Clinical Microbiology Reviews最新文献

Recent advances in therapeutic probiotics: insights from human trials 治疗性益生菌的最新进展：来自人体试验的见解

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-22 DOI: 10.1128/cmr.00240-24

Mu-Yeol ChoJe-Hyun EomEun-Mi ChoiSeung-Jo YangDahye LeeYoung Youn KimHye-Sung KimInseong Hwang1Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation, Goyang-si, South Korea2DOCSmedi, Co., Ltd., Goyang-si, South Korea3Department of Orthodontics, Apple Tree Dental Hospital, Goyang-si, South Korea4Department of Oral and Maxillofacial Surgery, Apple Tree Dental Hospital, Goyang-si, South KoreaChristopher Staley

引用次数: 0

Vaginal mycobiome characteristics and therapeutic strategies in vulvovaginal candidiasis (VVC): differentiating pathogenic species and microecological features for stratified treatment 外阴阴道念珠菌病（VVC）的阴道菌群特征和治疗策略：区分病原种类和微生态特征进行分层治疗

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-22 DOI: 10.1128/cmr.00284-24

Zimo LiuHua YangRoujie HuangXiaochuan LiTianshu SunLan Zhu1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collegehttps://ror.org/02drdmm93, Beijing, China2State Key Laboratory of Complex, Severe, and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China3Clinical Biobank, Center for Biomedical Technology, Institute of Clinical Medicine, National Science and Technology Key Infrastructure on Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collegehttps://ror.org/02drdmm93, Beijing, ChinaJorge CervantesLina Restrepo

引用次数: 0

Current perspectives in the epidemiology and control of lymphatic filariasis. 淋巴丝虫病流行病学和控制的最新进展。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-02 DOI: 10.1128/cmr.00126-23

Dziedzom K de Souza, Moses J Bockarie

{"title":"Current perspectives in the epidemiology and control of lymphatic filariasis.","authors":"Dziedzom K de Souza, Moses J Bockarie","doi":"10.1128/cmr.00126-23","DOIUrl":"https://doi.org/10.1128/cmr.00126-23","url":null,"abstract":"SUMMARYLymphatic filariasis (LF), a debilitating tropical disease caused by parasitic filarial worms, Wuchereria bancrofti, Brugia malayi, and Brugia timori, remains a significant public health challenge in tropical and subtropical settings where the disease is endemic. The disease affects millions worldwide, leading to severe disability and social stigma. Following the World Health Assembly resolution WHA50.29 in 1997 encouraging Member States to eliminate LF as a public health problem, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established in 2000. The establishment of the GPELF paced the way for global eradication efforts, with commitments from non-governmental organizations and Merck donating the drug ivermectin as long as it is needed to control the disease. The advances in the diagnosis and control of LF have shown promising results, including developing novel diagnostic tools, therapeutic agents, and integrated vector management and surveillance strategies. This review explores the latest advances in our understanding of LF epidemiology, transmission assessments, clinical manifestations, and immune response to infection. We further discuss the current state of diagnostic development, treatment approaches, and control measures, highlighting the importance of continued research in the fight against this disease.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0012623"},"PeriodicalIF":19.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral microbiota and respiratory diseases: advances and perspectives. 口腔微生物群与呼吸系统疾病：进展与展望。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-02 DOI: 10.1128/cmr.00150-24

Xiaohao Liu, Fengxiang Shi, Jiawei Zeng, Jiaming Bi, Chuzi Mo, Yan Chai, Buling Wu, Shuaimei Xu

引用次数: 0

BCG therapy in bladder cancer and its tumor microenvironment interactions. 卡介苗治疗膀胱癌及其肿瘤微环境相互作用。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-20 DOI: 10.1128/cmr.00212-24

