Clinical Psychopharmacology and Neuroscience最新文献_第4页

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-04-06 DOI: 10.9758/cpn.25.1394

Laura Garriga-Solé, Germán Ortega-Hernández, Xico Alberto Acosta-Villalobos, Lara Grau-López, Josep Antoni Ramos-Quiroga, Raúl Felipe Palma-Álvarez

{"title":"Psychosis Related to Nitrous Oxide Misuse: A Case Series and Systematic Review.","authors":"Laura Garriga-Solé, Germán Ortega-Hernández, Xico Alberto Acosta-Villalobos, Lara Grau-López, Josep Antoni Ramos-Quiroga, Raúl Felipe Palma-Álvarez","doi":"10.9758/cpn.25.1394","DOIUrl":"10.9758/cpn.25.1394","url":null,"abstract":"Nitrous oxide (N2O) has been linked to several neuropsychiatric complications. This paper aims to systematically review reported cases of psychosis associated with N2O use. Additionally, five new cases of N2O-related psychosis are presented. A systematic search was conducted in MedLine for cases of psychosis associated with N2O use, from database inception to April 2025. The five new cases are thoroughly analyzed, and the Naranjo criteria were applied to assess causality in both the new cases and those identified in the systematic review. A total of 15 articles were included, encompassing 15 patients. Including these and the five newly reported cases, the current manuscript analyzes 20 individuals (17 men and 3 women) aged 20 to 45 years. Most cases reported a history of substance use disorder (mainly alcohol) and escalating N2O use prior to the psychotic episode. Clinical manifestations included psychotic symptoms (delusions and hallucinations) as well as other psychopathological features. Neurological complications were also commonly described. Laboratory tests showed vitamin B12 abnormalities in some cases. All patients were hospitalized; abstinence from substance use was the first intervention, and most received antipsychotic treatment. N2O may be associated with psychotic episodes, particularly among young, heavy users with underlying vulnerabilities. Psychiatric and neurological symptoms are frequently observed. Although outcomes vary, treatment involving abstinence, vitamin B12 supplementation, and antipsychotic medication typically leads to improvement. Further research is warranted on this topic.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"252-276"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Naltrexone and Baclofen Combination in Reducing Craving among Patients with Alcohol Dependence: An Open-label Trial. 纳曲酮联合巴氯芬减少酒精依赖患者渴望的有效性：一项开放标签试验

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-03-31 DOI: 10.9758/cpn.25.1365

Aman Naqvi, Anil Nischal, Amit Singh, Anuradha Nischal

{"title":"Effectiveness of Naltrexone and Baclofen Combination in Reducing Craving among Patients with Alcohol Dependence: An Open-label Trial.","authors":"Aman Naqvi, Anil Nischal, Amit Singh, Anuradha Nischal","doi":"10.9758/cpn.25.1365","DOIUrl":"10.9758/cpn.25.1365","url":null,"abstract":"Objective: Alcohol use disorder is among the most prevalent mental disorders worldwide. Craving, a key feature of alcohol dependence, is also a major reason for relapse. We aimed to determine the efficacy of naltrexone, baclofen, and naltrexone-baclofen combination in reducing craving among patients with alcohol dependence.Methods: In this open-label, randomised trial of eight weeks duration, 97 participants were randomly allocated to three groups, namely naltrexone alone, baclofen alone, and naltrexone-baclofen combination, using a computer-generated random number table. The dosage was 40 to 60 mg/day for baclofen and 50 mg a day for naltrexone. Tools used for assessment included the Obsessive Compulsive Drinking Scale (OCDS), the visual analogue scale (VAS) for craving, World Health Organization Quality of Life BREF (WHOQoL BREF), and World Health Organization Well-being Scale (WHO-5). Mixed design ANOVA was used for analysis.Results: The naltrexone-baclofen combination group had a significantly greater decline in OCDS score as compared to the naltrexone group, but not as compared to the baclofen alone group. Also, there was a greater reduction in VAS, WHOQoL BREF, and WHO-5 score in the naltrexone-baclofen group compared to the other two groups; however, the difference was not significant. No significant differences were found in relapse rates and heavy episodic drinking between groups.Conclusion: The naltrexone-baclofen combination may be better in comparison to naltrexone used alone in reducing craving in alcohol dependence and is well tolerated.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"379-388"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Ceramide Metabolism in Autogenous and Reactive Obsessions: A Biomarker Perspective in OCD. 自体强迫和反应性强迫的神经酰胺代谢差异：强迫症的生物标志物视角。

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2025-11-06 DOI: 10.9758/cpn.25.1338

