{"title":"Response to “Kaspar Hauser, the Child of Europe: Are smallpox vaccination scars the clue to a 2-century-old mystery?”","authors":"D. Pfründer MD","doi":"10.1016/j.clindermatol.2024.06.006","DOIUrl":"10.1016/j.clindermatol.2024.06.006","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 673-674"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad Goldust MD , Marina Landau MD , Jane M. Grant-Kels MD
{"title":"Transforming dermatology through artificial intelligence and the Metaverse","authors":"Mohamad Goldust MD , Marina Landau MD , Jane M. Grant-Kels MD","doi":"10.1016/j.clindermatol.2024.08.002","DOIUrl":"10.1016/j.clindermatol.2024.08.002","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 683-684"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harrison Zhu BSA , Kritin K. Verma BS, MBA , Katherine Holder MD , Stephen K. Tyring MD, PhD, MBA
{"title":"Prevalence of tobacco use in patients with autoimmune blistering diseases: A nationwide, cross-sectional study","authors":"Harrison Zhu BSA , Kritin K. Verma BS, MBA , Katherine Holder MD , Stephen K. Tyring MD, PhD, MBA","doi":"10.1016/j.clindermatol.2024.08.003","DOIUrl":"10.1016/j.clindermatol.2024.08.003","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 680-682"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen Foong Tan AdvMDerm, Suganthy Robinson AdvMDerm, Min Moon Tang AdvMDerm, Malaysian Psoriasis Registry Working Group
{"title":"Psoriatic nail involvement in Malaysia: A 14-year registry review (2007-2020)","authors":"Wen Foong Tan AdvMDerm, Suganthy Robinson AdvMDerm, Min Moon Tang AdvMDerm, Malaysian Psoriasis Registry Working Group","doi":"10.1016/j.clindermatol.2024.09.017","DOIUrl":"10.1016/j.clindermatol.2024.09.017","url":null,"abstract":"<div><div>Nail psoriasis affects 20% to 30% of psoriasis patients and is an early predictor of psoriatic arthritis (PsA). We evaluated the prevalence, clinical characteristics, and impact on quality of life of patients with nail psoriasis. We conducted a multicenter retrospective cohort study of patients registered with The Malaysian Psoriasis Registry from January 1, 2007 to December 31, 2020. Of the 24,147 patients, 13,081 (54.2%) had nail psoriasis. Patients with nail psoriasis had later onset of psoriasis (34.0 ± 16.6 years vs 32.9 ± 17.6 years, <em>P</em> < .001) and longer disease duration (11.4 ± 10.5 years vs 8.5 ± 9.4 years, <em>P</em> < .01), with a man-to-woman ratio of 1.2:1. They were more likely to have a family history of psoriasis, cardiometabolic diseases, smoking history, higher body mass index, severe disease, PsA, face and scalp involvement, and higher mean Dermatology Life Quality Index scores (9.36 ± 6.84 vs 8.87 ± 6.60). Systemic treatment and biologics were more commonly prescribed in this cohort (25.0% vs 13.2%, <em>P</em> < .001). Overall, 54.2% of the Malaysian Psoriasis Registry patients had nail involvement. Nail psoriasis was associated with longer duration of psoriasis, older age of onset, male sex, and a family history of psoriasis. It proved to be an important predictor for PsA, severe psoriasis, face and scalp involvement, increased cardiometabolic risk, and a greater impairment of quality of life.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 616-624"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albert E. Zhou MD, PhD , Nathan Gasek BS , Christian Gronbeck MD , Brett Sloan MD , Hao Feng MD, MHS , Jane M. Grant-Kels MD
{"title":"Screened out: Ethically managing sunscreen misinformation by social media influencers","authors":"Albert E. Zhou MD, PhD , Nathan Gasek BS , Christian Gronbeck MD , Brett Sloan MD , Hao Feng MD, MHS , Jane M. Grant-Kels MD","doi":"10.1016/j.clindermatol.2024.07.013","DOIUrl":"10.1016/j.clindermatol.2024.07.013","url":null,"abstract":"<div><div>Rampant social media use allows individuals and organizations to broadcast their views to scoping audiences with minimal requirements for vetting or validating shared information. We discuss the impact of disinformation transmitted via social media and use the recent example of false information broadcast concerning sunscreens recently reported in the <em>Wall Street Journal</em>. We also highlight the ethical consequences of social media influencers who disseminate unchecked information and the need for health care professionals to be involved to enhance accountability, goodwill, and truthfulness.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 736-738"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Landau MD , Jerome Klein MD , Frank Rosengaus Leizgold MD , George Kroumpouzos MDPhD
{"title":"Rare and novel complications of botulinum neurotoxin type A and dermal filler injections","authors":"Marina Landau MD , Jerome Klein MD , Frank Rosengaus Leizgold MD , George Kroumpouzos MDPhD","doi":"10.1016/j.clindermatol.2024.06.023","DOIUrl":"10.1016/j.clindermatol.2024.06.023","url":null,"abstract":"<div><div>Botulinum neurotoxin type A (BoNTA) and filler injection procedures usually provide predicted outcomes with a low incidence of complications. Most of the complications after these procedures have been extensively discussed. In this study, we report on these injectables’ less well-known, recently reported, and novel complications and attempt to clarify the underlying mechanisms. Counterfeit or mishandled BoNTA has been associated with botulism. BoNTA has been linked to uncommon complications, including morphea-like lesions, nontuberculous mycobacterial infections, vascular occlusion, and pseudoaneurysm of the superficial temporal artery. Unusual complications from filler injection include nonscarring alopecia, intraoral necrosis, nontuberculous mycobacterial infections, xanthelasma-like reactions, intracranial perforation, and pneumosinus dilatans. Post-BoNTA injection nodules and filler infection from bone destruction due to cocaine use are new complications. These complications pose a challenge for diagnosis and treatment. This publication aims to assist in promptly identifying and managing these rare and novel complications when necessary.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 701-708"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cynthia M. Magro MD , Carla Stephan MD , Taylor Kalomeris DO
