Clinical Psychopharmacology and Neuroscience最新文献_第7页

Cerebellar Gray Matter Volume and its Role in Executive Function, and Attention: Sex Differences by Age in Adolescents. 小脑灰质体积及其在执行功能和注意力中的作用:青少年年龄的性别差异。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.621

Hayeon Kim, Bumhee Park, Shin-Young Kim, Jiyea Kim, Bora Kim, Kyu-In Jung, Seung-Yup Lee, Yerin Hyun, Bung-Nyun Kim, Subin Park, Min-Hyeon Park

{"title":"Cerebellar Gray Matter Volume and its Role in Executive Function, and Attention: Sex Differences by Age in Adolescents.","authors":"Hayeon Kim, Bumhee Park, Shin-Young Kim, Jiyea Kim, Bora Kim, Kyu-In Jung, Seung-Yup Lee, Yerin Hyun, Bung-Nyun Kim, Subin Park, Min-Hyeon Park","doi":"10.9758/cpn.2022.20.4.621","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.621","url":null,"abstract":"Objective: This research measures the regional GMV (rGMV) of the cerebellum, attention, Executive Function (EF) and we aimed to identify their correlation and sex differences in children and adolescents.Methods: Subjects comprised 114 children (male = 62, female = 52, 12.44 ± 2.99 years old) from South Korea. Participants were divided into three groups by age (age 6-9, 10-13, and 14-17). The Stroop Color and Word Test (SCWT), Wisconsin Card Sorting Test (WCST), and Advanced Test of Attention (ATA) were used to estimate executive function. Magnetic resonance imaging (MRI) images were analyzed with Regional Voxel-Based Morphometry Analysis.Results: The correlations between cerebellar rGMV and SCWT, WCST, and ATA subcategories showed difference by age and sex. In 6-9 age group, girls showed more overall correlations with cerebellar regions than boys, in WCST Categories Completed and ATA results. In age 10-13 group, more regions of cerebellum corresponded to SCWT subcategories in girls. Nevertheless, more correlation between cerebellar rGMV, WCST subcategories and some ATA subtests were observed in boys in the same age group. In the adolescent group, aged 14-17, boys showed more correlation with cerebellar rGMV, while girls showed little correlation.Conclusion: This study highlights that sex-different cerebellum maturation in adolescence might be correlated with EF and attention. These results provides evidence that cerebellum modulates higher cognitive functioning during child development.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"621-634"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/cf/cpn-20-4-621.PMC9606426.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40669180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DNA Methylation Pattern of Gene Promoters of MB-COMT, DRD2, and NR3C1 in Turkish Patients Diagnosed with Schizophrenia. 土耳其精神分裂症患者MB-COMT、DRD2和NR3C1基因启动子的DNA甲基化模式

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 Epub Date: 2021-06-14 DOI: 10.9758/cpn.2022.20.4.685

Hasan Mervan Aytac, Yasemin Oyaci, Mustafa Pehlivan, Sacide Pehlivan

{"title":"DNA Methylation Pattern of Gene Promoters of MB-COMT, DRD2, and NR3C1 in Turkish Patients Diagnosed with Schizophrenia.","authors":"Hasan Mervan Aytac, Yasemin Oyaci, Mustafa Pehlivan, Sacide Pehlivan","doi":"10.9758/cpn.2022.20.4.685","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.685","url":null,"abstract":"Objective: We aim to evaluate the methylation status of membrane-bound catechol-O-methyltransferase (MB-COMT) promotor, dopamine receptor D2 (DRD2), and nuclear receptor subfamily 3 group C member 1 (NR3C1) gene in pa- tients with SCZ by comparing healthy controls.Methods: A sample of 110 patients with SCZ and 100 age- and sex-matched healthy volunteers was included in the study. The interview was started by filling out data forms that included sociodemographic and clinical information. The Structured Clinical Interview for DSM-IV Axis I Disorders was used to confirming the diagnosis according to DSM-IV-TR criteria. Then the patients were evaluated with the Positive and Negative Symptoms Scale in terms of symp- tom severity. Methylation-specific polymerase chain reaction was used to determine the methylation status of MB-COMT promotor, DRD2 , and NR3C1 gene from DNA material.Results: When we compared the percentages of MB-COMT promotor, DRD2, and NR3C1 gene methylation status in SCZ patients with the healthy control group, the percentages of MB-COMT promotor (OR: 0.466; 95% CI: 0.268- 0.809; p = 0.006), DRD2 (OR: 0.439; 95% CI: 0.375-0.514; p < 0.001), and NR3C1 (OR: 0.003; 95% CI: 0.001- 0.011; p < 0.001) gene methylation status of SCZ was found to be significantly different from the control group. Whereas unmethylation of MB-COMT promotor and NR3C1 genes were associated with SCZ, the partial methylation of the DRD2 gene was related to the SCZ.Conclusion: The MB-COMT promotor, DRD2, and NR3C1 gene methylation status may be associated with the SCZ in the Turkish population.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"685-693"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/97/cpn-20-4-685.PMC9606422.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Risk of Breast Cancer in Association with the Use of Second-generation Antipsychotics. 乳腺癌风险与第二代抗精神病药物的使用有关。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.675

