Clinics in dermatology最新文献_第4页

Reframing psoriasis therapy: Tyrosine kinase 2 inhibition and the erosion of the oral-biologic divide 重塑银屑病治疗：TYK2抑制和口腔-生物分界线的侵蚀。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.clindermatol.2026.01.008

Sophia Ma BS , Tarek Zieneldien BS , Ali Aljassabi PharmD , Jane M. Grant-Kels MD

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Skin against time: “Old Women” and “The Young” by Goya 戈雅的《对抗时间的皮肤：老年妇女和年轻人》。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-01-06 DOI: 10.1016/j.clindermatol.2026.01.001

Bladimir Rodríguez-Lechtig MD , Adriana Motta MD

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The insight that went unnoticed: Nikolai Ivanovich Lunin (1853-1937) and research on some indispensable substance of nutrition 被忽视的洞察力：尼古拉·伊万诺维奇·鲁宁（1853 - 1937）和对一些不可或缺的营养物质的研究。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.clindermatol.2026.02.004

Amiya Kumar Mukhopadhyay MD, PhD, DNB (Derm), DNB (Derm & Vener), MNAMS

{"title":"The insight that went unnoticed: Nikolai Ivanovich Lunin (1853-1937) and research on some indispensable substance of nutrition","authors":"Amiya Kumar Mukhopadhyay MD, PhD, DNB (Derm), DNB (Derm & Vener), MNAMS","doi":"10.1016/j.clindermatol.2026.02.004","DOIUrl":"10.1016/j.clindermatol.2026.02.004","url":null,"abstract":"<div><div>Before the 18th century, many authorities expressed their individual opinions on how food helps maintain health. By the end of the 18th century, the First Chemical Revolution had examined all existing and new ideas from a fresh perspective. Foods were subjected to chemical analysis. Among the various scientists, Jean Baptiste André Dumas voiced his doubts about the nutritional value of artificially milk made to counter the shortage during the Siege of Paris (1870-1871). The traditional idea of five essential factors—namely carbohydrates, proteins, fats, salts (or minerals), and water—was also questioned. Josef Forster was the first to test the significance of minerals in nutrition and concluded that a certain critical amount of inorganic salts is needed to maintain nutrition. Gustav von Bunge, an influential scientist, criticized Forster’s observations and instructed his student Nikolai Ivanovich Lunin to investigate the idea. Lunin conducted methodical research and found that even if the artificial combination of all the nutritive factors present in milk was insufficient for complete nutrition, there must be some ‘indispensable substance’ necessary to complete the matter. This was the first experiment that initiated vitamin research. This work was not pursued further, and Nikolai Lunin’s groundbreaking contribution went unnoticed for decades.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"44 2","pages":"Pages 205-211"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Vitamin K in dermatology 皮肤病学中的维生素K。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.clindermatol.2026.02.010

Monika Bapna BS , Min Deng MD

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Vitamin D in dermatology 皮肤病学中的维生素D。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.clindermatol.2026.02.008

Dana Maria Khoury MD, Abdul-Ghani Kibbi MD

{"title":"Vitamin D in dermatology","authors":"Dana Maria Khoury MD, Abdul-Ghani Kibbi MD","doi":"10.1016/j.clindermatol.2026.02.008","DOIUrl":"10.1016/j.clindermatol.2026.02.008","url":null,"abstract":"<div><div>The fundamental role of vitamin D in health and disease is constantly expanding. The major sources of the “sunshine vitamin” are sunlight exposure with subsequent cutaneous synthesis and oral intake in the form of supplementation or dietary consumption. Not only crucial for skeletal health, vitamin D is also linked to numerous disorders of cardiovascular, neurologic, reproductive, infectious, autoimmune, and dermatologic origins. It is a pleiotropic fat-soluble hormone that affects key factors in the pathogenesis of numerous cutaneous disorders because of its effects on the innate and adaptive immune systems and the physiology of the skin, including the integrity of the epidermal barrier. Thus, it is implicated in the development and severity of many dermatoses. Vitamin D status is dependent on numerous modifiable and nonmodifiable factors including Fitzpatrick skin type, sun exposure, sex, body mass index, physical activity, alcohol intake, season, and latitude, in addition to polymorphisms in the vitamin D receptor. In view of increasing knowledge about the overall benefits of vitamin D, it now seems necessary to focus on reaching and maintaining an optimal vitamin D status. This article will discuss the potential determinants as well as the advantages of adequate vitamin D levels, with a special focus on the skin.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"44 2","pages":"Pages 248-256"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cover 2 - Editorial Board with barcode 封面二-编委会附条码