Ni Jian, Lei Yu, Lijuan Ma, Binbin Zheng, Weiren Huang

{"title":"BCG therapy in bladder cancer and its tumor microenvironment interactions.","authors":"Ni Jian, Lei Yu, Lijuan Ma, Binbin Zheng, Weiren Huang","doi":"10.1128/cmr.00212-24","DOIUrl":"https://doi.org/10.1128/cmr.00212-24","url":null,"abstract":"SUMMARYBacillus Calmette-Guérin (BCG) has been the standard treatment for non-muscle-invasive bladder cancer for over 30 years. Despite its proven efficacy, challenges persist, including unclear mechanisms of action, resistance in 30%-50% of patients, and significant side effects. This review presents an updated and balanced discussion of the antitumor mechanisms of BCG, focusing on its direct effects on bladder cancer and its interactions with various cell types within the bladder tumor microenvironment. Notably, recent research on the interactions between BCG and the bladder microbiome is also incorporated. We further summarize and analyze the latest preclinical and clinical studies regarding both intrinsic and adaptive resistance to BCG in bladder cancer. Based on the current understanding of BCG's therapeutic principles and resistance mechanisms, we systematically explore strategies to improve BCG-based tumor immunotherapy. These include the development of recombinant BCG, combination therapy with different drugs, optimization of therapeutic regimens and management, and the exploration of new approaches by targeting changes in the bladder microbiota and its metabolites. These measures aim to effectively address the BCG resistance in bladder cancer, reduce its toxicity, and ultimately enhance the clinical anti-tumor efficacy. Bacterial therapy, represented by genetically engineered oncolytic bacteria, has gradually emerged in the field of cancer treatment in recent years. As the only bacterial drug successfully approved for oncology use, BCG has provided decades of clinical experience. By consolidating lessons from BCG's successes and limitations, we hope to provide valuable insights for the development and application of bacterial therapies in cancer treatment.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0021224"},"PeriodicalIF":19.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Henipaviruses: epidemiology, ecology, disease, and the development of vaccines and therapeutics. 亨尼帕病毒：流行病学，生态学，疾病，以及疫苗和治疗方法的发展。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2024-12-23 DOI: 10.1128/cmr.00128-23

Jessica R Spengler, Michael K Lo, Stephen R Welch, Christina F Spiropoulou

引用次数: 0

The endothelium at the interface between tissues and Staphylococcus aureus in the bloodstream. 在组织和血液中的金黄色葡萄球菌之间的界面上的内皮。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2025-01-14 DOI: 10.1128/cmr.00098-24

Pietro Speziale, Timothy J Foster, Carla Renata Arciola

{"title":"The endothelium at the interface between tissues and Staphylococcus aureus in the bloodstream.","authors":"Pietro Speziale, Timothy J Foster, Carla Renata Arciola","doi":"10.1128/cmr.00098-24","DOIUrl":"10.1128/cmr.00098-24","url":null,"abstract":"SUMMARYStaphylococcus aureus is a major human pathogen. It can cause many types of infections, in particular bacteremia, which frequently leads to infective endocarditis, osteomyelitis, sepsis, and other debilitating diseases. The development of secondary infections is based on the bacterium's ability to associate with endothelial cells lining blood vessels. The success of endothelial colonization and infection by S. aureus relies on its ability to express a wide array of cell wall-anchored and secreted virulence factors. Establishment of endothelial infection by the pathogen is a multistep process involving adhesion, invasion, extravasation, and dissemination of the bacterium into surrounding tissues. The process is dependent on the type of endothelium in different organs (tissues) and pathogenetic potential of the individual strains. In this review, we report an update on the organization of the endothelium in the vessels, the structure and function of the virulence factors of S. aureus, and the several aspects of bacteria-endothelial cell interactions. After these sections, we will discuss recent advances in understanding the specific mechanisms of infections that develop in the heart, bone and joints, lung, and brain. Finally, we describe how neutrophils bind to endothelial cells, migrate to the site of infection to kill bacteria in the tissues, and how staphylococci counteract neutrophils' actions. Knowledge of the molecular details of S. aureus-endothelial cell interactions will promote the development of new therapeutic strategies and tools to combat this formidable pathogen.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0009824"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually transmitted human papillomavirus and related sequelae. 性传播的人乳头瘤病毒及其相关后遗症。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2025-02-14 DOI: 10.1128/cmr.00085-23

Wyatt Hanft, Helen Stankiewicz Karita, Nikka Khorsandi, Poonam Vohra, Rosalyn Plotzker

