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The Scientific Rationale for Long-Acting Biologics in Dermatology. 皮肤病学中长效生物制剂的科学依据。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-05-05 DOI: 10.1016/j.clindermatol.2026.04.015
Mohamad Goldust, Landau Marina, Jane M Grant-Kels
{"title":"The Scientific Rationale for Long-Acting Biologics in Dermatology.","authors":"Mohamad Goldust, Landau Marina, Jane M Grant-Kels","doi":"10.1016/j.clindermatol.2026.04.015","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2026.04.015","url":null,"abstract":"<p><p>The evolution of biologic therapies in dermatology increasingly emphasizes extending drug half-life to optimize pharmacokinetics and therapeutic durability. Mechanisms such as FcRn-mediated recycling, Fc engineering, albumin binding, PEGylation, and amino acid polymer technologies enhance systemic persistence and stabilize drug exposure. These advances enable sustained inhibition of key inflammatory pathways, including IL-23/Th17 and IL-4/IL-13, reducing disease relapse and improving long-term outcomes. Extended half-life biologics also improve adherence, reduce immunogenicity, and lessen treatment burden through infrequent dosing. Collectively, these innovations represent a shift toward precision pharmacology, matching drug kinetics with disease biology to enhance efficacy, patient satisfaction, and healthcare efficiency in chronic dermatologic conditions.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forensic Dermatology: An Integral Subspecialty of Dermatology. Introducing a New Section in Clinics in Dermatology. 法医皮肤病学：皮肤病学的一个完整的亚专业。介绍在皮肤科诊所一个新的部分。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-05-04 DOI: 10.1016/j.clindermatol.2026.04.016
Philip R Cohen, Leonard J Hoenig, Lawrence Charles Parish
{"title":"Forensic Dermatology: An Integral Subspecialty of Dermatology. Introducing a New Section in Clinics in Dermatology.","authors":"Philip R Cohen, Leonard J Hoenig, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2026.04.016","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2026.04.016","url":null,"abstract":"<p><p>Forensic dermatology is not only a worldwide phenomenon but also an important subspecialty of both forensic medicine and dermatology. It encompasses traditional forensic dermatology (by aiding in establishing the cause and manner of death of decedents) and clinical forensic dermatology (by assessing live victims of abuse and neglect, human trafficking, and torture). Forensic dermatology assists in the legal and criminal investigation by carefully examining the skin, mucosa, hair, and nails and accurately assessing the findings. The forensic dermatologist may use the forensic dermatology expert analytical report to summarize not only the observations but also the assessment of their evaluation as an expert witness during a trial. Collaboration, documentation, and education are the pillars of forensic dermatology. In order to provide a forum for the advancement of knowledge in forensic dermatology, a new section dedicated to this field of medicine has been added to Clinics in Dermatology.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamins and related substances in skin health: Use and restrictions in pregnancy. 维生素及相关物质对皮肤健康的影响：孕期的使用及限制。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-30 DOI: 10.1016/j.clindermatol.2026.04.004
Akash Rau, Paige Adams, Jenny E Murase
{"title":"Vitamins and related substances in skin health: Use and restrictions in pregnancy.","authors":"Akash Rau, Paige Adams, Jenny E Murase","doi":"10.1016/j.clindermatol.2026.04.004","DOIUrl":"10.1016/j.clindermatol.2026.04.004","url":null,"abstract":"<p><p>Vitamins are vital components of skin health and have well-established utility in managing various dermatologic conditions. Vitamin toxicity and deficiency can lead to multisystem effects, and there are additional concerns about adverse effects on the fetus in pregnancy. It is critically essential for dermatologists to be aware of the recommended dosage of vitamin supplementation in pregnancy to avoid toxicity and teratogenicity. We have reviewed the use of vitamins in treating dermatologic conditions during pregnancy and the maternal and fetal adverse effects associated with vitamin excess and deficiency.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cutaneous Realism in Lombard Renaissance Portraiture: Forehead Lipomas in Two Paintings by Giovanni Battista Moroni. 伦巴第文艺复兴时期肖像画中的皮肤写实主义：乔瓦尼·巴蒂斯塔·莫罗尼两幅画中的前额脂肪瘤。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-28 DOI: 10.1016/j.clindermatol.2026.04.014
Francesco Brigo
