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Testosterone for Treating Female Sexual Dysfunction. 睾酮治疗女性性功能障碍。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1097/GRF.0000000000000916
James A Simon, Kathleen Ohleth
{"title":"Testosterone for Treating Female Sexual Dysfunction.","authors":"James A Simon, Kathleen Ohleth","doi":"10.1097/GRF.0000000000000916","DOIUrl":"10.1097/GRF.0000000000000916","url":null,"abstract":"<p><p>Testosterone levels vary throughout a woman's reproductive life, reaching their lowest level following menopause, and their nadir at about age 60, when they experience higher levels of sexual dysfunction. Testosterone improved the frequency of sexually satisfying events, desire, arousal, and orgasm in several randomized, controlled studies of surgically and naturally postmenopausal women. Available evidence from large cohort and registry studies does not show potentially concerning cardiovascular or breast safety signals with physiological levels of testosterone. Although no female testosterone products are currently approved in most of the world, one-tenth of the male dose can enhance female sexual function.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"60-67"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ischemic Placental Disease: Epidemiology and Impact on Maternal and Offspring Health Along the Life Course. 缺血性胎盘疾病：流行病学及其对母婴健康的影响。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI: 10.1097/GRF.0000000000000914
Emily E Daggett, Cande V Ananth
{"title":"Ischemic Placental Disease: Epidemiology and Impact on Maternal and Offspring Health Along the Life Course.","authors":"Emily E Daggett, Cande V Ananth","doi":"10.1097/GRF.0000000000000914","DOIUrl":"10.1097/GRF.0000000000000914","url":null,"abstract":"<p><p>Ischemic placental disease (IPD) is a constellation of obstetrical complications that include preeclampsia, placental abruption, and fetal growth restriction and affects 12% to 15% of pregnancies. The unifying pathophysiological mechanism that precedes all 3 complications is uteroplacental ischemia as a consequence of inadequate (or failure of) physiological transformation of the maternal uterine spiral arteries, endothelial cell dysfunction, and increased oxidative stress. This review summarizes the IPD literature, focusing on the epidemiology and risk factors, the effects of IPD on short and long-term maternal complications, and the association of IPD with perinatal, childhood, and long-term complications in offspring.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"105-110"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors: Clinically Focused Insights on the Placenta and Umbilical Cord: An Evidence-Based Symposium. 贡献者：临床聚焦的见解在胎盘和脐带：循证研讨会。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1097/01.grf.0001098452.61969.1f
{"title":"Contributors: Clinically Focused Insights on the Placenta and Umbilical Cord: An Evidence-Based Symposium.","authors":"","doi":"10.1097/01.grf.0001098452.61969.1f","DOIUrl":"https://doi.org/10.1097/01.grf.0001098452.61969.1f","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 1","pages":"vii-ix"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors: Female Sexual Function and Dysfunction. 作者：女性性功能与功能障碍。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1097/01.grf.0001098448.19219.db
{"title":"Contributors: Female Sexual Function and Dysfunction.","authors":"","doi":"10.1097/01.grf.0001098448.19219.db","DOIUrl":"https://doi.org/10.1097/01.grf.0001098448.19219.db","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 1","pages":"v-vi"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential Receipt of Genetic Services Among Patients With Gynecologic Cancer and Their Relatives: A Review of Challenges to Health Equity. 妇科癌症患者及其亲属接受遗传服务的差异：健康公平挑战综述》。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI: 10.1097/GRF.0000000000000893
Alexa Kanbergs, J Alejandro Rauh-Hain, Roni N Wilke
