Clinical Microbiology Reviews最新文献

Current and future options for the treatment of serious infections due to carbapenem-resistant Pseudomonas aeruginosa

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-10-09 DOI: 10.1128/cmr.00233-24

Juan P. HorcajadaAna C. GalesBurcu IslerKeith S. KayeAndrea KwaCornelia B. LandersdorferMaria Milagro MonteroAntonio OliverJason M. PogueRyan K. ShieldsMaria Virginia VillegasDafna YahavDavid L. Paterson1Infectious Diseases Service, Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra (UPF)16548https://ror.org/03a8gac78, Barcelona, Spain2CIBER of Infectious Diseases, CIBERINFEC, Institute of Health Carlos III637284, Madrid, Spain3Division of Infectious Diseases, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP)58804, São Paulo, Brazil4Antimicrobial Resistance Institute of São Paulo, São Paulo, Brazil5Infectious Management Services, Princess Alexandra Hospital1966https://ror.org/04mqb0968, Brisbane, Australia6Centre for Clinical Research, Faculty of Medicine, University of Queensland420004https://ror.org/00rqy9422, Brisbane, Australia7Department of Medicine, Rutgers Robert Wood Johnson Medical School12287, New Brunswick, New Jersey, U..

引用次数: 0

Canonical fact versus hypothesis testing to decipher transmission of non-tuberculous and tuberculous mycobacteria: a comparative review. 规范事实与假设检验来破译非结核和结核分枝杆菌的传播：比较回顾。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-10-06 DOI: 10.1128/cmr.00228-24

Jean-François Guégan,Kayla M Fast,Christine Chevillon,Marina Cobos-Mayo,Alisa Aliaga-Samanez,Magdalene Dogbe,Matthew Scott,Kelly Waters,Melissa K Benbow,Jennifer L Pechal,Joseph P Receveur,Michael W Sandel,Heather R Jordan,M Eric Benbow

{"title":"Canonical fact versus hypothesis testing to decipher transmission of non-tuberculous and tuberculous mycobacteria: a comparative review.","authors":"Jean-François Guégan,Kayla M Fast,Christine Chevillon,Marina Cobos-Mayo,Alisa Aliaga-Samanez,Magdalene Dogbe,Matthew Scott,Kelly Waters,Melissa K Benbow,Jennifer L Pechal,Joseph P Receveur,Michael W Sandel,Heather R Jordan,M Eric Benbow","doi":"10.1128/cmr.00228-24","DOIUrl":"https://doi.org/10.1128/cmr.00228-24","url":null,"abstract":"SUMMARYDespite the clinical relevance of major tuberculous pathogens to domestic animals and humans, the understanding of mycobacterial transmission modes, pathways, and interactions in their natural habitats remains very limited. The reason for this is primarily because ecological and evolutionary concepts have not yet been widely applied to the understanding of these bacteria. Most existing research on mycobacterial transmission is not founded on hypothesis testing but rather tends to accept the most recent explanation and turn it into a canonical fact. In this comparative review, we discuss plausible alternative hypotheses against a null hypothesis of environmental origin to intensify research on mycobacterial pathogens and their capacity to spread in the context of global change. We highlight a major bias in perceptions of mycobacterial infection transmission, with most work concentrating only on the contagious stage of tuberculous clones. We suggest broadening the field to include research on environmental non-tuberculous mycobacteria and their life histories. A deeper understanding of mycobacterial ecology and evolution is more important now than ever, considering the vast diversity of known and unknown mycobacterial species in natural ecosystems. Infectious disease medicine, veterinary science, and public health surveillance should take a more integrative disease ecology approach to enhance the development of new approaches for control of these animal and human pathogens.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"3 1","pages":"e0022824"},"PeriodicalIF":36.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate. 二十年的人类博卡病毒研究：从一种致病性不明确的不可培养病毒到一种可培养的人类病原体和基因治疗载体候选。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-10-01 DOI: 10.1128/cmr.00173-24

