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Prurigo Nodularis. 结节性瘙痒 - 皮肤科临床。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.clindermatol.2025.03.002
Gil Yosipovitch, Sarah G Brooks
{"title":"Prurigo Nodularis.","authors":"Gil Yosipovitch, Sarah G Brooks","doi":"10.1016/j.clindermatol.2025.03.002","DOIUrl":"10.1016/j.clindermatol.2025.03.002","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo nodularis in 2025: Current and emerging treatments. 2025年结节性痒疹：当前和新兴的治疗方法。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-17 DOI: 10.1016/j.clindermatol.2025.03.013
Sarah G Brooks, Gil Yosipovitch
{"title":"Prurigo nodularis in 2025: Current and emerging treatments.","authors":"Sarah G Brooks, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.013","DOIUrl":"10.1016/j.clindermatol.2025.03.013","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is a chronic inflammatory dermatologic condition that is often incredibly itchy and imposes a debilitating burden on patient quality of life. Patients have historically faced the hurdles of limited knowledge regarding the mechanisms underlying PN, physician awareness, and effective therapies. Many of the conventional treatments offer minimal benefit or are accompanied by adverse effects. Over the last several years, striking advancements in the understanding of the pathogenesis contributing to PN have allowed for the development of novel treatments. The first and only medication approved by the US Food and Drug Administration is dupilumab, a biological agent targeting interleukins 4 and 13, has revolutionized management for patients with moderate-to-severe PN. Several other drugs are on the horizon that have the potential to become widely available. This contribution aims to review the current and emerging therapies for PN and address the challenges that may hinder effective treatment.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo nodularis imitators unmasked.
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.003
Elisabeth V Goessinger, Tobias Kliesener, Beda Muehleisen, Oliver Brandt, Simon Mueller
{"title":"Prurigo nodularis imitators unmasked.","authors":"Elisabeth V Goessinger, Tobias Kliesener, Beda Muehleisen, Oliver Brandt, Simon Mueller","doi":"10.1016/j.clindermatol.2025.03.003","DOIUrl":"10.1016/j.clindermatol.2025.03.003","url":null,"abstract":"<p><p>Prurigo nodularis (PN) is characterized by chronic, nodular lesions on the extensor surfaces of the extremities and back. For experienced clinicians, the recognition of this diagnosis is usually not difficult; however, it is essential to consider differential diagnoses and to identify PN imitators. We report five patients with severe chronic pruritus who presented with skin lesions resembling PN. They were treated accordingly but were subsequently diagnosed with a different underlying disease, including nodular marginal zone lymphoma (1 case), delusional parasitosis (1 case), well-differentiated squamous cell carcinomas arising among PN lesions (2 cases), and PN-like pemphigus foliaceus (1 case). Critical reassessment of the diagnosis of PN is important to avoid cognitive biases such as the availability bias, anchoring bias, or attribution bias, which could lead to delayed diagnosis of the actual disease, inappropriate treatment, and poorer outcome.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prurigo nodularis and acquired perforating dermatosis in chronic kidney disease: Are they the same entity? 慢性肾脏疾病的结节性痒疹和获得性穿孔性皮肤病：它们是同一个实体吗？
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.011
Rami H Mahmoud, Giulia Coscarella, Ruby Kwak, Gil Yosipovitch
{"title":"Prurigo nodularis and acquired perforating dermatosis in chronic kidney disease: Are they the same entity?","authors":"Rami H Mahmoud, Giulia Coscarella, Ruby Kwak, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.011","DOIUrl":"10.1016/j.clindermatol.2025.03.011","url":null,"abstract":"<p><p>Prurigo nodularis has been reported in itchy chronic kidney disease (CKD) patients, particularly those with end-stage renal failure. Acquired perforating dermatitis associated with CKD and diabetes is a group of disorders in which dermal materials are eliminated through the epidermis and is characterized by itchy papules and nodules. We focus on the relationship between prurigo nodularis and acquired perforating dermatitis in CKD and provide data to support that both entities share many of the same clinical and histologic features. These cutaneous diseases are often underreported in this patient population, leading to inadequate treatment and suboptimal patient outcomes. Our review of the literature suggests a relationship between prurigo nodularis/acquired perforating dermatitis and CKD, presumably driven by uremic pruritus, changes in the renin-angiotensin-aldosterone system, a predisposing immune dysregulation with increased interleukin-31 expression, and opioid system imbalances. A variety of pharmacologic therapies may be efficacious. The use of the new targeted biologics for prurigo nodularis and whether they are also helpful for CKD and acquired perforating dermatitis are welcome.