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Lymphogranuloma venereum, an invasive and destructive sexually transmitted infection with many faces. 性病性淋巴肉芽肿是一种侵袭性、破坏性的性传播感染，具有多面性。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-30 DOI: 10.1016/j.clindermatol.2025.09.009
Henry J C de Vries
{"title":"Lymphogranuloma venereum, an invasive and destructive sexually transmitted infection with many faces.","authors":"Henry J C de Vries","doi":"10.1016/j.clindermatol.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.009","url":null,"abstract":"<p><p>Lymphogranuloma venereum (LGV) is a serious, invasive, ulcerative sexually transmitted infection (STI) caused by C. trachomatis serovar L1, L2 and L3. Until 2003, we saw LGV among the general population of low- and middle-income countries (LMIC). Since 2003, we have also seen LGV in high-income countries (HIC), but exclusively in men who have sex with men (MSM). The number of patients with LGV has increased in the last decade, and the proportion in MSM without HIV has increased dramatically. In LMIC, LGV affects both women and men and often causes genital complaints. In the MSM population in HIC, the far majority of men suffer from ano-rectal infections that mimic chronic inflammatory bowel diseases like Crohns' disease. LGV is not always directly recognized, because the presentations are are often non-specific and additional diagnostics are not distinctive. When STI are not considered in the diagnostic work up, consequential delay and inappropriate treatments can occur. In patients with ano-rectal complaints, a properly conducted sexual history followed by STI diagnostics is key to diagnosing LGV. Early recognition and adequate antibiotic treatment can prevent complications, create unnecessary additional diagnostics, and halt further transmission.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contextualizing the Clinic: A Model for History and Ethics Curricula in Graduate Medical Education. 诊所情境化：研究生医学教育中历史与伦理学课程的模式。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-29 DOI: 10.1016/j.clindermatol.2025.09.016
Sana Kamboj, Saad Maan, Hala Idris, Ameya Gangal, Travis W Blalock
{"title":"Contextualizing the Clinic: A Model for History and Ethics Curricula in Graduate Medical Education.","authors":"Sana Kamboj, Saad Maan, Hala Idris, Ameya Gangal, Travis W Blalock","doi":"10.1016/j.clindermatol.2025.09.016","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.016","url":null,"abstract":"<p><p>The Accreditation Council of Graduate Medical Education (ACGME) requires ethics education for dermatology trainees; yet, less than half of American dermatology residencies currently include ethics in their curriculum. <sup>1, 2</sup> Barriers to establishing ethics curricula in dermatology residences include time restraints, lack of useful resources, and lack of faculty with expertise in dermatoethics.<sup>2</sup> We suggest a hybrid education model, involving a mix of virtual, lecture-based, and case-based didactics to incorporate ethics education longitudinally in dermatology residencies. Subject matter should align with the American Academy of Dermatology subcommittee's six domains of ethics education.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gonorrhea. 淋病。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-29 DOI: 10.1016/j.clindermatol.2025.09.006
David A Lewis
{"title":"Gonorrhea.","authors":"David A Lewis","doi":"10.1016/j.clindermatol.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.006","url":null,"abstract":"<p><p>Neisseria gonorrhoeae, a Gram-negative intracellular pathogen, causes gonorrhea. While usually sexually transmissible, it can be acquired by direct inoculation. Untreated gonococcal infections have deleterious impacts, including adverse pregnancy outcomes, ectopic pregnancy, infertility, and even blindness. Extended-spectrum cephalosporins remain the mainstay of therapy, and gonococcal culture is essential to determine susceptibility to these agents. Antimicrobial resistance is a global public health concern, and few new agents are in the pipeline. Gonorrhea control programs rely on health education, access to diagnostic testing (where possible), effective therapy, and partner notification. Introducing inexpensive, sensitive, and specific point-of-care tests will aid antimicrobial stewardship efforts in countries utilizing the syndromic management approach. Targeted vaccination of higher-risk populations with cross-protective outer membrane vesicle-based meningococcal B-vaccines could reduce N. gonorrhoeae transmission in the future. Doxycycline post-exposure prophylaxis may further reduce gonococcal incidence in the short term; however, its long-term impact on the human resistome/microbiome remains unknown.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natura sanat - nature heals - Dr. Heinrich Lahmann and his physiatric sanatorium. 自然疗养院-自然治疗-海因里希·拉赫曼博士和他的理疗疗养院。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-27 DOI: 10.1016/j.clindermatol.2025.09.015
Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish
{"title":"Natura sanat - nature heals - Dr. Heinrich Lahmann and his physiatric sanatorium.","authors":"Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.015","url":null,"abstract":"<p><p>Dr. Heinrich Lahmann was a German physician and health reformer who was especially active in Dresden and the surrounding area during the first half of the 20th century. He was born on December 11, 1860, in Bremen and died in Dresden in 1941. Lahmann was especially well-known for his efforts to improve general healthcare, promote naturopathy, and his role as a sanatorium director. His work and the institutions he established had a far-reaching impact on the medical landscape of his time. His sanatorium attracted patients from Europe and beyond, where he also tried to apply his therapeutic approach to sexually transmitted diseases and chronic dermatitis.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chlamydia trachomatis and Mycoplasma genitalium. 沙眼衣原体和生殖支原体。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-26 DOI: 10.1016/j.clindermatol.2025.09.008
Antoine Joly, Michael Rayment
{"title":"Chlamydia trachomatis and Mycoplasma genitalium.","authors":"Antoine Joly, Michael Rayment","doi":"10.1016/j.clindermatol.2025.09.008","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.008","url":null,"abstract":"<p><p>Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) share many similarities, but as much differentiates these two organisms as unites them. These common sexually transmitted bacteria are strongly associated with several acute syndromes in the genito-urinary tract. While the long-term severe sequelae of CT are well accepted, the data underpinning the complications of MG are less specific and largely observational. Efforts to control CT with comprehensive scale testing programs have yielded limited results, and the control paradigm will shift in the coming years. As diagnostic capabilities for detecting MG have improved, this organism is more widely diagnosed, and the emergence of complex antimicrobial resistance has complicated therapy options. This contribution describes the two organisms' epidemiology, clinical manifestations, and management and explores new approaches to their control and prevention.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DONOVANOSIS. 第五性病。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-26 DOI: 10.1016/j.clindermatol.2025.09.007
Nigel O'Farrell
{"title":"DONOVANOSIS.","authors":"Nigel O'Farrell","doi":"10.1016/j.clindermatol.2025.09.007","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.007","url":null,"abstract":"<p><p>Donovanosis usually causes genital ulcers with a distinct clinical appearance. The condition has been a problem in many developing countries, but recent years have seen a significant global decline in prevalence. It is well on the way to being eradicated. Donovanosis has been known under many different terminologies, and there is still debate about how the causative organism should be classified. Recent news agency and social media reports of an increase in the \"flesh-eating infection donovanosis\" have been false and unhelpful, only leading to hyperbole and increased stigma amongst those infected.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mpox (monkeypox). Mpox (monkeypox)。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-24 DOI: 10.1016/j.clindermatol.2025.09.011
Joseph Heskin, Ien Chan, Christopher Barry Bunker, Christopher James Scott