Sung Woo Joo, Boung Chul Lee, Jungsun Lee, Gi Hyeon Seo

{"title":"Risk of Breast Cancer in Association with the Use of Second-generation Antipsychotics.","authors":"Sung Woo Joo, Boung Chul Lee, Jungsun Lee, Gi Hyeon Seo","doi":"10.9758/cpn.2022.20.4.675","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.675","url":null,"abstract":"Objective Previous studies regarding the relationship between the risk of breast cancer (BC) and antipsychotics use have reported inconsistent findings. Insufficient sample size and/or observation period may have hindered revealing the risk of BC associated with antipsychotics use. We aimed to investigate whether the use of second-generation antipsychotics (SGA) is associated with increased risk of BC. Methods We used the Health Insurance Review Agency database in South Korea between 2008 and 2018. The index date was determined as the date of the first antipsychotic prescription. We selected women prescribed SGAs for more than 30 days within a year from the index date and age-matched controls, yielding 498,970 cases and 997,940 controls. The Cox proportional hazards regression model was used for estimating the risk. Results The incidence rates of BC were 109.74 and 101.51 per 100,000 person-years in the case and control groups, respectively. There was an increased risk of BC in the case group (hazard ratio [HR] = 1.08, 95% confidence interval [CI] 1.04−1.13). There was a higher risk of BC in subjects prescribed with ≥ 10,000 mg of olanzapine equivalent dose (HR = 1.29, 95% CI 1.14−1.46) than those with < 10,000 mg (HR = 1.05, 95% CI 1.00−1.11). The increased risk of BC in the case group became significant after six years of the observation period (≥ 6 years HR = 1.24, 95% CI 1.14−1.35, 3 to < 6 years HR = 1.06, 95% CI 0.97−1.15, < 3 years HR = 1.02, 95% CI 0.95−1.09). Conclusion This study indicated that the use of SGAs is associated with increased risk of BC in a long-term relationship with a dose-response pattern.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"675-684"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/b9/cpn-20-4-675.PMC9606429.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Botulinum Toxin in Facial Aesthetics Affects the Emotion Process: A Meta-analysis of Randomized Controlled Trials. 肉毒杆菌毒素影响面部美学的情绪过程:随机对照试验的荟萃分析。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.600

Ana Carolina de Figueiredo Costa, Everton Cavalcante da Silva, Delane Viana Gondim