{"title":"Cutaneous Realism in Lombard Renaissance Portraiture: Forehead Lipomas in Two Paintings by Giovanni Battista Moroni.","authors":"Francesco Brigo","doi":"10.1016/j.clindermatol.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2026.04.014","url":null,"abstract":"<p><p>Giovanni Battista Moroni (ca. 1520/1524-ca. 1579/1580) exemplifies the Lombard commitment to empirical naturalism, a tradition grounded in unidealized observation and meticulous physiognomic precision. Two of his late portraits, the Portrait of a Doctor (ca. 1560-1570) and the Portrait of a Nobleman of the Albani Family (ca. 1570), feature carefully modeled frontal soft-tissue swellings whose smooth contours, lack of erythema, and stable volume are consistent with benign lipomas. Their inclusion demonstrates Moroni's refusal to suppress visible bodily irregularities and reflects a broader regional attentiveness to dermatologic and subcutaneous detail. These works reaffirm his position within a Lombard visual culture committed to representing the human body with uncompromising observational fidelity.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamins and skin aging. 维生素和皮肤老化。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-15 DOI: 10.1016/j.clindermatol.2026.04.010
Jana Kazandjieva, Georgi Bogdanov, Ivan Bogdanov, Nikolai Tsankov
{"title":"Vitamins and skin aging.","authors":"Jana Kazandjieva, Georgi Bogdanov, Ivan Bogdanov, Nikolai Tsankov","doi":"10.1016/j.clindermatol.2026.04.010","DOIUrl":"10.1016/j.clindermatol.2026.04.010","url":null,"abstract":"<p><p>This comprehensive analysis sheds light on the crucial roles played by vitamins in anti-aging strategies across three key domains: topical care, cosmetic procedures, and systemic therapy. Vitamins significantly influence skin health, contributing to hydration, collagen synthesis, and protection against oxidative damage. In topical care, vitamins are harnessed in various formulations such as creams, serums, lotions, and wash products, directly benefiting the skin's surface. These formulations enhance hydration, promote collagen biosynthesis, and provide protection against oxidative stress. Cosmetic procedures leverage vitamins in peels, mesotherapy, and postlaser treatment products, aiding skin recovery and rejuvenation. Systemic therapy involves incorporating vitamins into dietary supplements designed to combat the aging process from within. The multifaceted roles of vitamins necessitate nuanced considerations for potential side effects, contraindications, and adherence to regulatory frameworks. Formulating safe and effective skincare products demands a deep understanding of these factors, highlighting the dynamic nature of cosmetic science. This exploration underscores the interconnectedness of topical, procedural, and systemic approaches in anti-aging strategies, emphasizing the importance of a holistic understanding of vitamin applications in skincare.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persona non grata: Identifying patients unsuitable for aesthetic dermatologic procedures. 不受欢迎的人：识别不适合皮肤美容手术的患者。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-11 DOI: 10.1016/j.clindermatol.2026.04.013
Belma Türsen, İçim Kömürcügil Yiğit, Ümit Türsen, Gisele Viana de Oliveira, George Kroumpouzos
{"title":"Persona non grata: Identifying patients unsuitable for aesthetic dermatologic procedures.","authors":"Belma Türsen, İçim Kömürcügil Yiğit, Ümit Türsen, Gisele Viana de Oliveira, George Kroumpouzos","doi":"10.1016/j.clindermatol.2026.04.013","DOIUrl":"10.1016/j.clindermatol.2026.04.013","url":null,"abstract":"<p><p>The rapid growth of aesthetic dermatology has been accompanied by an increasing demand for cosmetic procedures and heightened expectations for treatment outcomes. Although aesthetic procedures aim to enhance appearance, dermatologists are tasked with ensuring patient safety and adhering to ethical medical practices. In certain situations, refusing treatment may represent the most appropriate clinical decision. The term persona non grata, originally used in diplomacy, serves as a useful metaphor in aesthetic dermatology to describe patients for whom cosmetic procedures may be unsuitable due to ethical, medical, or psychologic concerns. We discuss situations in which dermatologists may need to decline aesthetic procedures and highlight specific patient profiles that require caution. We examine ethical considerations, including informed consent, patient autonomy, and the physician's duty to avoid harm. Additionally, we focus on psychologic aspects, particularly unrealistic expectations, social media-driven aesthetic demands, and psychiatric comorbidities like body dysmorphic disorder. Recognizing these high-risk situations is crucial for maintaining professional integrity and minimizing complications in aesthetic practice. Finally, we review legal safeguards for patients who may not be suitable for aesthetic procedures. Fundamental principles of responsible aesthetic dermatology include careful patient selection, comprehensive medical and psychologic assessments, and clear communication.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics of Unequal Compensation: Rethinking Reimbursement in Dermatology Clinical Trials. 不平等补偿的伦理：对皮肤科临床试验报销的再思考。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-11 DOI: 10.1016/j.clindermatol.2026.04.012
