Cognitive NeurosciencePub Date : 2022-07-01Epub Date: 2022-10-10DOI: 10.1080/17588928.2022.2131750
Chantal E Stern, Michael E Hasselmo
{"title":"Mechanisms for maintaining information in working memory.","authors":"Chantal E Stern, Michael E Hasselmo","doi":"10.1080/17588928.2022.2131750","DOIUrl":"10.1080/17588928.2022.2131750","url":null,"abstract":"<p><p>The review by Slotnick is valuable for raising the important question of how much the hippocampal activity induced by novel stimuli is due to mechanisms for encoding into long-term memory, and how much is due to working memory. Slotnick's paper implicitly defines working memory as being equivalent to sustained activation during the late delay period. In this commentary, we suggest that cognitive neuroscientists should consider a broader range of cellular and synaptic mechanisms for maintaining information in working memory.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"218-219"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121215/pdf/nihms-1888515.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9796906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"'Working memory is a distributed dynamic process'.","authors":"Susan M Courtney","doi":"10.1080/17588928.2022.2131747","DOIUrl":"https://doi.org/10.1080/17588928.2022.2131747","url":null,"abstract":"<p><p>I propose working memory be considered, not as a process for static maintenance in a particular set of brain regions, but rather as a dynamic process unfolding to serve future needs. Brain regions such as the hippocampus, or sensory and motor regions, may be necessarily recruited during this process, depending on task demands. Information stored in working memory is thus a distributed representation reflected in the structural and functional state of multiple brain areas and the trajectory of that state over time. Recent research is discussed in support of this view.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"208-209"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hippocampal activity in working memory tasks: sparse, yet relevant.","authors":"Judith C Peters, Joel Reithler","doi":"10.1080/17588928.2022.2131746","DOIUrl":"https://doi.org/10.1080/17588928.2022.2131746","url":null,"abstract":"<p><p>Recent studies suggest the hippocampus is involved in working memory (WM). Slotnick (this issue) critically reviewed relevant fMRI findings and concludes WM 'does not activate the hippocampus.' We extend Slotnick's review by discussing observations from human intracranial and lesion research. These studies do suggest hippocampal contributions to WM (beyond novelty encoding), which however are difficult to capture with conventional fMRI. Still, the advent of new fMRI techniques combined with a stronger emphasis on shared hippocampal mechanisms across short- and long-term memory pave an exciting path forward.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"212-214"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9796903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does working memory activate the hippocampus during the late delay period?","authors":"Scott D Slotnick","doi":"10.1080/17588928.2022.2075842","DOIUrl":"https://doi.org/10.1080/17588928.2022.2075842","url":null,"abstract":"<p><p>The aim of the present discussion paper was to identify whether any fMRI studies have provided convincing evidence that the hippocampus is associated with working memory. The key outcome variable was the phase in which hippocampal activity was observed: study, early delay, late delay, and/or test. During working memory tasks, long-term memory processes can operate during the study phase, early delay phase (due to extended encoding), or test phase. Thus, working memory processes can be isolated from long-term memory processes during only the late delay period. Twenty-six working memory studies that reported hippocampal activity were systematically analyzed. Many experimental protocol and analysis parameters were considered including number of participants, stimulus type(s), number of items during the study phase, delay duration, task during the test phase, behavioral accuracy, relevant fMRI contrast(s), whether the information was novel or familiar, number of phases modeled, and whether activation timecourses were extracted. For studies that were able to identify activity in different phases, familiar information sometimes produced activity during the study phase and/or test phase, but never produced activity during the delay period. When early-delay phase and late-delay phase activity could be distinguished via modeling these phases separately or inspecting activation timecourses, novel information could additionally produce activity during the early delay phase. There was no convincing evidence of hippocampal activity during the late delay period. These results indicate that working memory does not activate the hippocampus and suggest a model of working memory where maintenance of novel information can foster long-term memory encoding.