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Differential Receipt of Genetic Services Among Patients With Gynecologic Cancer and Their Relatives: A Review of Challenges to Health Equity. 妇科癌症患者及其亲属接受遗传服务的差异：健康公平挑战综述》。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI: 10.1097/GRF.0000000000000893
Alexa Kanbergs, J Alejandro Rauh-Hain, Roni N Wilke
{"title":"Differential Receipt of Genetic Services Among Patients With Gynecologic Cancer and Their Relatives: A Review of Challenges to Health Equity.","authors":"Alexa Kanbergs, J Alejandro Rauh-Hain, Roni N Wilke","doi":"10.1097/GRF.0000000000000893","DOIUrl":"10.1097/GRF.0000000000000893","url":null,"abstract":"<p><p>Up to 14% of endometrial cancers and 23% of epithelial ovarian cancers are associated with genetic predispositions. Referral for genetic testing and counseling can significantly impact a patient's oncologic outcomes. However, significant disparities in genetic referral and testing exist within medically underserved and minority populations in the United States. These disparities in care and access to care are multifactorial, often involving patient-level, health care-level, and system-level factors. In this review, we focus on disparities in genetic testing among patients with ovarian and uterine cancer, and the missed opportunities for primary cancer prevention among their relatives.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Germline Variants of Uncertain Significance in Gynecologic Oncology Patients. 妇科肿瘤患者中意义不明的基因变异。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1097/GRF.0000000000000898
Julia Cooper, Leigha Senter
{"title":"Germline Variants of Uncertain Significance in Gynecologic Oncology Patients.","authors":"Julia Cooper, Leigha Senter","doi":"10.1097/GRF.0000000000000898","DOIUrl":"10.1097/GRF.0000000000000898","url":null,"abstract":"<p><p>Germline and somatic genetic/genomic testing are commonly ordered for gynecologic oncology patients. Genetic tests can inform disease etiology, prognosis, treatment decisions, and risk to the patient's relatives. Variants of uncertain significance (VUSs) are frequently encountered and have a more nuanced interpretation than straightforward pathogenic or benign variant classifications. Clinical care providers should be familiar with why and how VUSs are reported, their clinical significance, variant reclassification practices, and patient perceptions of VUSs.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foreword: Advances in Prenatal and Intrapartum Ultrasound. 产前和产中超声的进展。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1097/GRF.0000000000000902
Tullio Ghi, Jimmy Espinoza
{"title":"Foreword: Advances in Prenatal and Intrapartum Ultrasound.","authors":"Tullio Ghi, Jimmy Espinoza","doi":"10.1097/GRF.0000000000000902","DOIUrl":"10.1097/GRF.0000000000000902","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Predisposition for Gynecologic Cancers. 妇科癌症的遗传倾向。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1097/GRF.0000000000000894
Tavia González Peña, Marilyn Huang
{"title":"Genetic Predisposition for Gynecologic Cancers.","authors":"Tavia González Peña, Marilyn Huang","doi":"10.1097/GRF.0000000000000894","DOIUrl":"10.1097/GRF.0000000000000894","url":null,"abstract":"<p><p>Hereditary cancer syndromes (HCS) are responsible for up to 10% of all cancers. At present, the majority of cancer susceptibility testing is initiated after a cancer diagnosis. There exists a significant opportunity for primary care providers including general obstetrician-gynecologists to engage in hereditary cancer risk assessment through adequate family history evaluation, initiation of genetic testing, and following the recommendations of national organizations. Identifying hereditary cancer genes may prompt primary prevention efforts such as enhanced screening, prevention, or personalized care strategies. We will review the literature regarding the approach and assessment of the most common gynecologic HCS.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foreword: Genetics and Gynecologic Cancer: Opportunity and Nuance. 前言：遗传学与妇科癌症：机遇与微妙之处。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1097/GRF.0000000000000901
Melissa K Frey, Stephanie V Blank
{"title":"Foreword: Genetics and Gynecologic Cancer: Opportunity and Nuance.","authors":"Melissa K Frey, Stephanie V Blank","doi":"10.1097/GRF.0000000000000901","DOIUrl":"10.1097/GRF.0000000000000901","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Implications for Cancer Management: The Changing Landscape of Poly (ADP-ribose) Polymerase Inhibitor Indications in the Treatment of Ovarian Cancer. 癌症管理中的基因问题：多聚（ADP-核糖）聚合酶抑制剂在卵巢癌治疗中的适应症变化》（The Changing Landscape of Poly (ADP-ribose) Polymerase Inhibitor Indications in the Treatment of Ovarian Cancer）。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1097/GRF.0000000000000896
Christine Walsh