Ebru Ozdemir, Filiz Kulacaoglu, Mehmet Atakay, Bekir Salih, Onur Senol

{"title":"Differential Ceramide Metabolism in Autogenous and Reactive Obsessions: A Biomarker Perspective in OCD.","authors":"Ebru Ozdemir, Filiz Kulacaoglu, Mehmet Atakay, Bekir Salih, Onur Senol","doi":"10.9758/cpn.25.1338","DOIUrl":"10.9758/cpn.25.1338","url":null,"abstract":"Objective: This study aimed to compare the levels of ceramide pathway metabolites between autogenous and reactive subtypes of patients with obsessive-compulsive disorder (OCD) and healthy controls (HC).Methods: Targeted lipid analyses of ceramide C24:1, hydroxy-ceramide (C24:0 and C18:0), sphingomyelin (SM 16:0), and sphingosine-1-phosphate (S1P) were performed in 52 OCD patients and 27 HC. Patients with OCD group were divided into subgroups based on their primary obsessions: autogenous obsession (AO) and reactive obsession (RO). Sphingolipid species of three groups were compared. Serum samples of ceramide pathway metabolites were analysed by liquid chromatography-mass spectrometry.Results: C18:0 hydroxy-ceramide and S1P levels were significantly higher in patients with OCD than in the HC (p < 0.001). The levels of C24:1 ceramide in the OCD patients with AO were significantly higher than in the OCD patients with RO (p = 0.013) and in the HC group (p < 0.001). In patients with OCD, significant positive correlations were found between C24:1 ceramide levels and C24:0 hydroxy-ceramide levels (r = 0.326, p = 0.019), between C24:0 hydroxy-ceramide levels and C18:0 hydroxy-ceramide (r = 0.569, p < 0.001) and S1P (r = 0.619, p < 0.001), and between C18:0 hydroxy-ceramide levels and S1P (r = 0.652, p < 0.001).Conclusion: The finding of significantly higher C24:1 ceramide levels in OCD patients with AO may be a novel biomarker that highlights the heterogeneous nature of OCD and the specific neurobiological differences between autogenous and reactive subtypes. This study highlights the role of ceramide pathway metabolites in the pathophysiology of OCD and provides new insights into its underlying mechanisms.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"286-296"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Psychiatry with Virtual Reality and Augmented Reality: Recent Advances and Limitations. 数字精神病学与虚拟现实和增强现实：最近的进展和局限性。

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-04-06 DOI: 10.9758/cpn.25.1382

June Ho Chang, Yoo Jin Jang, Se Chang Yoon, Ji Hyun An, Jung-Seok Choi, Hong Jin Jeon

{"title":"Digital Psychiatry with Virtual Reality and Augmented Reality: Recent Advances and Limitations.","authors":"June Ho Chang, Yoo Jin Jang, Se Chang Yoon, Ji Hyun An, Jung-Seok Choi, Hong Jin Jeon","doi":"10.9758/cpn.25.1382","DOIUrl":"10.9758/cpn.25.1382","url":null,"abstract":"Digital psychiatry has rapidly expanded with the integration of immersive technologies such as virtual reality (VR) and augmented reality (AR). These modalities allow for controlled, engaging, and ecologically valid interventions across a wide range of psychiatric disorders. In this review, a narrative synthesis was conducted based on systematic reviews, meta-analyses, and randomized controlled trials identified through PubMed, Google Scholar, complemented by seminal earlier works. VR-based therapies demonstrated robust efficacy for anxiety disorders and phobias, with meta-analytic evidence supporting large effect sizes. For post-traumatic stress disorder virtual reality exposure therapy was superior to waitlist control and comparable to established psychotherapies, although AR exposure therapy remains underexplored. In autism spectrum disorder, VR and AR interventions significantly enhanced cognitive, social, and communication skills. AR applications have additionally been validated for cognitive assessment in Alzheimer's disease, and VR/AR-supported rehabilitation showed promise in attention deficit hyperactivity disorder and neurodevelopmental disorders. Despite encouraging findings, challenges remain, including small sample sizes, short follow-up periods, heterogeneity of protocols, and risks such as cybersickness or fatigue. VR and AR represent innovative tools with growing empirical support across psychiatric practice, extending from diagnostic assessment to therapeutic and rehabilitative interventions. Standardized protocols, large-scale trials, and long-term outcome studies are needed to integrate these technologies into routine clinical care.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"240-251"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroxine Disrupts Synaptic Plasticity via Non-genomic Action in the Hippocampus. 甲状腺素通过海马的非基因组作用破坏突触可塑性。

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-02-11 DOI: 10.9758/cpn.25.1347

