Clinical Microbiology Reviews最新文献_第7页

Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections. 临床微生物实验室实用指南》：种植相关感染的微生物学诊断。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2024-06-13 Epub Date: 2024-03-20 DOI: 10.1128/cmr.00104-23

Marisa Ann Azad, Robin Patel

{"title":"Practical Guidance for Clinical Microbiology Laboratories: Microbiologic diagnosis of implant-associated infections.","authors":"Marisa Ann Azad, Robin Patel","doi":"10.1128/cmr.00104-23","DOIUrl":"10.1128/cmr.00104-23","url":null,"abstract":"SUMMARYImplant-associated infections (IAIs) pose serious threats to patients and can be associated with significant morbidity and mortality. These infections may be difficult to diagnose due, in part, to biofilm formation on device surfaces, and because even when microbes are found, their clinical significance may be unclear. Despite recent advances in laboratory testing, IAIs remain a diagnostic challenge. From a therapeutic standpoint, many IAIs currently require device removal and prolonged courses of antimicrobial therapy to effect a cure. Therefore, making an accurate diagnosis, defining both the presence of infection and the involved microorganisms, is paramount. The sensitivity of standard microbial culture for IAI diagnosis varies depending on the type of IAI, the specimen analyzed, and the culture technique(s) used. Although IAI-specific culture-based diagnostics have been described, the challenge of culture-negative IAIs remains. Given this, molecular assays, including both nucleic acid amplification tests and next-generation sequencing-based assays, have been used. In this review, an overview of these challenging infections is presented, as well as an approach to their diagnosis from a microbiologic perspective.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0010423"},"PeriodicalIF":19.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Broadly neutralizing antibodies for HIV prevention: a comprehensive review and future perspectives 用于预防艾滋病毒的广谱中和抗体：全面回顾与未来展望

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2024-04-30 DOI: 10.1128/cmr.00152-22

Sharana Mahomed1Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, Graeme N. Forrest

引用次数: 0

Vaccines and monoclonal antibodies: new tools for malaria control 疫苗和单克隆抗体：控制疟疾的新工具

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2024-04-24 DOI: 10.1128/cmr.00071-23

Kazutoyo MiuraYevel Flores-GarciaCarole A. LongFidel Zavala1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA2Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Malaria Research Institute, Baltimore, Maryland, USA, Louisa A. Messenger, Gordon A. AwandareKwadwo Asamoah Kusi

引用次数: 0

Recent development and fighting strategies for lincosamide antibiotic resistance 林可酰胺类抗生素耐药性的最新发展和应对策略

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2024-04-18 DOI: 10.1128/cmr.00161-23

Yingying YangShiyu XieFangjing HeYindi XuZhifang WangAwais IhsanXu Wang1National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei, China2MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China3MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei, China4Institute of Animal Husbandry Research, Henan Academy of Agricultural Sciences, Zhengzhou, Henan, China5Department of Biosciences, COMSATS University Islamabad, Sahiwal campus, Islamabad, Pakistan, Graeme N. Forrest

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Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease 新型抗真菌药物和治疗方法，解决抗药性问题，改善侵袭性真菌病的治疗效果

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2024-04-11 DOI: 10.1128/cmr.00074-23

Martin HoeniglAmir ArastehfarMaiken Cavling ArendrupRoger BrüggemannAgostinho CarvalhoTom ChillerSharon ChenMatthias EggerSimon FeysJean-Pierre GangneuxJeremy A. W. GoldAndreas H. GrollJannes HeylenJeffrey D. JenksRobert KrauseKatrien LagrouFrédéric LamothJuergen PrattesSarah SedikJoost WautersNathan P. WiederholdGeorge R. Thompson1Department of Internal Medicine, Division of Infectious Diseases, ECMM Excellence Center for Medical Mycology, Medical University of Graz, Graz, Austria2BiotechMed-Graz, Graz, Austria3Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA4Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA5Unit of Mycology, Statens Serum Institut, Copenhagen, Denmark6Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark7Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark8Department of Pharmacy and Radboudumc Institute for Medical Innovation, Radboud University ..

引用次数: 0

Evolving mechanisms and presentations of cardiovascular disease in people with HIV: implications for management. 艾滋病病毒感染者心血管疾病不断演变的机制和表现：对管理的影响。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2024-03-14 Epub Date: 2024-02-01 DOI: 10.1128/cmr.00098-22

Ilana Nazari, Matthew J Feinstein

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Advancements and challenges in antifungal therapeutic development. 抗真菌疗法开发的进展与挑战。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2024-03-14 Epub Date: 2024-01-31 DOI: 10.1128/cmr.00142-23

Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen

{"title":"Advancements and challenges in antifungal therapeutic development.","authors":"Emily Puumala, Sara Fallah, Nicole Robbins, Leah E Cowen","doi":"10.1128/cmr.00142-23","DOIUrl":"10.1128/cmr.00142-23","url":null,"abstract":"Over recent decades, the global burden of fungal disease has expanded dramatically. It is estimated that fungal disease kills approximately 1.5 million individuals annually; however, the true worldwide burden of fungal infection is thought to be higher due to existing gaps in diagnostics and clinical understanding of mycotic disease. The development of resistance to antifungals across diverse pathogenic fungal genera is an increasingly common and devastating phenomenon due to the dearth of available antifungal classes. These factors necessitate a coordinated response by researchers, clinicians, public health agencies, and the pharmaceutical industry to develop new antifungal strategies, as the burden of fungal disease continues to grow. This review provides a comprehensive overview of the new antifungal therapeutics currently in clinical trials, highlighting their spectra of activity and progress toward clinical implementation. We also profile up-and-coming intracellular proteins and pathways primed for the development of novel antifungals targeting their activity. Ultimately, we aim to emphasize the importance of increased investment into antifungal therapeutics in the current continually evolving landscape of infectious disease.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0014223"},"PeriodicalIF":19.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumocystis jirovecii pneumonia in people living with HIV: a review. 艾滋病毒感染者的肺孢子虫肺炎：综述。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2024-03-14 Epub Date: 2024-01-18 DOI: 10.1128/cmr.00101-22