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"182-207"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9741498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hippocampal involvement in working memory following refreshing.","authors":"Nathan S Rose, Chang-Mao Chao","doi":"10.1080/17588928.2022.2131749","DOIUrl":"https://doi.org/10.1080/17588928.2022.2131749","url":null,"abstract":"<p><p>Working memory (WM) and long-term memory (LTM) tests have both overlapping and distinct neurocognitive processes. Hippocampal activity in fMRI studies-a hallmark of LTM-also occurs on WM tasks, typically during encoding or retrieval and sometimes (albeit rarely) through 'late-delay' periods. The Synaptic Theory of WM suggests that 'activity-silent' synaptic weights retain temporary, WM-relevant codes without sustained, elevated activity. The hippocampus temporarily retains item-context bindings during WM-delays that are typically 'silent' to fMRI, probably via oscillatory patterns of informational connectivity among task-relevant regions of cortex. Advancing WM theory will require modeling this dynamic interplay, as in the 'Dynamic Processing Model of WM.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"215-217"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9741520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitivity of the hippocampus to objective but not subjective episodic memory judgments.","authors":"Preston P Thakral, Sarah S Yu, Michael D Rugg","doi":"10.1080/17588928.2022.2033713","DOIUrl":"https://doi.org/10.1080/17588928.2022.2033713","url":null,"abstract":"<p><p>We assessed whether neural activity in the hippocampus dissociates according to whether memory test items elicit a subjective sense of recollection or accurate retrieval of contextual information. We reanalyzed a previously acquired dataset from a study in which participants made both objective (source memory for spatial context) and subjective (Remember-Know) judgments for each test item. Results indicated that the hippocampus was exclusively sensitive to the amount of contextual information retrieved, such that accurate source memory judgments were associated with greater activity than inaccurate judgments, regardless of Remember/Know status. The findings add to the evidence that the hippocampus is insensitive to the subjective experience of recollection, but supports retrieval of contextual information.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"165-170"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365877/pdf/nihms-1780152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10106679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cognitive NeurosciencePub Date : 2022-07-01Epub Date: 2022-05-18DOI: 10.1080/17588928.2022.2076071
Adrian W Gilmore, Sam Audrain, Alex Martin
{"title":"Specifying 'where' and 'what' is critical for testing hippocampal contributions to memory retrieval.","authors":"Adrian W Gilmore, Sam Audrain, Alex Martin","doi":"10.1080/17588928.2022.2076071","DOIUrl":"10.1080/17588928.2022.2076071","url":null,"abstract":"<p><p>Tallman and colleagues' review of consolidation studies found that the length of the delay between 'recent' and 'remote' events is an influential determinant of detecting temporally graded hippocampal activity. Here, we discuss two additional factors - separate analysis of distinct regions within the hippocampus and the use of overt recall methods - that should be considered when testing competing theories of hippocampal contributions to memory.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"144-146"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9808613/pdf/nihms-1857298.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine W Tallman, Robert E Clark, Christine N Smith
{"title":"Human brain activity and functional connectivity as memories age from one hour to one month.","authors":"Catherine W Tallman, Robert E Clark, Christine N Smith","doi":"10.1080/17588928.2021.2021164","DOIUrl":"https://doi.org/10.1080/17588928.2021.2021164","url":null,"abstract":"<p><p>Theories of memory consolidation suggest the role of brain regions and connectivity between brain regions change as memories age. Human lesion studies indicate memories become hippocampus-independent over years, whereas animal studies suggest this process occurs across relatively short intervals, from days to weeks. Human neuroimaging studies suggest that changes in hippocampal and cortical activity and connectivity can be detected over these short intervals, but many of these studies examined only two time periods. We examined memory and fMRI activity for photos of indoor and outdoor scenes across four time periods to examine these neural changes more carefully. Participants (N = 21) studied scenes 1 