Ayushya Ajmani, Albert E Zhou, Jane M Grant-Kels, Daniel M Klufas
{"title":"Ethics of Unequal Compensation: Rethinking Reimbursement in Dermatology Clinical Trials.","authors":"Ayushya Ajmani, Albert E Zhou, Jane M Grant-Kels, Daniel M Klufas","doi":"10.1016/j.clindermatol.2026.04.012","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2026.04.012","url":null,"abstract":"<p><p>Industry-sponsored clinical trials in dermatology generate substantial institutional revenue; yet, participant compensation is frequently calibrated to minimum regulatory thresholds rather than to the actual costs of participation. Existing frameworks including IRB review under 21 Code of Federal Regulations (CFR) 50.20 and European Health Union (EU) Regulation 536/2014 provide essential protections against coercive payment practices, but approval does not guarantee that stipends adequately offset lost wages, transportation costs, or structural participation barriers. Drawing on the Belmont Report's principles of justice and respect for persons, we argue that regulatory compliance is a floor, not the full measure of ethical practice. We propose that dermatology research programs adopt tiered, burden-reflective compensation models, and integrate participant advisory perspectives into compensation design, not to circumvent existing oversight; but to exceed it in the service of research equity.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Military rice, civilian chicken, and Christiaan Eijkman (1858-1930): The beginning of the vitamin era. 军用大米、民用鸡肉和克里斯蒂安·艾克曼（1858-1930）：维生素时代的开端。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-08 DOI: 10.1016/j.clindermatol.2026.04.008
Amiya Kumar Mukhopadhyay
{"title":"Military rice, civilian chicken, and Christiaan Eijkman (1858-1930): The beginning of the vitamin era.","authors":"Amiya Kumar Mukhopadhyay","doi":"10.1016/j.clindermatol.2026.04.008","DOIUrl":"10.1016/j.clindermatol.2026.04.008","url":null,"abstract":"<p><p>Since the beginning of civilisation, our forefathers realized the importance of food for the proper maintenance of life. human civilisation had faced a number of incidences of ailments that took its toll originating from nutritional deficiency. In the history of nutritional science, the pathbreaking work of Christiaan Eijkman not only halted the march of death due to beriberi, but also opened the path for the discovery of various vitamins. These discoveries answered the various enigmas and showed how a very small amount of vitamins could prevent and cure the different disorders that took innumerable lives.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlights in the history of vitamins. Part-II. 维生素史上的亮点，第二部分。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-08 DOI: 10.1016/j.clindermatol.2026.04.002
Amiya Kumar Mukhopadhyay
{"title":"Highlights in the history of vitamins. Part-II.","authors":"Amiya Kumar Mukhopadhyay","doi":"10.1016/j.clindermatol.2026.04.002","DOIUrl":"10.1016/j.clindermatol.2026.04.002","url":null,"abstract":"<p><p>With the work of James Lind (1716-1794) on scurvy and Kanehiro Takaki (1849-1920) on beriberi, the initial journey of vitamin research began. The contributions from Joseph Goldberger (1874-1929), Cornelis Adrianus Pekelharing (1848-1922), Christiaan Eijkman (1858-1930), Casimir Funk (1884-1967), and many others led to the further advancement of vitamin research. Most vitamins were discovered within 50 years. These works not only remained confined to the identification of various vitamins but also led to the discovery of finer details on the subject. One after another, vitamins were discovered, and their chemical structures and biochemical properties were described. This contribution is a brief review of the fascinating story of the discovery of various vitamins, the research work associated with them, and their naming, the antivitamins, and some aspects of the research work, like the use of animal models.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamins and Skin Part II. 维生素和皮肤第二部分。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-08 DOI: 10.1016/j.clindermatol.2026.04.001
Amiya K Mukhopadhyay
{"title":"Vitamins and Skin Part II.","authors":"Amiya K Mukhopadhyay","doi":"10.1016/j.clindermatol.2026.04.001","DOIUrl":"10.1016/j.clindermatol.2026.04.001","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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