Elisabeth V Goessinger, Tobias Kliesener, Beda Muehleisen, Oliver Brandt, Simon Mueller
{"title":"Prurigo nodularis imitators unmasked.","authors":"Elisabeth V Goessinger, Tobias Kliesener, Beda Muehleisen, Oliver Brandt, Simon Mueller","doi":"10.1016/j.clindermatol.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.003","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is characterized by stereotypical, chronic, nodular lesions on the extensor surfaces of the extremities and back. For experienced clinicians, the recognition of this diagnosis is usually not difficult; however, it is essential to consider differential diagnoses and identify PN imitators. We report five patients with severe chronic pruritus who presented with skin lesions resembling PN. They were treated accordingly, but were subsequently diagnosed with a different underlying disease, including nodular marginal zone lymphoma (1 case), delusional parasitosis (1 case), well-differentiated squamous cell carcinomas arising amongst PN lesions (2 cases), and PN-like pemphigus foliaceus (1 case). Critical re-assessment of the diagnosis of PN is important to avoid cognitive biases such as availability bias, anchoring bias, or attribution bias, which could lead to delayed diagnosis of the actual disease, inappropriate treatment, and poorer outcomes.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolving Evidence in the Neural Sensitization of Prurigo Nodularis.","authors":"Sarah G Brooks, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.008","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish
{"title":"Xerosis cutis and Wounded Skin in Modern Art: Two Works by Alberto Burri.","authors":"Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.001","url":null,"abstract":"<p><p>The human skin has been a subject of medicine and art. The interest in the interaction of skin and the inner body had increased after the establishment of anatomy as a science long before dermatology was acknowledged as a medical discipline. In painting the body surface, the Inkarnat (flesh tone) represents a mixture of the superficial epidermis and dermis, plus the deeper musculature and vasculature, each contributing to the skin color. In the fine arts of the Renaissance, skin is understood as primarily a layer of material. The human skin can express feelings, emotions, and various states of mind. We analyze two works of the Italian artist Alberto Burri (1915-1995), who painted in the post-war period. He opens a window into human existence with his materials while showing both the tragedies and wounds.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis and management of prurigo nodularis in skin of color patients.","authors":"Akash Rau, Danyelle Dawes","doi":"10.1016/j.clindermatol.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.004","url":null,"abstract":"<p><p>Prurigo nodularis is a chronic, intensely pruritic eruption that results in excoriated papules mostly on the extensor surfaces of the arms and legs. Previous studies have indicated the condition disproportionally affects those of African descent. While the etiology has not been fully elucidated, patients with prurigo nodularis have been found to have associated comorbidities such as hypertension, renal disease, and HIV infection. This review covers the principles of work-up and diagnosis of prurigo nodularis in skin of color patients as well as management considerations in this population.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Functional Magnetic Resonance Imaging in Prurigo Nodularis: A Systematic Review.","authors":"Xuanyu Zhao, Jannis M Mueller, Simon M Mueller","doi":"10.1016/j.clindermatol.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.005","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is a chronic pruritic inflammatory skin condition characterized by nodular skin lesions in a typical distribution pattern caused by various dermatological and/or non-dermatological conditions. In recent years, significant advances have been made in the understanding of the cutaneous pathophysiology of PN resulting in novel treatment options such as Interleukin-4, -13, -17, -31- or Januskinase inhibitors. However, many aspects of the neurophysiology are largely unknown, including the processing in the central structural and functional network involved in PN. Functional neuroimaging allows non-invasive assessment of brain function and structure. Due to its high spatial resolution and temporal precision, functional magnetic resonance imaging (fMRI) has proven to be a suitable method for exploring neural mechanisms and assessing pharmacological effects in dermatological research. In this systematic review, the current knowledge of fMRI in the context of PN and its centrally active treatment options is summarized.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Definitions and Subtypes of Chronic Prurigo.","authors":"Lea Sophie Stahl, Sonja Ständer, Claudia Zeidler","doi":"10.1016/j.clindermatol.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2025.03.009","url":null,"abstract":"<p><p>Over the past few years, chronic prurigo, including prurigo nodularis, has become a focal point of considerable research attention, resulting in enhanced insights into this condition. For over two centuries, the term \"prurigo\" has been utilized in dermatology, often applied loosely to describe a range of pruritic, papulous conditions lacking clear diagnostic criteria. In 2017, the term \"chronic prurigo\" was introduced, delineating chronic prurigo including prurigo nodularis as a distinct disease entity characterized by chronic pruritus, a characteristic clinical history, and physical signs such as excoriations and the presence of pruriginous lesions. Pruriginous lesions exhibit diverse morphologies, encompassing papules (diameter < 1 cm), nodules (diameter > 1 cm), plaques, and umbilicated or linear lesions. Co-occurrence of multiple lesion types within an individual is frequently observed. The subtype and severity of chronic prurigo can be categorised on the basis of the type or number of pruriginous lesions.