Clinical Medicine Insights. Cardiology最新文献

{"title":"Benefits of Simultaneous Pacing Left Anterior/Posterior Fascicular Areas Combined with Atrioventricular Node Ablation in a Persistent Atrial Fibrillation Patient with Heart Failure: A Case Report.","authors":"Bingchen Guo, Yanzong Liu, Jian Xu, Huimin Xian, Xiaohan Lin, Guoqing Du, Bo Yu, Shufeng Li, Wenjuan Du","doi":"10.1177/11795468251358335","DOIUrl":"10.1177/11795468251358335","url":null,"abstract":"<p><p>A 50-year-old male had intermittent episodes of dyspnea for 7 days with persistent atrial fibrillation (AF) for 2 years. New York Heart Association (NYHA) functional class is IV status. The echocardiographic evaluation (Philps EPIQ 7C, S5-1 probe, 1.0-5.0 MHz) was performed showing a left ventricular ejection fraction (LVEF) of 48% (measured by the Simpson biplane method). His-Purkinje conduction system pacing (HPCSP) may enhance electrical resynchronization as well as the clinical and echocardiographic outcomes of patients with advanced heart failure (HF) who require resynchronization therapy (CRT). The use of left anterior fascicular areas pacing/left posterior fascicular areas pacing (LAFAP/LPFAP) may offer a significant advantage in patients for whom both biventricular pacing (BVP) and His bundle pacing (HBP) have not delivered substantial therapeutic benefits. In this study, we optimized electrical resynchronization by combining the concept of fused simultaneous pacing of LAFA/LPFA with an atrioventricular node ablation (AVNA) in a patient with HF and atrial fibrillation (AF). The maximal electrical resynchronization presented better hemodynamic and demonstrated comparable clinical and echocardiographic responses.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251358335"},"PeriodicalIF":2.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asundexian: A Friend or a Foe for Atrial Fibrillation?","authors":"Mohammad Waqas Danish, Abdul Rehman Shahid Khan, Luqman Bashir, Muhammad Usman Haider, Hasibullah Aminpoor, Qasim Mehmood, Hasiba Karimi","doi":"10.1177/11795468251356310","DOIUrl":"10.1177/11795468251356310","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251356310"},"PeriodicalIF":2.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Safety and Efficacy of SGLT-2 Inhibitors on Reducing Cardiovascular and Renal Mortality, Morbidity and Inflammatory Outcomes in Various Patient Populations: A Systematic Review and Meta-Analysis of 92 920 Patients.","authors":"Syed Hamza Haider, Areeka Irfan, Samir Mustafa Sheikh, Muhammad Omar Larik, Alishba Raza, Yumna Khabir","doi":"10.1177/11795468251347777","DOIUrl":"10.1177/11795468251347777","url":null,"abstract":"<p><strong>Background: </strong>The effect of Sodium Glucose Co-Transporter 2 inhibitors on cardiovascular, renal, dyslipidemia, and inflammatory markers has not been analyzed simultaneously. The goal is to determine if SGLT2 inhibitors significantly reduce cardiovascular and renal mortality, and improve these health outcomes.</p><p><strong>Methods: </strong>PubMed, Cochrane Library and MEDLINE databases were used to conduct a comprehensive literature search from inception to September 2023. Randomized control trials with follow-up for at least 8 weeks, with a group taking SGLT2 inhibitors being compared with a group taking either placebo or other medication, in which cardiovascular outcomes, renal outcomes, lipid biomarkers, and inflammatory markers were reported as the primary outcomes were included. The statistical analyses were conducted using Review Manager with a random-effects model.</p><p><strong>Results: </strong>Thirteen studies comprising 92 920 patients were analyzed for several outcomes. The analysis revealed a significant reduction in overall mortality, death due to heart failure, cardiovascular causes, and renal causes in the SGLT2 inhibitor group as compared to placebo. Pooled results also revealed a significant reduction in the frequency of renal replacement therapy and renal composite endpoint in patients on SGLT2 inhibitors. There was also a significant reduction in IL-6, TNF-a, systolic blood pressure in the same group. On the other hand, Flow Mediated Dilation (FMD), lipid profile, and the incidence of amputations and fractures showed no significant associated SGLT2 inhibitor therapy.</p><p><strong>Conclusion: </strong>Our analysis indicates that diabetics and non-diabetics suffering from cardiovascular and renal diseases experience a significant reduction in morbidity and mortality from SGLT2 inhibitor therapy, leading to a better prognosis of such conditions in the long-term.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251347777"},"PeriodicalIF":2.