{"title":"Differential Receipt of Genetic Services Among Patients With Gynecologic Cancer and Their Relatives: A Review of Challenges to Health Equity.","authors":"Alexa Kanbergs, J Alejandro Rauh-Hain, Roni N Wilke","doi":"10.1097/GRF.0000000000000893","DOIUrl":"10.1097/GRF.0000000000000893","url":null,"abstract":"<p><p>Up to 14% of endometrial cancers and 23% of epithelial ovarian cancers are associated with genetic predispositions. Referral for genetic testing and counseling can significantly impact a patient's oncologic outcomes. However, significant disparities in genetic referral and testing exist within medically underserved and minority populations in the United States. These disparities in care and access to care are multifactorial, often involving patient-level, health care-level, and system-level factors. In this review, we focus on disparities in genetic testing among patients with ovarian and uterine cancer, and the missed opportunities for primary cancer prevention among their relatives.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"666-671"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Germline Variants of Uncertain Significance in Gynecologic Oncology Patients. 妇科肿瘤患者中意义不明的基因变异。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1097/GRF.0000000000000898
Julia Cooper, Leigha Senter
{"title":"Germline Variants of Uncertain Significance in Gynecologic Oncology Patients.","authors":"Julia Cooper, Leigha Senter","doi":"10.1097/GRF.0000000000000898","DOIUrl":"10.1097/GRF.0000000000000898","url":null,"abstract":"<p><p>Germline and somatic genetic/genomic testing are commonly ordered for gynecologic oncology patients. Genetic tests can inform disease etiology, prognosis, treatment decisions, and risk to the patient's relatives. Variants of uncertain significance (VUSs) are frequently encountered and have a more nuanced interpretation than straightforward pathogenic or benign variant classifications. Clinical care providers should be familiar with why and how VUSs are reported, their clinical significance, variant reclassification practices, and patient perceptions of VUSs.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"672-675"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors: Genetics and Gynecologic Cancer: Opportunity and Nuance. 投稿人：遗传学和妇科癌症：机会和细微差别。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1097/01.grf.0001081336.90794.7f
{"title":"Contributors: Genetics and Gynecologic Cancer: Opportunity and Nuance.","authors":"","doi":"10.1097/01.grf.0001081336.90794.7f","DOIUrl":"https://doi.org/10.1097/01.grf.0001081336.90794.7f","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"67 4","pages":"vi-viii"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foreword: Advances in Prenatal and Intrapartum Ultrasound. 产前和产中超声的进展。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1097/GRF.0000000000000902
Tullio Ghi, Jimmy Espinoza
{"title":"Foreword: Advances in Prenatal and Intrapartum Ultrasound.","authors":"Tullio Ghi, Jimmy Espinoza","doi":"10.1097/GRF.0000000000000902","DOIUrl":"10.1097/GRF.0000000000000902","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"720"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Predisposition for Gynecologic Cancers. 妇科癌症的遗传倾向。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1097/GRF.0000000000000894
Tavia González Peña, Marilyn Huang
{"title":"Genetic Predisposition for Gynecologic Cancers.","authors":"Tavia González Peña, Marilyn Huang","doi":"10.1097/GRF.0000000000000894","DOIUrl":"10.1097/GRF.0000000000000894","url":null,"abstract":"<p><p>Hereditary cancer syndromes (HCS) are responsible for up to 10% of all cancers. At present, the majority of cancer susceptibility testing is initiated after a cancer diagnosis. There exists a significant opportunity for primary care providers including general obstetrician-gynecologists to engage in hereditary cancer risk assessment through adequate family history evaluation, initiation of genetic testing, and following the recommendations of national organizations. Identifying hereditary cancer genes may prompt primary prevention efforts such as enhanced screening, prevention, or personalized care strategies. We will review the literature regarding the approach and assessment of the most common gynecologic HCS.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"660-665"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foreword: Genetics and Gynecologic Cancer: Opportunity and Nuance. 前言：遗传学与妇科癌症：机遇与微妙之处。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1097/GRF.0000000000000901
Melissa K Frey, Stephanie V Blank
{"title":"Foreword: Genetics and Gynecologic Cancer: Opportunity and Nuance.","authors":"Melissa K Frey, Stephanie V Blank","doi":"10.1097/GRF.0000000000000901","DOIUrl":"10.1097/GRF.0000000000000901","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"659"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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