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Clinics in dermatology最新文献

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Irwin M. Braverman, MD - A pillar of dermatology.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-24 DOI: 10.1016/j.clindermatol.2025.03.015
Keith A Choate
{"title":"Irwin M. Braverman, MD - A pillar of dermatology.","authors":"Keith A Choate","doi":"10.1016/j.clindermatol.2025.03.015","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.015","url":null,"abstract":"<p><p>In Dermatology, there is a small cohort of luminaries who stand out for their contributions to our specialty. Irwin Braverman is one such individual, who has made significant contributions to our understanding of skin signs of systemic disease, the ultrastructure of cutaneous vasculature, and the use of art visual interpretation as a tool to teach clinical observation skills. This article provides a brief overview of Irwin's career, and the individuals and experiences that led him to become a pillar of dermatology.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo nodularis phenotype in the bullous dermatoses spectrum.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-19 DOI: 10.1016/j.clindermatol.2025.03.012
Valeria Mateeva, Aylin Kafelova, Kossara Drenovska, Snejina Vassileva
{"title":"Prurigo nodularis phenotype in the bullous dermatoses spectrum.","authors":"Valeria Mateeva, Aylin Kafelova, Kossara Drenovska, Snejina Vassileva","doi":"10.1016/j.clindermatol.2025.03.012","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.012","url":null,"abstract":"<p><p>Prurigo nodularis (PN) of Hyde is a highly pruritic condition that results from the vicious cycle of itching and scratching. An increasing number of case studies report PN-mimicking lesions in patients with confirmed autoimmune bullous dermatoses (AIBDs). The PN lesions usually precede the blister formation and thus raise the question about the pathogenic relation between the two conditions and the possible role of PN as a trigger of AIBDs. We shed light on PN in the context of AIBDs, especially about the clinical characteristics and the pathogenesis of the PN-like phenotype of bullous pemphigoid, linear IgA bullous dermatosis, and dermatitis herpetiformis, as well as in the hereditary bullous dermatoses setting, namely epidermolysis bullosa pruriginosa.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Big Four in the Pathogenesis and Pathophysiology of Prurigo Nodularis: Interplay among Type 2 Inflammation, Epidermal Hyperplasia, Dermal Fibrosis, and Itch from Neuroimmune Dysregulation.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-19 DOI: 10.1016/j.clindermatol.2025.03.010
Takashi Hashimoto, Satoshi Okuno
{"title":"The Big Four in the Pathogenesis and Pathophysiology of Prurigo Nodularis: Interplay among Type 2 Inflammation, Epidermal Hyperplasia, Dermal Fibrosis, and Itch from Neuroimmune Dysregulation.","authors":"Takashi Hashimoto, Satoshi Okuno","doi":"10.1016/j.clindermatol.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.010","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is a distinct inflammatory dermatosis. It is characterized by intensely pruritic, firm nodules, typically 1-2 cm in diameter, which usually develop on the extensor surfaces of the extremities. Histopathologically, the following characteristics are observed in PN lesions: (1) dermal cellular infiltrates composed of type 2 inflammation-associated immune cells with lesional overexpression of type 2 cytokines (including IL-4, IL-13, and IL-31); (2) dermal fibrosis; and (3) epidermal hyperplasia with hyperkeratosis. Additionally, functional and structural alterations of cutaneous sensory nerve fibers profoundly contribute to itch in cooperation with type 2 inflammation. This abnormal interaction is referred to as neuroimmune dysregulation. The scratching behavior induced by itching from neuroimmune dysregulation initiates the development of prurigo nodules. This distinctive pathogenic feature of \"itch-first\" in PN is distinct from \"inflammation-first\" in atopic dermatitis, another pruritic skin disease with type 2 inflammation. In atopic dermatitis, the skin initially exhibits type 2 inflammation, which is subsequently followed by itching. The interplay between the four elements, namely type 2 inflammation, epidermal hyperplasia, dermal fibrosis, and itch resulting from neuroimmune dysregulation, appears to be pivotal in the pathogenesis and pathophysiology of PN.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo Nodularis - Clinics in Dermatology. 结节性瘙痒 - 皮肤科临床。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.clindermatol.2025.03.002
Sarah G Brooks, Gil Yosipovitch
{"title":"Prurigo Nodularis - Clinics in Dermatology.","authors":"Sarah G Brooks, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.002","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo Nodularis in 2025: Current and Emerging Treatments.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-17 DOI: 10.1016/j.clindermatol.2025.03.013
Sarah G Brooks, Gil Yosipovitch
{"title":"Prurigo Nodularis in 2025: Current and Emerging Treatments.","authors":"Sarah G Brooks, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.013","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.013","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is a chronic inflammatory dermatologic condition that is often incredibly itchy and imposes a debilitating burden on patient quality of life. Historically, patients have faced the hurdles of limited knowledge regarding the mechanisms underlying PN, physician awareness, and effective therapies. Many of the conventional treatments offer minimal benefit or are accompanied by adverse effects. Fortunately, over the last several years, striking advancements in the understanding of the pathogenesis contributing to PN have allowed for the development of novel treatments. The first and only medication approved by the U.S. Food and Drug Administration is dupilumab, a biological agent targeting interleukins 4 and 13, that has revolutionized management for patients with moderate to severe PN. Several other drugs are on the horizon that have the potential to become widely available. This article aims to review the current and emerging therapies for prurigo nodularis, and address the challenges that may hinder effective treatment.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo Nodularis and Acquired Perforating Dermatosis in Chronic Kidney Disease: Are They the Same Entity?
