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Changes in fungal taxonomy: mycological rationale and clinical implications. 真菌分类学的变化：真菌学原理和临床意义。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-06 DOI: 10.1128/cmr.00099-22
Andrew M Borman, Elizabeth M Johnson
{"title":"Changes in fungal taxonomy: mycological rationale and clinical implications.","authors":"Andrew M Borman, Elizabeth M Johnson","doi":"10.1128/cmr.00099-22","DOIUrl":"10.1128/cmr.00099-22","url":null,"abstract":"<p><p>Numerous fungal species of medical importance have been recently subjected to and will likely continue to undergo nomenclatural changes as a result of the application of molecular approaches to fungal classification together with abandonment of dual nomenclature. Here, we summarize those changes affecting key groups of fungi of medical importance, explaining the mycological (taxonomic) rationale that underpinned the changes and the clinical relevance/importance (where such exists) of the key nomenclatural revisions. Potential mechanisms to mitigate unnecessary taxonomic instability are suggested, together with approaches to raise awareness of important changes to minimize potential clinical confusion.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71478798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets. 传染病中的微小RNA：潜在的诊断生物标志物和治疗靶点。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-01 DOI: 10.1128/cmr.00015-23
Muneyoshi Kimura, Sagar Kothari, Wajiha Gohir, Jose F Camargo, Shahid Husain
{"title":"MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets.","authors":"Muneyoshi Kimura, Sagar Kothari, Wajiha Gohir, Jose F Camargo, Shahid Husain","doi":"10.1128/cmr.00015-23","DOIUrl":"10.1128/cmr.00015-23","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They have been implicated in the pathogenesis of cancer and neurological, cardiovascular, and autoimmune diseases. Several recent studies have suggested that miRNAs are key players in regulating the differentiation, maturation, and activation of immune cells, thereby influencing the host immune response to infection. The resultant upregulation or downregulation of miRNAs from infection influences the protein expression of genes responsible for the immune response and can determine the risk of disease progression. Recently, miRNAs have been explored as diagnostic biomarkers and therapeutic targets in various infectious diseases. This review summarizes our current understanding of the role of miRNAs during viral, fungal, bacterial, and parasitic infections from a clinical perspective, including critical functional mechanisms and implications for their potential use as biomarkers and therapeutic targets.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2023 Acknowledgment of CMR Reviewers. 2023 感谢 CMR 评审员。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-12-20 DOI: 10.1128/cmr.00138-23
Graeme Forrest
{"title":"2023 Acknowledgment of CMR Reviewers.","authors":"Graeme Forrest","doi":"10.1128/cmr.00138-23","DOIUrl":"10.1128/cmr.00138-23","url":null,"abstract":"","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and management of cryptococcal meningitis in HIV-infected adults. 成人hiv感染者隐球菌性脑膜炎的诊断和治疗。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-12-20 Epub Date: 2023-11-28 DOI: 10.1128/cmr.00156-22
Thomas C McHale, David R Boulware, John Kasibante, Kenneth Ssebambulidde, Caleb P Skipper, Mahsa Abassi
{"title":"Diagnosis and management of cryptococcal meningitis in HIV-infected adults.","authors":"Thomas C McHale, David R Boulware, John Kasibante, Kenneth Ssebambulidde, Caleb P Skipper, Mahsa Abassi","doi":"10.1128/cmr.00156-22","DOIUrl":"10.1128/cmr.00156-22","url":null,"abstract":"<p><p>Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of all deaths related to advanced HIV disease, with the burden of disease predominantly experienced by people in resource-limited countries. Major advancements in diagnostics have introduced low-cost, easy-to-use antigen tests with remarkably high sensitivity and specificity. These tests have led to improved diagnostic accuracy and are essential for screening campaigns to reduce the burden of cryptococcosis. In the last 5 years, several high-quality, multisite clinical trials have led to innovations in therapeutics that have allowed for simplified regimens, which are better tolerated and result in less intensive monitoring and management of medication adverse effects. One trial found that a shorter, 7-day course of deoxycholate amphotericin B is as effective as the longer 14-day course and that flucytosine is an essential partner drug for reducing mortality in the acute phase of disease. Single-dose liposomal amphotericin B has also been found to be as effective as a 7-day course of deoxycholate amphotericin B. These findings have allowed for simpler and safer treatment regimens that also reduce the burden on the healthcare system. This review provides a detailed discussion of the latest evidence guiding the clinical management and special circumstances that make cryptococcal meningitis uniquely difficult to treat.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond 将废水监测作为公共卫生行动的工具：SARS-CoV-2 及其后