{"title":"Botulinum Toxin in Facial Aesthetics Affects the Emotion Process: A Meta-analysis of Randomized Controlled Trials.","authors":"Ana Carolina de Figueiredo Costa, Everton Cavalcante da Silva, Delane Viana Gondim","doi":"10.9758/cpn.2022.20.4.600","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.600","url":null,"abstract":"This study aimed to conduct a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of the btulinum toxin-A (BT-A) in patiets with mood disorders. PubMed, Scopus, Web of Science, Cochrane Library and LILACS were searched without restrictions up to July 2022. The PICOS strategy was used for the selection of studies and risk-of-bias assessment was performed using Cochrane's tool for RCTs. RCTs were included if they compared BT-A treatment on facial muscles in patients with mood disorders to placebo. After assessment of the full texts, seven studies were selected. Five studies had low risk of bias for the generation of random sequence and blinding of participants and professional domains. A total of four studies showed a low risk of bias for the allocation concealment and blinding of the evaluation of the domain results. The domain of selective reports showed a low risk of bias in all included studies. However, four studies presented a high risk of bias for the domain of other biases. The meta-analysis was based on the mean difference or standardized mean difference between the BT-A and placebo groups for each selected trial and revealed that the BT-A group showed a significant improvement in the symptoms of depression when compared to placebo. This study revealed that the BT-A application into mimic muscles of the upper third of the face improves the mood disorders, but it was not possible to guarantee whether the aesthetic benefits can contribute to reducing the severity of the depressive state.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"600-608"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/cd/cpn-20-4-600.PMC9606430.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40669178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence? 第2位和第4位手指长度的比例:甲基苯丙胺依赖的生物标志物?

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.694

YoungHo Kim, Sung-Doo Won, Hyejin Kwon, Changwoo Han

{"title":"The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence?","authors":"YoungHo Kim, Sung-Doo Won, Hyejin Kwon, Changwoo Han","doi":"10.9758/cpn.2022.20.4.694","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.694","url":null,"abstract":"Objective: The ratio of 2nd and 4th digit length (2D:4D) is considered to be a sexually dimorphic trait. Low 2D:4D is implicated in alcohol dependence and heroin dependence and correlated with psychological traits such as aggression, physical aggression, and sensation. The purpose of this study is to compare the 2D:4D between methamphetamine (METH) dependence and controls and the 2D:4D ratio that is a potential biomarker for METH dependence.Methods: In this study, 40 patients diagnosed with METH dependence in Eulji University Gangnam Eulji Hospital and 50 healthy volunteers were all employees in the same hospital. Images of participants' hands were created using a scanning device. The images contained both the right and left hands; computer software was used to measure the 2D:4D ratio for both hands. We compared the ratios, analyzed by t test, between the METH dependence group and the control group.Results: The mean 2D:4D values were 0.941 (right hand) and 0.943 (left hand) for the patients with METH dependence; in contrast, they were 0.961 (right hand) and 0.961 (left hand) for the control group. These values were significantly smaller than the control in patients' right hands (p = 0.003) and left hands (p = 0.012).Conclusion: Patients with METH dependence had smaller 2D:4D ratios than those in the control group, which is similar to the results from the previous substance use disorder studies. Thus, elevated prenatal testosterone levels during the gonadal period could be related to future METH problems. Furthermore, the 2D:4D ratio is a potential marker for the prediction of METH dependence.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"694-700"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/aa/05/cpn-20-4-694.PMC9606433.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Korean Medication Algorithm Project for Bipolar Disorder 2022, Fifth Revision: An Executive Summary. 韩国双相情感障碍药物算法项目2022，第五次修订:执行摘要。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.747

Young Sup Woo, Won-Myong Bahk, Jong-Hyun Jeong, Jung Goo Lee, Won Kim, InKi Sohn, Sung-Yong Park, Se-Hoon Shim, Jeong Seok Seo, Il Han Choo, Chan-Mo Yang, Myung Hun Jung, Duk-In Jon, Moon-Doo Kim, Bo-Hyun Yoon

