Clinical Microbiology Reviews最新文献_第10页

Human toxocariasis.

IF 20.7 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-07-07 DOI: 10.1128/cmr.00101-23

Susana Lopez-Alamillo, Pravallika Padyala, Megan Carey, Megan M Duffey, Jill E Weatherhead

{"title":"Human toxocariasis.","authors":"Susana Lopez-Alamillo, Pravallika Padyala, Megan Carey, Megan M Duffey, Jill E Weatherhead","doi":"10.1128/cmr.00101-23","DOIUrl":"10.1128/cmr.00101-23","url":null,"abstract":"SUMMARYHuman toxocariasis is a globally prevalent zoonotic parasitic infection caused by larvae of Toxocara species, primarily Toxocara canis and Toxocara cati. Toxocariasis is commonly transmitted to humans through the ingestion of embryonated Toxocara eggs found in contaminated soil, water, or on surfaces contaminated with animal feces. Unlike in dogs and cats, humans are not definitive hosts for Toxocara spp., and, as a result, Toxocara larvae do not complete their life cycle in humans. Instead, following accidental oral ingestion of embryonated eggs, Toxocara larvae undergo an aberrant larval migratory cycle to various organs including the lungs, liver, muscles, and central nervous system, and do not return to the intestines to develop into mature adult worms. As the Toxocara larvae do not complete their life cycle in the human host, they will ultimately die in human tissue. This comprehensive systematic review of human toxocariasis analyzes and synthesizes existing research to provide a detailed and updated understanding of this zoonotic parasitic infection of global importance. This review provides an in-depth analysis of various aspects of toxocariasis, including its epidemiology, microbiology, pathogenesis, clinical manifestations, diagnostic methods, and treatment strategies.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0010123"},"PeriodicalIF":20.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteus spp.-taxonomy, clinical significance, and antibiotic resistance of a highly versatile pathogen. 变形杆菌的分类，临床意义，和高度通用病原体的抗生素耐药性。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-08 DOI: 10.1128/cmr.00181-24

Linea Katharina Muhsal,Lisa Theis,Jörg Overmann,Axel Hamprecht

引用次数: 0

Integrating whole-genome sequencing into antimicrobial resistance surveillance: methodologies, challenges, and perspectives. 整合全基因组测序到抗菌素耐药性监测：方法，挑战和观点。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-05 DOI: 10.1128/cmr.00140-22

Yasufumi Matsumura,Masaki Yamamoto,Ryota Gomi,Yasuhiro Tsuchido,Koh Shinohara,Taro Noguchi,Miki Nagao

{"title":"Integrating whole-genome sequencing into antimicrobial resistance surveillance: methodologies, challenges, and perspectives.","authors":"Yasufumi Matsumura,Masaki Yamamoto,Ryota Gomi,Yasuhiro Tsuchido,Koh Shinohara,Taro Noguchi,Miki Nagao","doi":"10.1128/cmr.00140-22","DOIUrl":"https://doi.org/10.1128/cmr.00140-22","url":null,"abstract":"SUMMARYAntimicrobial resistance (AMR) poses a significant threat to global public health. Surveillance is a fundamental method for controlling AMR and guiding clinical decisions, public health interventions, and policymaking. Whole-genome sequencing (WGS) provides a comprehensive and accurate understanding of AMR mechanisms, gene profiling, and transmission dynamics. Public health authorities, academic scholars, hospitals, and laboratories have increasingly employed WGS-based surveillance for retrospective, real-time, and prospective monitoring of AMR and investigations of outbreaks. WGS-based surveillance has improved the accuracy and effectiveness of disease and AMR surveillance by identifying hidden transmissions and sources missed by conventional methods and by rapidly investigating and deploying infection control interventions. However, WGS analysis involves a complex combination of workflows of next-generation sequencing and bioinformatics data analysis, making it difficult to effectively compare surveillance results. It is crucial to understand the limitations of our existing WGS analyses by implementing rigorous validation practices across different WGS analyses, developing practice guidelines, and establishing appropriate quality assurance measures. These efforts will aid in the development of reliable and robust WGS systems, the harmonization and standardization of surveillance programs, and the development of public data sharing and governance frameworks. Despite these challenges, the expansion of WGS-based AMR surveillance is expected to be driven by technological advances, standardization efforts, and the recognition of its advantages among stakeholders. The integration of genomic data with nongenomic information, as well as interdisciplinary collaborations will further enhance knowledge regarding AMR and promote the development of countermeasures.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"30 1","pages":"e0014022"},"PeriodicalIF":36.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of post-exposure strategies for high-consequence viral pathogens in the laboratory 高后果病毒病原体实验室暴露后策略综述

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-29 DOI: 10.1128/cmr.00236-24

