Clinical Microbiology Reviews最新文献_第9页

MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets. 传染病中的微小RNA：潜在的诊断生物标志物和治疗靶点。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-01 DOI: 10.1128/cmr.00015-23

Muneyoshi Kimura, Sagar Kothari, Wajiha Gohir, Jose F Camargo, Shahid Husain

{"title":"MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets.","authors":"Muneyoshi Kimura, Sagar Kothari, Wajiha Gohir, Jose F Camargo, Shahid Husain","doi":"10.1128/cmr.00015-23","DOIUrl":"10.1128/cmr.00015-23","url":null,"abstract":"MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They have been implicated in the pathogenesis of cancer and neurological, cardiovascular, and autoimmune diseases. Several recent studies have suggested that miRNAs are key players in regulating the differentiation, maturation, and activation of immune cells, thereby influencing the host immune response to infection. The resultant upregulation or downregulation of miRNAs from infection influences the protein expression of genes responsible for the immune response and can determine the risk of disease progression. Recently, miRNAs have been explored as diagnostic biomarkers and therapeutic targets in various infectious diseases. This review summarizes our current understanding of the role of miRNAs during viral, fungal, bacterial, and parasitic infections from a clinical perspective, including critical functional mechanisms and implications for their potential use as biomarkers and therapeutic targets.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0001523"},"PeriodicalIF":19.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2023 Acknowledgment of CMR Reviewers. 2023 感谢 CMR 评审员。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2023-12-20 DOI: 10.1128/cmr.00138-23

Graeme Forrest

引用次数: 0

Diagnosis and management of cryptococcal meningitis in HIV-infected adults. 成人hiv感染者隐球菌性脑膜炎的诊断和治疗。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-28 DOI: 10.1128/cmr.00156-22

Thomas C McHale, David R Boulware, John Kasibante, Kenneth Ssebambulidde, Caleb P Skipper, Mahsa Abassi

{"title":"Diagnosis and management of cryptococcal meningitis in HIV-infected adults.","authors":"Thomas C McHale, David R Boulware, John Kasibante, Kenneth Ssebambulidde, Caleb P Skipper, Mahsa Abassi","doi":"10.1128/cmr.00156-22","DOIUrl":"10.1128/cmr.00156-22","url":null,"abstract":"Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of all deaths related to advanced HIV disease, with the burden of disease predominantly experienced by people in resource-limited countries. Major advancements in diagnostics have introduced low-cost, easy-to-use antigen tests with remarkably high sensitivity and specificity. These tests have led to improved diagnostic accuracy and are essential for screening campaigns to reduce the burden of cryptococcosis. In the last 5 years, several high-quality, multisite clinical trials have led to innovations in therapeutics that have allowed for simplified regimens, which are better tolerated and result in less intensive monitoring and management of medication adverse effects. One trial found that a shorter, 7-day course of deoxycholate amphotericin B is as effective as the longer 14-day course and that flucytosine is an essential partner drug for reducing mortality in the acute phase of disease. Single-dose liposomal amphotericin B has also been found to be as effective as a 7-day course of deoxycholate amphotericin B. These findings have allowed for simpler and safer treatment regimens that also reduce the burden on the healthcare system. This review provides a detailed discussion of the latest evidence guiding the clinical management and special circumstances that make cryptococcal meningitis uniquely difficult to treat.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0015622"},"PeriodicalIF":19.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond 将废水监测作为公共卫生行动的工具：SARS-CoV-2 及其后

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2023-12-14 DOI: 10.1128/cmr.00103-22

Michael D. ParkinsBonita E. LeeNicole AcostaMaria BautistaCasey R. J. HubertSteve E. HrudeyKevin FrankowskiXiao-Li Pang1Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada2Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada3O’Brien Institute of Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada4Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada5Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada6Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada7Advancing Canadian Water Assets, University of Calgary, Calgary, Alberta, Canada8Provincial Health Laboratory, Alberta Health Services, Calgary, Alberta, Canada, Graeme N. Forrest

引用次数: 0

Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management. 真菌性心内膜炎：病理生理学，流行病学，临床表现，诊断和管理。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2023-09-21 Epub Date: 2023-07-13 DOI: 10.1128/cmr.00019-23