{"title":"Korean Medication Algorithm Project for Bipolar Disorder 2022, Fifth Revision: An Executive Summary.","authors":"Young Sup Woo, Won-Myong Bahk, Jong-Hyun Jeong, Jung Goo Lee, Won Kim, InKi Sohn, Sung-Yong Park, Se-Hoon Shim, Jeong Seok Seo, Il Han Choo, Chan-Mo Yang, Myung Hun Jung, Duk-In Jon, Moon-Doo Kim, Bo-Hyun Yoon","doi":"10.9758/cpn.2022.20.4.747","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.747","url":null,"abstract":"Objective: We revised the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP), first published in 2002 and revised in 2006, 2010, 2014, and 2018, to reflect recent progress in the treatment of bipolar disorder.Methods: The questionnaires consisted of 56 items for adult patients and 7 items for child/adolescent patients, and were used to obtain the consensus of experts regarding pharmacological treatment strategies for various phases of bipolar disorder. The review committee included 87 Korean psychiatrists and 40 child and adolescent psychiatry experts.Results: For treatment of manic episodes, a combination of a mood stabilizer (MS) and atypical antipsychotics (AAP), or monotherapy with MS or AAP were recommended as first-line treatments. Combinations of MS and AAP, or AAP and lamotrigine (LMT) were recommended as first-line treatments for depressive episodes regardless of the severity. Monotherapy with MS, AAP, or LMT were also first-line treatments for mild to moderate depressive episodes. For mixed features, a combination of MS and AAP, or monotherapy with AAP or MS were recommended as first-line treatments, and a combination of AAP and LMT, or MS and LMT were the first-line treatments for depressive mixed state.Conclusion: The recommendations of the KMAP-BP 2022 have changed from the previous version, to reflect the evolution of the social culture and healthcare system in Korea and recent evidence regarding pharmacotherapy of bipolar disorder. The KMAP-BP 2022 provides clinicians with a wealth of information regarding appropriate strategies to treat patients with bipolar disorder.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"747-761"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/da/cpn-20-4-747.PMC9606436.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40560309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Targeting Three Brain Regions (Bilateral SMA, Left and Right DLPFC) Sequentially in One Session Using Combined Repetitive Transcranial Magnetic Stimulation and Intermittent Theta-burst Stimulation in Treatment-refractory Obsessive-compulsive Disorder: A Case Report. 重复性经颅磁刺激和间歇性Theta爆裂刺激联合治疗难治性强迫症，一次治疗中依次靶向三个脑区（双侧SMA、左右DLPFC）：一例报告。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.773

Po-Han Chou, Alexander T Sack, Kuan-Pin Su

引用次数: 3

Prediction Models for Suicide Attempts among Adolescents Using Machine Learning Techniques. 使用机器学习技术的青少年自杀企图预测模型。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.609

Jae Seok Lim, Chan-Mo Yang, Ju-Won Baek, Sang-Yeol Lee, Bung-Nyun Kim

{"title":"Prediction Models for Suicide Attempts among Adolescents Using Machine Learning Techniques.","authors":"Jae Seok Lim, Chan-Mo Yang, Ju-Won Baek, Sang-Yeol Lee, Bung-Nyun Kim","doi":"10.9758/cpn.2022.20.4.609","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.609","url":null,"abstract":"Objective: Suicide attempts (SAs) in adolescents are difficult to predict although it is a leading cause of death among adolescents. This study aimed to develop and evaluate SA prediction models based on six different machine learning (ML) algorithms for Korean adolescents using data from online surveys.Methods: Data were extracted from the 2011-2018 Korea Youth Risk Behavior Survey (KYRBS), an ongoing annual national survey. The participants comprised 468,482 nationally representative adolescents from 400 middle and 400 high schools, aged 12 to 18. The models were trained using several classic ML methods and then tested on internal and external independent datasets; performance metrics were calculated. Data analysis was performed from March 2020 to June 2020.Results: Among the 468,482 adolescents included in the analysis, 15,012 cases (3.2%) were identified as having made an SA. Three features (suicidal ideation, suicide planning, and grade) were identified as the most important predictors. The performance of the six ML models on the internal testing dataset was good, with both the area under the receiver operating characteristic curve (AUROC) and area under the precision-recall curve (AUPRC) ranging from 0.92 to 0.94. Although the AUROC of all models on the external testing dataset (2018 KYRBS) ranged from 0.93 to 0.95, the AUPRC of the models was approximately 0.5.Conclusion: The developed and validated SA prediction models can be applied to detect high risks of SA. This approach could facilitate early intervention in the suicide crisis and may ultimately contribute to suicide prevention for adolescents.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"609-620"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/92/cpn-20-4-609.PMC9606439.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40669179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Relationship of Circadian Rhythm in Behavioral Characteristics and Lipid Peroxidation of Brain Tissues in Mice. 小鼠行为特征的昼夜节律与脑组织脂质过氧化的关系。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.649

