Clinical Microbiology Reviews最新文献_第2页

Emerging hybrid shigatoxigenic and enteropathogenic Escherichia coli serotype O80:H2 in humans and calves. 人类和小牛中新出现的致病性和致病性大肠埃希菌O80:H2血清型。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-05-29 DOI: 10.1128/cmr.00011-25

Jacques G Mainil, Keiji Nakamura, Rie Ikeda, Florence Crombé, Jacob Diderich, Marc Saulmont, Denis Piérard, Damien Thiry, Tetsuya Hayashi

{"title":"Emerging hybrid shigatoxigenic and enteropathogenic Escherichia coli serotype O80:H2 in humans and calves.","authors":"Jacques G Mainil, Keiji Nakamura, Rie Ikeda, Florence Crombé, Jacob Diderich, Marc Saulmont, Denis Piérard, Damien Thiry, Tetsuya Hayashi","doi":"10.1128/cmr.00011-25","DOIUrl":"10.1128/cmr.00011-25","url":null,"abstract":"SUMMARYAttaching-effacing (AE) lesion- and Shiga toxin-producing Escherichia (E.) coli (AE-STEC), previously known as \"enterohemorrhagic E. coli\" (EHEC), are responsible for (hemorrhagic) enterocolitis (HC) and hemolytic uremic syndrome (HUS) in humans. The most frequent and pathogenic AE-STEC belong to a few O:H major serotypes that are responsible for the majority of cases and outbreaks worldwide. From time to time, one or another non-major O:H serotype can emerge, causing either local outbreaks or a a progressive increase in clinical cases. One of these minor serotypes is O80:H2, which has been progressively emerging in Western Europe, especially in France, since 2010. AE-STEC O80:H2 are responsible for not only HC and HUS but also invasive infections with bacteremia and internal organ infection. In parallel to their emergence in humans, AE-STEC and enteropathogenic E. coli (EPEC) O80:H2 have also been emerging in young calves suffering diarrhea and enteritis and, more rarely septicemia, in Belgium since 2009. In this manuscript, an overview of AE-STEC and EPEC O80:H2 infections in humans and calves is presented, with particular focus on the clinical manifestations, the prevalence and incidence in Western Europe, and the identification of the potential reservoir(s). In addition, the results of a large-scale whole genome-based phylogenetic analysis of 417 published and unpublished genome sequences currently available in the literature and in the NCBI and EnteroBase databases are presented with hypotheses on the origin and evolution of this new hybrid AE-STEC and EPEC serotype.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0001125"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human toxocariasis.

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-11 Epub Date: 2025-07-07 DOI: 10.1128/cmr.00101-23

Susana Lopez-Alamillo, Pravallika Padyala, Megan Carey, Megan M Duffey, Jill E Weatherhead

{"title":"Human toxocariasis.","authors":"Susana Lopez-Alamillo, Pravallika Padyala, Megan Carey, Megan M Duffey, Jill E Weatherhead","doi":"10.1128/cmr.00101-23","DOIUrl":"10.1128/cmr.00101-23","url":null,"abstract":"SUMMARYHuman toxocariasis is a globally prevalent zoonotic parasitic infection caused by larvae of Toxocara species, primarily Toxocara canis and Toxocara cati. Toxocariasis is commonly transmitted to humans through the ingestion of embryonated Toxocara eggs found in contaminated soil, water, or on surfaces contaminated with animal feces. Unlike in dogs and cats, humans are not definitive hosts for Toxocara spp., and, as a result, Toxocara larvae do not complete their life cycle in humans. Instead, following accidental oral ingestion of embryonated eggs, Toxocara larvae undergo an aberrant larval migratory cycle to various organs including the lungs, liver, muscles, and central nervous system, and do not return to the intestines to develop into mature adult worms. As the Toxocara larvae do not complete their life cycle in the human host, they will ultimately die in human tissue. This comprehensive systematic review of human toxocariasis analyzes and synthesizes existing research to provide a detailed and updated understanding of this zoonotic parasitic infection of global importance. This review provides an in-depth analysis of various aspects of toxocariasis, including its epidemiology, microbiology, pathogenesis, clinical manifestations, diagnostic methods, and treatment strategies.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0010123"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteus spp.-taxonomy, clinical significance, and antibiotic resistance of a highly versatile pathogen. 变形杆菌的分类，临床意义，和高度通用病原体的抗生素耐药性。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-08 DOI: 10.1128/cmr.00181-24

Linea Katharina Muhsal,Lisa Theis,Jörg Overmann,Axel Hamprecht

引用次数: 0

Dengue and severe dengue. 登革热和重症登革热。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-05 DOI: 10.1128/cmr.00244-24