Soner Bitiktaş, Cem Süer, Hamiyet Dönmez Altuntaş

{"title":"Thyroxine Disrupts Synaptic Plasticity via Non-genomic Action in the Hippocampus.","authors":"Soner Bitiktaş, Cem Süer, Hamiyet Dönmez Altuntaş","doi":"10.9758/cpn.25.1347","DOIUrl":"10.9758/cpn.25.1347","url":null,"abstract":"Objective: Numerous neurological deficiency disorders are caused by the thyroid hormones' early-life modulatory actions, which persist throughout adulthood. Pairing-pulse facilitation is used to assess hippocampal short-term plasticity, while long-term potentiation (LTP) is used to assess long-term plasticity. Thyroid hormones target the genes that cause synaptic plasticity to occur. This study focused on the non-genomic effects of T4 hormone in the hippocampus.Methods: After a 15-minute baseline recording, LTP was induced by applying high-frequency stimulation protocols. Infusions of artificial cerebrospinal fluid (aCSF) or L-thyroxine were performed during the stimulation protocols. We performed real-time quantitative polymerase chain reaction (RT-qPCR) to determine whether there was a difference in gene expression levels in the hippocampi of rats infuse with aCSF or T4 and how this correlated with LTP responses.Results: T4 infusion was observed to impair LTP. T4 increased CREB and GluN2B expression in all groups while decreasing GluN1 expression in unstimulated hippocampi and increasing it during the induction phase of LTP. It decreased GluN2A expression during the induction phase of LTP. During the maintenance phase of LTP, T4 prevented the increase in Elk-1 and p38MAPK expression levels observed in the aCSF group.Conclusion: When we evaluated LTP responses together with RT-qPCR analyses, we found that T4 impaired LTP responses and increased CREB and GluN2B expression. T4's reduction of GluN2A expression levels may be responsible for the impairment during the induction phase of LTP, while its inhibition of the increase in Elk-1 expression may be responsible for the impairment observed during the maintenance phase of LTP.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"320-332"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-limited Moderating Effect of Neuroticism on the Cortisol-Depression Relationship after Physical Injury. 神经质对躯体损伤后皮质醇-抑郁关系的限时调节作用。

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-02-19 DOI: 10.9758/cpn.25.1388

Jae-Min Kim, Hee-Ju Kang, Ju-Wan Kim, Hyunseok Jang, Jung-Chul Kim, Byung Jo Chun, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin

{"title":"Time-limited Moderating Effect of Neuroticism on the Cortisol-Depression Relationship after Physical Injury.","authors":"Jae-Min Kim, Hee-Ju Kang, Ju-Wan Kim, Hyunseok Jang, Jung-Chul Kim, Byung Jo Chun, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin","doi":"10.9758/cpn.25.1388","DOIUrl":"10.9758/cpn.25.1388","url":null,"abstract":"Objective: This study examined whether neuroticism moderates the association between baseline serum cortisol levels and the development of depressive disorder over two years following physical injury.Methods: Adults hospitalized for moderate-to-severe injuries were recruited within one month of trauma and completed baseline assessments of serum cortisol and personality traits. Depressive disorders were evaluated at 3, 6, 12, and 24 months using the Mini-International Neuropsychiatric Interview. Logistic regression models tested the independent and interactive effects of cortisol and neuroticism on depressive disorder at each time point, adjusting for demographic, clinical, and psychosocial covariates. Bonferroni correction was applied for repeated testing across four follow-up assessments.Results: Among 923 participants, 239 (25.9%) developed depressive disorder at least once during follow-up. Neither cortisol nor neuroticism independently predicted depressive disorder; however, their interaction was significant specifically at the 3-month post-injury assessment, indicating that individuals with higher neuroticism and lower cortisol were at increased early risk. Interaction terms at 6 and 12 months did not survive multiple comparison correction. Serum cortisol and neuroticism were modestly and inversely correlated.Conclusion: A time-limited interaction between low cortisol and high neuroticism predicted early depressive disorder after physical injury. These findings highlight a transient window in which personality-dependent modulation of hypothalamic- pituitary-adrenal axis function may confer vulnerability, underscoring the importance of early identification and targeted support for high-risk individuals.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"408-413"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delirious Mania with Mild Encephalitis and a Reversible Splenial Lesion Successfully Treated with Electroconvulsive Therapy: A Case Report. 电休克疗法成功治疗谵妄躁狂伴轻度脑炎及可逆性脾损害1例。

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2025-09-22 DOI: 10.9758/cpn.25.1324