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Left Atrial Reservoir Function During Sinus Rhythm Can Discriminate Between a History of Paroxysmal Atrial Fibrillation and its Absence.","authors":"Jiří Plášek, Valeria Skopelidou, Jan Strakoš, Diana Drieniková, Martin Ráchela, Jiří Pudich, Jiří Vrtal, Miroslav Homza, Jan Václavík","doi":"10.1177/11795468251333624","DOIUrl":"10.1177/11795468251333624","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is the most common arrhythmia and can lead in the long-term to atrial remodelling. Three-dimensional speckle-tracking echocardiography allows evaluation of left atrial function and the magnitude of remodelling processes.</p><p><strong>Methods: </strong>Echocardiography loops were collected between December 2021 and December 2022. Only valid atrial loops with sinus rhythm during examination were included. The Spearman test was used to establish correlation matrices of left atrial parameters, with uni-, multivariate and binary logistic regression to predict the presence or absence of AF.</p><p><strong>Results: </strong>A total of 116 patients (50% females) aged 76.9 ± 11.2 years were included in the analysis. Males and females differed in anthropometric and other clinical parameters. Intra- and interobserver variability was 1.12% and 1.85%, respectively. 2D and 3D left atrial volumes correlated significantly (<i>r</i> = .8, <i>P</i><.0001). Almost all left atrium strain measurements uni- and multivariately predicted the presence of AF, binary logistic regression model identified 2 independent parameters, left atrial longitudinal strain reservoir (LASr, <i>P</i> = .042) and LAS conduit phase (<i>P</i> = .044). LASr was significantly greater in patients without a history of AF than in patient with a history of AF (16 ± 16 and 10.5 ± 7.1, respectively; <i>P</i> = .012). LASr was able to discriminate between a history of paroxysmal AF and its absence with 72% specificity and 68% sensitivity with a cut-off value of 14% (AUC 0.72, 95% CI 0.62-0.82, <i>P</i> < .0001).</p><p><strong>Conclusions: </strong>Three-dimensional left atrial reservoir function can differentiate patients with paroxysmal AF from patients without a history of this arrhythmia.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251333624"},"PeriodicalIF":2.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Based Evaluation of Hypertension Awareness and Knowledge Among Underserved Bateyes in the Dominican Republic.","authors":"Dang Nguyen, Ryan Shargo, Nityanand Jain, Yusuf Qureshi, Lovepriya Suthaharan, Ramez M Odat, Cameron Sabet, Miyaz Ansari, Hamzah Khuddus, Phat K Huynh, Michael J Diaz, Reginald Kerolle, Ernest Kissi Kontor, Lindy G Davidson","doi":"10.1177/11795468251350224","DOIUrl":"10.1177/11795468251350224","url":null,"abstract":"<p><strong>Background: </strong>Globally, hypertension rates are rising, particularly in low-income nations where access to healthcare and education remains limited. In the Dominican Republic, marginalized Haitian migrant communities, known as Bateyes, face disproportionate burdens. However, limited information exists on their understanding of hypertension and related health risks. This program-based evaluation aimed to explore community knowledge as part of ongoing outreach efforts.</p><p><strong>Methods: </strong>We conducted a descriptive analysis of responses from 379 adults across three Bateyes in the Puerto Plata region. Participants completed a 15-item hypertension knowledge questionnaire during a routine mobile medical screening program (December 2022-January 2023) coordinated by the Kerolle Initiative. Hierarchical clustering was used to identify knowledge patterns and explore associations with community differences and systolic blood pressure (SBP) levels.</p><p><strong>Results: </strong>Average BP values were 133/84 mmHg for males and 125/84 mmHg for females, with 27% of respondents meeting the clinical threshold for hypertension. Knowledge levels varied with 44% of participants having insufficient knowledge, and only one participant demonstrating adequate knowledge. Knowledge was associated with education level and household income. Poor awareness of basic concepts emerged as a key driver of variation across Bateyes. Cluster analysis revealed three knowledge patterns: (1) awareness shaped by lived experience of hypertension; (2) gaps due to common misconceptions; and (3) protective behaviors likely influenced by broader public messaging.</p><p><strong>Conclusion: </strong>Findings from our educational outreach program evaluation suggest variable hypertension awareness across Batey communities. These observations highlight key areas for tailoring future community-centered health education efforts to the local needs of Bateyes.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251350224"},"PeriodicalIF":2.