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving evidence in the neural sensitization of prurigo nodularis. 结节性痒疹神经致敏的新证据。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-15 DOI: 10.1016/j.clindermatol.2025.03.008
Sarah G Brooks, Gil Yosipovitch
{"title":"Evolving evidence in the neural sensitization of prurigo nodularis.","authors":"Sarah G Brooks, Gil Yosipovitch","doi":"10.1016/j.clindermatol.2025.03.008","DOIUrl":"10.1016/j.clindermatol.2025.03.008","url":null,"abstract":"<p><p>Prurigo nodularis is a chronic inflammatory skin disorder characterized by relentlessly pruritic, hyperkeratotic nodules. Recent studies have provided compelling evidence for the pivotal role of dysregulated interactions between the nervous and immune systems in its pathogenesis. This article reviews the latest findings on the neurogenic mechanisms contributing to prurigo nodularis, particularly how these processes lead to the sensation of increased itch intensity. Peripheral sensitization is primarily driven by abnormal innervation of histamine-independent, small unmyelinated C fibers, epidermal hypoplasia, and dermal hyperinnervation. This sensitization is further amplified by the cyclic release of neuropeptides such as Substance P, calcitonin gene-related peptide, and nerve growth factor. Although the mechanisms underlying central sensitization in prurigo nodularis remain less understood, it likely involves enhanced itch signaling in the dorsal spinal cord or a lowered threshold for itch perception. Additionally, parallels between pruritus and pain-such as allodynia and alloknesis, as well as hyperalgesia and hyperknesis-along with the association of prurigo nodularis with various comorbid systemic conditions, offer valuable insights into the disorder's pathology. A deeper understanding of the complex neural sensitization mechanisms in prurigo nodularis may lead to the identification of novel therapeutic targets, ultimately alleviating the burden of this debilitating condition.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xerosis cutis and wounded skin in modern art: Two works by Alberto Burri. 现代艺术中的皮肤干燥症和受伤的皮肤：阿尔贝托-布里的两幅作品
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-14 DOI: 10.1016/j.clindermatol.2025.03.001
Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish
{"title":"Xerosis cutis and wounded skin in modern art: Two works by Alberto Burri.","authors":"Uwe Wollina, Leonhard J Hoenig, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2025.03.001","DOIUrl":"10.1016/j.clindermatol.2025.03.001","url":null,"abstract":"<p><p> The human skin has been a subject of medicine and art. The interest in the interaction of skin and the inner body had increased after the establishment of anatomy as a science long before dermatology was acknowledged as a medical discipline. In painting the body surface, the Inkarnat (flesh tone) represents a mixture of the superficial epidermis and dermis, plus the deeper musculature and vasculature, each contributing to the skin color. In the fine arts of the Renaissance, skin is understood as primarily a layer of material. The human skin can express feelings, emotions, and various states of mind. We analyze two works of the Italian artist Alberto Burri (1915-1995), who painted in the postwar period. He opens a window into human existence with his materials while showing tragedies and wounds.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and management of prurigo nodularis in skin of color patients. 有色皮肤结节性痒疹的诊断与治疗。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-14 DOI: 10.1016/j.clindermatol.2025.03.004
Akash Rau, Danyelle Dawes
