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Hypervitaminosis: The deleterious effects of vitamins on the skin. 维生素过多症：维生素对皮肤的有害影响。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-08 DOI: 10.1016/j.clindermatol.2026.04.011
Maggie Chen, Marcia S Driscoll
{"title":"Hypervitaminosis: The deleterious effects of vitamins on the skin.","authors":"Maggie Chen, Marcia S Driscoll","doi":"10.1016/j.clindermatol.2026.04.011","DOIUrl":"https://doi.org/10.1016/j.clindermatol.2026.04.011","url":null,"abstract":"<p><p>Vitamin supplementation has recently shown a dramatic increase in usage, especially during the COVID-19 pandemic, as a potential aid in preventing, treating, and recovering from infection. In dermatology, vitamin supplements may be used to support the management of a myriad of conditions. A common misconception is that vitamins are safe to consume and that taking more will improve overall health; however, hypervitaminosis may lead to harmful effects. We provide an overview illustrating the use of vitamins A, D, E, niacin, and biotin in dermatology and the potential adverse effects of hypervitaminosis.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sunscreen and Vitamin D. Part II: Sunscreen, SPF and Impact on Vitamin D. 防晒霜和维生素D。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-07 DOI: 10.1016/j.clindermatol.2026.04.007
Lawrence Chukwudi Nwabudike
{"title":"Sunscreen and Vitamin D. Part II: Sunscreen, SPF and Impact on Vitamin D.","authors":"Lawrence Chukwudi Nwabudike","doi":"10.1016/j.clindermatol.2026.04.007","DOIUrl":"10.1016/j.clindermatol.2026.04.007","url":null,"abstract":"<p><p>Sunscreens were available in ancient societies, such as Egypt, Greece, Arabia, and Japan, often to help keep the skin lighter and more fashionable. With the promotion of a tan as a sign of a leisurely, privileged lifestyle came the discovery of the harmful effects of sunlight on the skin. These include skin cancer, discovered by Unna and experimentally confirmed by Findlay, which paved the way for sunscreens to be used as protectors rather than just skin lighteners. The sun protection factor was born out of the recognition of the need to assess the ability of sunscreens to protect against skin damage from the sun. Sunscreens are now widely recognized as part of preventive therapy against skin cancer and several photodermatoses. Especially for protection against the former, the UV protection factor has been developed, which can be seen as the equivalent of the sun protection factor for clothing. Data from experimental and observational studies, which are often controversial, suggest that vitamin D levels may decline with increased sun protection, whether from sunscreens or clothing.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sunscreen and vitamin D: Part I. 防晒霜和维生素D——第一部分。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-07 DOI: 10.1016/j.clindermatol.2026.04.006
Lawrence Chukwudi Nwabudike
{"title":"Sunscreen and vitamin D: Part I.","authors":"Lawrence Chukwudi Nwabudike","doi":"10.1016/j.clindermatol.2026.04.006","DOIUrl":"10.1016/j.clindermatol.2026.04.006","url":null,"abstract":"<p><p>It is so ubiquitous in our medicine drawers, as a supplement and as a therapy, that we hardly give a thought to the process of its discovery. It feels as if we have always had vitamin D. Our early ancestors were thought to have had darkly pigmented skin and to have migrated out of Africa some 70,000 to 60,000 years ago. With their migration, they evolved to have lighter skin, thereby losing some of their sun protection. The rickets epidemic in early industrial Europe prompted the search for its cure, leading to the subsequent discovery of vitamin D and its connection to sunlight. Its discovery (vitamin D is better viewed as a steroid hormone) is a storied one and illustrates the often arduous trial-and-error work that scientists usually undertake to establish a new concept.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skin cancer and vitamins: In theory and practice. 皮肤癌与维生素：理论与实践。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-07 DOI: 10.1016/j.clindermatol.2026.04.005
Uwe Wollina
{"title":"Skin cancer and vitamins: In theory and practice.","authors":"Uwe Wollina","doi":"10.1016/j.clindermatol.2026.04.005","DOIUrl":"10.1016/j.clindermatol.2026.04.005","url":null,"abstract":"<p><p>Skin cancers are common malignant tumors with an increasing incidence worldwide. The major types are cutaneous malignant melanoma and keratinocytic tumors, such as basal cell carcinoma and cutaneous squamous cell carcinoma. The first treatment of choice is complete surgical removal, but nonsurgical treatment options and primary prevention may be requested. Vitamins may play a role in skin cancer prevention, because they are capable of reducing the deteriorating effects of sunlight (UV and visible light and infrared radiation) by scavenging reactive oxygen species. Patients with skin cancer are often undersupplied with certain vitamins such as vitamins C and D. Vitamin deficiency increases the risk for the primary development of skin cancer. Supplementation of certain vitamins supports conventional drug therapy in immunosuppressed patients and in those with advanced tumors under checkpoint inhibitor treatment. Supranormal vitamin C is prooxidative and prevents metastasis in animal models of cutaneous malignant melanoma.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical vitamins: Uses and limitations-part I. 局部维生素：使用和限制-第一部分。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-07 DOI: 10.1016/j.clindermatol.2026.04.009
