Clinical Psychopharmacology and Neuroscience最新文献_第5页

Transcranial Electrical Stimulation: Clinical Implication and Practice for Treatment of Psychiatric Illness 经颅电刺激:治疗精神疾病的临床意义与实践

4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-09-11 DOI: 10.9758/cpn.23.1118

Chaeyeon Yang, Bori Jung, Seung-Hwan Lee

引用次数: 0

The Importance of Low-frequency Alpha (8−10 Hz) Waves and Default Mode Network in Behavioral Inhibition 低频α(8−10 Hz)波和默认模式网络在行为抑制中的重要性

4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2023-05-30 DOI: 10.9758/cpn.22.1035

Yong-Wook Kim, Sungkean Kim, Min Jin Jin, Chang-Hwan Im, Seung-Hwan Lee

引用次数: 0

The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive Disorder 强迫症患者巯基/二硫化物稳态和DNA氧化损伤的评估

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.240

Faruk Kurhan, H. Alp, M. Işık, Yavuz Selim Atan

{"title":"The Evaluation of Thiol/Disulfide Homeostasis and Oxidative DNA Damage in Patients with Obsessive Compulsive Disorder","authors":"Faruk Kurhan, H. Alp, M. Işık, Yavuz Selim Atan","doi":"10.9758/cpn.2022.20.2.240","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.2.240","url":null,"abstract":"Objective In this study, we aimed to examine thiol/disulfide homeostasis and oxidative DNA damage in patients with OCD and compare them with healthy controls. Methods Thirty-five patients previously diagnosed with OCD in Van Yuzuncu Yil University Department of Psychiatry and thirty-three healthy volunteers were included in the study. The severity of the symptoms was measured using the Yale-Brown Obsessive-Compulsive Scale. Five μL of blood samples were taken from the patient and control groups. The samples were stored at appropriate conditions until use. Leukocyte DNA was isolated and the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine were detected to assess the oxidative DNA damage. The level of oxidative DNA damage was expressed as 8-OHdG/106dG. Total thiol/native thiol levels were measured for thiol/disulfide homeostasis. The level of disulfide was determined by subtracting the native thiol value from the total thiol value and the result was divided by two. Results were given as percentages. Results The total and native thiol levels in patients with OCD were significantly lower, and the disulfide levels were significantly higher in patients with OCD than healthy control subjects. In addition, 8-OHdG, an indicator of DNA damage, was significantly lower in the control group compared to the patient group. Conclusion Increased levels of disulfide/native thiol and disulfide/total thiol in patients with OCD show that levels of oxidative stress were elevated and therefore, higher 8-OHdG levels in patients with OCD is a marker of oxidative DNA damage.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 1","pages":"240 - 247"},"PeriodicalIF":3.2,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46205731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Corrigendum: Prevalence and Comorbidities of Attention Deficit Hyperactivity Disorder Among Adults and Children/Adolescents in Korea 更正：韩国成人和儿童/青少年注意力缺陷多动障碍的患病率和合并症

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.402

J. Seo, D. Jon, S. Shim, H. Sung, Y. Woo, Jeongwan Hong, Sung-Yong Park, J. Seo, W. Bahk

引用次数: 0

Potential Candidates for Biomarkers in Bipolar Disorder: A Proteomic Approach through Systems Biology 双相情感障碍生物标志物的潜在候选物:通过系统生物学的蛋白质组学方法