George R Thompson, Jeffrey D Jenks, John W Baddley, James S Lewis, Matthias Egger, Ilan S Schwartz, Johannes Boyer, Thomas F Patterson, Sharon C-A Chen, Peter G Pappas, Martin Hoenigl

{"title":"Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.","authors":"George R Thompson, Jeffrey D Jenks, John W Baddley, James S Lewis, Matthias Egger, Ilan S Schwartz, Johannes Boyer, Thomas F Patterson, Sharon C-A Chen, Peter G Pappas, Martin Hoenigl","doi":"10.1128/cmr.00019-23","DOIUrl":"10.1128/cmr.00019-23","url":null,"abstract":"Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high degree of clinical suspicion coupled with the judicious use of diagnostic tests is required for diagnosis. In addition to microbiological diagnostics (e.g., blood culture for Candida spp. or galactomannan testing and PCR for Aspergillus spp.), echocardiography remains critical for evaluation of potential infective endocarditis, although radionuclide imaging modalities such as 18F-fluorodeoxyglucose positron emission tomography/computed tomography are increasingly being used. A multimodal treatment approach is necessary: surgery is usually required and should be accompanied by long-term systemic antifungal therapy, such as echinocandin therapy for Candida endocarditis or voriconazole therapy for Aspergillus endocarditis.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0001923"},"PeriodicalIF":19.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10132286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations. 支气管败血博德菌和百日咳博德菌：感染、免疫调节和疫苗注意事项的异同。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2023-09-21 Epub Date: 2023-06-12 DOI: 10.1128/cmr.00164-22

Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stéphanie Longet, Egbert Mundt, Stéphane Paul

{"title":"Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations.","authors":"Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stéphanie Longet, Egbert Mundt, Stéphane Paul","doi":"10.1128/cmr.00164-22","DOIUrl":"10.1128/cmr.00164-22","url":null,"abstract":"Bordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At the same time, it is increasingly implicated in human infections, while remaining an important pathogen in the veterinary field. Both Bordetella can evade and modulate host immune responses to support their persistence, although it is more pronounced in B. bronchiseptica infection. The protective immune responses elicited by both pathogens are comparable, while there are important characteristics in the mechanisms that differ. However, B. pertussis pathogenesis is more difficult to decipher in animal models than those of B. bronchiseptica because of its restriction to humans. Nevertheless, the licensed vaccines for each Bordetella are different in terms of formulation, route of administration and immune responses induced, with no known cross-reaction between them. Moreover, the target of the mucosal tissues and the induction of long-lasting cellular and humoral responses are required to control and eliminate Bordetella. In addition, the interaction between both veterinary and human fields are essential for the control of this genus, by preventing the infections in animals and the subsequent zoonotic transmission to humans.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0016422"},"PeriodicalIF":36.8,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9668006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum for Nyaruaba et al., "Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future Outbreaks". Nyaruaba等人的勘误，“数字PCR在SARS-CoV-2/COVID-19时代的应用:未来疫情的路线图”。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2023-06-21 DOI: 10.1128/cmr.00052-23

Raphael Nyaruaba, Caroline Mwaliko, David Dobnik, Pavel Neužil, Patrick Amoth, Matilu Mwau, Junping Yu, Hang Yang, Hongping Wei

引用次数: 0

Congenital Syphilis: a Review of Global Epidemiology. 先天性梅毒：全球流行病学回顾。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2023-06-21 Epub Date: 2023-03-15 DOI: 10.1128/cmr.00126-22

Leeyan S Gilmour, Tony Walls

引用次数: 0

Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections. 治疗耐万古霉素肠球菌血流感染的药物。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2023-06-21 Epub Date: 2023-04-17 DOI: 10.1128/cmr.00059-22

Kelly A Cairns, Andrew A Udy, Trisha N Peel, Iain J Abbott, Michael J Dooley, Anton Y Peleg

引用次数: 0

Host Immunity and Immunization Strategies for Clostridioides difficile Infection. 艰难梭菌感染的宿主免疫和免疫策略。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2023-06-21 Epub Date: 2023-05-10 DOI: 10.1128/cmr.00157-22

Farha Naz, William A Petri

引用次数: 0