Partha Mukhopadhyay, Sujata, Mohammed Shafeeqe P
{"title":"Topical vitamins: Uses and limitations-part I.","authors":"Partha Mukhopadhyay, Sujata, Mohammed Shafeeqe P","doi":"10.1016/j.clindermatol.2026.04.009","DOIUrl":"10.1016/j.clindermatol.2026.04.009","url":null,"abstract":"<p><p>Topical formulations of vitamins are increasingly used for dermatologic conditions and cosmetic indications, owing to their anti-inflammatory and antioxidant effects, modulation of cell proliferation and differentiation, wound-healing effects, and moisturizing and photoprotective properties. Apart from well-established uses in psoriasis and acne vulgaris, they are helpful for various new indications, ranging from chemoprevention of cutaneous malignancies to photoaging and wound healing. They are active ingredients in cosmetic products such as moisturizers, serums, sunscreens, and shampoos. Topical formulations of vitamins are usually well tolerated, but their side effects, such as irritation and a burning sensation, can be troublesome. The formulation challenge is a significant limitation, as incorporating the active ingredient into an appropriate vehicle and delivering it to the desired site of action can be complicated for several vitamins. The stability of formulations and varying contradictions may create obstacles to the use of topical vitamins.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamins in pediatric skin: Myths, use, and misuse. 维生素在儿童皮肤：神话，使用和误用。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-04-06 DOI: 10.1016/j.clindermatol.2026.04.003
Bliss Colao, Genevieve Patrick, Sophie Bilik, Michael Joseph Lavery
{"title":"Vitamins in pediatric skin: Myths, use, and misuse.","authors":"Bliss Colao, Genevieve Patrick, Sophie Bilik, Michael Joseph Lavery","doi":"10.1016/j.clindermatol.2026.04.003","DOIUrl":"10.1016/j.clindermatol.2026.04.003","url":null,"abstract":"<p><p>The global use of dietary supplements is on the rise, with many children using nutritional supplements. The misuse of vitamins, whether obtained over-the-counter, reused from previous prescriptions, or used as cosmeceuticals, can pose risks to pediatric patients in dermatology. Proper medical supervision and guidance are crucial to ensure the safe and effective use of vitamins in addressing skin conditions in children. We explore the intricate relationship between vitamin supplements in the realm of dermatology and discuss myths, uses, and misuses of vitamins A, C, D, E, B<sub>1</sub>, B<sub>2</sub>, B<sub>3</sub>, B<sub>5</sub>, B<sub>6</sub>, B<sub>7</sub>, B<sub>9</sub>, and B<sub>12</sub> in the context of pediatrics.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-kosher collagen products for patients practicing Judaism: Addressing religious concerns. 非洁食胶原蛋白产品的患者实践犹太教：解决宗教问题。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-03-28 DOI: 10.1016/j.clindermatol.2026.03.006
Isha Gandhi, Robert Adler, Deena Fayyad, Chase Fishman, John Goncalves, Jessica Lori Feig
{"title":"Non-kosher collagen products for patients practicing Judaism: Addressing religious concerns.","authors":"Isha Gandhi, Robert Adler, Deena Fayyad, Chase Fishman, John Goncalves, Jessica Lori Feig","doi":"10.1016/j.clindermatol.2026.03.006","DOIUrl":"10.1016/j.clindermatol.2026.03.006","url":null,"abstract":"<p><p>Collagen-based therapies have become a driving force in antiaging procedures and wound healing<sup>1</sup>; however, many formulations are derived from porcine or bovine sources that may not meet kosher dietary standards. Even products marketed as \"kosher\" may not satisfy the requirements of halakha (Jewish law) regarding slaughter and supervision.<sup>2</sup> How should dermatologists counsel observant Jewish patients regarding collagen options that align with their faith while ensuring optimal outcomes?</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forensic dermatology and the crime scene investigation (CSI) effect: Are jurors influenced by forensic dermatologic investigations that they view on television, printed media, and the internet? 法医皮肤病学和犯罪现场调查（CSI）效应：陪审员是否受到他们在电视、印刷媒体和互联网上看到的法医皮肤病学调查的影响？
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-03-27 DOI: 10.1016/j.clindermatol.2026.03.007
Philip R Cohen, Jeffrey M Weinberg, Leonard J Hoenig, Lawrence Charles Parish