Chi Eun Oh, Hyun Ju Lim, Jeounghyun Park, Eunsoo Moon, Ji Kyoung Park

{"title":"Relationship of Circadian Rhythm in Behavioral Characteristics and Lipid Peroxidation of Brain Tissues in Mice.","authors":"Chi Eun Oh, Hyun Ju Lim, Jeounghyun Park, Eunsoo Moon, Ji Kyoung Park","doi":"10.9758/cpn.2022.20.4.649","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.649","url":null,"abstract":"Objective: This study aimed to explore the relationship among several indices of circadian rhythms and lipid peroxidation of brain tissue in mice.Methods: After entrainment of 4-week-old mice, one group was disrupted their circadian rhythms for three days and the other group for seven days (n = 10, respectively). After a recovery period, the Y-maze test, the elevated plus maze test, the tail suspension test, and the forced swimming test were conducted. To assess lipid peroxidation in brain tissue, thiobarbituric acid reactive substances were measured in the cortex, hippocampus, and cerebellum.Results: When circadian rhythms were disrupted and adapted back to their original rhythm, the recovery time of the 7-day disruption group (median 3.35 days) was significiantly faster than one of the 3-day disruption group (median 4.87 days). In the group with a 7-day disruption, mice that had recovered their rhythms early had higher malondialdehyde levels in their hippocampus compared to those with delayed recovery. The entrainment of circadian rhythms was negatively correlated with the malondialdehyde level of brain tissue. The behavioral test results showed no differences depending on the disruption durations or recovery patterns of circadian rhythms.Conclusion: These results suggest that disruption types, recovery patterns, and the entrainment of circadian rhythms are likely to affect oxidative stress in adolescents or young adult mice. Future study is needed to confirm and specify these results on the effects of circadian rhythms on oxidative stress and age-dependent effects.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"649-661"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/f4/cpn-20-4-649.PMC9606440.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders. 血清瘦素水平和身体共病对抑郁症药物治疗反应的相互作用。

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI: 10.9758/cpn.2022.20.4.662

Wonsuk Choi, Ju-Wan Kim, Hee-Ju Kang, Hee Kyung Kim, Ho-Cheol Kang, Ju-Yeon Lee, Sung-Wan Kim, Robert Stewart, Jae-Min Kim

{"title":"Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders.","authors":"Wonsuk Choi, Ju-Wan Kim, Hee-Ju Kang, Hee Kyung Kim, Ho-Cheol Kang, Ju-Yeon Lee, Sung-Wan Kim, Robert Stewart, Jae-Min Kim","doi":"10.9758/cpn.2022.20.4.662","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.4.662","url":null,"abstract":"Objective: To investigate individual and interactive associations of baseline serum leptin levels and physical comorbidity with short- and long-term treatment outcomes in outpatients with depressive disorders who received stepwise antidepressant treatment in a naturalistic prospective study design.Methods: Baseline serum leptin levels were measured, and the number of concurrent physical disorders ascertained from 1,094 patients. These patients received initial antidepressant monotherapy; then, for patients with an insufficient response or who experienced uncomfortable side effects, treatment was administered using alternative strategies every 3 weeks in the acute treatment phase (at 3, 6, 9, and 12 weeks) and every 3 months in the continuation treatment phase (at 6, 9, and 12 months). Then, 12-week and 12-month remission, defined as a Hamilton Depression Rating Scale score of ≤7, was estimated.Results: In multivariable logistic regression analyses, individual effects were found only between higher baseline serum leptin levels and 12-week non-remission. Significant interactive effects between higher leptin levels and fewer physical disorders (< 2 physical disorders) on 12-week non-remission were observed. However, neither individual nor interactive effects between leptin levels and physical comorbidity were associated with 12-month remission.Conclusion: The combination of serum leptin level and number of physical disorders may be a useful predictor of short-term treatment responses in patients with depressive disorders receiving pharmacotherapy.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 4","pages":"662-674"},"PeriodicalIF":3.2,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/7b/cpn-20-4-662.PMC9606432.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2