":"Débora Lopes Silva de Souza, Hosana Mirelle Goes E Silva Costa, Francisca Idalina Neta, Paulo Leonardo Araujo de Gois Morais, Luís Marcos de Medeiros Guerra, Fausto Pierdoná Guzen, Lucídio Clebeson de Oliveira, JoséRodolfo Lopes de Paiva Cavalcanti, Cynthia Cavalcanti de Albuquerque, Claudio Lopes de Vasconcelos","doi":"10.9758/cpn.23.1058","DOIUrl":"10.9758/cpn.23.1058","url":null,"abstract":"Epilepsy is a disease characterized by the periodic occurrence of seizures. Seizures can be controlled by antiseizure medications, which can improve the lives of individuals with epilepsy when given proper treatment. Therefore, this study aimed to review the scientific literature on brain neuroplasticity after treatment with antiseizure drugs in different regions of the brain. According to the findings, that several antiseizure, such as lamotrigine, diazepam, levetiracetam, and valproic acid, in addition to controlling seizures, can also act on neuroplasticity in different brain regions. The study of this topic becomes important, as it will help to understand the neuroplastic mechanisms of these drugs, in addition to helping to improve the effectiveness of these drugs in controlling the disease.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/82/cpn-21-4-665.PMC10591163.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48025230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability and Validity of the Korean Version of the Brief Resilience Scale. 韩文简易弹性量表的信度与效度

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-05-22 DOI: 10.9758/cpn.23.1049

Junhyung Kim, Hyun-Ghang Jeong, Moon-Soo Lee, Seung-Hoon Lee, Sang-Won Jeon, Changsu Han

{"title":"Reliability and Validity of the Korean Version of the Brief Resilience Scale.","authors":"Junhyung Kim, Hyun-Ghang Jeong, Moon-Soo Lee, Seung-Hoon Lee, Sang-Won Jeon, Changsu Han","doi":"10.9758/cpn.23.1049","DOIUrl":"10.9758/cpn.23.1049","url":null,"abstract":"Objective: : To translate the Brief Resilience Scale into Korean and evaluate its reliability and validity.Methods: : To investigate the factor structure of the Brief Resilience Scale, we examined a two-factor model comprising positively and negatively worded items. Congruent and divergent validity of the Brief Resilience Scale were investigated using correlation analysis between the Brief Resilience Scale and resilience, depression, and perceived stress. By conducting an analysis of variance among groups classified by suicidality (no suicidality, only suicidal ideation, and suicidal ideation or suicidal plan groups), we evaluated how well the Brief Resilience Scale could detect people with a high risk of suicide.Results: : Confirmatory factor analysis results supported the construct validity of the Brief Resilience Scale using a two-factor model. Cronbach's alpha (0.91) and McDonald's omega (0.91) scores indicated high internal consistency. Correlation analysis showed that the Brief Resilience Scale scores were strongly associated with a questionnaire evaluating resilience, depression, and perceived stress. Analysis of variance and post-hoc tests showed that he Brief Resilience Scale scores were highest in the no suicidality group (p ＜ 0.001).Conclusion: : The Korean version of the Brief Resilience Scale is a valid and reliable instrument for evaluating resilience as the capacity to recover from adversity and endure obstacles or stress. This study also provides important evidence regarding the sensitivity of the Brief Resilience Scale to suicidal risk.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/c5/cpn-21-4-732.PMC10591158.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48968649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impulsivity in Major Depressive Disorder Patients with Suicidal Ideation: Event-related Potentials in a GoNogo Task. 具有自杀意念的重度抑郁症患者的冲动性:GoNogo任务中的事件相关电位

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-06-22 DOI: 10.9758/cpn.23.1064