Oliver Schildgen,Jianming Qiu,Mario Mietzsch,Tobias Allander,Tuomas Jartti,Verena Schildgen,Dirk Grimm,Maria Söderlund-Venermo

{"title":"Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.","authors":"Oliver Schildgen,Jianming Qiu,Mario Mietzsch,Tobias Allander,Tuomas Jartti,Verena Schildgen,Dirk Grimm,Maria Söderlund-Venermo","doi":"10.1128/cmr.00173-24","DOIUrl":"https://doi.org/10.1128/cmr.00173-24","url":null,"abstract":"SUMMARYTwenty years after the first description of human bocavirus 1 (HBoV1) as a respiratory pathogen, significant progress has been made in both clinical and basic research; however, important clinical, diagnostic, and molecular challenges remain before bocavirus pathobiology is fully understood. The discovery of HBoV1 and its notorious prolonged shedding have challenged the new sensitive multiplex PCR panel-based diagnostic testing that replaced the old antigen assays, leading to erroneous classification of HBoV1 as an innocent bystander. Both sophisticated diagnostics and cytopathic effects in cell culture have now confirmed HBoV1 to be a common cause of upper and lower respiratory tract infections, mainly in children. While many questions have been answered, new questions have emerged as our understanding of parvoviruses has significantly expanded over the past two decades. In this review, key findings from 20 years of clinical, basic, and applied research on human bocaviruses are summarized and open questions highlighted to guide future investigations.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"53 1","pages":"e0017324"},"PeriodicalIF":36.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fastidious or rarely isolated gram-negative rods with a particular focus on Kingella kingae. 挑剔的或很少分离的革兰氏阴性杆状体，特别集中在Kingella kingae上。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-25 DOI: 10.1128/cmr.00048-25

Reinhard Zbinden,Pablo Yagupsky

{"title":"Fastidious or rarely isolated gram-negative rods with a particular focus on Kingella kingae.","authors":"Reinhard Zbinden,Pablo Yagupsky","doi":"10.1128/cmr.00048-25","DOIUrl":"https://doi.org/10.1128/cmr.00048-25","url":null,"abstract":"SUMMARYThe bacterial species covered in this review are taxonomically diverse. Kingella kingae, a well-known infectious agent of pediatric bacteremia and osteomyelitis as well as septic arthritis in children aged 6-36 months, is the focus of this review. Recent advances in molecular diagnostic tools have allowed new aspects of pathogenesis and transmission to be investigated since the last review of K. kingae in this journal. Asymptomatic oropharyngeal colonization with noninvasive strains can be distinguished from invasive clones, so that a positive detection in the oropharynx can be assumed to be compatible with a clinical entity caused by K. kingae. Furthermore, novel and uncommon infections could be attributed to K. kingae. Clinical and microbiological aspects of the other Kingella spp. and of the genera Actinobacillus, Aggregatibacter, Capnocytophaga, Cardiobacterium, Chromobacterium, Dysgonomonas, Eikenella, Pasteurella, Simonsiella, Streptobacillus, and Suttonella are discussed separately. The identification of most genera by phenotypic methods is difficult. Direct microscopy and phenotypic key reactions, as well as commercially available systems, allow identification of the frequently encountered human species. If accurate identification of uncommon isolates is a concern, molecular methods, such as 16S ribosomal RNA gene PCR/sequencing, are necessary. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry can also be helpful. Besides infections with only one infectious agent, all mentioned genera are often found in mixed infections. The accompanying bacteria and the clinical presentation might guide the antibiotic choice. In general, it can be said that empirical treatment of infections with the fastidious gram-negative rods based on the clinical picture sometimes fails due to antibiotic resistance. Susceptibility testing should be performed on all isolates according to the CLSI or EUCAST guidelines in order to adjust treatment if necessary.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"2 1","pages":"e0004825"},"PeriodicalIF":36.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized use and performance of culture for periprosthetic joint infection diagnosis: a comprehensive literature review. 优化使用和性能培养假体周围关节感染诊断：综合文献综述。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-18 DOI: 10.1128/cmr.00054-25