Shirin Kalimuddin, Po Ying Chia, Jenny G Low, Eng Eong Ooi

{"title":"Dengue and severe dengue.","authors":"Shirin Kalimuddin, Po Ying Chia, Jenny G Low, Eng Eong Ooi","doi":"10.1128/cmr.00244-24","DOIUrl":"https://doi.org/10.1128/cmr.00244-24","url":null,"abstract":"SUMMARYDengue is an acute mosquito-borne viral disease that is highly prevalent throughout the tropical world. The geographic footprint of the four dengue viruses (DENV-1 to -4) that cause this disease and their Aedes mosquito vector is expanding, extending into North America and Mediterranean Europe. Furthermore, although dengue has historically been a disease that disproportionately affects children, changing population demographics and increasing travel to and from the tropics have contributed to a growing incidence in adults. Dengue in adults, particularly older adults, brings fresh and complex challenges to case management. Although dengue is now a vaccine-preventable disease, the efficacy profiles of licensed vaccines as well as those in late-stage clinical development suggest that vaccination alone would not fully retard the global expansion of dengue. Other countermeasures, including antiviral drugs, will be needed. This paper reviews the molecular interplay underlying dengue pathogenesis, including from virological and immunological perspectives, which are foundational for developing antiviral therapies and new vaccines. It also reviews the hurdles facing antiviral development and discusses new insights on dengue immunity that can guide the deployment of imperfect vaccines to begin reversing the global burden of dengue.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0024424"},"PeriodicalIF":19.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating whole-genome sequencing into antimicrobial resistance surveillance: methodologies, challenges, and perspectives. 整合全基因组测序到抗菌素耐药性监测：方法，挑战和观点。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-05 DOI: 10.1128/cmr.00140-22

Yasufumi Matsumura,Masaki Yamamoto,Ryota Gomi,Yasuhiro Tsuchido,Koh Shinohara,Taro Noguchi,Miki Nagao

{"title":"Integrating whole-genome sequencing into antimicrobial resistance surveillance: methodologies, challenges, and perspectives.","authors":"Yasufumi Matsumura,Masaki Yamamoto,Ryota Gomi,Yasuhiro Tsuchido,Koh Shinohara,Taro Noguchi,Miki Nagao","doi":"10.1128/cmr.00140-22","DOIUrl":"https://doi.org/10.1128/cmr.00140-22","url":null,"abstract":"SUMMARYAntimicrobial resistance (AMR) poses a significant threat to global public health. Surveillance is a fundamental method for controlling AMR and guiding clinical decisions, public health interventions, and policymaking. Whole-genome sequencing (WGS) provides a comprehensive and accurate understanding of AMR mechanisms, gene profiling, and transmission dynamics. Public health authorities, academic scholars, hospitals, and laboratories have increasingly employed WGS-based surveillance for retrospective, real-time, and prospective monitoring of AMR and investigations of outbreaks. WGS-based surveillance has improved the accuracy and effectiveness of disease and AMR surveillance by identifying hidden transmissions and sources missed by conventional methods and by rapidly investigating and deploying infection control interventions. However, WGS analysis involves a complex combination of workflows of next-generation sequencing and bioinformatics data analysis, making it difficult to effectively compare surveillance results. It is crucial to understand the limitations of our existing WGS analyses by implementing rigorous validation practices across different WGS analyses, developing practice guidelines, and establishing appropriate quality assurance measures. These efforts will aid in the development of reliable and robust WGS systems, the harmonization and standardization of surveillance programs, and the development of public data sharing and governance frameworks. Despite these challenges, the expansion of WGS-based AMR surveillance is expected to be driven by technological advances, standardization efforts, and the recognition of its advantages among stakeholders. The integration of genomic data with nongenomic information, as well as interdisciplinary collaborations will further enhance knowledge regarding AMR and promote the development of countermeasures.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"30 1","pages":"e0014022"},"PeriodicalIF":36.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on clinically relevant, rare, and emerging Candida and Saccharomycotina yeasts that have been recently reclassified from Candida. 最近从念珠菌中重新分类的临床相关的，罕见的和新兴的念珠菌和酵母菌属酵母的更新。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-03 DOI: 10.1128/cmr.00064-23

Elaine Cristina Francisco, Diego H Caceres, José Guillermo Pereira Brunelli, Guillermo Garcia-Effron, Amir Arastehfar, Felipe de Camargo Ribeiro, Matheus Naves de Almeida, Sarah Santos Gonçalves, João Nóbrega de Almeida, Cornelia Lass-Flörl, Teun Boekhout, Arnaldo Lopes Colombo