{"title":"The utility of the normal thin section skin biopsy in the assessment of systemic/extracutaneous disease and small fiber neuropathy","authors":"Cynthia M. Magro MD , Carla Stephan MD , Taylor Kalomeris DO","doi":"10.1016/j.clindermatol.2024.09.020","DOIUrl":"10.1016/j.clindermatol.2024.09.020","url":null,"abstract":"<div><div>Diseases reflective of multiorgan vascular injury of diverse etiology, peripheral nerve disease, dysautonomia syndromes, and intravascular lymphoma may exhibit abnormalities on a normal skin biopsy that may be instrumental in establishing a diagnosis. A retrospective review of our database was conducted to uncover cases where a normal skin biopsy was performed to rule in or out such systemic diseases as complement-driven thrombotic microvascular disease (including atypical hemolytic uremic syndrome, posttransplant thrombotic microangiopathy, and severe or critical COVID-19), systemic capillary leak syndrome, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) intravascular B cell lymphoma, small fiber neuropathy, dysautonomia syndromes, and mast cell activation syndrome. Among the special studies were immunohistochemical staining to detect C5b-9, CD56, and myxovirus resistance protein A, as well as mast cell, B and T cell markers. Characteristic patterns were critical in establishing diagnoses such as : increased C5b-9 microvascular deposition in the deltoid area (atypical hemolytic uremic syndrome, posttransplant thrombotic microangiopathy, catastrophic antiphospholipid antibody syndrome, and severe or critical COVID-19); enhanced type I interferon signaling (systemic capillary leak syndrome); ultrastructural arteriopathic changes (CADASIL); reduced cutaneous autonomic innervation in the lower extremities (small fiber neuropathy and postural orthostatic tachycardia syndrome); presence of intravascular lymphocytes on biopsy of abdominal, thigh, and buttock skin (intravascular B cell lymphoma); and a higher than normal density of mast cells in the absence of other inflammatory cell types (mast cell activation syndrome). The skin is clearly a critical window for understanding extracutaneous disease, a concept well exemplified by the myriad of diseases suggested by the microscopic and/or ultrastructural examination of clinically normal skin and therefore establishing the normal skin biopsy as an important tool for understanding certain extracutaneous reactive, neoplastic and paraneoplastic syndromes as well as small fiber neuropathy.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 646-667"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uncommon neoplasms mistakenly diagnosed as hidradenitis suppurativa: Report of three consecutive cases","authors":"Valentina Caputo MD , Antonella Citterio MD , Franco Rongioletti MD","doi":"10.1016/j.clindermatol.2024.09.019","DOIUrl":"10.1016/j.clindermatol.2024.09.019","url":null,"abstract":"<div><div>Hidradenitis suppurativa (HS) poses diagnostic challenges due to its clinical overlap with various skin conditions and neoplasms, potentially leading to misdiagnoses. The absence of a definitive diagnostic test and infrequent use of histopathology contribute to diagnostic complexities, exacerbated by the recent increased focus on HS. Three cases initially diagnosed and treated as HS underwent clinical work-up and skin biopsies to resolve diagnostic complexities. Initially labeled as HS, the cases revealed a breast carcinoma on axillary ectopic tissue, a cutaneous gamma-delta T-cell lymphoma, and an infiltrating squamous cell carcinoma. Delayed recognition led to misguided therapies and adverse outcomes. This report stresses the need to explore alternative diagnoses for chronic skin nodules with or without ulcerations on the flexures. Timely skin biopsies are crucial for accurate diagnoses. Ongoing clinician education is essential to avoid misdiagnosis in challenging cases, in which histopathology aids in reaching a correct diagnosis.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 641-645"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waseem Hassan PhD , Mehreen Zafar MPhil , Antonia Eliene Duarte PhD , Siddig Ibrahim Abdelwahab PhD , Abdullah Farasani PhD , Ahmad Assiri MD
{"title":"Forty years of Clinics in Dermatology","authors":"Waseem Hassan PhD , Mehreen Zafar MPhil , Antonia Eliene Duarte PhD , Siddig Ibrahim Abdelwahab PhD , Abdullah Farasani PhD , Ahmad Assiri MD","doi":"10.1016/j.clindermatol.2024.09.028","DOIUrl":"10.1016/j.clindermatol.2024.09.028","url":null,"abstract":"<div><div>In 2023, <em>Clinics in Dermatology</em> marked its 40th anniversary, celebrating a remarkable journey of excellence since its inception in 1983. Led by its founding editor, Dr Lawrence Charles Parish, the journal has consistently delivered cutting-edge research and clinical insights, becoming a cornerstone resource in dermatology. The journal has published 3,667 documents. In all publications, 4,311 authors from 4,248 departments and 78 countries played a pivotal role. We provided data about the total number of publications and citations for each contributor (author, department, and country). By coword analysis, we presented the central theme of publications, which may offer a nuanced understanding of <em>Clinics in Dermatology</em>’s diverse and influential contributions to dermatologic science.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 566-569"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}