Clinical laboratory最新文献

{"title":"Age and Gender-Related Trajectories of Urine Osmolality in a Large-Scale Population Study: Physiological Mechanisms and Clinical Implications.","authors":"Miao-Liang Zhou, Qing Wang, Lin Zhang","doi":"10.7754/Clin.Lab.2025.250802","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250802","url":null,"abstract":"<p><strong>Background: </strong>To delineate the lifelong trajectories of urine osmolality (Uosm), a primary indicator of renal concentrating capacity, and to investigate the influence of age and gender in a large, non-Western population. This study aims to establish population-specific reference data and explore the underlying physiological mechanisms and clinical implications of observed trends.</p><p><strong>Methods: </strong>This cross-sectional study analyzed retrospective data from 128,889 individuals (65,625 males, 63,264 females), aged 20 to 89 years, who underwent routine physical examinations at a single center in Shaoxing, China, between 2019 and 2022. First-morning urine osmolality was estimated using the electrical conductivity method on a Sysmex UF-5000 analyzer. Data were stratified by gender and 10-year age increments. Statistical analyses included independent t-tests and one-way ANOVA to compare mean Uosm values across groups.</p><p><strong>Results: </strong>A profound and persistent sexual dimorphism was observed, with males exhibiting significantly higher mean Uosm than females across all age groups (p < 0.001). Overall mean Uosm was 657 mOsm/kg H2O (95% CI: 655 - 659) for males and 598 mOsm/kg H2O (95% CI: 596 - 600) for females. For both genders, Uosm peaked in the 20 - 30 year age group and demonstrated a progressive, inexorable decline with advancing age. This decline was gradual until age 70, after which it accelerated markedly. The absolute difference in Uosm between males and females was greatest in young adulthood and attenuated significantly in later life, with the narrowest gap observed in the > 70 - 80 year age group.</p><p><strong>Conclusions: </strong>This large-scale study provides the first high-resolution demographic map of renal concentrating capacity in an East Asian population, revealing distinct age- and gender-specific trajectories. The findings confirm a universal pattern of age-related decline in renal function, likely driven by renal senescence and hormonal shifts, and a significant sexual dimorphism attributable to the influence of gender hormones on renal water and solute handling. The data highlight specific vulnerabilities - an endemic risk of suboptimal hydration predisposing to urolithiasis in men and a heightened risk of dehydration in the elderly - underscoring the need for age- and gender-stratified approaches in clinical nephrology, geriatric medicine, and public health.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 9","pages":"1883-1891"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online and In-Person Instruction in Laboratory Diagnostics: a Four-Year Student Cohort Study.","authors":"Bo Wang, Ying Huang, Xiang Li, Xiajia Zhang, Qiong Lu, Yuanhong Xu, Meijuan Zheng, Min Zhang, Jinxing Xia","doi":"10.7754/Clin.Lab.2026.260532","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2026.260532","url":null,"abstract":"<p><strong>Background: </strong>The rapid shift to online medical education in practical disciplines like Laboratory Diagnostics during the COVID-19 pandemic raised widespread concerns about its effectiveness. This retrospective study aimed to compare the effectiveness of online and in-person instruction and to evaluate the impact of this pedagogical change on student academic performance.</p><p><strong>Methods: </strong>A retrospective mixed-methods study was conducted. Final exam scores from four consecutive cohorts of clinical medicine students for Laboratory Diagnostics (Classes of 2018 - 2021, 2021 - 2024 academic years) were analyzed, and 91 students with direct online learning experience were surveyed.</p><p><strong>Results: </strong>Quantitative results showed a significant academic performance decline during the online teaching period. Median scores (100-point scale) dropped from 83 (Class 2018) to 72 (Class 2019) and 79 (Class 2020), before recovering to 84 (Class 2021) (p < 0.001). The failure rate surged from 2.2% in Class 2018 to 18.3% in Class 2019, returning to 0% in Class 2021 (p < 0.001). The questionnaire revealed mixed experiences of students with online learning. A notable 18.7% of students felt online learning \"worse than in-person\", while 17.6% reported \"decreased learning efficiency\" and 42.9% had \"extended study time\". Although most students provided positive feedback on instructional support and teacher performance, a minority identified shortcomings including insufficient course materials (6.6%), platform instability (4.4%), and limited instructor-student interaction (8.8%).</p><p><strong>Conclusions: </strong>The findings firmly revealed that online instruction was associated with a significant performance decline in a practical discipline. The robust recovery upon returning to in-person instruction underscores its irre-placeable role. The four-year student cohort study recommends a strategic hybrid pedagogical model for Laboratory Diagnostics, combining online theory with dedicated in-person practical training.