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Closing the Gap: Prenatal Repair and the Reimagined Future of Spina Bifida. 缩小差距：产前修复和脊柱裂的重新想象的未来。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-23 DOI: 10.1097/GRF.0000000000000960
Emrah Aydin, Jose Luis Peiro, Monuira Habli
{"title":"Closing the Gap: Prenatal Repair and the Reimagined Future of Spina Bifida.","authors":"Emrah Aydin, Jose Luis Peiro, Monuira Habli","doi":"10.1097/GRF.0000000000000960","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000960","url":null,"abstract":"<p><p>Spina bifida, particularly myelomeningocele (MMC), represents a severe congenital anomaly with lifelong consequences. Advances in imaging and screening have improved prenatal detection, enabling early counseling and intervention. Over the past 2 decades, fetal surgical repair has transformed outcomes, as demonstrated by the Management of Myelomeningocele Study (MOMS), with reduced cerebrospinal shunting and improved motor function. However, fetal surgery carries maternal and fetal risks, including preterm delivery and uterine complications. This review examines current evidence on fetal open spina bifida repair, discusses patient selection, long-term outcomes, and emerging innovations, and highlights ongoing ethical and accessibility challenges.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evolving Landscape of Fetal Therapy: From Vision to Practice. 胎儿治疗的发展前景：从愿景到实践。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-21 DOI: 10.1097/GRF.0000000000000963
Eyal Krispin, Jena Miller
{"title":"The Evolving Landscape of Fetal Therapy: From Vision to Practice.","authors":"Eyal Krispin, Jena Miller","doi":"10.1097/GRF.0000000000000963","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000963","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Gynecologic Care of the Transfeminine Patient. 跨性别患者的综合妇科护理。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-21 DOI: 10.1097/GRF.0000000000000951
K Ashley Brandt, Sarah Dreibelbis
{"title":"Comprehensive Gynecologic Care of the Transfeminine Patient.","authors":"K Ashley Brandt, Sarah Dreibelbis","doi":"10.1097/GRF.0000000000000951","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000951","url":null,"abstract":"<p><p>As visibility of transfeminine individuals increases, so does the need for inclusive and competent gender-affirming health care. Regardless of a patient's stage during their transition, gynecologists are essential health care providers for transfeminine patients. With the proper education and training, gynecologists can provide gender-affirming hormone therapy, assess and manage postoperative complications, and conduct routine health screening. The goal of this article is to provide an overview of available feminizing hormone therapies and effects, review feminizing surgical procedures, discuss the management of their complications, and highlight evidence-based screening recommendations for transfeminine patients.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genital Gender Affirmation Surgery for the Transfeminine Patient. 变性患者生殖器性别确认手术。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-21 DOI: 10.1097/GRF.0000000000000961
Ann Tran, Trieu Do
{"title":"Genital Gender Affirmation Surgery for the Transfeminine Patient.","authors":"Ann Tran, Trieu Do","doi":"10.1097/GRF.0000000000000961","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000961","url":null,"abstract":"<p><p>Advancements in surgical techniques over time have enhanced both the safety and efficacy of vaginoplasty, resulting in consistently high levels of patient satisfaction in terms of both functional and aesthetic outcomes. Given the rising volume of these procedures, it is increasingly probable that gynecologists will encounter transgender and gender-diverse (TGD) patients seeking specialized care. As experts in pelvic anatomy and reconstructive procedures, gynecologists are uniquely positioned to contribute meaningfully to the care of individuals seeking genital gender-affirming surgical interventions. This document aims to provide a comprehensive review of genital gender-affirming surgery for the transfeminine patient.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Complications Associated With Vulvovaginoplasty. 外阴阴道成形术并发症的处理。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-21 DOI: 10.1097/GRF.0000000000000958
Meg Quint, Frances Grimstad
{"title":"Management of Complications Associated With Vulvovaginoplasty.","authors":"Meg Quint, Frances Grimstad","doi":"10.1097/GRF.0000000000000958","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000958","url":null,"abstract":"<p><p>Over the past few decades, vulvovaginoplasty for transfeminine patients has rapidly advanced in both technique and access. However, a variety of barriers, including geographical access to surgeons, may make it difficult to access the original surgical team for evaluation and management of complications. Given this, local gynecologists and other health professionals may play a vital role in the evaluation and management of nonsurgical complications. Here, we review common complications and provide an overview of their related nonsurgical and surgical management for vulvovaginoplasty for transfeminine patients.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contraception and Menstrual Suppression for Transmasculine Patients. 跨男性患者的避孕和月经抑制。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-16 DOI: 10.1097/GRF.0000000000000953
