Clinical Microbiology Reviews最新文献_第2页

Biologic drug development for treatment and prevention of sexually transmitted infections. 用于治疗和预防性传播感染的生物药物开发。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-05-29 DOI: 10.1128/cmr.00107-24

Davinder S Gill, Sanjay Ram, Peter A Rice

{"title":"Biologic drug development for treatment and prevention of sexually transmitted infections.","authors":"Davinder S Gill, Sanjay Ram, Peter A Rice","doi":"10.1128/cmr.00107-24","DOIUrl":"https://doi.org/10.1128/cmr.00107-24","url":null,"abstract":"SUMMARYSexually transmitted infections (STIs) represent a significant global health burden, with over one million new infections occurring daily. In some instances, the prevalence of antibiotic-resistant pathogens is rising, which exacerbates the challenge. STIs cause severe complications, including infertility, ectopic pregnancies, pre-term births, and heightened risks of HIV acquisition. These outcomes underscore the need for innovative therapeutic and prophylactic strategies. In this review, we provide a comprehensive analysis of the current state of biologic drug development targeting key STIs, focusing on Chlamydia trachomatis, Neisseria gonorrhoeae, herpes simplex virus type 2 (HSV-2), and Treponema pallidum. We examine the complexity of host-pathogen interactions that inform biologic drug design, such as multiple mechanisms of infection, immune evasion strategies, and pathogenic latency. We also explore the role of mucosal immunity, highlighting advances in resident memory T cells and cytokine-driven responses that guide therapeutic targeting, concentrating on Chlamydia trachomatis and Neisseria gonorrhoeae, where recent advances in vaccine development appear promising. We conduct a comprehensive survey of platforms, including vaccines, and explore modalities such as monoclonal antibodies and protein therapeutics. Additionally, we examine emerging technologies like nucleic acid-based therapies, microbiome modulation, and phage-based interventions, highlighting their potential against challenging pathogens like HSV-2 and Treponema pallidum. By examining these established and emerging approaches, this review prioritizes critical opportunities for innovation in biologic therapeutics, addressing unmet needs in STI management. It advocates for integrated strategies leveraging antigenic conservation, host immunity modulation, and novel delivery platforms to achieve durable prophylaxis and effective treatment for high-burden infections globally.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0010724"},"PeriodicalIF":19.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging hybrid shigatoxigenic and enteropathogenic Escherichia coli serotype O80:H2 in humans and calves. 人类和小牛中新出现的致病性和致病性大肠埃希菌O80:H2血清型。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-05-29 DOI: 10.1128/cmr.00011-25

Jacques G Mainil, Keiji Nakamura, Rie Ikeda, Florence Crombé, Jacob Diderich, Marc Saulmont, Denis Piérard, Damien Thiry, Tetsuya Hayashi

{"title":"Emerging hybrid shigatoxigenic and enteropathogenic Escherichia coli serotype O80:H2 in humans and calves.","authors":"Jacques G Mainil, Keiji Nakamura, Rie Ikeda, Florence Crombé, Jacob Diderich, Marc Saulmont, Denis Piérard, Damien Thiry, Tetsuya Hayashi","doi":"10.1128/cmr.00011-25","DOIUrl":"https://doi.org/10.1128/cmr.00011-25","url":null,"abstract":"SUMMARYAttaching-effacing (AE) lesion- and Shiga toxin-producing Escherichia (E.) coli (AE-STEC), previously known as \"enterohemorrhagic E. coli\" (EHEC), are responsible for (hemorrhagic) enterocolitis (HC) and hemolytic uremic syndrome (HUS) in humans. The most frequent and pathogenic AE-STEC belong to a few O:H major serotypes that are responsible for the majority of cases and outbreaks worldwide. From time to time, one or another non-major O:H serotype can emerge, causing either local outbreaks or a a progressive increase in clinical cases. One of these minor serotypes is O80:H2, which has been progressively emerging in Western Europe, especially in France, since 2010. AE-STEC O80:H2 are responsible for not only HC and HUS but also invasive infections with bacteremia and internal organ infection. In parallel to their emergence in humans, AE-STEC and enteropathogenic E. coli (EPEC) O80:H2 have also been emerging in young calves suffering diarrhea and enteritis and, more rarely septicemia, in Belgium since 2009. In this manuscript, an overview of AE-STEC and EPEC O80:H2 infections in humans and calves is presented, with particular focus on the clinical manifestations, the prevalence and incidence in Western Europe, and the identification of the potential reservoir(s). In addition, the results of a large-scale whole genome-based phylogenetic analysis of 417 published and unpublished genome sequences currently available in the literature and in the NCBI and EnteroBase databases are presented with hypotheses on the origin and evolution of this new hybrid AE-STEC and EPEC serotype.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0001125"},"PeriodicalIF":19.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections. 临床微生物实验室实用指南：二形真菌感染的抗体和抗原检测方法。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-05-21 DOI: 10.1128/cmr.00005-20