{"title":"An update on clinically relevant, rare, and emerging Candida and Saccharomycotina yeasts that have been recently reclassified from Candida.","authors":"Elaine Cristina Francisco, Diego H Caceres, José Guillermo Pereira Brunelli, Guillermo Garcia-Effron, Amir Arastehfar, Felipe de Camargo Ribeiro, Matheus Naves de Almeida, Sarah Santos Gonçalves, João Nóbrega de Almeida, Cornelia Lass-Flörl, Teun Boekhout, Arnaldo Lopes Colombo","doi":"10.1128/cmr.00064-23","DOIUrl":"10.1128/cmr.00064-23","url":null,"abstract":"SUMMARYMany yeast species causing life-threatening invasive infections that were formerly classified in the genus Candida have been reclassified due to their evolutionary and phylogenetic relationships elucidated by DNA sequencing methods that are increasingly using whole genomes. This review explores the evolving taxonomy, epidemiology, and clinical implications of clinically relevant, rare, emerging Candida and Saccharomycotina yeasts that have recently been reclassified from Candida. This article highlights the urgent need for intensified research efforts to enhance knowledge and improve outcomes in the management of infections caused by these yeasts. Communicating results from molecular phylogenetic studies of yeasts, which lead to their reclassification, is of great importance to the medical mycology community to implement such results in clinical practice.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0006423"},"PeriodicalIF":19.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The oral penems and carbapenems. 口服青霉烯类和碳青霉烯类。

IF 19.3 1区医学

Clinical Microbiology Reviews Pub Date : 2025-09-03 DOI: 10.1128/cmr.00042-24

Sena Sayood, Elizabeth Neuner, Rebekah Dumm, Sumanth Gandra

引用次数: 0

A review of post-exposure strategies for high-consequence viral pathogens in the laboratory 高后果病毒病原体实验室暴露后策略综述

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-29 DOI: 10.1128/cmr.00236-24

Grace Butel-SimoesMichael A. MosoPrashanth RamachandranMaryza GrahamDeborah A. WilliamsonChuan Kok Lim1Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity534133, Melbourne, Victoria, Australia2Department of Infectious Diseases, University of Melbourne, Peter Doherty Institute for Infection and Immunity2281https://ror.org/01ej9dk98, Melbourne, Victoria, Australia3Victorian Infectious Diseases Service, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity534133, Melbourne, Victoria, Australia4Monash University2541https://ror.org/02bfwt286, Clayton, Victoria, Australia5School of Medicine, University of St Andrews7486https://ror.org/02wn5qz54, Fife, ScotlandAudrey N. SchuetzAaron M. T. BarnesAditya Shah

引用次数: 0

Adoptive T-cell therapy for virus-associated diseases 过继t细胞治疗病毒相关疾病

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-22 DOI: 10.1128/cmr.00198-24

Corey SmithRajiv Khanna1Queensland Immunology Research Centre and Inflammation and Infection Program, QIMR Berghofer Medical Research Institutehttps://ror.org/004y8wk30, Brisbane, Australia2School of Biological Sciences, University of Queensland1974https://ror.org/00rqy9422, Brisbane, AustraliaGraeme N. Forrest

引用次数: 0

Drug-resistant Acinetobacter baumannii: mortality, emerging treatments, and future pharmacological targets for a WHO priority pathogen. 耐药鲍曼不动杆菌：世卫组织重点病原体的死亡率、新出现的治疗方法和未来的药理学靶点。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-08-11 DOI: 10.1128/cmr.00279-24

Vineet Dubey,Nada Reza,William Hope

{"title":"Drug-resistant Acinetobacter baumannii: mortality, emerging treatments, and future pharmacological targets for a WHO priority pathogen.","authors":"Vineet Dubey,Nada Reza,William Hope","doi":"10.1128/cmr.00279-24","DOIUrl":"https://doi.org/10.1128/cmr.00279-24","url":null,"abstract":"SUMMARYAcinetobacter baumannii has emerged as a formidable global health concern and is a major contributor to infection-related mortality in critically ill patients worldwide. This versatile Gram-negative bacterium is notorious for its highly plastic genome, which enables the rapid emergence and dissemination of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, severely limiting the available treatment options. The genetic flexibility of A. baumannii underpins its arsenal of molecular mechanisms, enabling it to resist a range of antibiotics, from traditional agents to the latest therapeutic advancements available. With the progress made in treatments against Acinetobacter infections and various drugs undergoing clinical trials, the effectiveness of these treatments is often outpaced by the pathogen's swift evolution of resistance, resulting in alarmingly high rates of treatment failure. In this systematic review of literature spanning 2004-2024, we highlight the high mortality rates associated with infections caused by XDR strains and carbapenem-resistant A. baumannii (CRAB). This review provides a comprehensive examination of the resistance mechanisms deployed by A. baumannii, encompassing both conventional antibiotics and novel agents used in global healthcare settings. In addition, we discuss emerging druggable targets and the inherent challenges in their development, offering strategic insights into next-generation therapeutic programs. A deep profound understanding of the pathogen's molecular defenses is essential to guide the design of innovative therapies aimed at mitigating the escalating threat posed by A. baumannii.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":"12 1","pages":"e0027924"},"PeriodicalIF":36.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0