Ibrahim Sungur, Cenk Eraslan, Mehmet Cagdas Eker

{"title":"Delirious Mania with Mild Encephalitis and a Reversible Splenial Lesion Successfully Treated with Electroconvulsive Therapy: A Case Report.","authors":"Ibrahim Sungur, Cenk Eraslan, Mehmet Cagdas Eker","doi":"10.9758/cpn.25.1324","DOIUrl":"10.9758/cpn.25.1324","url":null,"abstract":"Delirious mania is a rare but severe neuropsychiatric condition characterized by the acute onset of manic symptoms, agitation, delirium, and catatonia. It constitutes a psychiatric emergency and is often misdiagnosed as infectious or autoimmune encephalitis due to overlapping clinical features. Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a radiological entity typically associated with viral infections, metabolic imbalances, or neuroinflammation, presenting as an acute encephalopathic state. We report the case of a 37-year-old male with bipolar disorder who presented with acute-onset aggressive behavior, delusions, disorganized speech, and autonomic instability. Despite the initial pharmacological intervention, his symptoms persisted. Brain magnetic resonance imaging revealed a splenial lesion consistent with MERS. Given the poor response to conventional treatment, electroconvulsive therapy (ECT) was initiated, resulting in significant clinical improvement. This case illustrates the rare co-occurrence of delirious mania and MERS, emphasizing the diagnostic and therapeutic challenges posed by such presentations. It further underscores the potential utility of ECT in managing treatment-resistant delirious mania, particularly in the context of neuroinflammatory involvement. The observed clinical improvement suggest that ECT may exert therapeutic effects beyond conventional psychiatric symptom management. Although this report may help clinicians in the treatment of similar presentations, further research is warranted to elucidate the relationship between neuroinflammation and psychiatric disorders and to establish the role of ECT in similar cases.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"414-418"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of NOS3 rs1799983 Polymorphism with Cognitive Function in Patients with First Episode Depression. 首发抑郁症患者NOS3 rs1799983多态性与认知功能的关系

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-02-03 DOI: 10.9758/cpn.25.1361

Yina Yin, Lingkai Tang, Jiaojiao Xia, Junxiao Chang, Min Qian, Feifei Chen, Shuming Li, Xiaoping Gu

{"title":"Association of NOS3 rs1799983 Polymorphism with Cognitive Function in Patients with First Episode Depression.","authors":"Yina Yin, Lingkai Tang, Jiaojiao Xia, Junxiao Chang, Min Qian, Feifei Chen, Shuming Li, Xiaoping Gu","doi":"10.9758/cpn.25.1361","DOIUrl":"10.9758/cpn.25.1361","url":null,"abstract":"Objective: Global aging has led to a steady rise in the number of older adults suffering from the first-episode depression with cognitive impairment (FEDCI), which imposes a huge medical and financial burden on patients and their families. The aim of this study was to explore the influence of the NOS3 rs1799983 polymorphism on the FEDCI.Methods: A total of 224 first-episode depression (FED) and 295 FEDCI patients were included in the study, whose serum levels of NOS3 and inflammatory factors were detected by RT-qPCR. The TaqMan probe method was used to detect the rs1799983 genotype distribution. GDS-15 and HAMD-17 were used to detect the level of depression, and MMSE was used to detect cognitive impairment. Chi-square analysis was used to detect the correlation between clinical characteristics and NOS3 expression. Risk factors for FEDCI were analyzed by logistic regression.Results: The NOS3 expression decreased, and TNF-α, IL-1β, and IL-6 expression increased in the FEDCI group, and these two factors' expression was negatively correlated. The MMSE score was positively correlated with the NOS3 expression. The TT genotype and T gene frequency in the distribution of FEDCI patients accounted for a high percentage, with the TT genotype being the causative genotype. Education, GDS-15, HAMD-17, and MMSE are correlated with the NOS3 expression. MMSE, NOS3 expression, and the rs1799983 TT genotype were risk factors of FEDCI.Conclusion: The NOS3 expression was decreased in FEDCI, and the rs1799983 TT genotype was pathogenic. The NOS3 rs1799983 polymorphism in FEDCI provided a potential diagnostic and therapeutic target.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"368-378"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Olanzapine Long-acting Injection in Schizophrenia and Schizoaffective Disorder: A Systematic Review and Meta-analysis. 长效注射奥氮平治疗精神分裂症和分裂情感性障碍的疗效和安全性：系统综述和meta分析。

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2026-04-02 DOI: 10.9758/cpn.25.1372

