{"title":"Evidence-based Diagnosis and Treatment of Vasa Previa.","authors":"Naima Ross, Ashley S Roman","doi":"10.1097/GRF.0000000000000913","DOIUrl":"10.1097/GRF.0000000000000913","url":null,"abstract":"<p><p>Vasa previa is an abnormality of the umbilical cord and fetal membranes that affects ∼1 in 1300 pregnancies. The diagnosis is made by visualization of velamentous fetal vessels coursing within the membranes over the cervix unprotected by Wharton jelly or placenta. When it is not diagnosed prenatally, it is associated with a high risk of fetal death. Prenatal diagnosis of vasa previa using ultrasound, followed by close surveillance, and appropriately timed late preterm delivery by cesarean is associated with intact survival in >95% of cases. In this review, we review epidemiology, risk factors, diagnosis, and management of patients with vasa previa.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 1","pages":"93-97"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging of the Placenta.","authors":"Ozhan M Turan, Suleyman Bozkurt, Shifa Turan","doi":"10.1097/GRF.0000000000000905","DOIUrl":"10.1097/GRF.0000000000000905","url":null,"abstract":"<p><p>Placental imaging is crucial in prenatal care, offering insights into both normal and abnormal pregnancies. Traditional methods like grayscale ultrasound and magnetic resonance imaging evaluate placental anatomy, whereas Doppler ultrasound is used for functional assessment. Recent advancements include functional magnetic resonance imaging and advanced Doppler software for demonstrating placental density and visualizing spiral arteries. B-flow and spatio-temporal image correlation are pivotal, sensitive tools for quantifying spiral artery distensibility and volume flow in early pregnancy. These techniques enhance our understanding of placental vascular architecture and promise early diagnosis and intervention for pregnancies at risk. This paper emphasizes the importance of advanced imaging in prenatal care.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 1","pages":"72-85"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Persistent Genital Arousal Disorder/Genitopelvic Dysesthesia.","authors":"Caroline F Pukall","doi":"10.1097/GRF.0000000000000908","DOIUrl":"10.1097/GRF.0000000000000908","url":null,"abstract":"<p><p>Persistent genital arousal disorder/genitopelvic dysesthesia (PGAD/GPD) is a distressing condition characterized by persistent or recurrent, unwanted, or intrusive sensations of genital arousal that occur in the absence of subjective feelings of sexual desire that persist for at least 3 months. Despite its negative psychosocial impact, including high levels of suicidal ideation, it is not well known by most health care providers and can easily be misdiagnosed or remain undiagnosed. This paper describes a detailed biopsychosocial regional algorithm for the assessment and management of PGAD/GPD and draws attention to the need for multidisciplinary approaches to its effective management.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"32-36"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychotherapy in Treating Female Sexual Dysfunction.","authors":"Erika L Kelley, Stanley E Althof","doi":"10.1097/GRF.0000000000000904","DOIUrl":"10.1097/GRF.0000000000000904","url":null,"abstract":"<p><p>This paper provides a summary of the biopsychosocial approach to the identification of female sexual dysfunction, with a particular focus on psychological, interpersonal, and sociocultural components. A summary of psychotherapeutic approaches to the management of female sexual dysfunction, for cases warranting a specialist referral, is provided. Approaches including sensate focus sex therapy, cognitive behavioral therapy, mindfulness-based approaches, and systematic desensitization are summarized. This information may support obstetric and gynecologic health care professionals in engaging in interdisciplinary care and in providing an informative and warm referral to patients who would benefit from psychotherapeutic approaches.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"3-9"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foreword: Female Sexual Function and Dysfunction.","authors":"Sheryl A Kingsberg","doi":"10.1097/GRF.0000000000000923","DOIUrl":"10.1097/GRF.0000000000000923","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"1-2"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew How, Christopher Jowdy, Elli Novatcheva, Anita H Clayton