Jaime Esteban,Robin Patel,John-Jairo Aguilera-Correa,Sandra B Nelson,

引用次数: 0

Sexually transmitted enteric infections in men who have sex with men. 男男性行为者的性传播肠道感染。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-17 DOI: 10.1128/cmr.00075-23

Kira L Newman,Gretchen Snoeyenbos Newman,Chase A Cannon,Ferric C Fang

引用次数: 0

Skin microbiota in atopic dermatitis: victim or executioner? 特应性皮炎的皮肤微生物群：受害者还是刽子手？

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-06-03 DOI: 10.1128/cmr.00277-24

Chiara Maria Teresa Boggio, Federica Veronese, Marta Armari, Elisa Zavattaro, Elia Esposto, Paola Savoia, Barbara Azzimonti

{"title":"Skin microbiota in atopic dermatitis: victim or executioner?","authors":"Chiara Maria Teresa Boggio, Federica Veronese, Marta Armari, Elisa Zavattaro, Elia Esposto, Paola Savoia, Barbara Azzimonti","doi":"10.1128/cmr.00277-24","DOIUrl":"10.1128/cmr.00277-24","url":null,"abstract":"SUMMARYAtopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder, affecting 10%-20% of the population, characterized by dryness, intense itching, and recurrent rashes. The pathophysiology of AD is multifactorial, involving skin barrier dysfunction, immune dysregulation, genetic factors (such as filaggrin mutations), and environmental factors. The skin microbiota also plays a pivotal role in AD, serving both as a target and a driver of the disease. In AD, the delicate balance of the skin microbiota is disrupted, leading to a decrease in beneficial bacteria such as Streptococcus, Cutibacterium, and Corynebacterium. Concurrently, bacterial pathobionts, notably Staphylococcus aureus, proliferate and express their virulence factors excessively. This imbalance exacerbates symptoms by damaging the skin barrier, releasing toxins, and triggering a Th2-driven immune response, thus weakening the skin defenses and making individuals with AD more susceptible to bacterial, fungal, and viral infections, thereby complicating treatment and worsening disease outcomes. Effective AD management requires a thorough understanding of the interplay among the skin microbiota, the immune system, and microbial pathobionts. Strategies that restore the microbial balance, preserve the skin barrier, and modulate the immune response show significant potential for reducing infections and improving AD symptoms, highlighting the microbiota's dual role in AD pathology. This review examines the complex role of the skin microbiota in AD, emphasizing how dysbiosis both drives disease progression and influences immune responses, and vice versa. It also explores emerging microbiota-targeted therapies aimed at improving disease outcomes.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0027724"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial and fungal infections in persons who inject drugs. 注射毒品者的细菌和真菌感染。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-06-13 DOI: 10.1128/cmr.00162-23

Jeffrey Masters, David Goodman-Meza, Danielle Russell, Laura Marks, Erin McCreary, Brendan Jacka, Kate Seear, Joshua S Davis, Gail Matthews, Marianne Martinello, Steven Y C Tong, Gregory J Dore

