Clinics in dermatology最新文献_第3页

Mucosal Melanoma: Review from a Pathologist Point of View. 粘膜黑色素瘤：从病理学家的角度回顾。

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-12 DOI: 10.1016/j.clindermatol.2024.09.008

Priyadharsini Nagarajan, Sook Jung Yun, Victor G Prieto

{"title":"Mucosal Melanoma: Review from a Pathologist Point of View.","authors":"Priyadharsini Nagarajan, Sook Jung Yun, Victor G Prieto","doi":"10.1016/j.clindermatol.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2024.09.008","url":null,"abstract":"Mucosal melanomas are rare malignant tumors arising from the epithelia lining the inner mucosal surfaces of the body. Unlike cutaneous melanoma, we have a limited understanding of mucosal melanomas is currently limited. Mucosal melanomas are characterized by genetic alterations quite distinct from cutaneous melanomas; however, their causative and promoting factors are unknown. These melanomas are characteristically diagnosed at a later stage due to their occult locations, leading to a worse prognosis. Dedicated staging systems for mucosal melanomas exist only for sinonasal and conjunctival melanomas. Therefore, risk stratification of patients with mucosal melanomas, particularly those arising from the anogenital area, is challenging. Recent studies have shown that minor modifications of the AJCC 8th Edition cutaneous melanoma staging system can group patients fairly robustly; however, the proposed T-categorization systems have yet to be validated in larger cohorts. We summarize the demographic, clinical, histopathologic, and molecular features of common subtypes of mucosal melanomas and highlight the outstanding needs in this field.","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncommon neoplasms mistakenly diagnosed as hidradenitis suppurativa: Report of three consecutive cases. 被误诊为化脓性扁桃体炎的罕见肿瘤：三个连续病例的报告。

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-12 DOI: 10.1016/j.clindermatol.2024.09.019

Valentina Caputo, Antonella Citterio, Franco Rongioletti

引用次数: 0

The Tiber Island in the history of dermatology and venereology, including the curious history of "K syndrome," the fictitious disease that scared the Nazis. 皮肤病学和性病学历史上的台伯河岛，包括 "K 综合征 "这一令纳粹闻风丧胆的虚构疾病的奇特历史。

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-11 DOI: 10.1016/j.clindermatol.2024.09.018

Luigi Valenzano, Angela Maria Ferraris, Leonard J Hoenig, Franco Rongioletti

引用次数: 0

Current Views on Melanoma: I. 目前对黑色素瘤的看法：I.

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-11 DOI: 10.1016/j.clindermatol.2024.09.011

Jane M Grant-Kels

引用次数: 0

Analysis of international publication trends in artificial intelligence in skin cancer. 皮肤癌人工智能国际出版趋势分析。

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-10 DOI: 10.1016/j.clindermatol.2024.09.012

Lu Yuan, Kai Jin, An Shao, Jia Feng, Caiping Shi, Juan Ye, Andrzej Grzybowski

{"title":"Analysis of international publication trends in artificial intelligence in skin cancer.","authors":"Lu Yuan, Kai Jin, An Shao, Jia Feng, Caiping Shi, Juan Ye, Andrzej Grzybowski","doi":"10.1016/j.clindermatol.2024.09.012","DOIUrl":"10.1016/j.clindermatol.2024.09.012","url":null,"abstract":"Bibliometric methods were used to analyze publications on the use of artificial intelligence (AI) in skin cancer from 2010 to 2022, aiming to explore current publication trends and future directions. A comprehensive search using four terms, \"artificial intelligence,\" \"machine learning,\" \"deep learning,\" and \"skin cancer,\" was performed in the Web of Science database for original English language publications on AI in skin cancer from 2010 to 2022. We visually analyzed publication, citation, and coupling information, focusing on authors, countries and regions, publishing journals, institutions, and core keywords. The analysis of 989 publications revealed a consistent year-on-year increase in publications from 2010 to 2022 (0.51% versus 33.57%). The United States, India, and China emerged as the leading contributors. IEEE Access was identified as the most prolific journal in this area. Key journals and influential authors were highlighted. Examination of the top 10 most cited publications highlights the significant potential of AI in oncology. Co-citation network analysis identified four primary categories of classical literature on AI in skin tumors. Keyword analysis indicated that \"melanoma,\" \"classification,\" and \"deep learning\" were the most prevalent keywords, suggesting that deep learning for melanoma diagnosis and grading is the current research focus. The term \"pigmented skin lesions\" showed the strongest burst and longest duration, whereas \"texture\" was the latest emerging keyword. AI represents a rapidly growing area of research in skin cancer with the potential to significantly improve skin cancer management. Future research will likely focus on machine learning and deep learning technologies for screening and diagnostic purposes.","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spitz melanoma. 斯皮茨黑色素瘤

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-10 DOI: 10.1016/j.clindermatol.2024.09.010