{"title":"Sexually transmitted human papillomavirus and related sequelae.","authors":"Wyatt Hanft, Helen Stankiewicz Karita, Nikka Khorsandi, Poonam Vohra, Rosalyn Plotzker","doi":"10.1128/cmr.00085-23","DOIUrl":"10.1128/cmr.00085-23","url":null,"abstract":"SUMMARYMore than 40 types of sexually transmitted human papillomavirus (HPV) infect the oropharyngeal and anogenital mucosa-high-risk types are associated with precancerous and cancerous lesions of the cervix, vagina, vulva, penis, anus, and oropharynx, and low-risk types cause non-malignant disease, such as anogenital warts. Though most HPV infections resolve spontaneously, immunodeficiencies may result in persistent infection and increased risk of HPV-related sequelae. The mechanism by which HPV results in malignant transformation is multifaceted, involving interactions with numerous cellular pathways, the host immune system, and potentially the host microbiome. Vaccination against HPV is highly efficacious in the prevention of infection and related sequelae, and there now exist several approved formulations that protect against both high- and low-risk types. Despite the advent of vaccination, early detection and treatment of cervical and anal precancerous lesions continues to be integral to secondary prevention-molecular HPV testing, cytology, and tissue biopsy allow for triaging of patients, after which appropriate treatment with close follow-up can avert cancer development.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0008523"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Group B streptococcal infections in pregnancy and early life. 孕期和生命早期的 B 组链球菌感染。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2024-11-25 DOI: 10.1128/cmr.00154-22

Gygeria Manuel, Joy Twentyman, Kristen Noble, Alison J Eastman, David M Aronoff, Ravin Seepersaud, Lakshmi Rajagopal, Kristina M Adams Waldorf

{"title":"Group B streptococcal infections in pregnancy and early life.","authors":"Gygeria Manuel, Joy Twentyman, Kristen Noble, Alison J Eastman, David M Aronoff, Ravin Seepersaud, Lakshmi Rajagopal, Kristina M Adams Waldorf","doi":"10.1128/cmr.00154-22","DOIUrl":"10.1128/cmr.00154-22","url":null,"abstract":"SUMMARYBacterial infections with Group B Streptococcus (GBS) are an important cause of adverse outcomes in pregnant individuals, neonates, and infants. GBS is a common commensal in the genitourinary and gastrointestinal tracts and can be detected in the vagina of approximately 20% of women globally. GBS can infect the fetus either during pregnancy or vaginal delivery resulting in preterm birth, stillbirth, or early-onset neonatal disease (EOD) in the first week of life. The mother can also become infected with GBS leading to postpartum endometritis, and rarely, maternal sepsis. An invasive GBS infection of the neonate may present after the first week of life (late-onset disease, LOD) through transmission from caregivers, breast milk, and other sources. Invasive GBS infections in neonates can result in sepsis, pneumonia, meningitis, neurodevelopmental impairment, death, and lifelong disability. A policy of routine screening for GBS rectovaginal colonization in well-resourced countries can trigger the administration of intrapartum antibiotic prophylaxis (IAP) when prenatal testing is positive, which drastically reduces rates of EOD. However, many countries do not routinely screen pregnant women for GBS colonization but may administer IAP in cases with a high risk of EOD. IAP does not reduce rates of LOD. A global vaccination campaign is needed to reduce the significant burden of invasive GBS disease that remains among infants and pregnant individuals. In this narrative review, we provide a comprehensive overview of the global impact of GBS colonization and infection, virulence factors and pathogenesis, and current and future prophylactics and therapeutics.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0015422"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracutaneous sporotrichosis. 真皮外的孢子丝菌病。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2025-01-14 DOI: 10.1128/cmr.00140-24

Max Carlos Ramírez-Soto

{"title":"Extracutaneous sporotrichosis.","authors":"Max Carlos Ramírez-Soto","doi":"10.1128/cmr.00140-24","DOIUrl":"10.1128/cmr.00140-24","url":null,"abstract":"SUMMARYSporotrichosis is a subacute-to-chronic infection endemic to tropical and subtropical regions. It usually involves subcutaneous tissue but can occasionally cause extracutaneous infections, especially in hyperendemic areas. Extracutaneous infections are classified based on the anatomic location of the lesion and the route of infection (primary or multifocal). The clinical forms are as follows: (i) pulmonary (primary or multifocal); (ii) osteoarticular (primary or multifocal); (iii) ocular (ocular adnexal lesions including eyelid lesions, conjunctivitis and dacryocystitis, and intraocular infections); (iv) central nervous system; and (v) mucosal (primary or disseminated). Multifocal clinical presentations are observed mainly in immunocompromised individuals. The diagnosis must be confirmed in the laboratory by mycological examination of the clinical samples. Itraconazole and amphotericin B are the most commonly used antifungal agents for treating pulmonary, osteoarticular, ocular, and mucosal forms. Treatment may include surgical excision of the initial lesions in pulmonary and osteoarticular forms. The treatment of neurological involvement is far from optimal and is associated with a high mortality rate despite long treatment periods.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0014024"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0