Jithin Thekkelkuthiyathottil Joseph, Rashmi Vishwanath, Sonia Shenoy

{"title":"Efficacy and Safety of Olanzapine Long-acting Injection in Schizophrenia and Schizoaffective Disorder: A Systematic Review and Meta-analysis.","authors":"Jithin Thekkelkuthiyathottil Joseph, Rashmi Vishwanath, Sonia Shenoy","doi":"10.9758/cpn.25.1372","DOIUrl":"10.9758/cpn.25.1372","url":null,"abstract":"Olanzapine long-acting injection (LAI) is a second-generation antipsychotic used in patients with schizophrenia-spectrum disorders, particularly those with poor adherence. However, evidence on its comparative efficacy, safety, and tolerability remains limited. We conducted a systematic review and meta-analysis following PRISMA 2020 guidelines. Six databases (PubMed, Embase, Scopus, Web of Science, Cochrane CENTRAL, ProQuest) were searched through May 2025. We included randomized controlled trials (RCTs), quasi-experimental, and observational studies evaluating olanzapine LAI in adults with schizophrenia or schizoaffective disorder. Risk of bias was assessed using Revised Cochrane Risk-of-Bias Tool for Randomized Trials (Version 2), Risk Of Bias In Non-randomized Studies - of Interventions, and the Newcastle-Ottawa Scale. Data were synthesized using RevMan 5.4. Nine studies (n = 2,915) met inclusion criteria; only two RCTs were eligible for meta-analysis. Olanzapine LAI showed no significant difference from oral olanzapine in reducing Positive and Negative Syndrome Scale scores (mean difference = 1.41; 95% CI: -0.22 to 3.04; p = 0.09) or Clinical Global Impression-Severity scores (mean difference = 0.03; 95% CI: -0.15 to 0.21; p = 0.73). Relapse (OR = 1.15; 95% CI: 0.82 to 1.61), adverse events (OR = 1.12; 95% CI: 0.88 to 1.42), and weight gain were also similar. Across included studies, post-injection delirium/sedation syndrome was reported in 47 participants and resolved without hospitalization or long-term sequelae. Based on low-certainty evidence from limited RCTs, olanzapine LAI appears comparable in efficacy and tolerability to oral olanzapine. It may be considered for patients with adherence difficulties, but careful safety monitoring is required and further head-to-head trials are needed.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"226-239"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Social Support on Suicide Risk among Posttraumatic Stress Disorder, Depressive, and Comorbid Symptom Groups in Elderly Living Alone in Korea. 社会支持对韩国独居老人创伤后应激障碍、抑郁和共病症状组自杀风险的影响

IF 3.4 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2026-05-31 Epub Date: 2025-11-06 DOI: 10.9758/cpn.25.1353

Hae-Joo Ahn, Moon-Doo Kim, Hyun-Ju Yang, Won-Myong Bahk

{"title":"Effect of Social Support on Suicide Risk among Posttraumatic Stress Disorder, Depressive, and Comorbid Symptom Groups in Elderly Living Alone in Korea.","authors":"Hae-Joo Ahn, Moon-Doo Kim, Hyun-Ju Yang, Won-Myong Bahk","doi":"10.9758/cpn.25.1353","DOIUrl":"10.9758/cpn.25.1353","url":null,"abstract":"Objective: With the rapid increase in elderly individuals living alone, concerns about their vulnerability to psychiatric disorders and suicide have grown. Jeju Island's population endures the intergenerational impact of the 4ㆍ3 Incident, a collective trauma resulting from a large-scale civilian massacre. This study aimed to classify elderly living alone in Jeju into four psychiatric groups-healthy, PTSD symptoms, depressive symptoms and comorbid PTSD and depressive symptoms-and to investigate the effect of social support on suicide risk within these groups.Methods: A complete enumeration survey was conducted among 5,138 eligible individuals, with 4,680 completing structured, face-to-face interviews. Standardized instruments were used: PC-PTSD-5 for PTSD symptoms, SGDS-K for depression, MINI-Plus for suicide risk, and MOS-SSS for social support. Multivariate logistic regression analyzed associations between social support and suicide risk across psychiatric groups.Results: Among the participants, 7.8% had PTSD symptoms, 40.4% had depressive symptoms, and 5.8% had comorbid symptoms. Overall, 10.2% reported suicide risk, with the highest rate in the comorbid group (29.5%), followed by the depressive (17.1%) and PTSD (12.8%) groups. Social support significantly decreased suicide risk in the healthy (OR = 0.976), depressive (OR = 0.980), and comorbid groups (OR = 0.979), but not in the PTSD group (OR = 0.957, p = 0.179).Conclusion: These findings highlight the importance of developing tailored social support interventions that consider the psychiatric profiles of elderly individuals, especially those living alone and exposed to community-wide historical trauma.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"24 2","pages":"297-307"},"PeriodicalIF":3.4,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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