Grace Butel-SimoesMichael A. MosoPrashanth RamachandranMaryza GrahamDeborah A. WilliamsonChuan Kok Lim1Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity534133, Melbourne, Victoria, Australia2Department of Infectious Diseases, University of Melbourne, Peter Doherty Institute for Infection and Immunity2281https://ror.org/01ej9dk98, Melbourne, Victoria, Australia3Victorian Infectious Diseases Service, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity534133, Melbourne, Victoria, Australia4Monash University2541https://ror.org/02bfwt286, Clayton, Victoria, Australia5School of Medicine, University of St Andrews7486https://ror.org/02wn5qz54, Fife, ScotlandAudrey N. SchuetzAaron M. T. BarnesAditya Shah

引用次数: 0

Adoptive T-cell therapy for virus-associated diseases 过继t细胞治疗病毒相关疾病

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-22 DOI: 10.1128/cmr.00198-24

Corey SmithRajiv Khanna1Queensland Immunology Research Centre and Inflammation and Infection Program, QIMR Berghofer Medical Research Institutehttps://ror.org/004y8wk30, Brisbane, Australia2School of Biological Sciences, University of Queensland1974https://ror.org/00rqy9422, Brisbane, AustraliaGraeme N. Forrest

引用次数: 0

Drug-resistant Acinetobacter baumannii: mortality, emerging treatments, and future pharmacological targets for a WHO priority pathogen. 耐药鲍曼不动杆菌：世卫组织重点病原体的死亡率、新出现的治疗方法和未来的药理学靶点。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-11 DOI: 10.1128/cmr.00279-24

Vineet Dubey,Nada Reza,William Hope

{"title":"Drug-resistant Acinetobacter baumannii: mortality, emerging treatments, and future pharmacological targets for a WHO priority pathogen.","authors":"Vineet Dubey,Nada Reza,William Hope","doi":"10.1128/cmr.00279-24","DOIUrl":"https://doi.org/10.1128/cmr.00279-24","url":null,"abstract":"SUMMARYAcinetobacter baumannii has emerged as a formidable global health concern and is a major contributor to infection-related mortality in critically ill patients worldwide. This versatile Gram-negative bacterium is notorious for its highly plastic genome, which enables the rapid emergence and dissemination of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, severely limiting the available treatment options. The genetic flexibility of A. baumannii underpins its arsenal of molecular mechanisms, enabling it to resist a range of antibiotics, from traditional agents to the latest therapeutic advancements available. With the progress made in treatments against Acinetobacter infections and various drugs undergoing clinical trials, the effectiveness of these treatments is often outpaced by the pathogen's swift evolution of resistance, resulting in alarmingly high rates of treatment failure. In this systematic review of literature spanning 2004-2024, we highlight the high mortality rates associated with infections caused by XDR strains and carbapenem-resistant A. baumannii (CRAB). This review provides a comprehensive examination of the resistance mechanisms deployed by A. baumannii, encompassing both conventional antibiotics and novel agents used in global healthcare settings. In addition, we discuss emerging druggable targets and the inherent challenges in their development, offering strategic insights into next-generation therapeutic programs. A deep profound understanding of the pathogen's molecular defenses is essential to guide the design of innovative therapies aimed at mitigating the escalating threat posed by A. baumannii.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"12 1","pages":"e0027924"},"PeriodicalIF":36.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of respiratory syncytial virus and human metapneumovirus transmission. 呼吸道合胞病毒和人偏肺病毒传播的决定因素。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-01 DOI: 10.1128/cmr.00203-24

David A Foley,David W Smith,Ian Barr,Hannah C Moore,Mark Nicol,Christopher C Blyth

引用次数: 0

Genetic diversity, biochemical properties, epidemiology, and detection methods of IMP- and VIM-type carbapenemases. IMP型和vim型碳青霉烯酶的遗传多样性、生化特性、流行病学及检测方法。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-01 DOI: 10.1128/cmr.00129-23

Rémy A Bonnin,Agnès B Jousset,Aymeric Jacquemin,Cécile Emeraud,Delphine Girlich,Thierry Naas,Laurent Dortet

{"title":"Genetic diversity, biochemical properties, epidemiology, and detection methods of IMP- and VIM-type carbapenemases.","authors":"Rémy A Bonnin,Agnès B Jousset,Aymeric Jacquemin,Cécile Emeraud,Delphine Girlich,Thierry Naas,Laurent Dortet","doi":"10.1128/cmr.00129-23","DOIUrl":"https://doi.org/10.1128/cmr.00129-23","url":null,"abstract":"SUMMARYMetallo-beta-lactamases are an ever-growing problem. Since the discovery of the beta-lactamase of Bacillus cereus in the late 1960s, many class B beta-lactamases have been reported, with three main families being NDM-, IMP-, and VIM-like. IMP- and VIM-like carbapenemases have been identified in a wide variety of Gram-negative bacteria. VIM-type carbapenemases are widely distributed, primarily represented by two main clusters, VIM-1 and VIM-2, and have been found in both Enterobacterales and non-fermenters. IMP-type carbapenemases are characterized by a significant genetic diversity and low identity between subgroups. This carbapenemase is more prevalent in Asia but has been identified globally, in both Enterobacterales and non-fermenters, as observed for VIM-type carbapenemases. The genetic diversity of IMP- and some VIM-type carbapenemases limits their detection. This review aims to discuss the genetic diversity, epidemiology, and biochemical characteristics of VIM- and IMP-type carbapenemases. It also evaluates the efficacy of commercially available detection tests and the in vitro activity of recently developed inhibitors.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"27 1","pages":"e0012923"},"PeriodicalIF":36.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Streptococcus pneumoniae β-lactam resistance: epidemiological trends, molecular drivers, and innovative control strategies in the post-pandemic era. 肺炎链球菌β-内酰胺耐药性：大流行后时代的流行病学趋势、分子驱动因素和创新控制策略