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 9","pages":"1986-1997"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Vitamin D Deficiency and Nutrition Knowledge Among University Students in Durres, Albania.","authors":"Jorida Zoga, Majlinda Kallco, Indrit Bimi, Daniela Bimi, Daniela Haxhihyseni, Marsida Krasniqi","doi":"10.7754/Clin.Lab.2025.250457","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250457","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine 25 OH-vitamin D status and frequency of its determinants related to diet, lifestyle, and exposure to sunlight among young, healthy nursing students, first-year living in Durres, in Durres, Albania.</p><p><strong>Methods: </strong>This cross-sectional study included responses gathered on a questionnaire from nursing students at the University \"Aleksander Moisiu\" Durres (UAMD), Durres, from March through April 2024. Questions regarding demographics, sun exposure, and diet were recorded. Serum 25 (OH) vitamin D3, calcium, and phosphorus levels were measured through laboratory examination. For serum 25 OHD, the cutoff values ≤ 12 ng/mL, ≤ 20 ng/mL, ≥ 21 - 29 ng/mL, and ≥ 30 ng/mL were defined as very deficient, deficient, insufficient, and sufficient, respectively. The reference values for calcium are 8.6 - 10.3 mg/dL and 2.7 - 4.9 mg/dL for phosphorus.</p><p><strong>Results: </strong>The total number of nursing students enrolled in the study was 187. Among those, 161 (86.43%) were female and 26 (13.57%) were male. Mean ± SD of age was almost similar between the gender groups (19.00 ± 2.56 vs. 19.03 ± 2.05). In total, 148 (79.40%) of the students had BMI within normal range. Further, 25 OH-vitamin D deficiency was found in 164 (87.7%) participants, insufficiency in 16 (8.5%) participants, and only 7 (3.7%) participants had sufficient levels. In total, 31.6% of students eat one egg per day, 33.1% drink 250 mL of milk per day, and the percentage of students that eat fresh fish was less common, with only 23.8%.</p><p><strong>Conclusions: </strong>Deficiency of 25 OH-vitamin D is common among healthy young adults, particularly females, which emphasizes the need to add vitamin D supplements to routine diet.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 9","pages":"1871-1875"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Anemia among Patients with Solid Cancer at the Time of Diagnosis in Saudi Arabia.","authors":"Haytham Dahlawi, Atheer S Almasoudi, Afaq S Joharji, Luluah Alboraie, Doaa Alamoudi, Anwar Borai","doi":"10.7754/Clin.Lab.2025.250944","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250944","url":null,"abstract":"<p><strong>Background: </strong>Cancer represents a significant global health challenge, with elevated incidence and mortality rates, particularly in Saudi Arabia. Anemia frequently manifests as a common complication in patients diagnosed with solid tumors, often remaining undiagnosed. This study aims to evaluate the prevalence of anemia in individuals recently diagnosed with solid tumors, addressing the lack of comprehensive data on this issue.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using the records of 508 newly diagnosed cancer patients at King Abdulaziz Medical City (2014 - 2024). Eligible patients had confirmed histological diagnoses and no prior cancer treatment. Data included demographics, tumor types, and blood parameters (RBC, hemoglobin, hematocrit, MCV, MCH). Anemia was defined as hemoglobin < 11.5 g/dL in females and < 13.0 g/dL in males.</p><p><strong>Results: </strong>Among the 508 patients analyzed, 47.9% were classified as anemic. Microcytic hypochromic anemia (MCHC) was the most prevalent subtype, observed in 25.2% of patients. Colorectal-related malignancies - including colon, rectal, and sigmoid cancers - showed the highest prevalence of MCHC anemia, suggesting chronic gastrointestinal blood loss and iron deficiency as major contributors. In contrast, breast, endometrial, and skin cancers exhibited predominantly non-anemic profiles.</p><p><strong>Conclusions: </strong>Anemia was prevalent in 47.9% of newly diagnosed solid tumor patients, most commonly in colorectal cancers (colon 61%, sigmoid 58%, rectal 52%), with microcytic hypochromic anemia (25.2%) as the leading type. Excluding patients with chronic illnesses and prior treatments allowed a clearer estimate of the true burden. Early screening and management are essential to reduce treatment-induced anemia and improve patient outcomes.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 9","pages":"1932-1940"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148962965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges of Nocardia beijingensis Pneumonia: a Microbiological and Multidisciplinary Analysis in an Immunocompetent Patient.","authors":"Xiang Lu, Xiaoyang Zhao, Xiaoshun Feng, Yongchao Qiao, Songzhe He","doi":"10.7754/Clin.Lab.2025.250959","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250959","url":null,"abstract":"<p><strong>Background: </strong>Nocardia species are ubiquitously distributed in natural environments and typically cause opportunistic infections through inhalation into the respiratory tract or invasion of damaged skin or mucosal barriers. The clinical manifestations and imaging findings of Nocardia infections often lack specificity, which can lead to misdiagnosis or delayed diagnosis. However, etiological examinations (e.g., microbiological culture, PCR, or metagenomic sequencing) can facilitate accurate diagnosis and prompt therapeutic intervention.