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.011
Rami H Mahmoud, Giulia Coscarella, Ruby Kwak, Gil Yosipovitch
{"title":"Prurigo Nodularis and Acquired Perforating Dermatosis in Chronic Kidney Disease: Are They the Same Entity?","authors":"Rami H Mahmoud, Giulia Coscarella, Ruby Kwak, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.011","url":null,"abstract":"<p><p>Prurigo nodularis (PN) has been reported in itchy chronic kidney disease (CKD) patients, in particular, in end-stage renal failure. Acquired perforating dermatitis (APD) associated with CKD and diabetes is a group of disorders where dermal materials are eliminated through the epidermis and is characterized by itchy papules and nodules. We focus on the relationship between PN and APD in CKD and provide data to support that both entities share many of the same clinical and histologic features. These cutaneous diseases often go underreported in this patient population, leading to inadequate treatment and suboptimal patient outcomes. Our review of the literature suggests a relationship between PN/APD and CKD, presumably driven by uremic pruritus, changes in the renin-angiotensin-aldosterone system, a predisposing immune dysregulation with increased IL-31 expression, and opioid system imbalances. A variety of pharmacologic therapies may be efficacious. The use of the new targeted biologics for PN and whether they are also helpful for CKD and APD are welcome..</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo nodularis imitators unmasked.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.003
Elisabeth V Goessinger, Tobias Kliesener, Beda Muehleisen, Oliver Brandt, Simon Mueller
{"title":"Prurigo nodularis imitators unmasked.","authors":"Elisabeth V Goessinger, Tobias Kliesener, Beda Muehleisen, Oliver Brandt, Simon Mueller","doi":"10.1016/j.clindermatol.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.003","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is characterized by stereotypical, chronic, nodular lesions on the extensor surfaces of the extremities and back. For experienced clinicians, the recognition of this diagnosis is usually not difficult; however, it is essential to consider differential diagnoses and identify PN imitators. We report five patients with severe chronic pruritus who presented with skin lesions resembling PN. They were treated accordingly, but were subsequently diagnosed with a different underlying disease, including nodular marginal zone lymphoma (1 case), delusional parasitosis (1 case), well-differentiated squamous cell carcinomas arising amongst PN lesions (2 cases), and PN-like pemphigus foliaceus (1 case). Critical re-assessment of the diagnosis of PN is important to avoid cognitive biases such as availability bias, anchoring bias, or attribution bias, which could lead to delayed diagnosis of the actual disease, inappropriate treatment, and poorer outcomes.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving Evidence in the Neural Sensitization of Prurigo Nodularis.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.008
Sarah G Brooks, Gil Yosipovitch
{"title":"Evolving Evidence in the Neural Sensitization of Prurigo Nodularis.","authors":"Sarah G Brooks, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.008","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xerosis cutis and Wounded Skin in Modern Art: Two Works by Alberto Burri. 现代艺术中的皮肤干燥症和受伤的皮肤：阿尔贝托-布里的两幅作品
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-14 DOI: 10.1016/j.clindermatol.2025.03.001
Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish
{"title":"Xerosis cutis and Wounded Skin in Modern Art: Two Works by Alberto Burri.","authors":"Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.001","url":null,"abstract":"<p><p>The human skin has been a subject of medicine and art. The interest in the interaction of skin and the inner body had increased after the establishment of anatomy as a science long before dermatology was acknowledged as a medical discipline. In painting the body surface, the Inkarnat (flesh tone) represents a mixture of the superficial epidermis and dermis, plus the deeper musculature and vasculature, each contributing to the skin color. In the fine arts of the Renaissance, skin is understood as primarily a layer of material. The human skin can express feelings, emotions, and various states of mind. We analyze two works of the Italian artist Alberto Burri (1915-1995), who painted in the post-war period. He opens a window into human existence with his materials while showing both the tragedies and wounds.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and management of prurigo nodularis in skin of color patients.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-14 DOI: 10.1016/j.clindermatol.2025.03.004
Akash Rau, Danyelle Dawes
{"title":"Diagnosis and management of prurigo nodularis in skin of color patients.","authors":"Akash Rau, Danyelle Dawes","doi":"10.1016/j.clindermatol.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.004","url":null,"abstract":"<p><p>Prurigo nodularis is a chronic, intensely pruritic eruption that results in excoriated papules mostly on the extensor surfaces of the arms and legs. Previous studies have indicated the condition disproportionally affects those of African descent. While the etiology has not been fully elucidated, patients with prurigo nodularis have been found to have associated comorbidities such as hypertension, renal disease, and HIV infection. This review covers the principles of work-up and diagnosis of prurigo nodularis in skin of color patients as well as management considerations in this population.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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