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricuspid Regurgitation Following Cavotricuspid Isthmus Ablation: A Case Report.","authors":"Pablo Pineda-Sanabria, Catalina Arbelaez-Hoyos, Antonio Villamizar-Romero, Mauricio Pineda-Gomez","doi":"10.1177/11795468251350228","DOIUrl":"10.1177/11795468251350228","url":null,"abstract":"<p><strong>Introduction: </strong>Tricuspid valve prolapse (TVP) is characterized by the tricuspid valve leaflets' displacement beyond the annular plane during midsystole. Although less common than mitral valve prolapse, TVP often coexists with it, sharing similar pathophysiological mechanisms. This case highlights new-onset tricuspid regurgitation (TR) following cavotricuspid isthmus ablation for atrial flutter, stressing the need for vigilant monitoring after such procedures.</p><p><strong>Case: </strong>A 68-year-old male with atrial flutter, coronary artery disease, and type 2 diabetes underwent cavotricuspid isthmus ablation in August 2023 after failed rate control. By September 2023, he developed a grade 4/6 systolic murmur. Imaging confirmed TVP with mild to moderate TR, though he remained asymptomatic. Conservative management was adopted. Follow-up in October 2024 showed mild TR without prolapse, indicating improvement.</p><p><strong>Conclusion: </strong>This case underscores the importance of recognizing valvular complications after atrial flutter ablation and conducting thorough post-procedural imaging to enable timely intervention and improved outcomes.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251350228"},"PeriodicalIF":2.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takayasu's Arteritis with Systemic Lupus Erythematosus: A Case Report.","authors":"Himanshu Jindal, Vinay Suresh, Balakrishnan Kamaraj, Mayank Jha, Nikhil Verma, Awadhesh Kumar Sharma, P Purushothaman, Shubham Kumar, Rachana Mehta, Ranjana Sah, Amogh Verma","doi":"10.1177/11795468251350222","DOIUrl":"10.1177/11795468251350222","url":null,"abstract":"<p><p>Takayasu arteritis (TA) is a rare granulomatous vasculitis affecting the aorta and its major branches, while systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder known for vascular and serological involvement. Although both diseases share certain immunopathological pathways, their co-occurrence is exceedingly rare. We report a case of a 44-year-old Indian female with a prior diagnosis of SLE who presented with breathlessness, palpitations, and nodular episcleritis. Cardiovascular evaluation revealed carotid bruit, diminished peripheral pulses, blood pressure discrepancies, and murmurs suggestive of valvular dysfunction. Laboratory investigations demonstrated elevated erythrocyte sedimentation rate, hypochromic microcytic anemia, hypocomplementemia, positive antinuclear and anti-dsDNA antibodies, and proteinuria. Imaging confirmed circumferential thickening of the ascending and descending aorta and occlusive disease in the left carotid system. Based on the 2022 ACR/EULAR classification criteria, a diagnosis of concomitant TA was established. Management included corticosteroids and mycophenolate mofetil, chosen over cyclophosphamide due to borderline renal function and fertility considerations. Despite planning for aortic root replacement, the patient deteriorated and succumbed to complications of severe aortic regurgitation. This case highlights the diagnostic complexities of overlapping autoimmune vasculitides and emphasizes the need for early recognition, rigorous application of classification criteria, and individualized immunosuppressive strategies to optimize outcomes in such rare presentations.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251350222"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Visit-to-Visit Mean Arterial Pressure Variability and the Risk of Ischemic Heart Disease and Ischemic Stroke Among Patients With Hypertension in Thailand.","authors":"Boonsub Sakboonyarat, Jaturon Poovieng, Ram Rangsin","doi":"10.1177/11795468251342338","DOIUrl":"10.1177/11795468251342338","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP) variability has been recognized as a significant risk factor for cardiovascular diseases (CVD). We aim to evaluate the association between mean arterial pressure (MAP) variability and the increased risk of ischemic heart disease (IHD) and ischemic stroke (IS) among hypertensive patients in Thailand.</p><p><strong>Methods: </strong>We analyzed data from the Thailand DM/HT study, which included hypertensive patients nationwide in 2014 to 2015 and 2018. MAP variability was computed based on the MAP values across 3 visits within 1 year and expressed as standard deviation (SD). We used multivariable log-binomial regression models to evaluate the associations between MAP variability and the risk of IHD and IS.