</p><p><strong>Methods: </strong>In November 2024, a 74-year-old female presented with a cough and sputum production. Sputum and bronchoalveolar lavage fluid (BALF) samples were collected by the Department of Respiratory and Critical Care Medicine and subjected to Gram staining, modified acid-fast staining, and cultured on blood agar plates at a constant temperature of 35℃ with 5% CO2. Gram staining of sputum smears revealed Gram-positive bacilli with right-angle branching, which were also positive on modified acid-fast staining. After 48 hours of culture on blood agar, dry, white colonies were observed. Finally, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) identified the isolate as Nocardia beijingensis (N. beijingensis), which was further confirmed by targeted next-generation sequencing (tNGS).</p><p><strong>Results: </strong>The patient was definitively diagnosed with Nocardia pneumonia and achieved complete recovery following antibiotic therapy. After hospitalization, the patient was treated with piperacillin sodiumtazobactam sodium (4.5 g, Q8h) combined with compound sulfamethoxazole (2 tablets, Q6h), along with adjunctive symptomatic and supportive management such as antitussive agents and gastric protection.</p><p><strong>Conclusions: </strong>Nocardia pneumonia remains a clinical challenge due to its rarity and nonspecific symptoms. A systematic analysis of laboratory findings, definitive pathogen identification, and therapeutic interventions in this case offers valuable insights to improve diagnostic proficiency for Nocardia-related pulmonary infections and enhance patient prognosis.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 9","pages":"2024-2029"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABO and Rhesus (D, C, c, E, and e) Antigen Frequencies Among Blood Donors in Saudi Arabia.","authors":"Saadiya Nazli, Laila Nomani, Rana Hasanato, Ghazi Alotaibi, Sarah Sewaralthahab, Aamer Aleem","doi":"10.7754/Clin.Lab.2025.251009","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.251009","url":null,"abstract":"<p><strong>Background: </strong>Knowledge of blood group antigen frequencies in a population is essential for the efficient working of transfusion services. This study aimed to report the frequencies of ABO antigens and the 5 main Rhesus (Rh) antigens (D, C, c, E, and e) in Saudi Arabian blood donors.</p><p><strong>Methods: </strong>Blood samples were collected in EDTA tubes from 6,188 blood donors for determination of ABO and Rh blood group antigens and Rh phenotypes over a 6-month period. The testing was done using the TANGO Optimo automated blood bank analyzer system. The criteria for selection of blood donors were according to the recommendations of the Saudi Central Board for Accreditation of Healthcare Institutions (CBAHI).</p><p><strong>Results: </strong>Blood donors aged 17 - 60 years with a mean age of 30 ± 6 years were included in this study. The ABO frequencies observed in this study were as follows: A, 26.5%; B, 19.2%; O, 48.2%, and AB, 6.1%. In the Rh system, the e antigen (97.2%) was the most frequent antigen, followed by D (91.3%), c (77.7%), C (69.2%), and E (29.1%). The most common phenotype found was R1r (32.7%), followed by R1R1 (22%). Presence of C antigen was more common in D-positive donors (75.8%) compared to D-negative donors (8%), while 99.4% of the D-negative donors were c-positive.</p><p><strong>Conclusions: </strong>The observed frequencies and distribution of ABO and Rh antigens in Saudi Arabs are different from the reported results for white people, Asians, and black people. Knowledge about the frequency and phenotype distribution of red cell antigens would help in providing antigen-negative compatible blood for patients with multiple alloantibodies and will also help the blood banks in improving their inventory management.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 9","pages":"1966-1971"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarkable Response to Pembrolizumab in Metastatic Cancer of Unknown Primary.","authors":"Mehmet Turker, Alpay Dusgun, Ali Turker, Seher Selvi, Irfan Alisan, Mahmut Buyuksimsek","doi":"10.7754/Clin.Lab.2026.260709","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2026.260709","url":null,"abstract":"<p><strong>Background: </strong>Cancer of unknown primary (CUP) is aggressive, with limited options and poor prognosis. Mismatch repair-deficient (dMMR) CUP is rare, and reports of its response to immunotherapy are scarce.</p><p><strong>Case presentation: </strong>A 52-year-old man presented with extensive liver metastases and severe hepatic dysfunction (bilirubin 14 mg/dL, ECOG 3). The primary site could not be identified; biopsy showed poorly differentiated carcinoma. Immunohistochemistry showed loss of MSH2, MLH1, and PMS2 (dMMR). Pembrolizumab produced rapid improvement, with bilirubin normalizing within three months and complete response by six months, sustained beyond 30 months.