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic and molecular drivers of scleroderma pathogenesis","authors":"Ian D. Odell MD, PhD","doi":"10.1016/j.clindermatol.2024.12.007","DOIUrl":"10.1016/j.clindermatol.2024.12.007","url":null,"abstract":"<div><div>Scleroderma is a heterogeneous disease with various clinical findings involving immune dysregulation, vasculopathy, and fibrosis. Biological and genetic studies over recent decades have elucidated molecular mechanisms of scleroderma pathogenesis. Genetic association studies have identified interferon and other immune regulatory genes as strongly linked to scleroderma risk, highlighting the immune system as a fundamental determinant of disease. Human and murine biological studies have identified growth factor signaling as a central feature linking tissue damage to the clinical phenotype. Growth factors activated in vascular endothelial cells overlap with those of other diseases having vascular abnormalities, such as hereditary hemorrhagic telangiectasia. Activated growth factor receptors in fibroblasts drive excessive collagen expression in the skin and lungs. Because growth factor signaling is overactivated in multiple malignancies, biological insights and therapeutic approaches may be translated from oncology to understand scleroderma better. Enhanced understanding of the molecular drivers of scleroderma pathogenesis has given greater insight into patient phenotypes and new therapeutic approaches, including those that target immune and growth factor signaling.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 2","pages":"Pages 153-159"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonard J. Hoenig MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)
{"title":"Three dermatologists who were nominated for a Nobel Prize: Albert Neisser, Erich Hoffmann, and Aaron B. Lerner","authors":"Leonard J. Hoenig MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)","doi":"10.1016/j.clindermatol.2024.08.005","DOIUrl":"10.1016/j.clindermatol.2024.08.005","url":null,"abstract":"<div><div>During the past 125 years, three dermatologists have been nominated for the Nobel Prize in Physiology or Medicine: Albert Neisser (1855-1916), Erich Hoffmann (1868-1959), and Aaron B. Lerner (1920-2007). Neisser was nominated 22 times for his discovery of the gonococcus and for his work on the serologic testing for syphilis through complement fixation. Hoffmann was nominated three times for his role in the discovery of <em>Treponema pallidum.</em> Lerner was nominated twice, once for his work on melanocyte-stimulating hormone and a second time for his work on melatonin. Although neither Neisser, Hoffmann, nor Lerner won the Nobel Prize, it is still a notable accomplishment that each of them was nominated multiple times for this prestigious award. This contribution highlights the lives and careers of these three distinguished dermatologists, including the landmark discoveries they made that led to their being nominated for a Nobel Prize.</div><div>As of 2023, there were 114 Nobel Prizes in Physiology or Medicine awarded to 227 individuals, none of whom were dermatologists. There were, however, three distinguished dermatologists who were nominated for this illustrious prize: Albert Neisser (1855-1916), Erich Hoffmann (1868-1959), and Aaron Bunsen Lerner (1920-2007) (<span><span>Fig. 1</span></span>, <span><span>Fig. 2</span></span>, <span><span>Fig. 3</span></span>). Although these three dermatologists failed to win the Nobel Prize, it remains a signal accomplishment for each of them to have been nominated for such a prestigious award on multiple occasions in recognition of their outstanding discoveries that have had a significant impact on modern-day medicine. This <em>Fun Facts About Dermatology</em> presentation highlights the lives and careers of Neisser, Hoffmann, and Lerner and the important scientific contributions that led to their nominations for medicine's most coveted award: the Nobel Prize.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 2","pages":"Pages 253-258"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siddig Ibrahim Abdelwahab PhD , Abdullah Farasani PhD , Hassan Ahmad Alfaifi PhD , Ahmed S. Alamer PhD , Tawfeeq Altherwi MD , Saeed Alshahrani PhD , Ahmad Assiri MD , Waseem Hassan PhD
{"title":"A comprehensive bibliometric analysis of prurigo nodularis literature (1951-2024): Key contributors, trends, and thematic evolution","authors":"Siddig Ibrahim Abdelwahab PhD , Abdullah Farasani PhD , Hassan Ahmad Alfaifi PhD , Ahmed S. Alamer PhD , Tawfeeq Altherwi MD , Saeed Alshahrani PhD , Ahmad Assiri MD , Waseem Hassan PhD","doi":"10.1016/j.clindermatol.2024.11.004","DOIUrl":"10.1016/j.clindermatol.2024.11.004","url":null,"abstract":"<div><div>This study provides a comprehensive bibliometric analysis of prurigo nodularis (PN) literature, identifying influential studies, key contributors, and emerging trends to understand the evolution of research and guide future investigations. A total of 499 contributions published between 1951 and October 2024, containing the term “prurigo nodularis” in their abstracts, were analyzed. Keyword analysis was conducted to determine the main themes across these publications. Additionally, the top 100 most cited articles on PN from 1979 to 2023 were examined, involving 51 journals. Metrics such as mean total citations per contribution (MeanTCperArt) and mean total citations per year (MeanTCperYear) were calculated for these top 100 articles. The analysis of the top 100 most cited articles revealed contributions from 453 authors. The number of publications, citations, h-index, g-index, m-index, hg composite, and Q2 index were calculated for each author. We have illustrated the dynamics of top authors, universities, and countries, as well as their respective collaboration networks. The thematic evolution of PN research was assessed using coword analysis, followed by a systematic discussion of the findings. This bibliometric analysis provides a comprehensive overview of the key contributors and research trends in PN literature, offering valuable insights for guiding future investigations.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 2","pages":"Pages 231-241"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}