hour, 1 day, 1 week, or 1 month before scanning. During scanning, participants viewed scenes, made old/new recognition memory judgments, and gave confidence ratings. Memory accuracy, confidence ratings, and response times changed with memory age. Brain activity in a widespread cortical network either increased or decreased with memory age, whereas hippocampal activity was not related to memory age. These findings were almost identical when effects of behavioral changes across time periods were minimized. Functional connectivity of the ventromedial prefrontal cortex with the posterior parietal cortex increased with memory age. By contrast, functional connectivity of the hippocampus with the parahippocampal cortex and fusiform gyrus decreased with memory age. In sum, we detected changes in cortical activity and changes in hippocampal and cortical connectivity with memory age across short intervals. These findings provide support for the predictions of systems consolidation and suggest that these changes begin soon after memories are formed.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"115-133"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308837/pdf/nihms-1769153.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9732907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The hippocampus and long-term memory.","authors":"Scott D Slotnick","doi":"10.1080/17588928.2022.2128736","DOIUrl":"https://doi.org/10.1080/17588928.2022.2128736","url":null,"abstract":"<p><p>This special issue of <i>Cognitive Neuroscience</i> focuses on the roles of the hippocampus during long-term memory. A discussion paper by Tallman, Clark, and Smith (this issue) found that functional connectivity of the hippocampus with the parahippocampal cortex and fusiform gyrus decreased with memory age, providing support for systems consolidation. Commentaries were received by Berdugo-Vega and Gräff (this issue), Feld and Gerchen (this issue), Gellersen and Simons (this issue), Gobbo, Mitchell-Heggs, and Tse (this issue), Gilmore, Audrain, and Martin (this issue), Kirwan (this issue), Manns (this issue), Runyan and Brooks (this issue), Santangelo (this issue), and Yang (this issue). The author response considered the content and context of memorial information along with neuroanatomy and functional specialization and conducted new analyses to clarify their findings. An empirical fMRI paper by Thakral, Yu, and Rugg (this issue) reported that the hippocampus was sensitive to the amount of contextual information retrieved, regardless of remember-know status. Another empirical study by Bjornn, Van, and Kirwan (this issue) found that hippocampal activation changes were correlated with the number of fixations at study for correct but not incorrect mnemonic discrimination judgments. A second discussion paper (Slotnick, this issue) concluded that no fMRI studies have provided evidence that the hippocampus is associated with working memory. Commentaries were received by Courtney (this issue), Kessels and Bergmann (this issue), Peters and Reithler (this issue), Rose and Chao (this issue), Stern and Hasselmo (this issue), and Wood, Clark, and Nee (this issue). The articles in this special issue illustrate that the roles of the hippocampus in long-term memory (and other types of memory) are under active investigation and provide many directions for research in the immediate future.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"113-114"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10415857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Gobbo, Rufus Mitchell-Heggs, Dorothy Tse
{"title":"Changes in brain activity and connectivity as memories age.","authors":"Francesco Gobbo, Rufus Mitchell-Heggs, Dorothy Tse","doi":"10.1080/17588928.2022.2076076","DOIUrl":"https://doi.org/10.1080/17588928.2022.2076076","url":null,"abstract":"<p><p>The role of the hippocampus during memory consolidation is not fully understood, with human and animal experiments producing conflicting conclusions. In particular, human lesion studies tend to indicate that the hippocampus gradually becomes independent from memory over years, whilst animal studies suggest that this can happen over days. Tallman et al. (this issue) used fMRI to investigate activity and functional connectivity in the brain at four different time points following memory encoding. Their findings include a decrease in functional connectivity between the hippocampus and parahippocampal cortex with memory age, which supports the system consolidation theory, but also argues against the reduced involvement of the hippocampus over time. This study sheds new light on the neurobiology of memory.</p>","PeriodicalId":10413,"journal":{"name":"Cognitive Neuroscience","volume":"13 3-4","pages":"141-143"},"PeriodicalIF":2.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10374257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}