</p><p><strong>Results: </strong>Among 92 854 individuals, 594 new-onset IHD events (0.64%) and 187 IS incidents among 95 486 individuals (0.20%). Compared to the lowest quartile (Q1), higher quartiles of SD were associated with increased risk of IHD, with adjusted risk ratios (aRRs) of 1.06 (95% confidence interval [CI]: 0.82-1.38) for Q2, 1.35 (95% CI: 1.06-1.72) for Q3, and 1.50 (95% CI: 1.18-1.90) for Q4. Similarly, higher SD quartiles raised the risk of IS, with aRRs of 1.35 (95% CI: 0.83-2.20) for Q2, 1.56 (95% CI: 0.98-2.48) for Q3, and 1.97 (95% CI: 1.26-3.07) for Q4, when compared to Q1.</p><p><strong>Conclusion: </strong>Our study demonstrated that higher visit-to-visit MAP variability in hypertensive patients was strongly associated with an increased risk of CVD. We emphasize the importance of incorporating BP variability into management strategies to help reduce the risk of CVD in these patients.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251342338"},"PeriodicalIF":2.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Real-World Retrospective Analysis of Secondary Prevention Patients Treated with Inclisiran over 27 Months.","authors":"Carl Deaney, Meredith Donaldson, Agne Meskauskiene","doi":"10.1177/11795468251337425","DOIUrl":"10.1177/11795468251337425","url":null,"abstract":"<p><p>ASCVD is a global concern as it has become central to significant morbidity and mortality. LDL-C is the most important modifiable risk factor in developing ASCVD. Therefore, lowering LDL-C levels is paramount to tackling ASCVD; the lower the LDL-C, the better. Finding the right combination of medications patients are willing to adhere to is necessary for optimal lipid lowering. Inclisiran is a novel LDL-C lowering LLT that has demonstrated around 50% reduction in LDL-C with a low side effect profile. As long-term data is limited for Inclisiran, this retrospective analysis aims to observe whether Inclisiran's benefits are sustained as monotherapy and in combination with other LLTs. After 27 months, the clinic found sustained drops in LDL-C of 59% with good adherence. Only 4% of patients reported experiencing side effects, with 1 individual needing to discontinue the medication due to these effects. Our data indicates that incorporating Inclisiran into a patient's LDL-C treatment plan can provide long-term LDL-C reduction, thereby helping to decrease cardiovascular events.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251337425"},"PeriodicalIF":2.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing MitraClip Outcomes: The Case for Routine Iatrogenic ASD Closure.","authors":"Witold Streb, Roland Fiszer, Katarzyna Mitręga, Tomasz Podolecki, Tomasz Kurek, Monika Lazar, Wiktoria Kowalska, Anna Wizner, Anita Stanjek-Cichoracka, Zbigniew Kalarus","doi":"10.1177/11795468251332236","DOIUrl":"https://doi.org/10.1177/11795468251332236","url":null,"abstract":"<p><strong>Introduction: </strong>Iatrogenic atrial septal defect (iASD) resulting from MitraClip procedures may cause volume overload and deterioration of right ventricular (RV) function. The concurrent MitraClip procedure, along with an intervention to close iASD appears to yield a potentially favorable impact on the functioning of the right ventricle.</p><p><strong>Aim of the study: </strong>The study aims to evaluate the effect of iASD closure with an occluder immediately after the MitraClip procedure on RV function, pulmonary resistance, and right ventricle-pulmonary artery coupling (RV-PAc).</p><p><strong>Methods: </strong>The study group (ASDc) consisted of consecutive patients who underwent concomitant iASD closure with the Amplatzer occluder (n = 10). The control group (n = 9) comprised patients with iASD left untreated (CT group). RV assessment before MitraClip and during follow-up visits was based on transthoracic echocardiography (TTE).</p><p><strong>Results: </strong>In the CT group, fractional area change (FAC) increased from 33.3 ± 15.6% to 38.2 ± 14.0%; <i>P</i> = .28, and in the ASDc group, from 38.9 ± 11.6% to 40.4 ± 13.7%; <i>P</i> = .76. In the CT group, tricuspid annular plane systolic excursion (TAPSE) decreased from 19.2 ± 4.3 mm to 17.3 ± 3.8 mm; <i>P</i> = .47, and in the ASDc group from 19.1 ± 6.8 mm to 16.5 ± 6.1 mm; <i>P</i> = .04. In the entire group, right ventricular systolic pressure (RVSP) dropped from 52.7 ± 16.0 mmHg to 45.1 ± 8.1 mmHg; <i>P</i> = .01. The reduction in RVSP was 11 mmHg in the ASDc group versus 4 mmHg in the CT group (<i>P</i> = .35). Pulmonary vascular resistance (PVR) itself did not change significantly before and after the procedure. RV-PAc increased respectively by 36% and 9.75% from baseline values in the ASDc and CT groups.</p><p><strong>Conclusion: </strong>Closure of the iASD results in a greater reduction in RVSP but also TAPSE. RV-PAc, a parameter unaffected by RV preload, reveals notably improved hemodynamic conditions for RV performance after iASD closure.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"19 ","pages":"11795468251332236"},"PeriodicalIF":2.3,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}