Stephen P Emery, Stephanie Greene, Youngjae Chun, Tiffany E Deihl, Nika M Hazen
{"title":"In-utero Therapy for Fetal Aqueductal Stenosis.","authors":"Stephen P Emery, Stephanie Greene, Youngjae Chun, Tiffany E Deihl, Nika M Hazen","doi":"10.1097/GRF.0000000000000926","DOIUrl":"10.1097/GRF.0000000000000926","url":null,"abstract":"<p><p>Advances in prenatal diagnosis, bioengineering, and minimally invasive surgical techniques have led investigators to reconsider in-utero therapy for fetal aqueductal stenosis, a form of congenital hydrocephalus that has been held under a moratorium since the 1980s. This article will review the definition, history, prenatal diagnosis, contemporary management, and future directions in clinical and basic science research for in-utero intervention for fetal aqueductal stenosis.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"448-452"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Percy Pacora-Portella, Edgar Hernandez-Andrade, Anthony Johnson
{"title":"Fetal Therapy for Renal Anomalies and Anhydramnios.","authors":"Percy Pacora-Portella, Edgar Hernandez-Andrade, Anthony Johnson","doi":"10.1097/GRF.0000000000000956","DOIUrl":"10.1097/GRF.0000000000000956","url":null,"abstract":"<p><p>Congenital anomalies of the kidneys and urinary tract (CAKUT) are developmental defects affecting 1 in 465 live births and constitute 28% to 33% of neonatal ultrasound anomalies. CAKUT is a major contributor to chronic kidney disease in children and is the leading cause of end-stage kidney disease (ESKD) in this population, accounting for 40% to 50% of cases. Amniotic fluid volume reflects renal function. CAKUT that decreases amniotic fluid can result in serious complications. Although treatments such as amnioinfusion, vesicoamniotic shunting, and cystoscopy shows promise, they carry risks and uncertain long-term outcomes. This highlights the importance of further research to improve management of these conditions.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"399-414"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Creating Safe Spaces in Gynecology for Transgender and Gender-diverse People.","authors":"John Hayden, Emile Redwood, Angela Chaudhari","doi":"10.1097/GRF.0000000000000962","DOIUrl":"10.1097/GRF.0000000000000962","url":null,"abstract":"<p><p>Transgender and gender-diverse patients seeking gynecologic care often have significant barriers to receiving inclusive care. These barriers can occur at every step of the care process from making appointments to seeing a clinician to reading a progress note in the medical record. By recognizing the shortcomings of current care models and incorporating inclusive practices into daily workflows, safer spaces can be achieved for patients obtaining gynecologic care.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 3","pages":"322-327"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Minnihan, Dana Baraki, Mindy S Christianson
{"title":"Fertility Preservation for Transgender and Gender-diverse Individuals: Current Practices and Future Directions.","authors":"Alexandra Minnihan, Dana Baraki, Mindy S Christianson","doi":"10.1097/GRF.0000000000000950","DOIUrl":"10.1097/GRF.0000000000000950","url":null,"abstract":"<p><p>It is recommended that transgender individuals undergo fertility preservation counseling before initiating gender-affirming hormone therapy and gender-affirming surgery. Counseling should include reviewing both the short-term and long-term impacts of medical and surgical therapy on fertility, as well as fertility preservation and assisted reproduction options for current or future reproduction. Fertility preservation options for transgender males include embryo, oocyte, and ovarian tissue cryopreservation, and options for transgender females include sperm cryopreservation. Testicular tissue cryopreservation is the only option available for prepubertal males and is considered experimental at this time.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":"68 3","pages":"340-346"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felicia V LeMoine, Sami Backley, Edgar Hernandez-Andrade, Neha Agarwal, Eric P Bergh, Gustavo Vilchez Lagos, Ramesha Papanna, Sarah Naranjo, Anthony Johnson, Jimmy Espinoza
{"title":"Prenatal Diagnosis, In Utero Management, and Perinatal Outcomes of Congenital Diaphragmatic Hernia.","authors":"Felicia V LeMoine, Sami Backley, Edgar Hernandez-Andrade, Neha Agarwal, Eric P Bergh, Gustavo Vilchez Lagos, Ramesha Papanna, Sarah Naranjo, Anthony Johnson, Jimmy Espinoza","doi":"10.1097/GRF.0000000000000946","DOIUrl":"10.1097/GRF.0000000000000946","url":null,"abstract":"<p><p>Congenital diaphragmatic hernia (CDH) is a complex malformation complicating 0.02% to 0.03% of live births. The etiology of CDH is often multifactorial. Sonographic screening can aid in the detection of ~70% of CDH cases. Sonographic measures, that is, lung-to-head ratio, can also be utilized to predict the severity of fetal/neonatal disease and guide fetal eligibility for prenatal interventions, such as the FETO procedure. The FETO procedure has provided improved overall morbidity and mortality among fetuses with severe left-sided CDH, although limited data on its role in the treatment of right-sided CDH and long-term infant and childhood outcomes are limited.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"387-398"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enaja V Sambatur, May Abiad, Faezeh Aghajani, Alireza A Shamshirsaz