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-12-14 DOI: 10.1128/cmr.00103-22
Michael D. ParkinsBonita E. LeeNicole AcostaMaria BautistaCasey R. J. HubertSteve E. HrudeyKevin FrankowskiXiao-Li Pang1Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada2Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada3O’Brien Institute of Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada4Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada5Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada6Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada7Advancing Canadian Water Assets, University of Calgary, Calgary, Alberta, Canada8Provincial Health Laboratory, Alberta Health Services, Calgary, Alberta, Canada, Graeme N. Forrest
{"title":"Wastewater-based surveillance as a tool for public health action: SARS-CoV-2 and beyond","authors":"Michael D. ParkinsBonita E. LeeNicole AcostaMaria BautistaCasey R. J. HubertSteve E. HrudeyKevin FrankowskiXiao-Li Pang1Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada2Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada3O’Brien Institute of Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada4Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada5Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada6Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada7Advancing Canadian Water Assets, University of Calgary, Calgary, Alberta, Canada8Provincial Health Laboratory, Alberta Health Services, Calgary, Alberta, Canada, Graeme N. Forrest","doi":"10.1128/cmr.00103-22","DOIUrl":"https://doi.org/10.1128/cmr.00103-22","url":null,"abstract":"Clinical Microbiology Reviews, Ahead of Print. <br/>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138582749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management. 真菌性心内膜炎：病理生理学，流行病学，临床表现，诊断和管理。
IF 19 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-09-21 Epub Date: 2023-07-13 DOI: 10.1128/cmr.00019-23
George R Thompson, Jeffrey D Jenks, John W Baddley, James S Lewis, Matthias Egger, Ilan S Schwartz, Johannes Boyer, Thomas F Patterson, Sharon C-A Chen, Peter G Pappas, Martin Hoenigl
{"title":"Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.","authors":"George R Thompson, Jeffrey D Jenks, John W Baddley, James S Lewis, Matthias Egger, Ilan S Schwartz, Johannes Boyer, Thomas F Patterson, Sharon C-A Chen, Peter G Pappas, Martin Hoenigl","doi":"10.1128/cmr.00019-23","DOIUrl":"10.1128/cmr.00019-23","url":null,"abstract":"<p><p>Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. <i>Candida</i> spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by <i>Aspergillus</i> and <i>Histoplasma</i> spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high degree of clinical suspicion coupled with the judicious use of diagnostic tests is required for diagnosis. In addition to microbiological diagnostics (e.g., blood culture for <i>Candida</i> spp. or galactomannan testing and PCR for <i>Aspergillus</i> spp.), echocardiography remains critical for evaluation of potential infective endocarditis, although radionuclide imaging modalities such as <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography are increasingly being used. A multimodal treatment approach is necessary: surgery is usually required and should be accompanied by long-term systemic antifungal therapy, such as echinocandin therapy for <i>Candida</i> endocarditis or voriconazole therapy for <i>Aspergillus</i> endocarditis.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":19.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10132286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations. 支气管败血博德菌和百日咳博德菌：感染、免疫调节和疫苗注意事项的异同。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-09-21 Epub Date: 2023-06-12 DOI: 10.1128/cmr.00164-22
Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stéphanie Longet, Egbert Mundt, Stéphane Paul
{"title":"<i>Bordetella bronchiseptica</i> and <i>Bordetella pertussis</i>: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations.","authors":"Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stéphanie Longet, Egbert Mundt, Stéphane Paul","doi":"10.1128/cmr.00164-22","DOIUrl":"10.1128/cmr.00164-22","url":null,"abstract":"<p><p><i>Bordetella pertussis</i> and <i>Bordetella bronchiseptica</i> belong to the genus <i>Bordetella</i>, which comprises 14 other species. <i>B. pertussis</i> is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. <i>B. bronchiseptica</i> is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At the same time, it is increasingly implicated in human infections, while remaining an important pathogen in the veterinary field. Both <i>Bordetella</i> can evade and modulate host immune responses to support their persistence, although it is more pronounced in <i>B. bronchiseptica</i> infection. The protective immune responses elicited by both pathogens are comparable, while there are important characteristics in the mechanisms that differ. However, <i>B. pertussis</i> pathogenesis is more difficult to decipher in animal models than those of <i>B. bronchiseptica</i> because of its restriction to humans. Nevertheless, the licensed vaccines for each <i>Bordetella</i> are different in terms of formulation, route of administration and immune responses induced, with no known cross-reaction between them. Moreover, the target of the mucosal tissues and the induction of long-lasting cellular and humoral responses are required to control and eliminate <i>Bordetella</i>. In addition, the interaction between both veterinary and human fields are essential for the control of this genus, by preventing the infections in animals and the subsequent zoonotic transmission to humans.