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-03-28 DOI: 10.1016/S0738-081X(26)00073-8

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Natura sanat—nature heals—Dr Heinrich Lahmann and his physiatric sanatorium 自然疗养院-自然治疗-海因里希·拉赫曼博士和他的理疗疗养院。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2025-09-27 DOI: 10.1016/j.clindermatol.2025.09.015

Uwe Wollina MD , Leonard J. Hoenig MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)

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Red marble and the art for peace: An example from the Great Northern Wars (1700-1772) 红色大理石与和平艺术。以北方大战争（1700-1772）为例。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2025-10-28 DOI: 10.1016/j.clindermatol.2025.10.007

Uwe Wollina MD , Andreas Nowak MD , Leonard J. Hoenig MD , Lawrence Charles Parish MD, MD (Hon), FRCP (Edin)

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Vitamins and hair: Sham or science? 维生素和头发：假的还是科学的？

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.clindermatol.2026.02.011

Advaitaa Ravipati MS, Antonella Tosti MD

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Platelet-rich plasma in the management of genital lichen sclerosus: A review of mechanisms, evidence, and future directions 富血小板血浆治疗生殖器硬化地衣：机制、证据和未来发展方向综述。

IF 2.2 4区医学

Clinics in dermatology Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.clindermatol.2026.02.001

Ayman El Attar MD , Carolyn DeLucia MD , Marina Landau MD , George Kroumpouzos MD, PhD

{"title":"Platelet-rich plasma in the management of genital lichen sclerosus: A review of mechanisms, evidence, and future directions","authors":"Ayman El Attar MD , Carolyn DeLucia MD , Marina Landau MD , George Kroumpouzos MD, PhD","doi":"10.1016/j.clindermatol.2026.02.001","DOIUrl":"10.1016/j.clindermatol.2026.02.001","url":null,"abstract":"<div><div>Lichen sclerosus (LS) is a chronic, relapsing, inflammatory skin condition that primarily affects the anogenital region. Treatment with potent topical corticosteroids (TCS) can help control symptoms for many patients, but complications such as atrophy and scarring often persist. Platelet‐rich plasma (PRP) has emerged as a regenerative therapy with potential application in LS. We review the clinical evidence and highlight gaps and future research needs. We searched PubMed and Web of Science databases for studies of PRP in LS. The outcomes evaluated included symptom relief, quality of life (QoL), tissue repair, and safety. The evidence regarding PRP monotherapy includes one randomized controlled trial, 11 single-arm studies, one case series, and one case report. Four studies included PRP combined with other regenerative therapies such as adipose-derived stem cells. Most studies reported benefits in symptomatic relief, sexual function, vaginal health, tissue quality, and QoL after PRP therapy. PRP appeared to work effectively alongside other regenerative treatments. The evidence is limited due to small sample sizes, lack of control groups, short follow‐up periods, inconsistent objective measures of treatment efficacy, variability in PRP preparation and injection protocols, limited use of objective endpoints, and a lack of standardized outcome measures. The safety profile of PRP appears favorable. In conclusion, PRP can serve as an adjuvant therapy for genital LS in patients who do not respond to TCS treatment or when such treatment is discontinued. More rigorous studies are needed nonetheless. The potential of combining PRP with other regenerative therapies warrants further investigation.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"44 2","pages":"Pages 356-362"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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