Philip E LeBoit

{"title":"Spitz melanoma.","authors":"Philip E LeBoit","doi":"10.1016/j.clindermatol.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2024.09.010","url":null,"abstract":"It has long been recognized that the histopathologic differential diagnosis between Spitz nevus and melanoma is sometimes extraordinarily difficult. Both can be composed of large oval to spindled melanocytes with abundant cytoplasm and large nuclei. Genomic studies over the last decade have clarified that Spitz tumors have diverse genetic initiating events, and that for each of these, there are benign, intermediate grade, and malignant lesions. Another discovery is that some melanomas can morphologically resemble Spitz tumors but have conventional initiating mutations (e.g., BRAF, NRAS). The current WHO definition of Spitz tumors restricts the spectrum to neoplasms with an activating mutation affecting the MAP kinase pathway, mostly fusions involving kinase genes. Whether splitting off Spitz tumors from other neoplasms that are only morphologically spitzoid will stand the test of time is uncertain, but for now, it does bring order to what has been a complex area. The recognition of Spitz melanoma will enable classification, follow-up, and the delineation of rational treatment guidelines for this important group of tumors, most of which are in young people. I have reviewed the logic of the WHO definition of Spitz tumors, the spectrum of tumors produced by initiating mutations, problems with the definition of Spitz melanoma, and have provided an example of this rare entity in the context of related tumors.","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jewish women dermatologists who escaped the perils of National Socialism: Triumph over adversity 逃离国家社会主义危险的犹太女皮肤科医生：战胜逆境

IF 2.7 4区医学

Clinics in dermatology Pub Date : 2024-09-10 DOI: 10.1016/j.clindermatol.2024.09.015

Sophie Walter BMed MD BSc(Med)(Hons), Lawrence Charles Parish MD MD (Hon) FRCP (Edin)

{"title":"Jewish women dermatologists who escaped the perils of National Socialism: Triumph over adversity","authors":"Sophie Walter BMed MD BSc(Med)(Hons), Lawrence Charles Parish MD MD (Hon) FRCP (Edin)","doi":"10.1016/j.clindermatol.2024.09.015","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2024.09.015","url":null,"abstract":"The period of National Socialism (1933-1945), including the Holocaust and World War II, has had a profound impact on dermatology. We have identified Jewish women dermatologists who escaped the perils of National Socialism, document their struggles, and describe their contribution to medicine and dermatology. Medical, history, and media databases were searched. Relevant contributions in languages other than English were translated into English. Fourteen dermatologists were identified, and for seven, there was sufficient information to describe their lives in more detail: Helen Ollendorff-Curth (née Ollendorff) (1899-1982), Bertha Ottenstein (1891-1956), Sidonie Fürst (1891-1973), Marianne Bauer (née Jokl) (1885-1980), Hedwig Fischer (née Hoffmann) (1888-1983), Vera Shukhman (1900-1987) and Lili Farkas (1899–1992). The challenges that confronted the dermatologists were sizeable. Status as a woman, antisemitism, persecution in various forms during National Socialism, murder of family and dermatology colleagues, untimely death of family members in other ways, loss of jobs and status, the stress of relocation, and myriad obstacles in a newly adopted country were among hurdles that they faced; nevertheless, collectively, the seven dermatologists could make a range of contributions in clinical, academic, and administrative areas. The dermatologists displayed courage, tenacity, and determination and served as role models of resilience for current and future generations of women in the dermatology field.","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer and hidradenitis suppurativa. 癌症与化脓性扁桃体炎

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-10 DOI: 10.1016/j.clindermatol.2024.09.014

Philip R Cohen, Rena A Cohen-Kurzrock, Ryan R Riahi

{"title":"Cancer and hidradenitis suppurativa.","authors":"Philip R Cohen, Rena A Cohen-Kurzrock, Ryan R Riahi","doi":"10.1016/j.clindermatol.2024.09.014","DOIUrl":"10.1016/j.clindermatol.2024.09.014","url":null,"abstract":"Patients with hidradenitis suppurativa (HS) have an increased risk of developing cancer. This includes not only hematologic malignancies and solid tumors but also cutaneous squamous cell carcinoma (SCC) originating within the HS lesions. The development of SCC is most commonly associated with Caucasian men who smoke and have severe gluteal or perianal lesions of more than 25 years. Other factors that have occasionally been associated with HS-related SCC include treatment with a tumor necrosis factor-alpha inhibitor (such as infliximab and adalimumab), genodermatoses (such as keratitis-ichthyosis-deafness syndrome and Dowling-Degos disease), and paraneoplastic syndromes (such as hypercalcemia, hypercalcemia-leukocytosis, and paraneoplastic neuropathy). The tumor may demonstrate the presence of human papillomavirus; even after treatment, patients have a poor prognosis because cancer metastasis, recurrence, or both commonly occur. The potential role of human papillomavirus vaccination for cancer prevention and early treatment of SCC with targeted therapy (with an epidermal growth factor inhibitor such as cetuximab) and/or checkpoint inhibitor immunotherapy (such as cemiplimab and pembrolizumab) remains to be determined. Rarely, HS lesions have mimicked cutaneous metastases in patients with visceral malignancy by demonstrating an increased uptake of fluorine-18 fluorodeoxyglucose on positron emission tomography and/or computed tomography scans. Primary cancers (such as cutaneous SCC and mucinous adenocarcinoma) and breast cancer skin metastases can masquerade as HS lesions. When a lesion is located at a current or earlier site of HS that is new or rapidly growing and/or does not respond to HS-directed therapy, prompt evaluation to establish or exclude the diagnosis of cancer should be considered.","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Implications of Mentor Influence on Career Choices in Dermatology. 导师对皮肤科职业选择影响的伦理意义。

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-09 DOI: 10.1016/j.clindermatol.2024.09.001

Albert E Zhou, Timothy Klufas, Philip Kerr, Brett Sloan, Hao Feng, Jane M Grant-Kels

引用次数: 0

Malignant blue melanoma. 恶性蓝色黑色素瘤

IF 2.3 4区医学

Clinics in dermatology Pub Date : 2024-09-09 DOI: 10.1016/j.clindermatol.2024.09.002

Yo Kaku, Arnaud de la Fouchardière

引用次数: 0