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.211

P. Ziani, J. Feiten, J. Goularte, R. Colombo, Bárbara Antqueviezc, L. Géa, A. Rosa

{"title":"Potential Candidates for Biomarkers in Bipolar Disorder: A Proteomic Approach through Systems Biology","authors":"P. Ziani, J. Feiten, J. Goularte, R. Colombo, Bárbara Antqueviezc, L. Géa, A. Rosa","doi":"10.9758/cpn.2022.20.2.211","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.2.211","url":null,"abstract":"Bipolar disorder (BD) is one of the most disabling diseases characterized by severe humor fluctuation. It is accompanied by cognitive and functional impairment in addiction to high suicide rates. BD is often underdiagnosed and treated incorrectly because many of the reported symptoms are not exclusive to the disorder. Once the diagnosis is exclusively clinical, it is not possible to state precisely. From that, proteomic approaches were used to identify, in a large scale, all proteins involved in cellular or tissue processes. This review aggregate data from blood proteomes, by using protein association network, of subjects with BD and healthy controls to suggest dysfunctional molecular pathways involved in disease. Original articles containing proteomic analysis were searched in PubMed. Seven studies were selected and data were extracted for posterior analysis. A protein-protein interaction network was created by STRING database. A final set of proteins in this network were employed as input in ClueGO and, the main biological process was visualized using R package pathview. The analysis revealed proteins associated with many biological processes, including growth and endocrine regulation, iron transportation, protease inhibition, protection against pathogens and cholesterol transport. Moreover, pathway analysis indicated the association of uncovered proteins with two main metabolic pathways: complement system and coagulation cascade. Thus, a better understanding on the pathophysiology of psychiatric disorders and the identification of potential biomarker candidates are essential to improve diagnostic, prognostic and design pharmacological strategies.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 1","pages":"211 - 227"},"PeriodicalIF":3.2,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43319326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Proposed Pathway Linking Respiratory Infections with Depression 将呼吸道感染与抑郁症联系起来的新途径

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.199

Z. Karimi, Maryam Chenari, F. Rezaie, Shima Karimi, N. Parhizgari, T. Mokhtari-azad

引用次数: 4

Effects of Methylphenidate on Somatic Symptoms and Brain Functional Connectivity in Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study 哌醋甲酯对青少年注意缺陷多动障碍的躯体症状和脑功能连通性的影响:一项初步研究

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.259

S. Kim, K. Min, D. Han

{"title":"Effects of Methylphenidate on Somatic Symptoms and Brain Functional Connectivity in Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study","authors":"S. Kim, K. Min, D. Han","doi":"10.9758/cpn.2022.20.2.259","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.2.259","url":null,"abstract":"Objective This study aimed to evaluate whether somatic symptoms in adolescents with attention deficit hyperactivity disorder (ADHD) are associated with a dissociative pattern of functional connectivity (FC) within the default mode network (DMN) and whether methylphenidate administration can improve clinical and somatic symptoms. We also evaluated whether the improvement of somatic symptoms is associated with increased FC within the DMN in response to methylphenidate treatment. Methods Fifteen male adolescents with somatic symptoms of ADHD and 15 male adolescents with ADHD without somatic symptoms were included. At baseline and after 6 months of methylphenidate treatment, all adolescents were asked to complete questionnaires for the Korean version of the Dupaul’s ADHD rating scale, the symptom checklist-90- revised-somatization subscales, the Beck Depression Inventory, and the Beck Anxiety Inventory. Additionally, a resting-state functional magnetic resonance imaging scan was conducted. Results Methylphenidate treatment improved clinical and somatic symptoms in adolescents with ADHD. In addition, it increased brain FC within the DMN from the posterior cingulate cortex (posterior DMN) to the middle prefrontal cortex (anterior DMN). The improvement of somatic symptoms was associated with FC within the DMN from the posterior cingulate cortex to the middle prefrontal cortex in ADHD adolescents with somatic symptoms. Conclusion Methylphenidate increased brain FC between the anterior and posterior DMN. The improvement of somatic symptoms in adolescents with ADHD was associated with FC within the DMN. The DMN in adolescents with ADHD seems to be associated with the severity of the clinical and somatic symptoms of ADHD.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 1","pages":"259 - 270"},"PeriodicalIF":3.2,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43019349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Risperidone Induced DNA Methylation Changes in Dopamine Receptor and Stathmin Genes in Mice Exposed to Social Defeat Stress 利培酮诱导社交失败应激小鼠多巴胺受体和安定素基因的DNA甲基化变化