Elitza S Theel,Julianne V Kus,Thomas E Grys,Neil M Ampel,Ilan S Schwartz,Sean X Zhang

引用次数: 0

Correction for Moreland et al., "Rapid and accurate testing for urinary tract infection: new clothes for the emperor". 更正Moreland等人的“快速准确的尿路感染检测：皇帝的新衣”。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-05-14 DOI: 10.1128/cmr.00103-25

Robert B Moreland,Linda Brubaker,Lana Tinawi,Alan J Wolfe

引用次数: 0

Recent advances in therapeutic probiotics: insights from human trials 治疗性益生菌的最新进展：来自人体试验的见解

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-22 DOI: 10.1128/cmr.00240-24

Mu-Yeol ChoJe-Hyun EomEun-Mi ChoiSeung-Jo YangDahye LeeYoung Youn KimHye-Sung KimInseong Hwang1Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation, Goyang-si, South Korea2DOCSmedi, Co., Ltd., Goyang-si, South Korea3Department of Orthodontics, Apple Tree Dental Hospital, Goyang-si, South Korea4Department of Oral and Maxillofacial Surgery, Apple Tree Dental Hospital, Goyang-si, South KoreaChristopher Staley

引用次数: 0

Vaginal mycobiome characteristics and therapeutic strategies in vulvovaginal candidiasis (VVC): differentiating pathogenic species and microecological features for stratified treatment 外阴阴道念珠菌病（VVC）的阴道菌群特征和治疗策略：区分病原种类和微生态特征进行分层治疗

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-22 DOI: 10.1128/cmr.00284-24

Zimo LiuHua YangRoujie HuangXiaochuan LiTianshu SunLan Zhu1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collegehttps://ror.org/02drdmm93, Beijing, China2State Key Laboratory of Complex, Severe, and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China3Clinical Biobank, Center for Biomedical Technology, Institute of Clinical Medicine, National Science and Technology Key Infrastructure on Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collegehttps://ror.org/02drdmm93, Beijing, ChinaJorge CervantesLina Restrepo

引用次数: 0

Henipaviruses: epidemiology, ecology, disease, and the development of vaccines and therapeutics. 亨尼帕病毒：流行病学，生态学，疾病，以及疫苗和治疗方法的发展。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2024-12-23 DOI: 10.1128/cmr.00128-23

Jessica R Spengler, Michael K Lo, Stephen R Welch, Christina F Spiropoulou

引用次数: 0

The endothelium at the interface between tissues and Staphylococcus aureus in the bloodstream. 在组织和血液中的金黄色葡萄球菌之间的界面上的内皮。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2025-01-14 DOI: 10.1128/cmr.00098-24

Pietro Speziale, Timothy J Foster, Carla Renata Arciola

{"title":"The endothelium at the interface between tissues and Staphylococcus aureus in the bloodstream.","authors":"Pietro Speziale, Timothy J Foster, Carla Renata Arciola","doi":"10.1128/cmr.00098-24","DOIUrl":"10.1128/cmr.00098-24","url":null,"abstract":"SUMMARYStaphylococcus aureus is a major human pathogen. It can cause many types of infections, in particular bacteremia, which frequently leads to infective endocarditis, osteomyelitis, sepsis, and other debilitating diseases. The development of secondary infections is based on the bacterium's ability to associate with endothelial cells lining blood vessels. The success of endothelial colonization and infection by S. aureus relies on its ability to express a wide array of cell wall-anchored and secreted virulence factors. Establishment of endothelial infection by the pathogen is a multistep process involving adhesion, invasion, extravasation, and dissemination of the bacterium into surrounding tissues. The process is dependent on the type of endothelium in different organs (tissues) and pathogenetic potential of the individual strains. In this review, we report an update on the organization of the endothelium in the vessels, the structure and function of the virulence factors of S. aureus, and the several aspects of bacteria-endothelial cell interactions. After these sections, we will discuss recent advances in understanding the specific mechanisms of infections that develop in the heart, bone and joints, lung, and brain. Finally, we describe how neutrophils bind to endothelial cells, migrate to the site of infection to kill bacteria in the tissues, and how staphylococci counteract neutrophils' actions. Knowledge of the molecular details of S. aureus-endothelial cell interactions will promote the development of new therapeutic strategies and tools to combat this formidable pathogen.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0009824"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually transmitted human papillomavirus and related sequelae. 性传播的人乳头瘤病毒及其相关后遗症。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2025-02-14 DOI: 10.1128/cmr.00085-23