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9668006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for Nyaruaba et al., "Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future Outbreaks". Nyaruaba等人的勘误，“数字PCR在SARS-CoV-2/COVID-19时代的应用:未来疫情的路线图”。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-06-21 DOI: 10.1128/cmr.00052-23
Raphael Nyaruaba, Caroline Mwaliko, David Dobnik, Pavel Neužil, Patrick Amoth, Matilu Mwau, Junping Yu, Hang Yang, Hongping Wei
{"title":"Erratum for Nyaruaba et al., \"Digital PCR Applications in the SARS-CoV-2/COVID-19 Era: a Roadmap for Future Outbreaks\".","authors":"Raphael Nyaruaba,&nbsp;Caroline Mwaliko,&nbsp;David Dobnik,&nbsp;Pavel Neužil,&nbsp;Patrick Amoth,&nbsp;Matilu Mwau,&nbsp;Junping Yu,&nbsp;Hang Yang,&nbsp;Hongping Wei","doi":"10.1128/cmr.00052-23","DOIUrl":"https://doi.org/10.1128/cmr.00052-23","url":null,"abstract":"https://doi.org/10.1128/cmr.00168-21","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283480/pdf/cmr.00052-23.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9761308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Syphilis: a Review of Global Epidemiology. 先天性梅毒：全球流行病学回顾。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-06-21 Epub Date: 2023-03-15 DOI: 10.1128/cmr.00126-22
Leeyan S Gilmour, Tony Walls
{"title":"Congenital Syphilis: a Review of Global Epidemiology.","authors":"Leeyan S Gilmour, Tony Walls","doi":"10.1128/cmr.00126-22","DOIUrl":"10.1128/cmr.00126-22","url":null,"abstract":"<p><p>In 2007, the World Health Organization (WHO) launched a global health initiative for the elimination of mother-to-child transmission (MTCT) of syphilis. This condition is highly preventable through antenatal identification of syphilis infection and treatment with penicillin during pregnancy. This review summarizes the global status of MTCT of syphilis and concludes that this condition remains a significant issue worldwide. There are large variations in case rates by region, with the highest numbers of cases in the African and Eastern Mediterranean regions, where there are also the least data available. There are also pockets of high-incidence areas within the other regions. Although the general trend is of decreasing rates over time, there are concerning indications of consistently increasing congenital syphilis cases in some areas, particularly in areas which have previously had very low case numbers. A concerted effort will be required to achieve the 2007 WHO goal of worldwide elimination of MTCT of syphilis in the near future.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9759571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections. 治疗耐万古霉素肠球菌血流感染的药物。
IF 36.8 1区 医学
Clinical Microbiology Reviews Pub Date : 2023-06-21 Epub Date: 2023-04-17 DOI: 10.1128/cmr.00059-22
Kelly A Cairns, Andrew A Udy, Trisha N Peel, Iain J Abbott, Michael J Dooley, Anton Y Peleg
{"title":"Therapeutics for Vancomycin-Resistant Enterococcal Bloodstream Infections.","authors":"Kelly A Cairns, Andrew A Udy, Trisha N Peel, Iain J Abbott, Michael J Dooley, Anton Y Peleg","doi":"10.1128/cmr.00059-22","DOIUrl":"10.1128/cmr.00059-22","url":null,"abstract":"<p><p>Vancomycin-resistant enterococci (VRE) are common causes of bloodstream infections (BSIs) with high morbidity and mortality rates. They are pathogens of global concern with a limited treatment pipeline. Significant challenges exist in the management of VRE BSI, including drug dosing, the emergence of resistance, and the optimal treatment for persistent bacteremia and infective endocarditis. Therapeutic drug monitoring (TDM) for antimicrobial therapy is evolving for VRE-active agents; however, there are significant gaps in the literature for predicting antimicrobial efficacy for VRE BSIs. To date, TDM has the greatest evidence for predicting drug toxicity for the three main VRE-active antimicrobial agents daptomycin, linezolid, and teicoplanin. This article presents an overview of the treatment options for VRE BSIs, the role of antimicrobial dose optimization through TDM in supporting clinical infection management, and challenges and perspectives for the future.</p>","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":null,"pages":null},"PeriodicalIF":36.8,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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