{"title":"Mpox (monkeypox).","authors":"Joseph Heskin, Ien Chan, Christopher Barry Bunker, Christopher James Scott","doi":"10.1016/j.clindermatol.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.011","url":null,"abstract":"<p><p>Mpox, a zoonotic orthopoxvirus, originally identified in 1958, exhibits two distinct genetic strains or clades, Clade 1 and Clade 2. Prior to 2022, mpox was predominantly isolated in the endemic regions of West and Central Africa. Sporadic outbreaks of travel-associated Clade 2 mpox had previously occurred in non-endemic areas, but persistent human-to-human transmission within non-endemic regions had not been documented until recently. In May 2022, a global mpox outbreak emerged, impacting over 100 countries worldwide. This prompted the World Health Organization to declare mpox a public health emergency of international concern.<sup>1</sup>.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinics in Dermatology: Herpes Simplex (Update on dermatological aspects of STD and HIV)NEED SOME PICTURES. 皮肤科诊所：单纯疱疹（性病和艾滋病毒皮肤病方面的更新）需要一些图片。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-24 DOI: 10.1016/j.clindermatol.2025.09.010
Emily Clarke
{"title":"Clinics in Dermatology: Herpes Simplex (Update on dermatological aspects of STD and HIV)NEED SOME PICTURES.","authors":"Emily Clarke","doi":"10.1016/j.clindermatol.2025.09.010","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.010","url":null,"abstract":"<p><p>Herpes simplex virus (HSV) is the most common cause of anogenital ulceration worldwide. There are two distinct viruses: HSV-1 associated with oro-labial cold sores and genital infection, and HSV-2 associated with genital infection. Infection is lifelong, and typically presents with painful anogenital ulceration which may recur after periods of latency. Asymptomatic shedding is common and may lead to transmission to sexual partners. Antiviral suppression with aciclovir, valaciclovir or famciclovir is useful to treat initial painful episodes, or troublesome recurrent infection. Suppressive antiviral therapy, condoms, selective abstinence and disclosure to sexual partners have all been demonstrated to reduce the risk of transmission.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updates on Kaposi Sarcoma. 卡波西肉瘤最新进展
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-24 DOI: 10.1016/j.clindermatol.2025.09.013
Kyaw Zin Htet, Eman Bahrani, Kieron S Leslie
{"title":"Updates on Kaposi Sarcoma.","authors":"Kyaw Zin Htet, Eman Bahrani, Kieron S Leslie","doi":"10.1016/j.clindermatol.2025.09.013","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.013","url":null,"abstract":"<p><p>Kaposi sarcoma (KS) is an angioproliferative tumor that is associated with Human Herpesvirus 8 (HHV-8) or Kaposi sarcoma-associated herpes virus (KSHV) infection. KS typically presents in the skin as isolated or multiple, violaceous macules or papulonodular lesions or plaques. The four different KS clinical categories: classic, endemic, epidemic or AIDS-related and iatrogenic KS are heterogenous in epidemiology, manifestations and complications. Clinical features, diagnostic modalities and therapeutic regimens for all types of KS are summarized in this review. It is important for clinicians to promptly recognize and approach the treatment of KS in a multidisciplinary fashion for optimal therapeutic outcomes. Newer targeted therapies based on its pathogenesis are being studied.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPV: An Update. HPV：最新进展。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2025-09-24 DOI: 10.1016/j.clindermatol.2025.09.012
Manik Kohli, Christopher Bunker, Georgios Kravvas
{"title":"HPV: An Update.","authors":"Manik Kohli, Christopher Bunker, Georgios Kravvas","doi":"10.1016/j.clindermatol.2025.09.012","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.09.012","url":null,"abstract":"<p><p>Human Papillomaviruses (HPV) are a group of DNA viruses with over 450 types identified. HPV represents one of the most common viral infections globally. HPV can cause a wide spectrum of clinical disease depending on type, including benign lesions (cutaneous or anogenital warts), pre-malignant lesions (intraepithelial neoplasia), and anogenital cancers; however, infection may also frequently remain subclinical. Even though the role of HPV in the pathogenesis of penile, vulval, and anal intraepithelial neoplasia and other cutaneous diseases has been recognized, robust evidence for the role of screening and effective management is often lacking. The implementation of prophylactic vaccination for young people and at-risk adults in high-income countries has proven successful, and now there is growing interest in post-exposure vaccination.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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