Daniel S Lee, Christopher R Douglas
{"title":"Contraception and Menstrual Suppression for Transmasculine Patients.","authors":"Daniel S Lee, Christopher R Douglas","doi":"10.1097/GRF.0000000000000953","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000953","url":null,"abstract":"<p><p>Transmasculine individuals require patient-centered and shared decision-making approaches to address menstrual suppression and contraceptive needs. Gender-affirming testosterone therapy may be utilized by individuals to achieve menstrual suppression but is not a reliable form of contraception. While menstrual suppression and contraception are not mutually exclusive, this article provides a framework to help determine patient goals and points of consideration when selecting treatments. A table (Table 1) and decision tree (Fig. 1) of options are provided to assist clinicians in addressing a patient's unique reproductive needs with a focus on individualized and informed care.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Therapy for Renal Anomalies and Anhydramnios. 胎儿治疗肾异常和羊水不足。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-07 DOI: 10.1097/GRF.0000000000000956
Percy Pacora-Portella, Edgar Hernandez-Andrade, Anthony Johnson
{"title":"Fetal Therapy for Renal Anomalies and Anhydramnios.","authors":"Percy Pacora-Portella, Edgar Hernandez-Andrade, Anthony Johnson","doi":"10.1097/GRF.0000000000000956","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000956","url":null,"abstract":"<p><p>Congenital anomalies of the kidneys and urinary tract (CAKUT) are developmental defects affecting 1 in 465 live births and constitute 28% to 33% of neonatal ultrasound anomalies. CAKUT is a major contributor to chronic kidney disease in children and is the leading cause of end-stage kidney disease (ESKD) in this population, accounting for 40% to 50% of cases. Amniotic fluid volume reflects renal function. CAKUT that decreases amniotic fluid can result in serious complications, although treatment such as amnioinfusion, vesicoamniotic shunting, and cystoscopy shows promise but comes with risks and uncertain long-term benefits, emphasizing the need for further research in managing these conditions.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Anemia: A Narrative Review of Current Clinical Approaches. 胎儿贫血：当前临床方法的叙述回顾。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-07-01 DOI: 10.1097/GRF.0000000000000949
Enaja V Sambatur, May Abiad, Faezeh Aghajani, Alireza A Shamshirsaz
{"title":"Fetal Anemia: A Narrative Review of Current Clinical Approaches.","authors":"Enaja V Sambatur, May Abiad, Faezeh Aghajani, Alireza A Shamshirsaz","doi":"10.1097/GRF.0000000000000949","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000949","url":null,"abstract":"<p><p>Fetal anemia encompasses a wide range of etiologies, most notably red cell alloimmunization, and poses serious risks to fetal and neonatal health if unrecognized. This narrative review outlines the pathophysiology, screening strategies, and evolving diagnostic tools such as noninvasive genotyping and MCA Doppler. We examine immunomodulatory therapies like IVIg and nipocalimab, and discuss technical considerations for intrauterine transfusions. Finally, we address neonatal management and long-term outcomes. With increasing access to prenatal diagnostics and targeted interventions, timely recognition and treatment of fetal anemia can significantly improve perinatal survival and reduce complications.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gynecologic Care of the Transgender Patient. 跨性别患者的妇科护理。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-06-23 DOI: 10.1097/GRF.0000000000000959
Cecile A Ferrando
{"title":"Gynecologic Care of the Transgender Patient.","authors":"Cecile A Ferrando","doi":"10.1097/GRF.0000000000000959","DOIUrl":"10.1097/GRF.0000000000000959","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovations in Fetal Therapy: Cardiac Anomalies and Interventions. 胎儿治疗的创新：心脏异常和干预。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2025-06-11 DOI: 10.1097/GRF.0000000000000955
Andrii Kurkevych, Domitilla Polidori, Roland Axt-Fliedner
{"title":"Innovations in Fetal Therapy: Cardiac Anomalies and Interventions.","authors":"Andrii Kurkevych, Domitilla Polidori, Roland Axt-Fliedner","doi":"10.1097/GRF.0000000000000955","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000955","url":null,"abstract":"<p><p>Congenital heart disease is the most common major congenital abnormality with a prevalence of ∼1% of all live births and is associated with a high perinatal and long-term postnatal morbidity and mortality. This review describes recent results regarding invasive and noninvasive interventions for cardiac anomalies during gestation. Early diagnosis and intervention remain crucial for optimizing fetal outcomes and for reducing the risk of long-term cardiovascular sequelae.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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