</p><p><strong>Conclusions: </strong>Pembrolizumab can achieve durable responses in dMMR CUP despite advanced disease and poor performance.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Intervals for Thyroid-Stimulating Hormone and Free Thyroxine Established in Pregnant Women in Lhasa.","authors":"Ni Zhen, Huihui Ren, Danzeng Zhuoga, Bingliang Guo, Gusang Zhuoma, Yang Jin, Chilie Jiumei, Yingying Li","doi":"10.7754/Clin.Lab.2025.251006","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.251006","url":null,"abstract":"<p><strong>Background: </strong>Standard reference intervals derived from non-pregnant populations are unsuitable for evaluating thyroid hormone levels in pregnancy. Each geographical region should establish pregnancy-specific thyroid hormone reference intervals that consider local population characteristics, instrumentation, and analytical methods. This research aimed to assess variations in thyroid hormone concentrations during first, second, and third trimester stages among women residing in Lhasa, Xizang. Consequently, the study developed local reference intervals for thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) to facilitate improved management and prevention of thyroid diseases among pregnant women in this area.</p><p><strong>Methods: </strong>Adhering to the National Academy of Clinical Biochemistry (NACB) guidelines, the study enrolled 1,016 healthy pregnant women undergoing routine antenatal check-ups across different pregnancy stages from October 2023 to October 2024. Additionally, 120 non-pregnant healthy women who participated in health screenings dur-ing the identical period served as the control group. Measurements of FT3, FT4, and TSH were performed utilizing the Abbott Architect i2000 automated chemiluminescence immunoassay system. Established reference intervals for each pregnancy stage were represented as medians and corresponding 2.5th to 97.5th percentile values.</p><p><strong>Results: </strong>1) The derived reference intervals were: First trimester: FT3 (3.79 - 5.80 pmol/L), FT4 (10.42 - 16.43 pmol/L), TSH (0.40 - 3.41 mIU/L), second trimester: FT3 (3.36 - 5.80 pmol/L), FT4 (9.40 - 16.22 pmol/L), TSH (0.52 - 3.97 mIU/L), third trimester: FT3 (3.01 - 5.09 pmol/L), FT4 (9.52 - 15.05 pmol/L), TSH (0.69 - 4.43 mIU/L). 2) Significant differences in FT3, FT4, and TSH concentrations were identified among pregnancy stages and between pregnant participants and non-pregnant controls (p < 0.001). Specifically, FT3 and FT4 demonstrated a continuous decline with advancing pregnancy, while TSH exhibited a progressive increase.</p><p><strong>Conclusions: </strong>For the first time, this study successfully established distinct reference intervals for TSH, FT3, and FT4 specific to healthy pregnant women in Lhasa, Xizang. These locally applicable intervals can enhance early detection accuracy for thyroid-related disorders in pregnant populations, thus mitigating risks associated with inappropriate application of general population-based reference standards.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 8","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROC Curves Can be Used to Determine the Optimal Criterion of ALT for Reflex-to-AST Testing.","authors":"Zhong Yan, Guo-Ming Zhang","doi":"10.7754/Clin.Lab.2025.250911","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250911","url":null,"abstract":"","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 8","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening and Diagnostic Strategies for Sarcomatoid Carcinoma of the Pancreas.","authors":"Jian-Hao Zhang, Qiu-Bo Xu","doi":"10.7754/Clin.Lab.2025.250841","DOIUrl":"https://doi.org/10.7754/Clin.Lab.2025.250841","url":null,"abstract":"<p><strong>Background: </strong>Sarcomatoid carcinoma of the pancreas (SCP) is an exceptionally rare variant of pancreatic ductal adenocarcinoma. A detailed evaluation of its clinical manifestations, laboratory findings, and imaging characteristics may contribute to earlier detection and intervention, thereby improving survival outcomes and quality of life.</p><p><strong>Methods: </strong>We retrospectively reviewed the clinical presentation, laboratory investigations, and imaging findings of a patient with pathologically confirmed SCP. In addition, relevant literature was analyzed to summarize strategies for early screening and diagnosis.</p><p><strong>Results: </strong>A 78-year-old female presented with persistent dull epigastric pain accompanied by nausea and vomiting. Laboratory evaluation revealed elevated CA19-9 levels. Imaging demonstrated a mass in the pancreatic body and tail. Dynamic contrast-enhanced CT showed moderate heterogeneous enhancement in the arterial phase with progressive enhancement during the portal venous phase. Dynamic contrast-enhanced MRI revealed rim enhancement.</p><p><strong>Conclusions: </strong>The integration of serum CA19-9 measurement with characteristic imaging features may facilitate the early identification of SCP.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"72 8","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}