Minjae Kim, Yeon Jung Lee, Jaeuk Hwang, Sung-Il Woo, Sang-Woo Hahn

{"title":"Impulsivity in Major Depressive Disorder Patients with Suicidal Ideation: Event-related Potentials in a GoNogo Task.","authors":"Minjae Kim, Yeon Jung Lee, Jaeuk Hwang, Sung-Il Woo, Sang-Woo Hahn","doi":"10.9758/cpn.23.1064","DOIUrl":"10.9758/cpn.23.1064","url":null,"abstract":"Objective: : Suicidal ideation is one of the strongest predictors of suicide, and its relevance to impulsivity in depressed patients has been accumulated. Furthermore, high impulsivity patients show the attenuation of the Nogo amplitude in the GoNogo event-related potential (ERP). The purpose of the current study is to determine the correlation of Nogo ERP to the suicidal ideation depending on the condition of its presence or absence in major depressive disorder (MDD) patients.Methods: : A total 162 participants (104 patients with suicidal ideation, 31 patients without suicidal ideation, and 27 healthy controls) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, suicidal ideation and impulsivity were assessed by self-rating scales. The clinical measures, behavioral data and Nogo ERP were compared among groups.Results: : The MDD with suicidal ideation (SI) group showed significantly decreased Nogo P3 amplitudes compared to MDD without SI (Fz and Cz electrodes) and control group (all electrodes). The MDD with SI group also had significantly low accuracy of both Go and Nogo trails, compared to the MDD without group. The Nogo P3 amplitudes showed the negative relation to the scores of impulsivity, depression, anxiety and SI.Conclusion: : Our results concluded that the Nogo P3 ERP amplitude was decreased in MDD patients with SI compared to MDD patients without SI and controls. These findings suggest that the decreased Nogo P3 amplitude is the one of the candidate biomarker for impulsivity in MDD patients to evaluating SI.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10591160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47010324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System. 多巴胺D2、D3激动剂喹匹罗对小鼠运动活动的影响

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-05-22 DOI: 10.9758/cpn.22.1016

Jeonghyun Park, Eunsoo Moon, Hyun Ju Lim, Kyungwon Kim, Yoo Rha Hong, Jung Hyun Lee

{"title":"Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System.","authors":"Jeonghyun Park, Eunsoo Moon, Hyun Ju Lim, Kyungwon Kim, Yoo Rha Hong, Jung Hyun Lee","doi":"10.9758/cpn.22.1016","DOIUrl":"10.9758/cpn.22.1016","url":null,"abstract":"Objective: : As dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. However, most of animal studies were performed for a short period that there is a lack of longitudinal study on the effects of dopaminergic agents on locomotor activities. This study aimed to examine the longterm effect of a dopamine D2, D3 agonist quinpirole on locomotor activities in mice using a home-cage monitoring system.Methods: : The locomotor activities of Institute Cancer Research mice were measured by infrared motion detectors in home-cages under the 12-hour dark and 12-hour light condition for three days after the quinpirole injection. Quinpirole was injected at a concentration of 0.5 mg/kg intraperitoneally in the beginning of the dark phase. The locomotor activities before and after the quinpirole administration were compared by the Wilcoxon signed-rank test and one-way repeated measures ANOVA.Results: : After the quinpirole administration, the 24-hour total locomotor activity did not change (p = 0.169), but activities were significantly increased in the 12-hour dark phase sum (p = 0.013) and decreased in the 12-hour light phase sum (p = 0.009). Significant increases in the activities were observed in the dark-light difference (p = 0.005) and dark-light ratio (p = 0.005) as well.Conclusion: : This study suggests that quinpirole injection entrains the circadian rest-activity rhythm of locomotor activities. Therefore, quinpirole can be a drug that mediates locomotor activity as a dopamine agonist as well as a modulator of the circadian rhythms.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/ac/cpn-21-4-686.PMC10591172.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43660612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase. 抗氧化应激标记物谷胱甘肽和谷胱甘肽还原酶对认知障碍潜在保护作用的初步研究

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-07-14 DOI: 10.9758/cpn.23.1053

Sang-A Park, Gihwan Byeon, Jin Hyeong Jhoo, Hyung-Chun Kim, Myoung-Nam Lim, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim

{"title":"A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase.","authors":"Sang-A Park, Gihwan Byeon, Jin Hyeong Jhoo, Hyung-Chun Kim, Myoung-Nam Lim, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim","doi":"10.9758/cpn.23.1053","DOIUrl":"10.9758/cpn.23.1053","url":null,"abstract":"Objective: : To investigate the relationship between reduced glutathione (GSH), a key molecule of the antioxidant defense system in the blood, and glutathione reductase (GR), which reduces oxidized glutathione (glutathione disulfide [GSSG]) to GSH and maintains the redox balance, with the prevalence of Alzheimer's dementia and cognitive decline.Methods: : In all, 20 participants with Alzheimer's dementia who completed the third follow-up clinical evaluation over 6 years were selected, and 20 participants with normal cognition were selected after age and sex matching. The GSH and GR concentrations were the independent variables. Clinical diagnosis and neurocognitive test scores were the dependent variables indicating cognitive status.Results: : The higher the level of GR, the greater the possibility of having normal cognition than of developing Alzheimer's dementia. Additionally, the higher the level of GR, the higher the neurocognitive test scores. However, this association was not significant for GSH. After 6 years, the conversion rate from normal cognition to cognitive impairment was significantly higher in the lower 50th percentile of the GR group than in the upper 50th percentile.Conclusion: : The higher the GR, the lower the prevalence of Alzheimer's dementia and incidence of cognitive impairment and the higher the cognitive test scores. Therefore, GR is a potential protective biomarker against Alzheimer's dementia and cognitive decline.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/33/cpn-21-4-758.PMC10591176.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46426581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolactin Level Changes according to Atypical Antipsychotics Use: A Study Based on Clinical Data Warehouse. 非典型抗精神病药物使用对催乳素水平的影响:基于临床数据仓库的研究