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-07-31 DOI: 10.1128/cmr.00082-25

Jiaqi Li,Guixue Cheng,Xiaosong Qin,Jianhua Liu

{"title":"Streptococcus pneumoniae β-lactam resistance: epidemiological trends, molecular drivers, and innovative control strategies in the post-pandemic era.","authors":"Jiaqi Li,Guixue Cheng,Xiaosong Qin,Jianhua Liu","doi":"10.1128/cmr.00082-25","DOIUrl":"https://doi.org/10.1128/cmr.00082-25","url":null,"abstract":"SUMMARYStreptococcus pneumoniae (S. pneumoniae) is a major human pathogen that can cause severe diseases such as meningitis and bacteremia. β-lactam antibiotics are the most essential antimicrobial agents for treating S. pneumoniae infections, but the resistance has become a significant challenge in clinical therapy. Analyses reveal notable regional disparities in the prevalence of β-lactam resistance in S. pneumoniae. The use of pneumococcal conjugate vaccines effectively reduces the spread of highly resistant clones, indirectly improving resistance patterns. Interestingly, resistance is inversely correlated with bacterial invasiveness, suggesting mutual selective pressures. Additionally, the COVID-19 pandemic may have influenced the evolution of S. pneumoniae resistance by altering host immune states and healthcare resource allocation. Immunocompromised patients face a higher risk of invasive pneumococcal disease, driving increased antimicrobial use that fuels the rise of resistance. Beyond the single-molecular mechanism, the resistance gene acquisition order plays a critical role in the successful resistance evolution. Analyzing the dynamic principles and key nodes involved in the evolution of drug resistance could offer novel insights for developing precise antibacterial treatment strategies. Current research efforts focus on the development of novel antibiotics, antimicrobial peptides, lysins, and other innovative therapeutic agents. Artificial intelligence shows immense potential in the screening of antimicrobial drugs and the prediction of resistance mechanisms. This review synthesizes recent advances in the epidemiology, molecular mechanisms, and management of β-lactam resistance in S. pneumoniae, with the aim of informing evidence-based antimicrobial stewardship and accelerating the development of innovative therapeutics to combat this evolving public health threat.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"31 1","pages":"e0008225"},"PeriodicalIF":36.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The long reach of influenza and other respiratory viruses: from acute epithelial injury to post-viral lung disease. 流感和其他呼吸道病毒的长期传播范围：从急性上皮损伤到病毒感染后肺部疾病。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-07-24 DOI: 10.1128/cmr.00243-24

Piotr P Janas,Christoforos Rozario,Christopher D Lucas,Pieter S Hiemstra,Jürgen Schwarze,Caroline Chauché

{"title":"The long reach of influenza and other respiratory viruses: from acute epithelial injury to post-viral lung disease.","authors":"Piotr P Janas,Christoforos Rozario,Christopher D Lucas,Pieter S Hiemstra,Jürgen Schwarze,Caroline Chauché","doi":"10.1128/cmr.00243-24","DOIUrl":"https://doi.org/10.1128/cmr.00243-24","url":null,"abstract":"SUMMARYRespiratory viral infections cause extensive cell death in the lung epithelium, resulting from both direct viral action and exuberant immune responses. Recovery following viral infection requires rapid and coordinated repair programs, ensuring the replacement of the damaged tissue through proliferation, migration, and differentiation of respiratory epithelial progenitor cells. Viral infection and the resulting inflammatory milieu alter host gene expression. Notably, growing evidence indicates that these infections can induce long-term changes in epithelial progenitor cells, which persist even after the infection has resolved. These alterations may play a key role in the development of post-viral lung disease (PVLD). In this review, we discuss current knowledge regarding respiratory viral infections and how these may alter the gene expression and function of epithelial progeny cells arising from the surviving progenitors. We do so by exploring the influenza virus as an example and comparing it with what is known about other important respiratory viruses, such as respiratory syncytial virus (RSV), rhinovirus (HRV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). We highlight the impact of respiratory viral infection and ensuing inflammation on lung epithelial memory, considering the importance of viral strains, and discuss potential new therapeutic strategies that could maximize long-term lung health.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"46 48 1","pages":"e0024324"},"PeriodicalIF":36.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0