{"title":"Bacterial and fungal infections in persons who inject drugs.","authors":"Jeffrey Masters, David Goodman-Meza, Danielle Russell, Laura Marks, Erin McCreary, Brendan Jacka, Kate Seear, Joshua S Davis, Gail Matthews, Marianne Martinello, Steven Y C Tong, Gregory J Dore","doi":"10.1128/cmr.00162-23","DOIUrl":"10.1128/cmr.00162-23","url":null,"abstract":"SUMMARYPersons who inject drugs are at increased risk of bacterial and fungal injecting-related infections due to many physiological, societal, and structural factors. An estimated 15 million persons inject drugs worldwide, with recent increases in the burden of injecting-related infections. Acquisition of these infections has distinct pathophysiology and microbiology related to drug supply, drug composition, and the process of injecting. Clinical management of these infections is complicated by usual factors such as the need for source control and effective antibiotics, as well as the complex challenges faced by persons who inject drugs while in hospital. These challenges include drug withdrawal, difficult pain control related to opioid tolerance, stigma, discrimination, and lack of access to outpatient parenteral antibiotic therapy, which can lead to high rates of patient-directed discharge and non-completion of treatment with subsequent poor outcomes. This review seeks to provide an evidence-based summary of what is known about the risks, epidemiology, microbiology, and presentation of injecting-related bacterial and fungal infections, as well as provide recommendations for treatment, including pharmacological considerations, opportunistic screening, multidisciplinary team care, and approaches to outpatient therapy. It also provides insight into the medicolegal and ethical considerations of care for persons who inject drugs and a first-person perspective of someone with lived experience.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0016223"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum for Kramer et al., 'How long do bacteria, fungi, protozoa, and viruses retain their replication capacity on inanimate surfaces? A systematic review examining environmental resilience versus healthcare-associated infection risk by "fomite-borne risk assessment"'. 对Kramer等人的勘误，“细菌、真菌、原生动物和病毒在无生命表面上的复制能力能保持多久？”通过“污染物传播风险评估”对环境恢复力与卫生保健相关感染风险进行系统审查。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-06-04 DOI: 10.1128/cmr.00129-25

Axel Kramer, Franziska Lexow, Anna Bludau, Antonia Milena Köster, Martin Misailovski, Ulrike Seifert, Maren Eggers, William Rutala, Stephanie J Dancer, Simone Scheithauer

引用次数: 0

Biologic drug development for treatment and prevention of sexually transmitted infections. 用于治疗和预防性传播感染的生物药物开发。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-05-29 DOI: 10.1128/cmr.00107-24

Davinder S Gill, Sanjay Ram, Peter A Rice

{"title":"Biologic drug development for treatment and prevention of sexually transmitted infections.","authors":"Davinder S Gill, Sanjay Ram, Peter A Rice","doi":"10.1128/cmr.00107-24","DOIUrl":"10.1128/cmr.00107-24","url":null,"abstract":"SUMMARYSexually transmitted infections (STIs) represent a significant global health burden, with over one million new infections occurring daily. In some instances, the prevalence of antibiotic-resistant pathogens is rising, which exacerbates the challenge. STIs cause severe complications, including infertility, ectopic pregnancies, pre-term births, and heightened risks of HIV acquisition. These outcomes underscore the need for innovative therapeutic and prophylactic strategies. In this review, we provide a comprehensive analysis of the current state of biologic drug development targeting key STIs, focusing on Chlamydia trachomatis, Neisseria gonorrhoeae, herpes simplex virus type 2 (HSV-2), and Treponema pallidum. We examine the complexity of host-pathogen interactions that inform biologic drug design, such as multiple mechanisms of infection, immune evasion strategies, and pathogenic latency. We also explore the role of mucosal immunity, highlighting advances in resident memory T cells and cytokine-driven responses that guide therapeutic targeting, concentrating on Chlamydia trachomatis and Neisseria gonorrhoeae, where recent advances in vaccine development appear promising. We conduct a comprehensive survey of platforms, including vaccines, and explore modalities such as monoclonal antibodies and protein therapeutics. Additionally, we examine emerging technologies like nucleic acid-based therapies, microbiome modulation, and phage-based interventions, highlighting their potential against challenging pathogens like HSV-2 and Treponema pallidum. By examining these established and emerging approaches, this review prioritizes critical opportunities for innovation in biologic therapeutics, addressing unmet needs in STI management. It advocates for integrated strategies leveraging antigenic conservation, host immunity modulation, and novel delivery platforms to achieve durable prophylaxis and effective treatment for high-burden infections globally.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0010724"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0