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.373

F. Rami, Thong Ba Nguyen, Young-Eun Oh, Maryam Karamikheirabad, Thi-Hung Le, Y. Chung

{"title":"Risperidone Induced DNA Methylation Changes in Dopamine Receptor and Stathmin Genes in Mice Exposed to Social Defeat Stress","authors":"F. Rami, Thong Ba Nguyen, Young-Eun Oh, Maryam Karamikheirabad, Thi-Hung Le, Y. Chung","doi":"10.9758/cpn.2022.20.2.373","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.2.373","url":null,"abstract":"Objective Understanding complex epigenetic mechanisms is necessary to fully elucidate the effects of antipsychotic drug. This study investigated DNA methylation and mRNA expression levels of dopamine D2 and D1 receptor (Drd2 and Drd1, respectively), nuclear receptor subfamily 3, group C, member 1 (Nr3c1) and stathmin 1 (Stmn1) in brain regions of mice exposed to social defeat stress (SDS) and effects of risperidone on altered methylation and mRNA expression levels induced by SDS. Methods Following SDS for 10 days, risperidone (0.2 mg/kg) or vehicle was administered to adult mice for 7 days. Brain tissues from the prefrontal cortex (PFC), hippocampus (HIP) and amygdala (AMY) were processed to measure methylation and mRNA levels of Drd2, Drd1, Nr3c1 and Stmn1 using pyrosequencing and real time-polymerase chain reaction. Results We found altered methylation status of Nr3c1 and Stmn1 in the HIP and AMY of mice exposed to SDS. These changes were reversed by risperidone treatment. In addition, different methylation patterns of Drd2 and Drd1 in the PFC and AMY between defeated and control mice were identified with risperidone treatment. Conclusion These findings suggest that risperidone can cause epigenetic changes in Drd2, Drd1, Nr3c1 and Stmn1 in defeated mice. These changes could be epigenetic mechanisms underlying antipsychotic efficacy.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 1","pages":"373 - 388"},"PeriodicalIF":3.2,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42153950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Capsaicin Reduces Ethanol Consumption in C57BL/6 but not DBA/2 Mice 辣椒素降低C57BL/6小鼠的乙醇消耗，但不降低DBA/2小鼠的乙醇消费

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.343

S. Huh, Sung-Gon Kim, Hyeon-Kyeong Kim

{"title":"Capsaicin Reduces Ethanol Consumption in C57BL/6 but not DBA/2 Mice","authors":"S. Huh, Sung-Gon Kim, Hyeon-Kyeong Kim","doi":"10.9758/cpn.2022.20.2.343","DOIUrl":"https://doi.org/10.9758/cpn.2022.20.2.343","url":null,"abstract":"Objective Capsaicin, the pungent analgesic substance of hot peppers which produces a burning sensation and pain is known to affect Substance P and central opioid activities. This experiment was designed to test the effect of capsaicin on alcohol consumption in C57BL/6 and DBA/2 mice. These two strains are known to differ in both their alcohol consumption and their endogenous opioid distribution and response to alcohol. It is hypothesized that this effect may be mediated by both increases Substance P and decreases beta-endorphin. Methods After i.p. administration of 0.01 and 0.001 mg/kg of capsaicin with a vehicle or the vehicle alone as the control for eight days in C57BL/6 and DBA/2 mice on limited access alcohol model, Capsaicin’s effects on 2-hour alcohol, 22-hours water, 24-hours food intake and body weight were studied. Results In this study, as expected, C57BL/6 mice drank significantly more alcohol than DBA/2 mice under baseline conditions. Capsaicin at both doses tested significantly reduced baseline alcohol consumption in C57BL/6 but not DBA/2 mice. These effects were selective for alcohol as capsaicin did not disrupt food or water consumption. Conclusion These results demonstrate that capsaicin differentially affects those mechanisms underlying alcohol consumption in two strains of mice known to differ in their preference for and consumption of alcohol. This effect is hypothesized to be related to differences in the response of the endogenous opioid system.","PeriodicalId":10420,"journal":{"name":"Clinical Psychopharmacology and Neuroscience","volume":"20 1","pages":"343 - 349"},"PeriodicalIF":3.2,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49298328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature 沃替西汀诱发的躁狂症一例报告及文献复习

IF 3.2 4区医学

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI: 10.9758/cpn.2022.20.2.394

Ece Tunç, S. Tunç

引用次数: 5