{"title":"Forensic dermatology and the crime scene investigation (CSI) effect: Are jurors influenced by forensic dermatologic investigations that they view on television, printed media, and the internet?","authors":"Philip R Cohen, Jeffrey M Weinberg, Leonard J Hoenig, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2026.03.007","DOIUrl":"10.1016/j.clindermatol.2026.03.007","url":null,"abstract":"<p><p>The crime scene investigation effect manifests as unrealistic attitudes among jurors based on fictional crime scene cases they have seen on television; jurors are influenced by the accuracy of forensic evidence and the speed with which these televised cases are resolved, and they expect the same standards they observe on television to be upheld in the courtroom. The definition of the crime scene investigation effect can be expanded to include information accessible not only from magazines that are readily available to the public but also from the internet and social media because these sources can provide jurors with unrealistic expectations of a crime scene evaluation similar to those they acquire from television. Forensic dermatology focuses on the evaluation of lesions involving the skin, mucosa, hair, and nails to determine the cause and manner of death in a decedent. In addition, clinical forensic dermatology includes the assessment of living victims of abuse and neglect, human trafficking, and torture. A comparison of real-world circumstances regarding dermatologic information and crime scene dermatologic evidence from other sources that may influence jurors is provided. Evaluation of heavy metal exposure, identification of decedents and suspects based on their tattoos, and microscopic evaluation of tissue specimens from mucocutaneous lesions are potential aspects of forensic dermatology that may lead the jury to unrealistic, preconceived standards based on their exposure to these topics on television, in magazines, and on social media. To minimize the crime scene investigation effect, dermatologists should testify in a clear, concise manner that engages jurors and provides them with relevant, reliable information so they can appropriately evaluate whether a defendant is guilty.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nationwide cross-sectional analysis of pending state legislation related to dermatology. 一项全国范围内与皮肤病学相关的待定州立法的横断面分析。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-03-24 DOI: 10.1016/j.clindermatol.2026.03.005
Timothy Klufas, Ayushya Ajmani, Erik Choi, Danielle M Khalilzadeh, Albert E Zhou, Jane M Grant-Kels
{"title":"A nationwide cross-sectional analysis of pending state legislation related to dermatology.","authors":"Timothy Klufas, Ayushya Ajmani, Erik Choi, Danielle M Khalilzadeh, Albert E Zhou, Jane M Grant-Kels","doi":"10.1016/j.clindermatol.2026.03.005","DOIUrl":"10.1016/j.clindermatol.2026.03.005","url":null,"abstract":"<p><p>State-level legislation is a principle driver of structural change in American health care; yet, physician participation in the policymaking process remains limited. Using the members-only American Academy of Dermatology Association legislative tracker, we conducted a nationwide cross-sectional analysis of 295 dermatology-related state bills through February 14, 2025. The scope of practice (29.5%) and pharmaceutical reform and drug access (25.1%) were the dominant legislative categories. Physician sponsors were involved in only 7.5% of bills compared with 26.8% sponsored by nonphysician health care professionals; the remaining 62.7% had sponsors with no documented health care background. These findings reflect persistent structural forces, scope of practice expansion, and pharmaceutical policy dysfunction that fundamentally shape dermatologic practice. We discuss the clinical implications of these trends, the organized nonmarket competition facing physician interests, and actionable pathways through which dermatologists can meaningfully engage in the legislative process, including through state dermatology societies, SkinPAC, and grassroots advocacy.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Declaration of Independence from a dermatology perspective. 从皮肤病学的角度看独立宣言。
IF 2.2 4区 医学
Clinics in dermatology Pub Date : 2026-03-23 DOI: 10.1016/j.clindermatol.2026.03.004
Leonard J Hoenig, Uwe Wollina, Nick J Levell, Lawrence Charles Parish
{"title":"The Declaration of Independence from a dermatology perspective.","authors":"Leonard J Hoenig, Uwe Wollina, Nick J Levell, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2026.03.004","DOIUrl":"10.1016/j.clindermatol.2026.03.004","url":null,"abstract":"<p><p>This contribution celebrates the 250th Anniversary of the Declaration of Independence by presenting the dermatology-related conditions of five of the signers: Caesar Rodney's nonmelanotic skin cancer, Richard Stockton's lip cancer, Samuel Chase's facial flushing, Benjamin Franklin's psoriasis, and Thomas Jefferson's boils. Also discussed are Benjamin Rush's early description of dengue fever in North America as well as the issue of slavery, in which the color of one's skin determined who was a slave and who was the master.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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