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-06-07 DOI: 10.9758/cpn.23.1057

Suhyung Kim, Jong-Hyun Jeong, Yoo Hyun Um, Tae-Won Kim, Ho-Jun Seo, Seung-Chul Hong

{"title":"Prolactin Level Changes according to Atypical Antipsychotics Use: A Study Based on Clinical Data Warehouse.","authors":"Suhyung Kim, Jong-Hyun Jeong, Yoo Hyun Um, Tae-Won Kim, Ho-Jun Seo, Seung-Chul Hong","doi":"10.9758/cpn.23.1057","DOIUrl":"10.9758/cpn.23.1057","url":null,"abstract":"Objective: : Antipsychotic drugs are known as the major cause of non-neoplastic hyperprolactinemia. This study aimed to investigate the levels of serum prolactin depending on the use of antipsychotic drugs in patients through the Clinical Data Warehouse (CDW).Methods: : We conducted a cohort search in the CDW application and got 260 patients' medical records diagnosed with schizophrenia, schizotypal and delusional disorders, manic episodes, and bipolar affective disorders who were taking one of risperidone, blonanserin, amisulpride, and olanzapine. After that, we reviewed the medical data and used the ANCOVA analysis and the post hoc test to compare serum prolactin levels among four antipsychotic drug groups.Results: : Among the 117 subjects included in the analysis, the mean serum prolactin level was 64.6 ± 54.6 ng/ml. Serum prolactin levels were significantly higher in subjects taking risperidone or amisulpride compared to blonanserin and olanzapine. The female subjects who took blonanserin, olanzapine, and risperidone had significantly higher prolactin levels, but there was no difference in serum prolactin levels between sex in the subjects who took amisulpride.Conclusion: : This study suggests the need for regular monitoring of serum prolactin levels in patients who are taking antipsychotics, especially in female patients. And we showed that there is a possibility to conduct more effective and simpler big data research using the CDW. Further studies on the subjects with controlled confounding variables and larger sample groups are needed.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/42/78/cpn-21-4-769.PMC10591174.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49230802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention Circuits Mediate the Connection between Emotional Experience and Expression within the Emotional Circuit. 注意回路在情绪回路中调解情绪体验和表达之间的联系

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-11-30 Epub Date: 2023-05-22 DOI: 10.9758/cpn.22.1029

Na Rae Won, Young-Don Son, Sun Mi Kim, Sujin Bae, Jeong Hee Kim, Jong-Hoon Kim, Doug Hyun Han

{"title":"Attention Circuits Mediate the Connection between Emotional Experience and Expression within the Emotional Circuit.","authors":"Na Rae Won, Young-Don Son, Sun Mi Kim, Sujin Bae, Jeong Hee Kim, Jong-Hoon Kim, Doug Hyun Han","doi":"10.9758/cpn.22.1029","DOIUrl":"10.9758/cpn.22.1029","url":null,"abstract":"Objective: : Most affective neuroscience studies use pictures from the International Affective Picture System or standard facial expressions to elicit emotional experiences. The attention system, including the prefrontal cortex, can mediate emotional regulation in response to stimulation with emotional faces. We hypothesized that emotional experience is associated with brain activity within the neocortex. In addition, modification within the neocortex may be associated with brain activity within the attention system.Methods: : Thirty-one healthy adult participants were recruited to be assessed for emotional expression using clinical scales of happiness, sadness, anxiety, and anger as and for emotional experience using brain activity in response to pictures of facial emotional expressions. The attention system was assessed using brain activity in response to the go-no-go task.Results: : We found that emotional experience was associated with brain activity within the frontotemporal cortices, while emotional expression was associated with brain activity within the temporal and insular cortices. In addition, the association of brain activity between emotional experiences and expressions of sadness and anxiety was affected by brain activity within the anterior cingulate gyrus in response to the go-no-go task.Conclusion: : Emotional expression may be associated with brain activity within the temporal cortex, whereas emotional experience may be associated with brain activity within the frontotemporal cortices. In addition, the attention system may interfere with the connection between emotional expression and experience.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/5f/cpn-21-4-715.PMC10591168.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45343574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0