Wyatt Hanft, Helen Stankiewicz Karita, Nikka Khorsandi, Poonam Vohra, Rosalyn Plotzker

{"title":"Sexually transmitted human papillomavirus and related sequelae.","authors":"Wyatt Hanft, Helen Stankiewicz Karita, Nikka Khorsandi, Poonam Vohra, Rosalyn Plotzker","doi":"10.1128/cmr.00085-23","DOIUrl":"10.1128/cmr.00085-23","url":null,"abstract":"SUMMARYMore than 40 types of sexually transmitted human papillomavirus (HPV) infect the oropharyngeal and anogenital mucosa-high-risk types are associated with precancerous and cancerous lesions of the cervix, vagina, vulva, penis, anus, and oropharynx, and low-risk types cause non-malignant disease, such as anogenital warts. Though most HPV infections resolve spontaneously, immunodeficiencies may result in persistent infection and increased risk of HPV-related sequelae. The mechanism by which HPV results in malignant transformation is multifaceted, involving interactions with numerous cellular pathways, the host immune system, and potentially the host microbiome. Vaccination against HPV is highly efficacious in the prevention of infection and related sequelae, and there now exist several approved formulations that protect against both high- and low-risk types. Despite the advent of vaccination, early detection and treatment of cervical and anal precancerous lesions continues to be integral to secondary prevention-molecular HPV testing, cytology, and tissue biopsy allow for triaging of patients, after which appropriate treatment with close follow-up can avert cancer development.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0008523"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Group B streptococcal infections in pregnancy and early life. 孕期和生命早期的 B 组链球菌感染。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2024-11-25 DOI: 10.1128/cmr.00154-22

Gygeria Manuel, Joy Twentyman, Kristen Noble, Alison J Eastman, David M Aronoff, Ravin Seepersaud, Lakshmi Rajagopal, Kristina M Adams Waldorf

{"title":"Group B streptococcal infections in pregnancy and early life.","authors":"Gygeria Manuel, Joy Twentyman, Kristen Noble, Alison J Eastman, David M Aronoff, Ravin Seepersaud, Lakshmi Rajagopal, Kristina M Adams Waldorf","doi":"10.1128/cmr.00154-22","DOIUrl":"10.1128/cmr.00154-22","url":null,"abstract":"SUMMARYBacterial infections with Group B Streptococcus (GBS) are an important cause of adverse outcomes in pregnant individuals, neonates, and infants. GBS is a common commensal in the genitourinary and gastrointestinal tracts and can be detected in the vagina of approximately 20% of women globally. GBS can infect the fetus either during pregnancy or vaginal delivery resulting in preterm birth, stillbirth, or early-onset neonatal disease (EOD) in the first week of life. The mother can also become infected with GBS leading to postpartum endometritis, and rarely, maternal sepsis. An invasive GBS infection of the neonate may present after the first week of life (late-onset disease, LOD) through transmission from caregivers, breast milk, and other sources. Invasive GBS infections in neonates can result in sepsis, pneumonia, meningitis, neurodevelopmental impairment, death, and lifelong disability. A policy of routine screening for GBS rectovaginal colonization in well-resourced countries can trigger the administration of intrapartum antibiotic prophylaxis (IAP) when prenatal testing is positive, which drastically reduces rates of EOD. However, many countries do not routinely screen pregnant women for GBS colonization but may administer IAP in cases with a high risk of EOD. IAP does not reduce rates of LOD. A global vaccination campaign is needed to reduce the significant burden of invasive GBS disease that remains among infants and pregnant individuals. In this narrative review, we provide a comprehensive overview of the global impact of GBS colonization and infection, virulence factors and pathogenesis, and current and future prophylactics and therapeutics.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0015422"},"PeriodicalIF":19.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0