{"title":"Novel Pharmacologic Treatments of Female Sexual Dysfunction.","authors":"Andrew How, Christopher Jowdy, Elli Novatcheva, Anita H Clayton","doi":"10.1097/GRF.0000000000000922","DOIUrl":"10.1097/GRF.0000000000000922","url":null,"abstract":"<p><p>This review evaluates pharmacologic treatments for female sexual dysfunction (FSD), focusing on hypoactive sexual desire disorder (HSDD). We provide clinically relevant applications for Food and Drug Administration (FDA)-approved medications (flibanserin and bremelanotide) and investigational therapies (Lorexys and testosterone combinations). Detailed study outcomes, safety profiles, and clinical strategies guide clinicians in appropriate diagnosis, patient selection, expectation setting, side effect management, and patient education, improving treatment outcomes and patient satisfaction.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 1","pages":"10-14"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation and Treatment of Sexual Pain Disorders.","authors":"Analea Beckman, Chailee Moss, Andrew T Goldstein","doi":"10.1097/GRF.0000000000000909","DOIUrl":"10.1097/GRF.0000000000000909","url":null,"abstract":"<p><p>Pain that occurs during sexual activity is highly prevalent during a woman's lifetime, affecting ∼15% of women. The etiology of dyspareunia is multifactorial. Therefore, treatment must be individualized. This paper reviews the evaluation and treatment of the several common causes of dyspareunia and/or pelvic pain, including hormonally associated vestibulodynia, inflammation-associated vestibulodynia, neuroproliferative vestibulodynia, overactive pelvic floor muscle dysfunction, vulvar dysesthesia, persistent genital arousal disorder, and painful bladder syndrome.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 1","pages":"21-31"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chromosomal Mosaicism in the Placenta.","authors":"Caitlin Baptiste, Francesca R Grati, Brynn Levy","doi":"10.1097/GRF.0000000000000906","DOIUrl":"10.1097/GRF.0000000000000906","url":null,"abstract":"<p><p>The clinical implications of placental chromosomal mosaicism can be challenging for patients and health care providers. Key considerations include the specific characteristics of the chromosomal abnormality (such as size, gene content, and copy number), the timing of the mosaicism's onset during embryogenesis or fetal development, the types of tissues involved, and the level of mosaicism (the ratio of normal to abnormal cells within those tissues). Genetic counseling can help inform patients about the chances of having a live-born child with a chromosomal abnormality. Each case requires individual assessment to provide accurate guidance. This chapter will explore the clinical implications of detecting mosaicism at 3 critical diagnostic stages: (1) chorionic villus sampling (CVS); (2) amniocentesis; and (3) cell-free DNA (cfDNA) testing.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"130-138"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Poonam Khullar, Jane Date Hon, Shalini Sethi, Julia Kim, Momin Iqbal, Martin R Chavez
{"title":"Placental Infections.","authors":"Poonam Khullar, Jane Date Hon, Shalini Sethi, Julia Kim, Momin Iqbal, Martin R Chavez","doi":"10.1097/GRF.0000000000000919","DOIUrl":"10.1097/GRF.0000000000000919","url":null,"abstract":"<p><p>This comprehensive review examines the effects of various infections on pregnancy, focusing on maternal symptoms, fetal outcomes, diagnostic methods, and placental pathology. The paper covers bacterial, viral, and parasitic infections, their mechanisms of transmission, clinical presentations, and histopathologic findings in the placenta. It emphasizes the importance of early detection and intervention, highlighting the challenges in diagnosis due to often asymptomatic presentations. The review also discusses the placenta's role as a protective barrier and its immune defense mechanisms against pathogens. Overall, this paper serves as a comprehensive resource for understanding the complex interplay between maternal infections, placental pathology, and fetal outcomes.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"119-129"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Foreword: Clinically Focused Insights on the Placenta and Umbilical Cord: An Evidence-based Symposium.","authors":"Justin S Brandt, Yinka Oyelese","doi":"10.1097/GRF.0000000000000920","DOIUrl":"10.1097/GRF.0000000000000920","url":null,"abstract":"<p><p>In this symposium, we introduce a collection of reviews that delve into the diverse clinically relevant aspects of the placenta and umbilical cord. The symposium addresses placenta previa and abruption; pathology, genetics, and imaging of the placenta; infections of the placenta; and ischemic placental disease. The umbilical cord's essential function as a fetal lifeline is explored, with an emphasis on the clinical repercussions of its dysfunction, including vasa previa and other umbilical cord abnormalities. This curated collection of reviews, which synthesizes the placenta's and umbilical cord's fundamental role in maternal-fetal health, underscores the clinical importance of these structures in pregnancy.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"68-71"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}