{"title":"Fetal Anemia: A Narrative Review of Current Clinical Approaches.","authors":"Enaja V Sambatur, May Abiad, Faezeh Aghajani, Alireza A Shamshirsaz","doi":"10.1097/GRF.0000000000000949","DOIUrl":"10.1097/GRF.0000000000000949","url":null,"abstract":"<p><p>Fetal anemia encompasses a wide range of etiologies, most notably red cell alloimmunization, and poses serious risks to fetal and neonatal health if unrecognized. This narrative review outlines the pathophysiology, screening strategies, and evolving diagnostic tools such as noninvasive genotyping and MCA Doppler. We examine immunomodulatory therapies like IVIg and nipocalimab, and discuss technical considerations for intrauterine transfusions. Finally, we address neonatal management and long-term outcomes. With increasing access to prenatal diagnostics and targeted interventions, timely recognition and treatment of fetal anemia can significantly improve perinatal survival and reduce complications.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"415-424"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Future Directions in Enhanced Recovery After Surgery (ERAS) for Gynecologic Surgery.","authors":"Leah Rusnell, Gregg Nelson","doi":"10.1097/GRF.0000000000000967","DOIUrl":"https://doi.org/10.1097/GRF.0000000000000967","url":null,"abstract":"<p><p>Enhanced recovery after surgery (ERAS) represents a global, multidisciplinary surgical quality improvement initiative to improve preoperative, intraoperative, and postoperative patient care with demonstrable economic benefit. In this narrative review, we outline 5 innovative ERAS initiatives, including an improved surgical safety checklist, ongoing advocacy for same-day discharge postoperatively, the role of application-based telehealth in supporting patients after hospital discharge, patient engagement in ERAS protocols and appropriate postoperative opioid prescribing. These innovative strategies are applicable to a broad array of disciplines; however, our focus in this paper is within the fields of gynecology and gynecologic oncology.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anesthetic Considerations and Blood Utilization for Placenta Accreta Spectrum.","authors":"Philip E Hess, Yunping Li","doi":"10.1097/GRF.0000000000000921","DOIUrl":"10.1097/GRF.0000000000000921","url":null,"abstract":"<p><p>The anesthetic management of the patient with placenta accreta spectrum begins before surgery by assessing the patient and their comorbidities and providing psychological preparation for the perioperative period. Choosing neuraxial or general anesthesia for surgery balances the procedure's clinical needs with the patient's desires. Intraoperatively, management of homeostasis during acute blood loss requires assessments of central volume to avoid over-transfusion. Viscoelastic testing may be useful to assess coagulation to target the replacement of coagulation factors. Postoperative care is an essential continuum of the procedure, and the availability of bedside ultrasound can aid rapid decision-making.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"275-282"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lorenza Della Valle, Alessandro Lucidi, Marina Piergianni, Francesco D'Antonio
{"title":"Recent Advances in Diagnosis and Management of Cesarean Scar Pregnancy.","authors":"Lorenza Della Valle, Alessandro Lucidi, Marina Piergianni, Francesco D'Antonio","doi":"10.1097/GRF.0000000000000943","DOIUrl":"10.1097/GRF.0000000000000943","url":null,"abstract":"<p><p>Cesarean scar pregnancy (CSP) is among the most severe iatrogenic complications of cesarean delivery (CD) and is associated with a high risk of severe hemorrhage, uterine rupture, and progression towards placenta accreta spectrum disorders. Prenatal diagnosis of CSP has been recently standardized through a modified Delphi consensus, which also allows risk stratification according of this anomaly. However, several issues on the management of CSP are still under debate. The aim of the present review is to provide an up-to-date on the diagnosis and management of CSP.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"234-241"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging Modalities for the Diagnosis of Placenta Accreta Spectrum.","authors":"Jerri Waller, Alfred Abuhamad","doi":"10.1097/GRF.0000000000000940","DOIUrl":"10.1097/GRF.0000000000000940","url":null,"abstract":"<p><p>Placenta accreta spectrum (PAS) is the result of the invasion of the placental trophoblasts into the myometrium. The rate of PAS continues to increase due to the increased number of cesarean sections. Other risk factors include increasing maternal age, multiparity, uterine surgeries, and placenta previa. Due to the high risk of maternal morbidity and mortality, prenatal diagnosis is essential to ensure proper resources and surgical planning before delivery. Ultrasound is considered the gold standard for diagnosis of PAS. Ultrasound findings include placental lacuna, loss of placental clear space, lower uterine segment thickness, and increased vascularity between the placenta and bladder.</p>","PeriodicalId":10415,"journal":{"name":"Clinical obstetrics and gynecology","volume":" ","pages":"242-250"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}