{"title":"Genetic Implications for Cancer Management: The Changing Landscape of Poly (ADP-ribose) Polymerase Inhibitor Indications in the Treatment of Ovarian Cancer.","authors":"Christine Walsh","doi":"10.1097/GRF.0000000000000896","DOIUrl":"10.1097/GRF.0000000000000896","url":null,"abstract":"<p><p>Between December 2014 and May 2020, the United States Food and Drug Administration approved 9 indications for poly (ADP-ribose) polymerase (PARP) inhibitor use in ovarian cancer. Between June 2022 and September 2022, all 3 indications for PARP inhibitor treatment of recurrent ovarian cancer were withdrawn. Between November 2022 and September 2023, all 3 indications for PARP inhibitor maintenance therapy in recurrent ovarian cancer were restricted. The 3 indications for PARP inhibitor maintenance therapy in newly diagnosed advanced ovarian cancer are unchanged. This article reviews the timelines and data leading to regulatory changes for PARP inhibitor use in ovarian cancer in the United States.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Science and Practice of Surgical and Nonsurgical Opportunities for Ovarian Cancer Prevention. 预防卵巢癌的手术和非手术机会的当前科学与实践。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1097/GRF.0000000000000900
Emily MacArthur, Rebecca Stone
{"title":"Current Science and Practice of Surgical and Nonsurgical Opportunities for Ovarian Cancer Prevention.","authors":"Emily MacArthur, Rebecca Stone","doi":"10.1097/GRF.0000000000000900","DOIUrl":"10.1097/GRF.0000000000000900","url":null,"abstract":"<p><p>Due to improved understanding of ovarian cancer pathogenesis, we have an unprecedented chance to decrease the burden of disease by maximizing opportunities for prevention. Innovations in surgical options for prevention stem from the discovery that many cases directly or indirectly arise from the fallopian tube. Surgical prevention with salpingectomy alone decreases risk by ≥50%. Effective hormonal and nonhormonal chemopreventive agents are also available. Risk stratification is key to ensuring that options for prevention are appropriately matched to individual risk profile. This evidence-based review provides a critical appraisal of the translational health research endeavors supporting ovarian cancer prevention in clinical practice.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors: Advances in Prenatal and Intrapartum Ultrasound. 贡献者：产前和产中超声的进展。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1097/01.grf.0001081340.52747.90
{"title":"Contributors: Advances in Prenatal and Intrapartum Ultrasound.","authors":"","doi":"10.1097/01.grf.0001081340.52747.90","DOIUrl":"https://doi.org/10.1097/01.grf.0001081340.52747.90","url":null,"abstract":"","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial and Venous Doppler in Evaluation of the "At-risk" Fetus. 动脉和静脉多普勒在 "高危 "胎儿评估中的应用。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1097/GRF.0000000000000890
Sifa Turan, Mevlut Bucak, Ozhan M Turan
{"title":"Arterial and Venous Doppler in Evaluation of the \"At-risk\" Fetus.","authors":"Sifa Turan, Mevlut Bucak, Ozhan M Turan","doi":"10.1097/GRF.0000000000000890","DOIUrl":"10.1097/GRF.0000000000000890","url":null,"abstract":"<p><p>Our practice utilizes Doppler ultrasound as one of the most objective and effective methods to assess at-risk pregnancies. This review will discuss the application of arterial and venous Doppler techniques in assessing and managing various diseases and conditions for high-risk fetuses.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrapartum Ultrasound Guidance to Make Safer Any Obstetric Intervention: Fetal Head Rotation, Assisted Vaginal Birth, Breech Delivery of the Second Twin. 产前超声波指导使任何产科干预更安全：胎头旋转、阴道助产、第二胎臀位分娩。
IF 1.4 4区 医学
Clinical obstetrics and gynecology Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1097/GRF.0000000000000891
Andrea Dall'Asta, Chiara Melito, Tullio Ghi
{"title":"Intrapartum Ultrasound Guidance to Make Safer Any Obstetric Intervention: Fetal Head Rotation, Assisted Vaginal Birth, Breech Delivery of the Second Twin.","authors":"Andrea Dall'Asta, Chiara Melito, Tullio Ghi","doi":"10.1097/GRF.0000000000000891","DOIUrl":"10.1097/GRF.0000000000000891","url":null,"abstract":"<p><p>Intrapartum ultrasound (US) is more reliable than clinical assessment in determining parameters of crucial importance to optimize the management of labor including the position and station of the presenting part. Evidence from the literature supports the role of intrapartum US in predicting the outcome of labor in women diagnosed with slow progress during the first and second stage of labor, and randomized data have demonstrated that transabdominal US is far more accurate than digital examination in assessing fetal position before performing an instrumental delivery. Intrapartum US has also been shown to outperform the clinical skills in predicting the outcome and improving the technique of instrumental vaginal delivery. On this basis, some guidelines recommend intrapartum US to ascertain occiput position before performing an instrumental delivery. Manual rotation of occiput posterior position (MROP) and assisted breech delivery of the second twin are other obstetric interventions that can be performed during the second stage of labor with the support of intrapartum US. In this review article we summarize the existing evidence on the role of intrapartum US in assisting different types of obstetric intervention with the aim to improve their safety.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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