Emily G McDonald, Avideh Afshar, Bander Assiri, Tom Boyles, Jimmy M Hsu, Ninh Khuong, Connor Prosty, Miranda So, Zahra N Sohani, Guillaume Butler-Laporte, Todd C Lee

{"title":"Pneumocystis jirovecii pneumonia in people living with HIV: a review.","authors":"Emily G McDonald, Avideh Afshar, Bander Assiri, Tom Boyles, Jimmy M Hsu, Ninh Khuong, Connor Prosty, Miranda So, Zahra N Sohani, Guillaume Butler-Laporte, Todd C Lee","doi":"10.1128/cmr.00101-22","DOIUrl":"10.1128/cmr.00101-22","url":null,"abstract":"Pneumocystis jirovecii is a ubiquitous opportunistic fungus that can cause life-threatening pneumonia. People with HIV (PWH) who have low CD4 counts are one of the populations at the greatest risk of Pneumocystis jirovecii pneumonia (PCP). While guidelines have approached the diagnosis, prophylaxis, and management of PCP, the numerous studies of PCP in PWH are dominated by the 1980s and 1990s. As such, most studies have included younger male populations, despite PCP affecting both sexes and a broad age range. Many studies have been small and observational in nature, with an overall lack of randomized controlled trials. In many jurisdictions, and especially in low- and middle-income countries, the diagnosis can be challenging due to lack of access to advanced and/or invasive diagnostics. Worldwide, most patients will be treated with 21 days of high-dose trimethoprim sulfamethoxazole, although both the dose and the duration are primarily based on historical practice. Whether treatment with a lower dose is as effective and less toxic is gaining interest based on observational studies. Similarly, a 21-day tapering regimen of prednisone is used for patients with more severe disease, yet other doses, other steroids, or shorter durations of treatment with corticosteroids have not been evaluated. Now with the widespread availability of antiretroviral therapy, improved and less invasive PCP diagnostic techniques, and interest in novel treatment strategies, this review consolidates the scientific body of literature on the diagnosis and management of PCP in PWH, as well as identifies areas in need of more study and thoughtfully designed clinical trials.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0010122"},"PeriodicalIF":19.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming barriers and stigma: new frontiers in solid organ transplantation for people with HIV. 克服障碍和耻辱：艾滋病病毒感染者实体器官移植的新领域。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2024-03-14 Epub Date: 2024-01-19 DOI: 10.1128/cmr.00111-22

K Storm, C M Durand

{"title":"Overcoming barriers and stigma: new frontiers in solid organ transplantation for people with HIV.","authors":"K Storm, C M Durand","doi":"10.1128/cmr.00111-22","DOIUrl":"10.1128/cmr.00111-22","url":null,"abstract":"There is a growing need for solid organ transplantation (SOT) for people living with human immunodeficiency virus (HIV). With the advent of antiretroviral therapy, people living with HIV are experiencing increased life expectancies and are, therefore, developing more comorbidities, including end-stage organ disease. In cases of advanced organ failure, SOT is often the best therapeutic option to improve quality of life and overall survival. As organ shortages persist, transplantation of organs from donors with HIV to recipients with HIV has become a potential therapeutic option. This article first reviews the current state of organ transplantation from donors without HIV to recipients with HIV (HIV D-/R+) by organ and discusses key lessons learned from these transplant trials, including those about drug-drug interactions, rejection, and opportunistic infections. It then explores transplantation from donors with HIV to recipients with HIV (HIV D+/R+), a new frontier. Finally, it investigates challenges of implementation, including public awareness and regulatory requirements, and explores future directions for SOT in people living with HIV.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0011122"},"PeriodicalIF":19.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control. 克隆氏癣菌病和乳头癣菌病：流行病学、传播、临床特征、发病率、诊断、治疗和控制。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2024-03-14 Epub Date: 2024-01-03 DOI: 10.1128/cmr.00009-23

Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou

{"title":"Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control.","authors":"Men-Bao Qian, Jennifer Keiser, Jürg Utzinger, Xiao-Nong Zhou","doi":"10.1128/cmr.00009-23","DOIUrl":"10.1128/cmr.00009-23","url":null,"abstract":"Clonorchis sinensis, Opisthorchis viverrini, and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma. With regard to diagnosis, stool microscopy is widely used in epidemiologic surveys and for individual diagnosis. Immunologic techniques are employed for screening purposes, and molecular techniques facilitate species differentiation in reference laboratories. The mainstay of control is preventive chemotherapy with praziquantel, usually combined with behavioral change through information, education and communication, and environmental control. Tribendimidine, a drug registered in the People's Republic of China for soil-transmitted helminth infections, shows potential against both C. sinensis and O. viverrini and, hence, warrants further clinical development. Novel control approaches include fish vaccine and biological control. Considerable advances have been made using multi-omics which may trigger the development of new interventions. Pressing research needs include mapping the current distribution, disentangling the transmission, accurately estimating the disease burden, and developing new diagnostic and treatment tools, which would aid to optimize control and elimination measures.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0000923"},"PeriodicalIF":19.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0