{"title":"Diagnosis and management of prurigo nodularis in skin of color patients.","authors":"Akash Rau, Danyelle Dawes","doi":"10.1016/j.clindermatol.2025.03.004","DOIUrl":"10.1016/j.clindermatol.2025.03.004","url":null,"abstract":"<p><p>Prurigo nodularis is a chronic, intensely pruritic eruption that results in excoriated papules, mostly on the extensor surfaces of the arms and legs. Previous studies have indicated that the condition disproportionally affects those of African descent. Although the etiology has not been fully elucidated, patients with prurigo nodularis have been found to have associated comorbidities such as hypertension, renal disease, and HIV infection. This review covers the principles of work-up and diagnosis of prurigo nodularis in skin of color patients as well as management considerations in this population.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional magnetic resonance imaging in prurigo nodularis: A call to study neural sensitization phenomena. 结节性痒疹的功能磁共振成像：系统综述。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-14 DOI: 10.1016/j.clindermatol.2025.03.005
Xuanyu Zhao, Jannis M Mueller, Simon M Mueller
{"title":"Functional magnetic resonance imaging in prurigo nodularis: A call to study neural sensitization phenomena.","authors":"Xuanyu Zhao, Jannis M Mueller, Simon M Mueller","doi":"10.1016/j.clindermatol.2025.03.005","DOIUrl":"10.1016/j.clindermatol.2025.03.005","url":null,"abstract":"<p><p>Prurigo nodularis is a chronic pruritic, inflammatory skin condition characterized by nodular skin lesions in a typical distribution pattern caused by various dermatologic and/or nondermatologic conditions. In recent years, significant advances have been made in the understanding of the cutaneous pathophysiology of prurigo nodularis, resulting in novel treatment options such as interleukin-4, -13, -17, and -31 or Janus kinase inhibitors. Many aspects of the neurophysiology are largely unknown, including the processing in the central structural and functional network involved in prurigo nodularis. Functional neuroimaging allows noninvasive assessment of brain function and structure. Due to its high spatial resolution and temporal precision, functional magnetic resonance imaging has proven to be a suitable method for exploring neural mechanisms and assessing pharmacologic effects in dermatologic research. In this systematic review, the current knowledge of functional magnetic resonance imaging in the context of prurigo nodularis and its centrally active treatment options is summarized.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New definitions and subtypes of chronic prurigo. 慢性痒疹的新定义和亚型。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-14 DOI: 10.1016/j.clindermatol.2025.03.009
Lea Sophie Stahl, Sonja Ständer, Claudia Zeidler
{"title":"New definitions and subtypes of chronic prurigo.","authors":"Lea Sophie Stahl, Sonja Ständer, Claudia Zeidler","doi":"10.1016/j.clindermatol.2025.03.009","DOIUrl":"10.1016/j.clindermatol.2025.03.009","url":null,"abstract":"<p><p>During the past few years, chronic prurigo, including prurigo nodularis, has become a focal point of considerable research attention, resulting in enhanced insights into this condition. For over two centuries, the term \"prurigo\" has been used in dermatology, often applied loosely to describe a range of pruritic, papulous conditions lacking clear diagnostic criteria. In 2017, the term \"chronic prurigo\" was introduced, delineating chronic prurigo, including prurigo nodularis, as a distinct disease entity characterized by chronic pruritus, a characteristic clinical history, and physical signs such as excoriations and the presence of pruriginous lesions. Pruriginous lesions exhibit diverse morphologies, encompassing papules (diameter < 1 cm), nodules (diameter > 1 cm), plaques, and umbilicated or linear lesions. The co-occurrence of multiple lesion types in an individual is frequently observed. The subtype and severity of chronic prurigo can be categorized on the basis of the type or number of pruriginous lesions.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to “Persian contributions to dermatology” [Clin Dermatol 2024:42 515-516] 对“波斯人对皮肤病学的贡献”的勘误[临床皮肤病学杂志，2014:42 515-516]。
IF 2.3 4区 医学
Clinics in dermatology Pub Date : 2025-03-01 DOI: 10.1016/j.clindermatol.2025.01.007
Mohamad Goldust MD , Marina Landau MD , Jane M. Grant-Kels MD
{"title":"Erratum to “Persian contributions to dermatology” [Clin Dermatol 2024:42 515-516]","authors":"Mohamad Goldust MD ,&nbsp;Marina Landau MD ,&nbsp;Jane M. Grant-Kels MD","doi":"10.1016/j.clindermatol.2025.01.007","DOIUrl":"10.1016/j.clindermatol.2025.01.007","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"43 2","pages":"Page 300"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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